List of works - Roger L. Williams

A Role for the ESCRT System in Cell Division in Archaea

scientific article

A computer method for scanning and analysis of dot blots

scientific article

Ab initio self-consistent field and potential-dependent partial equalization of orbital electronegativity calculations of hydration properties of N-acetyl-N'-methyl-alanineamide

scientific article

Activation of GCN2 by the ribosomal P-stalk

scientific article published on 25 February 2019

Allosteric activation of PI3Kα by oncogenic mutations.

scientific article published in February 2013

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

scientific article published on 01 October 2019

Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

scientific article

C2 domain conformational changes in phospholipase C-delta 1

scientific article

Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically.

scientific article published in July 1998

Connecting with an old partner in a new way.

scientific article published in May 2013

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

scientific article

Crystal structure of Myxococcus xanthus nucleoside diphosphate kinase and its interaction with a nucleotide substrate at 2.0 A resolution

scientific article

Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2

scientific article published in January 1998

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

scientific article

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA ⬇️

scientific article (publication date: July 1993)

Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 A: evidence for conformational lability

scientific article

Crystallization and preliminary X-ray diffraction analysis of oucleoside diphosphate kinase from Myxococcus xanthus

scientific article

Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract x-rays to 3.5-A resolution

scientific article published on December 1991

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity

scientific article

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).

scientific article

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α

scientific article

ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.

scientific article

ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes

scientific article

Empirical solvation models can be used to differentiate native from near-native conformations of bovine pancreatic trypsin inhibitor

scientific article

Empirical solvation models in the context of conformational energy searches: application to bovine pancreatic trypsin inhibitor

scientific article

Evolution and assembly of ESCRTs.

scientific article

Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor

scientific article published on 03 August 2010

Form and flexibility in phosphoinositide 3-kinases

scientific article

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness

scientific article published on 04 December 2012

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils

scientific article published on 03 November 2020

Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology

scientific article published on 25 September 2019

Kinases charging to the membrane

scientific article published on 01 December 2010

Mammalian phosphoinositide-specific phospholipase C.

scientific article

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

scientific article

Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

scientific article published on 30 June 2020

Membrane trafficking: Arls squeeze the fat out

scientific article published on 15 November 2011

Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry.

scientific article published in January 2016

Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division

scientific article

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

scientific article

Nm23/nucleoside diphosphate kinase: toward a structural and biochemical understanding of its biological functions

scientific article

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

scientific article

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

scientific article published on 10 December 2021

PI3Kβ downstream of GPCRs - crucial partners in oncogenesis.

scientific article published in December 2012

PIKKs--the solenoid nest where partners and kinases meet

scientific article

PTEN regulates cilia through Dishevelled ⬇️

scientific article

Phosphoinositide 3-kinases as drug targets in cancer

scientific article

Phosphoinositide-Specific Phospholipase C δ1 Activity toward Micellar Substrates, Inositol 1,2-Cyclic Phosphate, and Other Water-Soluble Substrates: A Sequential Mechanism and Allosteric Activation ⬇️

scientific article published on September 16, 1997

Phospholipase C delta 1 requires a pleckstrin homology domain for interaction with the plasma membrane

scientific article

Propidium binding to a ribonuclease-DNA complex: X-ray and fluorescence studies.

scientific article

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

article published in the Proceedings of the National Academy of Sciences of the United States of America

Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing

scientific article published on 29 November 2017

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway

scientific article published on April 2016

Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases

scientific article

Replacements of single basic amino acids in the pleckstrin homology domain of phospholipase C-delta1 alter the ligand binding, phospholipase activity, and interaction with the plasma membrane

scientific article

Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific diabody

scientific article

Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi

scientific article published on 29 June 2016

Structural Mechanisms of PTEN Regulation

scientific article published on 02 March 2020

Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C

scientific article published on 01 January 1998

Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.

scientific article

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α

scientific article

Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus

scientific article

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases

scientific article published on 18 October 2011

Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4

scientific article

Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta

scientific article

Structural insight into the ESCRT-I/-II link and its role in MVB trafficking

scientific article

Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins.

scientific article

Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C

scientific article

Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication.

scientific article published on June 2006

Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies.

scientific article published on January 2007

Structural views of phosphoinositide-specific phospholipase C: signalling the way ahead

scientific article

Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.

scientific article published on September 2008

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

scientific article

Structure of HIV-1 reverse transcriptase/DNA complex at 7 A resolution showing active site locations

scientific article published in May 1992

Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase

scientific article

Structure of a ribonuclease B+d(pA)4 complex

scientific article

Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectors

scientific article

Structures of closed and open conformations of dimeric human ATM

scientific article (publication date: May 2017)

Synergy in activating class I PI3Ks

scientific article published on 05 January 2015

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

scientific article

The 2.0-A resolution crystal structure of a trimeric antibody fragment with noncognate VH-VL domain pairs shows a rearrangement of VH CDR3

scientific article

The Crystal Structure of Human Nucleoside Diphosphate Kinase, NM23-H2 ⬇️

scientific article published on August 25, 1995

The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain

scientific article

The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate

scientific article

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

scientific journal article

The intrinsic helix-forming tendency of L-alanine

scientific article published on August 1992

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

scientific article

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

scientific article published on 21 November 2019

The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase

scientific article

The structural basis for mTOR function

scientific article published on 05 October 2014

The structure of a tunicate C-type lectin from Polyandrocarpa misakiensis complexed with D -galactose

scientific article

Tor forms a dimer through an N-terminal helical solenoid with a complex topology.

scientific article

Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS

scientific article

Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11

scientific article

Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi

scientific article published on 4 August 2013

[Roles of ESCRT complexes in the MVB pathway]

scientific article published on 01 December 2008

List of works by Roger L. Williams

A Role for the ESCRT System in Cell Division in Archaea

A computer method for scanning and analysis of dot blots

Ab initio self-consistent field and potential-dependent partial equalization of orbital electronegativity calculations of hydration properties of N-acetyl-N'-methyl-alanineamide

Activation of GCN2 by the ribosomal P-stalk

Allosteric activation of PI3Kα by oncogenic mutations.

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

C2 domain conformational changes in phospholipase C-delta 1

Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically.

Connecting with an old partner in a new way.

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

Crystal structure of Myxococcus xanthus nucleoside diphosphate kinase and its interaction with a nucleotide substrate at 2.0 A resolution

Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA ⬇️

Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 A: evidence for conformational lability

Crystallization and preliminary X-ray diffraction analysis of oucleoside diphosphate kinase from Myxococcus xanthus

Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract x-rays to 3.5-A resolution

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α

ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.

ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes

Empirical solvation models can be used to differentiate native from near-native conformations of bovine pancreatic trypsin inhibitor

Empirical solvation models in the context of conformational energy searches: application to bovine pancreatic trypsin inhibitor

Evolution and assembly of ESCRTs.

Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor

Form and flexibility in phosphoinositide 3-kinases

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness

Guidelines for the use and interpretation of assays for monitoring autophagy

Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils

Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology

Kinases charging to the membrane

Mammalian phosphoinositide-specific phospholipase C.

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

Membrane trafficking: Arls squeeze the fat out

Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry.

Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

Nm23/nucleoside diphosphate kinase: toward a structural and biochemical understanding of its biological functions

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

PI3Kβ downstream of GPCRs - crucial partners in oncogenesis.

PIKKs--the solenoid nest where partners and kinases meet

PTEN regulates cilia through Dishevelled ⬇️

Phosphoinositide 3-kinases as drug targets in cancer

Phosphoinositide-Specific Phospholipase C δ1 Activity toward Micellar Substrates, Inositol 1,2-Cyclic Phosphate, and Other Water-Soluble Substrates: A Sequential Mechanism and Allosteric Activation ⬇️

Phospholipase C delta 1 requires a pleckstrin homology domain for interaction with the plasma membrane

Propidium binding to a ribonuclease-DNA complex: X-ray and fluorescence studies.

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway

Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases

Replacements of single basic amino acids in the pleckstrin homology domain of phospholipase C-delta1 alter the ligand binding, phospholipase activity, and interaction with the plasma membrane

Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific diabody

Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi

Structural Mechanisms of PTEN Regulation

Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C

Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α

Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases

Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4

Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta

Structural insight into the ESCRT-I/-II link and its role in MVB trafficking

Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins.

Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C

Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication.

Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies.

Structural views of phosphoinositide-specific phospholipase C: signalling the way ahead

Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

Structure of HIV-1 reverse transcriptase/DNA complex at 7 A resolution showing active site locations

Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase

Structure of a ribonuclease B+d(pA)4 complex

Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectors

Structures of closed and open conformations of dimeric human ATM

Synergy in activating class I PI3Ks