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List of works by Andrew N. J. McKenzie

A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity

scientific article

A critical role of SHP-1 in regulation of type 2 inflammation in the lung

scientific article published on 23 October 2008

A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells

scientific article published on 24 April 2015

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome

scientific article

A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.

scientific article published on 09 December 2013

A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

scientific article published on 27 June 2019

Advances in the 5q- syndrome

scientific article published on 23 August 2010

An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers.

scientific article

An essential role for IL-13 in maintaining a non-healing response following Leishmania mexicana infection

scientific article published in October 2002

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation

Bcl11b is essential for group 2 innate lymphoid cell development

scientific article published on 11 May 2015

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

scientific article published on 07 June 2021

Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma

scientific article published on 24 September 2007

Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13 ⬇️

scientific article published on April 27, 2012

C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide

scientific article published on 03 February 2010

CD1a presentation of endogenous antigens by group 2 innate lymphoid cells.

scientific article published in December 2017

Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells

scientific article

Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease

scientific article published on 14 April 2008

Complete inhibition of allergic airway inflammation and remodelling in quadruple IL-4/5/9/13-/- mice.

scientific article published in October 2007

Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice.

scientific article published on 28 October 2013

Decoy receptors in the regulation of T helper cell type 2 responses

scientific article published on March 2003

Demonstrating the utility of a drought termination framework: prospects for groundwater level recovery in England and Wales in 2018 or beyond

article

Direct control of hepatic glucose production by interleukin-13 in mice.

scientific article

Eotaxin expression by epithelial cells and plasma cells in chronic asthma

scientific article published on 01 April 2002

Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population.

scientific article

Erratum to: Single cell analysis of CD4+ T cell differentiation reveals three major cell states and progressive acceleration of proliferation

scientific article published on 22 June 2016

Erratum: Corrigendum: The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

article

Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.

scientific article

Full-Length IL-33 Promotes Inflammation but not Th2 Response In Vivo in an ST2-Independent Fashion ⬇️

scientific article published on May 25, 2012

Granulocyte macrophage colony-stimulating factor-driven respiratory mucosal sensitization induces Th2 differentiation and function independently of interleukin-4.

scientific article published in October 2002

Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11

scientific article published on 26 May 2020

Helminth-modified pulmonary immune response protects mice from allergen-induced airway hyperresponsiveness

scientific article published in January 2006

Hydrological Outlook UK: an operational streamflow and groundwater level forecasting system at monthly to seasonal time scales

IL-13 Mediates In Vivo IL-9 Activities on Lung Epithelial Cells but Not on Hematopoietic Cells

scientific article published on 01 March 2007

IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans

scientific article published in October 2007

IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen

scientific article published in March 2003

IL-13 regulates the immune response to inhaled antigens

scientific article published on 01 June 2005

IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation.

scientific article published on 14 June 2017

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.

scientific article published on 16 December 2013

IL-25 as a potential therapeutic target in allergic asthma

scientific article published on 23 June 2015

IL-25 drives remodelling in allergic airways disease induced by house dust mite

scientific article (publication date: 2013)

IL-25: a key requirement for the regulation of type-2 immunity

scientific article published on March 2009

IL-33 Activates B1 Cells and Exacerbates Contact Sensitivity

scientific article published on 14 January 2011

IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system

scientific journal article

IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex

scientific article

IL-33 exacerbates antigen-induced arthritis by activating mast cells

scholarly article

IL-33 exacerbates autoantibody-induced arthritis

scientific article published on 5 February 2010

IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4.

scientific article published in October 2008

IL-33 is a chemoattractant for human Th2 cells

scientific article

IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction

scientific article published on 27 June 2013

IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells

scientific article published on 2 June 2016

IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondii

scientific article published in February 2010

IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13.

scientific article published in July 2002

IL-4/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled cerebral cryptococcosis

scientific article published on 15 January 2009

IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression

scientific article

IL-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa

scientific article published in April 2009

IL-9 regulates intestinal barrier function in experimental T cell-mediated colitis

scientific article published on 3 April 2015

IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity.

scientific article

ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.

