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List of works by Cord Brakebusch

90K (MAC-2 BP) gene expression in breast cancer and evidence for the production of 90K by peripheral-blood mononuclear cells

scientific article

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

scientific article

A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory

scientific article

A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair

scientific article published on 01 May 2002

A function for Rac1 in the terminal differentiation and pigmentation of hair

scientific article

A new genetic tool to improve immune-compromised mouse models: Derivation and CRISPR/Cas9-mediated targeting of NRG embryonic stem cell lines

scientific article published on 01 September 2018

A radial glia-specific role of RhoA in double cortex formation

scientific journal article

Adgrf5 contributes to patterning of the endothelial deep layer in retina

scientific article published on 29 June 2019

Adult murine hematopoiesis can proceed without beta1 and beta7 integrins

scientific article published on 30 May 2006

Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity ⬇️

scientific article published on August 25, 1990

Author Correction: FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42

scientific article published on 26 November 2019

Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response

article

Beta1 integrin promotes but is not essential for metastasis of ras-myc transformed fibroblasts.

scientific article published on July 1999

Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion

scientific article

Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance

scientific article

Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity

scientific article

Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis

scientific journal article

Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory

scientific article

CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression

scientific article published on 01 April 2019

Cancer-associated fibroblasts: how do they contribute to metastasis?

scientific article published on 07 March 2019

Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice

scientific article published on 22 February 2012

Cdc42 and Rac1 Signaling Are Both Required for and Act Synergistically in the Correct Formation of Myelin Sheaths in the CNS

scientific article published on 01 October 2006

Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways

scientific article

Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin

scientific journal article

Cdc42 controls vascular network assembly through protein kinase Cι during embryonic vasculogenesis

scientific article

Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin

scientific article

Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity.

scientific article

Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development

article

Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1.

scientific article

Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells

scientific article

Cdc42 promotes host defenses against fatal infection

scientific article published on 20 May 2013

Cdc42 regulates cofilin during the establishment of neuronal polarity.

scientific article published in November 2007

Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development

scientific article

Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells

scientific article

Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration

scientific article published on 3 February 2009

Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthood

scientific article

Cdc42-mediated tubulogenesis controls cell specification

scientific article

Changes in dermal matrix in the absence of Rac1 in keratinocytes

Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate

scientific article

Cofilin phosphorylation is elevated after F-actin disassembly induced by Rac1 depletion

scientific article published in September 2015

Commentary 5

Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo

scientific article published on 5 February 2003

Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis

scientific article published on 10 November 2003

Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system

scientific article published on 14 July 2004

Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver

scientific article published on 9 January 2008

Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA.

scientific article published on 25 September 2015

Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin

scientific article published on 18 February 2017

Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets.

scientific article published on 23 February 2015

Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor ⬇️

scientific article published on March 1, 1992

Cytoskeletal Stability in the Auditory Organ In Vivo: RhoA Is Dispensable for Wound Healing but Essential for Hair Cell Development

scientific article published on 18 September 2017

Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations

scholarly article by Bàrbara Laviña published in May 2018

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42.

scientific article

Discoidin domain receptor 1 is activated independently of beta(1) integrin

scientific article (publication date: 25 February 2000)

Distinct roles for dystroglycan, beta1 integrin and perlecan in cell surface laminin organization.

scientific article published on March 2001

Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury

scientific article published on 15 May 2013

Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity.

scientific article published on August 1994

Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency.

scientific article published on August 2016

Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation

scientific article published on 12 April 2018

Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development

scientific article

Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1.

scientific article published on 31 May 2013

Expression of the 90K immunostimulator gene is controlled by a promoter with unique features

scientific article

FMNL formins boost lamellipodial force generation

scientific article

FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42.

scientific article published on 29 August 2017

FMNL2 drives actin-based protrusion and migration downstream of Cdc42.

scientific article

Functional discrepancies between tumor necrosis factor and lymphotoxin alpha explained by trimer stability and distinct receptor interactions.

scientific article published on August 1995

Genetic analysis of beta1 integrin "activation motifs" in mice

scientific article

Genetic analysis of β1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules ⬇️

scientific article published on December 1, 1997

Genetic deletion of cdc42 reveals a crucial role for astrocyte recruitment to the injury site in vitro and in vivo.

scientific article published in August 2011

Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen

scientific article

Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice

scientific article (2009)

How to bury the dead: elimination of apoptotic hair cells from the hearing organ of the mouse

scientific article

Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1.

scientific article

Increased levels of apoptosis in the prefusion neural folds underlie the craniofacial disorder, Treacher Collins syndrome.

scientific article published in June 2000

Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice

scientific article published on 11 July 2019

Integrin Gene Targeting

article

Interactions of the integrin subunit beta1A with protein kinase B/Akt, p130Cas and paxillin contribute to regulation of radiation survival

scientific article published on August 2005

Lack of 1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype

scientific article published on 29 March 2006

Leukocyte extravasation as a target for anti-inflammatory therapy - Which molecule to choose?

scientific article published on 01 January 2005

Loss of RhoA promotes skin tumor formation and invasion by upregulation of RhoB.

scientific article

Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta 1 integrins, collagens and fibronectin ⬇️

scientific article published on March 16, 1998

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis.

scientific article

Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation

scientific article

Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration

scientific article published on 01 June 2020

Mouse macrophages completely lacking Rho subfamily GTPases (RhoA, RhoB, and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and altered motility.

scientific article

Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.

scientific article

Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo

scientific article

N-WASP is a novel regulator of hair-follicle cycling that controls antiproliferative TGF{beta} pathways

scientific article

NADPH oxidase complex-derived reactive oxygen species, the actin cytoskeleton, and Rho GTPases in cell migration

scientific article published on 21 February 2014

Negative Regulation of p53-Induced Senescence by N-WASP Is Crucial for DMBA/TPA-Induced Skin Tumor Formation

scientific article published on 20 March 2019

Neuronal Rac1 is required for learning-evoked neurogenesis

scientific article published on July 2013

Neuronal Rho GTPase Rac1 elimination confers neuroprotection in a mouse model of permanent ischemic stroke.

scientific article published on 28 September 2017

None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion

scientific journal article

Opposing roles for RhoH GTPase during T-cell migration and activation

scientific article

PATHBIO: an international training program for precision mouse phenotyping

scientific article published on 22 February 2020

Podocyte-specific loss of Cdc42 leads to congenital nephropathy

scientific article

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

scientific article published on 04 September 2019

Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues

scientific article published on 11 July 2012

RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1

scientific article published in 2012

Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation

scientific article

Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo

scientific article published on 12 April 2010

Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis

scientific article

Rac1 is essential for basement membrane-dependent epiblast survival

scientific article

Rac1 is essential for phospholipase C-gamma2 activation in platelets

scientific article published on 13 August 2008

Rac1 regulates neuronal polarization through the WAVE complex

scientific article published in May 2010

Rac1-dependent recruitment of PAK2 to G2 phase centrosomes and their roles in the regulation of mitotic entry

scientific article published on 19 May 2014

Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice

scientific article published on 8 January 2016

Regulation of neural progenitor proliferation and survival by beta1 integrins

scientific article

Rho GTPase function in development: how in vivo models change our view

scientific article published on 29 May 2012

Rho GTPase function in tumorigenesis

scientific article published on 24 March 2009

Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation

scientific article

Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo

scientific article published on 3 December 2012

RhoA Controls Axon Extension Independent of Specification in the Developing Brain

scientific article published on 31 October 2019

RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis.

scientific article published on 31 May 2018

RhoA controls retinoid signaling by ROCK dependent regulation of retinol metabolism.

scientific article

RhoA determines disease progression by controlling neutrophil motility and restricting hyperresponsiveness

scientific article published on 29 April 2014

RhoA in tyrosine hydroxylase neurones regulates food intake and body weight via altered sensitivity to peripheral hormones

scientific article published on 01 July 2019

RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes

scientific article

RhoA, Rac1 and Cdc42 differentially regulate aSMA and collagen I expression in mesenchymal stem cells.

scientific article published on 26 April 2018

RhoH is important for positive thymocyte selection and T-cell receptor signaling

scientific journal article

Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection

scholarly article by Štefan Porubský et al published 11 November 2010 in European Journal of Immunology

Role of the beta1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia.

scientific article published on July 2002

Selective decrease in cell surface expression and mRNA level of the 55-kDa tumor necrosis factor receptor during differentiation of HL-60 cells into macrophage-like but not granulocyte-like cells ⬇️

scientific article published on June 1, 1992

Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair

scientific article published on 16 April 2015

Senescence regulation by nuclear N-WASP: a role in cancer?

scientific article published on 01 July 2019

Sequence and chromosomal localization of the mouse brevican gene.

scientific article published on August 1997

Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins

scientific article (publication date: 7 December 2001)

Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes

scientific article

Soluble and cell surface receptors for tumor necrosis factor.

scientific article

Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor

scientific article

Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation but disrupts polarity establishment and cytokinesis in mouse oocytes

scientific article

Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors ⬇️

scientific article published on February 1, 1992

Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1.

scientific article published in March 2009

Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis.

scientific article

Structural requirements for inducible shedding of the p55 tumor necrosis factor receptor

scientific article published in Journal of Biological Chemistry

Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin

scientific article published on 31 January 2020

The Interaction between Laminin-332 and α3β1 Integrin Determines Differentiation and Maintenance of CAFs, and Supports Invasion of Pancreatic Duct Adenocarcinoma Cells

scientific article published on 21 December 2018

The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface

scientific journal article

The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis

scientific article

The integrin-actin connection, an eternal love affair

scientific article

The rho GTPase Rac1 is required for proliferation and survival of progenitors in the developing forebrain

scientific article

The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse

scholarly article

The small GTPase Rac1 is required for smooth muscle contraction

scientific article published on 2 December 2013

The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool.

scientific article published on March 2011

Threonine 788 in integrin subunit beta1 regulates integrin activation

scientific article published on 6 January 2006

Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases

scientific article published on August 2004

beta 1 integrin function in vivo: adhesion, migration and more

scientific article

beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia

scientific article published in June 2005

beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury.

scientific article published in March 2006

p21-activated kinase 1 (PAK1) can promote ERK activation in a kinase-independent manner

scientific article published on 07 May 2013

β1 Integrin Is Essential for Teratoma Growth and Angiogenesis ⬇️

scientific article published on October 6, 1997

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