List of works - Claudia Höbartner

A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class.

scientific article

A Multicolor Large Stokes Shift Fluorogen-Activating RNA Aptamer with Cationic Chromophores

scientific article published on 11 January 2019

A dual-mode microwave resonator for double electron-electron spin resonance spectroscopy at W-band microwave frequencies.

scientific article

Aptamers provide superior stainings of cellular receptors studied under super-resolution microscopy

scientific article

Bistable secondary structures of small RNAs and their structural probing by comparative imino proton NMR spectroscopy

scientific article published on 01 January 2003

Chemical RNA modifications for studies of RNA structure and dynamics.

scientific article published on March 2010

Chemical synthesis of selenium-modified oligoribonucleotides and their enzymatic ligation leading to an U6 SnRNA stem-loop segment

scientific article published on 01 February 2004

Chemoselective labeling and site-specific mapping of 5-formylcytosine as a cellular nucleic acid modification

scientific article published on 08 May 2018

Combinatorial mutation interference analysis reveals functional nucleotides required for DNA catalysis.

scientific article

Combinatorial nucleoside-deletion-scanning mutagenesis of functional DNA

scientific article published on 01 February 2013

Control of membrane gaps by synaptotagmin-Ca2+ measured with a novel membrane distance ruler

scientific article published on 15 December 2014

Cover Picture: N 6 -Methyladenosine-Sensitive RNA-Cleaving Deoxyribozymes (Angew. Chem. Int. Ed. 46/2018)

article published in 2018

Crystal structure of a DNA catalyst

scientific article

DNA-catalyzed formation of nucleopeptide linkages

scientific article published on 01 January 2008

Debranchase-resistant labeling of RNA using the 10DM24 deoxyribozyme and fluorescent modified nucleotides

scientific article published on 6 October 2017

Deoxyribozyme-mediated ligation for incorporating EPR spin labels and reporter groups into RNA.

scientific article published in January 2014

Direct in Vitro Selection of Trans-Acting Ribozymes for Posttranscriptional, Site-Specific, and Covalent Fluorescent Labeling of RNA

scientific article published on 04 December 2019

Efficiency and precision of microRNA biogenesis modes in plants

article

Engineering a selective small-molecule substrate binding site into a deoxyribozyme

scientific article published in January 2007

Enzymatic Labeling of 5‐Hydroxymethylcytosine in DNA ⬇️

scientific article published on April 11, 2011

Enzymatic combinatorial nucleoside deletion scanning mutagenesis of functional RNA.

scientific article

Enzymatic ligation strategies for the preparation of purine riboswitches with site-specific chemical modifications

scientific article

Eukaryotic 5-methylcytosine (m⁵C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease

Fluorogenic Labeling of 5-Formylpyrimidine Nucleotides in DNA and RNA.

scientific article published on 17 December 2015

Functional Hallmarks of a Catalytic DNA that Makes Lariat RNA.

scientific article published on 3 November 2015

Fundamental studies of functional nucleic acids: aptamers, riboswitches, ribozymes and DNAzymes

scientific article published on 18 September 2020

High-resolution measurement of long-range distances in RNA: pulse EPR spectroscopy with TEMPO-labeled nucleotides† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc04631a.

scientific article published on 3 February 2016

How RNA modification allows non-conventional decoding in mitochondria

scientific article published on 29 September 2016

Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs.

scientific article

In Vitro Assays for RNA Methyltransferase Activity.

scientific article published in January 2017

Incorporation of 4'-C-aminomethyl-2'-O-methylthymidine into DNA by thermophilic DNA polymerases.

scientific article published in October 2012

Lanthanide cofactors accelerate DNA-catalyzed synthesis of branched RNA.

scientific article published on 14 August 2013

Large Stokes shift fluorescence activation in an RNA aptamer by intermolecular proton transfer to guanine

scientific article published on 10 June 2021

Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes

scientific article published on 25 February 2020

Measurement of Angstrom to Nanometer Molecular Distances with 19 F Nuclear Spins by EPR/ENDOR Spectroscopy

scientific article published on 13 November 2019

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

scientific article

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

scholarly article by Florian Kabinger et al published 11 August 2021 in Nature Structural & Molecular Biology

Methylation of the nucleobases in RNA oligonucleotides mediates duplex-hairpin conversion

scientific article

Mg2+-dependent conformational changes and product release during DNA-catalyzed RNA ligation monitored by Bimane fluorescence.

scientific article published on 10 December 2014

Modulation of RNA tertiary folding by incorporation of caged nucleotides

scientific article published on 01 November 2005

Multimodal optical sensing and analyte specificity using single-walled carbon nanotubes

scientific article published on 14 December 2008

N 6 -Methyladenosine-Sensitive RNA-Cleaving Deoxyribozymes

N 6-isopentenyladenosine in RNA determines the cleavage site of endonuclease deoxyribozymes

scientific article published on 18 July 2020

N6-methyladenosine-sensitive RNA-cleaving deoxyribozymes

scholarly article by Claudia Höbartner et al published 1 October 2018 in Angewandte Chemie International Edition

NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A-T phosphoramidite building blocks

scientific article

NOseq: amplicon sequencing evaluation method for RNA m6A sites after chemical deamination

scientific article published on 11 December 2020

NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation

scientific journal article

NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs

scientific journal article

New Deoxyribozymes for the Native Ligation of RNA

scientific article published on 11 August 2020

On secondary structure rearrangements and equilibria of small RNAs.

scientific article published on October 2003

One pot synthesis of Cu(II) 2,2'-bipyridyl complexes of 5-hydroxy-hydurilic acid and alloxanic acid: synthesis, crystal structure, chemical nuclease activity and cytotoxicity.

scientific article published on 13 November 2010

Orientation selection in distance measurements between nitroxide spin labels at 94 GHz EPR with variable dual frequency irradiation

scientific article published on 04 February 2013

Preparation of 2′-Deoxy-2′-Methylseleno-Modified Phosphoramidites and RNA

scientific article published on 01 January 2007

Probing essential nucleobase functional groups in aptamers and deoxyribozymes by nucleotide analogue interference mapping of DNA.

scientific article

Probing secondary structures of spin-labeled RNA by pulsed EPR spectroscopy

scientific article published on 01 August 2010

Recent advances in DNA catalysis.

scientific article published on December 2007

Repurposing Antiviral Drugs for Orthogonal RNA-Catalyzed Labeling of RNA

scientific article published on 11 March 2020

Site-selective depurination by a periodate-dependent deoxyribozyme

scientific article

Site-specific RNA methylation by a methyltransferase ribozyme

scientific article published on 28 October 2020

Site-specific labeling of RNA at internal ribose hydroxyl groups: terbium-assisted deoxyribozymes at work.

scientific article

Strategies for Characterization of Enzymatic Nucleic Acids

scientific article published on 23 June 2017

Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation

scientific article

Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs

scientific article

Structure and mechanism of the methyltransferase ribozyme MTR1

scientific article published on 17 March 2022

Structure-fluorescence activation relationships of a large Stokes shift fluorogenic RNA aptamer ⬇️

scientific article published on 01 December 2019

Substrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase

scientific article published on 27 June 2016

Supramolecular Fluorescence Resonance Energy Transfer in Nucleobase-Modified Fluorogenic RNA Aptamers

scientific article published on 12 February 2020

Syntheses of RNAs with up to 100 nucleotides containing site-specific 2'-methylseleno labels for use in X-ray crystallography.

scientific article published in August 2005

Synthesis and characterization of RNA containing a rigid and nonperturbing cytidine-derived spin label

scientific article published on 20 August 2012

Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure

scientific article published on 01 November 2014

Synthesis of a norcantharidin-tethered guanosine: Protein phosphatase-1 inhibitors that change alternative splicing.

scientific article published on 18 December 2015

Synthesis of spin-labeled riboswitch RNAs using convertible nucleosides and DNA-catalyzed RNA ligation

scientific article published on 15 April 2013

Synthesis, gene silencing, and molecular modeling studies of 4'-C-aminomethyl-2'-O-methyl modified small interfering RNAs

scientific article published on 16 March 2012

The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome

scientific article

The mA reader protein YTHDC2 interacts with the small ribosomal subunit and the 5'-3' exoribonuclease XRN1

scientific article published on 03 July 2018

Titelbild: N 6 ‐Methyladenosine‐Sensitive RNA‐Cleaving Deoxyribozymes (Angew. Chem. 46/2018)

Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions

scientific article published in Nature Communications

Triggering of RNA Secondary Structures by a Functionalized Nucleobase

scientific article published on 01 July 2004

Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing

scientific article published on September 2017

List of works by Claudia Höbartner

A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class.

A Multicolor Large Stokes Shift Fluorogen-Activating RNA Aptamer with Cationic Chromophores

A dual-mode microwave resonator for double electron-electron spin resonance spectroscopy at W-band microwave frequencies.

Aptamers provide superior stainings of cellular receptors studied under super-resolution microscopy

Bistable secondary structures of small RNAs and their structural probing by comparative imino proton NMR spectroscopy

Chemical RNA modifications for studies of RNA structure and dynamics.

Chemical synthesis of selenium-modified oligoribonucleotides and their enzymatic ligation leading to an U6 SnRNA stem-loop segment

Chemoselective labeling and site-specific mapping of 5-formylcytosine as a cellular nucleic acid modification

Combinatorial mutation interference analysis reveals functional nucleotides required for DNA catalysis.

Combinatorial nucleoside-deletion-scanning mutagenesis of functional DNA

Control of membrane gaps by synaptotagmin-Ca2+ measured with a novel membrane distance ruler

Cover Picture: N 6 -Methyladenosine-Sensitive RNA-Cleaving Deoxyribozymes (Angew. Chem. Int. Ed. 46/2018)

Crystal structure of a DNA catalyst

DNA-catalyzed formation of nucleopeptide linkages

Debranchase-resistant labeling of RNA using the 10DM24 deoxyribozyme and fluorescent modified nucleotides

Deoxyribozyme-mediated ligation for incorporating EPR spin labels and reporter groups into RNA.

