List of works - Anna K. H. Hirsch

A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1

scientific article published on 12 April 2019

A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate

scientific article published on 06 July 2020

Artificial intelligence for natural product drug discovery ⬇️

scientific article from 2023

Biodynamers: self-organization-driven formation of doubly dynamic proteoids

scientific article published on 21 February 2012

Combinatorial screening for specific drug solubilizers with switchable release profiles.

scientific article published on 29 December 2014

Comparing the Self-Assembly of Sexiphenyl-Dicarbonitrile on Graphite and Graphene on Cu(111)

scientific article published on 12 March 2019

Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs.

scientific article published on 6 June 2017

Delivery system for budesonide based on lipid-DNA

scientific article published on 14 June 2018

Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin

scientific article published on 09 October 2018

Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors

scientific article published on 20 May 2022

Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.

scientific article published on 25 September 2014

Donepezil-melatonin hybrids as butyrylcholinesterase inhibitors: Improving binding affinity through varying mode of linking fragments

scientific article published on 05 October 2018

Double Conjugate Addition of Dithiols to Propargylic Carbonyl Systems To Generate Protected 1,3-Dicarbonyl Compounds

article

Druggability Assessment of Targets Used in Kinetic Target-Guided Synthesis

scientific article published on 27 June 2018

Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine

scientific article published on 27 September 2017

Dynamic Proteoids Generated From Dipeptide-Based Monomers

scientific article published on 28 May 2018

Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets.

scientific article

Exploiting Specific Interactions toward Next-Generation Polymeric Drug Transporters ⬇️

scientific article published on January 23, 2013

Fighting malaria: structure-guided discovery of nonpeptidomimetic plasmepsin inhibitors

scientific article published on 17 March 2015

Fine-tuning Nanocarriers Specifically toward Cargo: A Competitive Study on Solubilizing Related Photosensitizers for Photodynamic Therapy

scientific article

Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry

scientific article

Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin

scientific article published on 7 September 2016

François Diederich - In Memoriam*

scientific article published on 14 December 2020

From Wood to Tetrahydro-2-benzazepines in Three Waste-Free Steps: Modular Synthesis of Biologically Active Lignin-Derived Scaffolds

scientific article published on 11 October 2019

Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site.

scientific article published on 19 July 2016

Glucansucrase (mutant) enzymes from Lactobacillus reuteri 180 efficiently transglucosylate Stevia component rebaudioside A, resulting in a superior taste.

scientific article

Harnessing dynamic combinatorial chemistry in the search for new ligands for protein targets.

scientific article published on 29 October 2015

Lipid-DNAs as Solubilizers of mTHPC.

scientific article published in December 2017

Mastering the Gram-negative bacterial barrier – Chemical approaches to increase bacterial bioavailability of antibiotics

scientific article published on 09 March 2021

Molecular Biodynamers: Dynamic Covalent Analogues of Biopolymers.

scientific article published on 7 February 2017

Molecular insight into specific 14-3-3 modulators: Inhibitors and stabilisers of protein-protein interactions of 14-3-3.

scientific article published on 24 April 2017

Optimized Inhibitors of MDM2 via an Attempted Protein-Templated Reductive Amination

scientific article published on 12 December 2019

Phage Display on the Anti-infective Target 1-Deoxy-d-xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor

scientific article published on 8 November 2017

Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol

scientific article published on 29 May 2019

Rational Adaptation of L3MBTL1 Inhibitors to Create Small-Molecule Cbx7 Antagonists

scientific article published on 22 July 2019

Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry

scientific article published on 02 May 2019

Reversible immobilization of a protein to a gold surface through multiple host-guest interactions

scientific article published on 01 October 2019

Saccharide-Containing Dynamic Proteoids

scientific article published on 5 October 2017

Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin

scientific article

Structure-based design of potent small-molecule binders to the S-component of the ECF transporter for thiamine

scientific article

Supramolecular chemistry … and beyond

scientific article published on 26 August 2015

Surface state tunable energy and mass renormalization from homothetic quantum dot arrays

scientific article published on 03 December 2019

The isoprenoid-precursor dependence of Plasmodium spp.

scientific article published on 04 May 2012

Theoretical and structural analysis of long C-C bonds in the adducts of polycyanoethylene and anthracene derivatives and their connection to the reversibility of Diels-Alder reactions.

scientific article published on 11 December 2013

List of works by Anna K. H. Hirsch

A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1

A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate

Artificial intelligence for natural product drug discovery ⬇️

Biodynamers: self-organization-driven formation of doubly dynamic proteoids

Combinatorial screening for specific drug solubilizers with switchable release profiles.

Comparing the Self-Assembly of Sexiphenyl-Dicarbonitrile on Graphite and Graphene on Cu(111)

Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs.

Delivery system for budesonide based on lipid-DNA

Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin

Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors

Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.

Donepezil-melatonin hybrids as butyrylcholinesterase inhibitors: Improving binding affinity through varying mode of linking fragments

Double Conjugate Addition of Dithiols to Propargylic Carbonyl Systems To Generate Protected 1,3-Dicarbonyl Compounds

Druggability Assessment of Targets Used in Kinetic Target-Guided Synthesis

Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine

Dynamic Proteoids Generated From Dipeptide-Based Monomers

Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets.

Exploiting Specific Interactions toward Next-Generation Polymeric Drug Transporters ⬇️

Fighting malaria: structure-guided discovery of nonpeptidomimetic plasmepsin inhibitors

Fine-tuning Nanocarriers Specifically toward Cargo: A Competitive Study on Solubilizing Related Photosensitizers for Photodynamic Therapy

Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry

Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin

François Diederich - In Memoriam*

From Wood to Tetrahydro-2-benzazepines in Three Waste-Free Steps: Modular Synthesis of Biologically Active Lignin-Derived Scaffolds

Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site.

Glucansucrase (mutant) enzymes from Lactobacillus reuteri 180 efficiently transglucosylate Stevia component rebaudioside A, resulting in a superior taste.

Harnessing dynamic combinatorial chemistry in the search for new ligands for protein targets.

Lipid-DNAs as Solubilizers of mTHPC.

Mastering the Gram-negative bacterial barrier – Chemical approaches to increase bacterial bioavailability of antibiotics

Molecular Biodynamers: Dynamic Covalent Analogues of Biopolymers.

Molecular insight into specific 14-3-3 modulators: Inhibitors and stabilisers of protein-protein interactions of 14-3-3.

Optimized Inhibitors of MDM2 via an Attempted Protein-Templated Reductive Amination

Phage Display on the Anti-infective Target 1-Deoxy-d-xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor

Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol

Rational Adaptation of L3MBTL1 Inhibitors to Create Small-Molecule Cbx7 Antagonists

Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry

Reversible immobilization of a protein to a gold surface through multiple host-guest interactions

Saccharide-Containing Dynamic Proteoids

Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin

Structure-based design of potent small-molecule binders to the S-component of the ECF transporter for thiamine

Supramolecular chemistry … and beyond

Surface state tunable energy and mass renormalization from homothetic quantum dot arrays

The isoprenoid-precursor dependence of Plasmodium spp.

Theoretical and structural analysis of long C-C bonds in the adducts of polycyanoethylene and anthracene derivatives and their connection to the reversibility of Diels-Alder reactions.