scientific article

IL‐33 citrine reporter mice reveal the temporal and spatial expression of IL‐33 during allergic lung inflammation ⬇️

scientific article published on December 26, 2012

Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion

scientific article

Immunological function in mice lacking the Rac-related GTPase RhoG

scientific article

Induction of p53 and up-regulation of the p53 pathway in the human 5q- syndrome

scientific article published on 01 April 2010

Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism

scientific article published on 01 April 2007

Inflammation-induced formation of fat-associated lymphoid clusters

scientific article published on 29 June 2015

Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity ⬇️

scientific article published on November 12, 2011

Innate Lymphoid Cells in Immunity and Disease ⬇️

scientific article published on January 1, 2013

Innate Lymphoid Cells: 10 Years On

scientific article published on 01 August 2018

Innate lymphoid cells in inflammation and immunity

scientific article

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.

scientific article

Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity.

scientific article published on 25 November 2011

Innate lymphoid cells — how did we miss them? ⬇️

scientific article published on 07 January 2013

Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology

scientific article published on 21 May 2015

Insights into the initiation of type 2 immune responses

scientific article

Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia

scientific article

Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice

scientific article published on 3 July 2003

Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells ⬇️

scientific article published on April 1, 2011

Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis

scientific article published on 15 August 2013

Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma

scientific article

Lethal, neonatal ichthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome

scientific article published on 8 December 2004

Lymphomagenesis, hydronephrosis, and autoantibodies result from dysregulation of IL-9 and are differentially dependent on Th2 cytokines

scientific article published in July 2004

MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion

scientific article

Measurement of interleukin-13.

scientific article

Mice lacking SIGNR1 have stronger T helper 1 responses to Mycobacterium tuberculosis

scientific article published on 14 December 2006

MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity

article published in 2018

New insights into 5q- syndrome as a ribosomopathy.

scientific article

New kids on the block: group 2 innate lymphoid cells and type 2 inflammation in the lung

scientific article published in November 2013

Nuocytes and beyond: new insights into helminth expulsion ⬇️

scientific article published on February 1, 2011

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

scientific article

Nuocytes: expanding the innate cell repertoire in type-2 immunity ⬇️

scientific article published on June 28, 2011

Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals

scientific article published on 27 April 2006

Polymorphisms in IL-4R alpha correlate with airways hyperreactivity, eosinophilia, and Ym protein expression in allergic IL-13-/- mice

scientific journal article

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

scientific article published on 31 December 2013

Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype

scientific article published on 19 March 2009

Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells

scientific article

Retraction. The cytokine interleukin-33 mediates anaphylactic shock

scientific article published on 13 August 2012

Roles for T/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease.

scientific article published on 27 September 2018

SIGN-R1 contributes to protection against lethal pneumococcal infection in mice.

scientific article

SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation

scientific article published on 16 September 2021

ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis

scientific article published on 13 March 2009

ST2 deletion enhances innate and acquired immunity to murine mammary carcinoma

scientific article published on July 2011

ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance

scientific article

STAT3 Activation Impairs the Stability of Th9 Cells

scientific article published on 30 January 2017

Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity

scientific article

Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages

scientific article published in July 2004

Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis

scientific article

Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway

scientific article published on 29 September 2016

Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation

scientific article published on 12 May 2016

Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β

scientific article published on 29 April 2019

Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity

scientific article published on 20 August 2015

T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation

scientific article published on 01 May 2007

TH2 cell development and function

scientific article published on 30 October 2017

TH9 cell generation. TH9: the latest addition to the expanding repertoire of IL-25 targets

scientific article published on 23 March 2010

TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

article by Katharina Gerlach et al published 8 June 2014 in Nature Immunology

TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens

scientific article published on 18 May 2016

Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M

scientific article published on 01 June 2002

The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection

scientific article published on 3 November 2008

The IL-33/ST2 axis is associated with human visceral leishmaniasis and suppresses Th1 responses in the livers of BALB/c mice infected with Leishmania donovani

scientific article published on 17 September 2013

The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development

scientific article

The ST2 pathway is involved in acute pancreatitis: a translational study in humans and mice.

scientific article

The cytokine interleukin-33 mediates anaphylactic shock

scholarly article

The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism.

scientific article published on 21 October 2015

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

scientific article

Tim-1 is induced on germinal centre B cells through B-cell receptor signalling but is not essential for the germinal centre response.

scientific article published on 26 May 2010

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.

scientific article published on 12 June 2018

Transcription factor RORα is critical for nuocyte development

scientific article

Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease

scientific article published on 4 April 2017

Type 2 innate lymphoid cells: new players in asthma and allergy.

scientific article published on 15 September 2012

Type-2 innate lymphoid cells control the development of atherosclerosis in mice

scientific article

Type-2 innate lymphoid cells in human allergic disease

scientific article published on October 2014

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