Direct in Vitro Selection of Trans-Acting Ribozymes for Posttranscriptional, Site-Specific, and Covalent Fluorescent Labeling of RNA

Efficiency and precision of microRNA biogenesis modes in plants

Engineering a selective small-molecule substrate binding site into a deoxyribozyme

Enzymatic Labeling of 5‐Hydroxymethylcytosine in DNA ⬇️

Enzymatic combinatorial nucleoside deletion scanning mutagenesis of functional RNA.

Enzymatic ligation strategies for the preparation of purine riboswitches with site-specific chemical modifications

Eukaryotic 5-methylcytosine (m⁵C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease

Fluorogenic Labeling of 5-Formylpyrimidine Nucleotides in DNA and RNA.

Functional Hallmarks of a Catalytic DNA that Makes Lariat RNA.

Fundamental studies of functional nucleic acids: aptamers, riboswitches, ribozymes and DNAzymes

High-resolution measurement of long-range distances in RNA: pulse EPR spectroscopy with TEMPO-labeled nucleotides† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc04631a.

How RNA modification allows non-conventional decoding in mitochondria

Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs.

In Vitro Assays for RNA Methyltransferase Activity.

Incorporation of 4'-C-aminomethyl-2'-O-methylthymidine into DNA by thermophilic DNA polymerases.

Lanthanide cofactors accelerate DNA-catalyzed synthesis of branched RNA.

Large Stokes shift fluorescence activation in an RNA aptamer by intermolecular proton transfer to guanine

Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes

Measurement of Angstrom to Nanometer Molecular Distances with 19 F Nuclear Spins by EPR/ENDOR Spectroscopy

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

Methylation of the nucleobases in RNA oligonucleotides mediates duplex-hairpin conversion

Mg2+-dependent conformational changes and product release during DNA-catalyzed RNA ligation monitored by Bimane fluorescence.

Modulation of RNA tertiary folding by incorporation of caged nucleotides

Multimodal optical sensing and analyte specificity using single-walled carbon nanotubes

N 6 -Methyladenosine-Sensitive RNA-Cleaving Deoxyribozymes

N 6-isopentenyladenosine in RNA determines the cleavage site of endonuclease deoxyribozymes

N6-methyladenosine-sensitive RNA-cleaving deoxyribozymes

NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A-T phosphoramidite building blocks

NOseq: amplicon sequencing evaluation method for RNA m6A sites after chemical deamination

NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation

NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs

New Deoxyribozymes for the Native Ligation of RNA

On secondary structure rearrangements and equilibria of small RNAs.

One pot synthesis of Cu(II) 2,2'-bipyridyl complexes of 5-hydroxy-hydurilic acid and alloxanic acid: synthesis, crystal structure, chemical nuclease activity and cytotoxicity.

Orientation selection in distance measurements between nitroxide spin labels at 94 GHz EPR with variable dual frequency irradiation

Preparation of 2′-Deoxy-2′-Methylseleno-Modified Phosphoramidites and RNA

Probing essential nucleobase functional groups in aptamers and deoxyribozymes by nucleotide analogue interference mapping of DNA.

Probing secondary structures of spin-labeled RNA by pulsed EPR spectroscopy

Recent advances in DNA catalysis.

Repurposing Antiviral Drugs for Orthogonal RNA-Catalyzed Labeling of RNA

Site-selective depurination by a periodate-dependent deoxyribozyme

Site-specific RNA methylation by a methyltransferase ribozyme

Site-specific labeling of RNA at internal ribose hydroxyl groups: terbium-assisted deoxyribozymes at work.

Strategies for Characterization of Enzymatic Nucleic Acids

Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation

Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs

Structure and mechanism of the methyltransferase ribozyme MTR1

Structure-fluorescence activation relationships of a large Stokes shift fluorogenic RNA aptamer ⬇️

Substrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase

Supramolecular Fluorescence Resonance Energy Transfer in Nucleobase-Modified Fluorogenic RNA Aptamers

Syntheses of RNAs with up to 100 nucleotides containing site-specific 2'-methylseleno labels for use in X-ray crystallography.

Synthesis and characterization of RNA containing a rigid and nonperturbing cytidine-derived spin label

Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure

Synthesis of a norcantharidin-tethered guanosine: Protein phosphatase-1 inhibitors that change alternative splicing.

Synthesis of spin-labeled riboswitch RNAs using convertible nucleosides and DNA-catalyzed RNA ligation

Synthesis, gene silencing, and molecular modeling studies of 4'-C-aminomethyl-2'-O-methyl modified small interfering RNAs

The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome

The mA reader protein YTHDC2 interacts with the small ribosomal subunit and the 5'-3' exoribonuclease XRN1

Titelbild: N 6 ‐Methyladenosine‐Sensitive RNA‐Cleaving Deoxyribozymes (Angew. Chem. 46/2018)

Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions

Triggering of RNA Secondary Structures by a Functionalized Nucleobase

Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing