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List of works by Claudio Franceschi

-174 G>C polymorphism of interleukin 6 gene promoter affects interleukin 6 serum level in patients with colorectal cancer

scientific article

2-deoxy-d-ribose induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione

scientific article

50 Hz sinusoidal magnetic fields do not affect human lymphocyte activation and proliferation in vitro

article

A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features

article

A Geroscience approach for Parkinson's Disease: conceptual framework and design of PROPAG-AGEING project

scientific article published on 29 December 2020

A Mediterranean-like dietary pattern with vitamin D3 (10 µg/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline: results of a 1-y randomized controlled trial

scientific article published on 01 September 2018

A Novel Approach to Improve the Estimation of a Diet Adherence Considering Seasonality and Short Term Variability - The NU-AGE Mediterranean Diet Experience

scientific article published on 05 March 2019

A centenarian-only approach for assessing gene-gene interaction in human longevity

scientific article published on 01 February 2002

A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G)-308 polymorphism

scientific article published on 01 May 2008

A meta-analysis of genome-wide association studies identifies multiple longevity genes

scientific article published on 14 August 2019

A meta-analysis on age-associated changes in blood DNA methylation: results from an original analysis pipeline for Infinium 450k data.

scientific article

A new cognitive clock matching phenotypic and epigenetic ages

scientific article published in 2022

A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.

scientific article

A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene

scientific article published in March 2004

A novel sampling design to explore gene-longevity associations: the ECHA study

scientific article published on 7 November 2007

A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: design of the NU-AGE dietary intervention study

scientific article published on 5 November 2013

A patient with PMP22-related hereditary neuropathy and DBH-gene-related dysautonomia

article

A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity.

scientific article

A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging?

scientific article published on 24 August 2020

A review of the biomedical innovations for healthy longevity

scientific article

A structural model of 20S immunoproteasomes: effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanisms

scientific article published in April 2006

A study of serum immunoglobulin levels in elderly persons that provides new insights into B cell immunosenescence

scientific article published on 01 November 2006

Aberrant methylation patterns in colorectal cancer: a meta-analysis

scientific article published on 10 January 2017

Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies.

scientific article

Accelerated epigenetic aging in Down syndrome

scientific article

Acceleration of leukocytes' epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer.

scientific article

Activity of mannose-binding lectin in centenarians

scientific article

Adenosine A3 receptors and viability of astrocytes

Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells.

scientific article

Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence.

scientific article

Age-Related DNA Methylation Changes: Potential Impact on Skeletal Muscle Aging in Humans

scientific article published on 02 August 2019

Age-Related Epigenetic Derangement upon Reprogramming and Differentiation of Cells from the Elderly

scientific article published on 16 January 2018

Age-dependent alteration in muscle regeneration: the critical role of tissue niche

scientific article published on 12 May 2013

Age-dependent changes in the susceptibility to apoptosis of peripheral blood CD4+ and CD8+ T lymphocytes with virgin or memory phenotype

scientific article published in April 2003

Age-dependent effects of in vitro radiofrequency exposure (mobile phone) on CD95+ T helper human lymphocytes

Age-dependent skewing of X chromosome inactivation appears delayed in centenarians' offspring. Is there a role for allelic imbalance in healthy aging and longevity?

scientific article published in February 2012

Age-related changes of adaptive and neuropsychological features in persons with Down Syndrome

scientific article

Age-related changes on platelet membrane: a study on elderly and centenarian monozygotic twins

scientific article published on June 2005

Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging

Age-related modifications in circulating IL-15 levels in humans

scientific article

Aged-related increase of high sensitive Troponin T and its implication in acute myocardial infarction diagnosis of elderly patients.

scientific article published on 16 March 2012

Ageing and gut microbes: perspectives for health maintenance and longevity

scientific article published on 16 October 2012

Ageing, longevity, exceptional longevity and related genetic and non genetics markers: panel statement

scientific article published on 01 January 2014

Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver

scientific article published on 21 January 2020

Aging and Imaging Assessment of Body Composition: From Fat to Facts

scientific article published on 01 January 2019

Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis

scientific article published on 25 October 2017

Aging of the human metaorganism: the microbial counterpart

scientific article published on 24 February 2011

Aging of the immune system as a prognostic factor for human longevity

scientific article published on April 2008

Aging, longevity, inflammation, and cancer

scientific article

Allele frequencies of +874T --> A single nucleotide polymorphism at the first intron of IFN-gamma gene in Alzheimer's disease patients

scientific article

Allele frequencies of +874T-->A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians

scientific article

Alpha1-antitrypsin heterozygosity plays a positive role in attainment of longevity

scientific article published on 20 September 2006

An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease

scientific article published in January 2011

An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity

scientific article published on 01 March 2002

Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians

scientific article published on January 2006

Analysis of HLA-DRB1, DQA1, DQB1 haplotypes in Sardinian centenarians.

scientific article published on 04 July 2007

Analysis of population substructure in two sympatric populations of Gran Chaco, Argentina

scientific article

Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study

scientific article published on 29 August 2016

Ancient pathogen-driven adaptation triggers increased susceptibility to non-celiac wheat sensitivity in present-day European populations.

scientific article published on 23 May 2016

Anti-inflammatory effect of ubiquinol-10 on young and senescent endothelial cells via miR-146a modulation

scientific article published on 30 May 2013

Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study

scientific article published on 30 April 2018

Apoptosis induced by 2-chloro-adenosine and 2-chloro-2?-deoxy-adenosine in a human astrocytoma cell line: Differential mechanisms and possible clinical relevance

article by Stefania Ceruti et al published 1 May 2000 in Journal of Neuroscience Research

Apoptosis remodeling in immunosenescence: implications for strategies to delay ageing.

scientific article published on January 2007

Application of Wavelet Packet Transform to detect genetic polymorphisms by the analysis of inter-Alu PCR patterns ⬇️

scientific article published on December 9, 2010

Applying hydrodynamic pressure to efficiently generate induced pluripotent stem cells via reprogramming of centenarian skin fibroblasts

scientific article published on 25 April 2019

Are Nutrition-Related Knowledge and Attitudes Reflected in Lifestyle and Health Among Elderly People? A Study Across Five European Countries

article

Association between longevity and cytokine gene polymorphisms. A study in Sardinian centenarians

scientific article published on 01 June 2004

Association between the HFE mutations and longevity: a study in Sardinian population.

scientific article published in April 2003

Association between the HFE mutations and unsuccessful ageing: a study in Alzheimer's disease patients from Northern Italy

scientific article published in April 2003

Association between the HLA-A2 allele and Alzheimer disease

scientific article published on 01 January 2006

Association between the HLA-DR alleles and longevity: a study in Sardinian population.

scientific article

Association between the interleukin-1beta polymorphisms and Alzheimer's disease: a systematic review and meta-analysis

scientific article published on 21 July 2008

Association of metabolic syndrome with cognitive function: the role of sex and age.

scientific article

Association of the mitochondrial DNA haplogroup J with longevity is population specific

scientific article published on 01 December 2004

Association studies on human mitochondrial DNA: methodological aspects and results in the most common age-related diseases

scientific article published on 5 December 2006

Associations between Pro- and Anti-Inflammatory Gastro-Intestinal Microbiota, Diet, and Cognitive Functioning in Dutch Healthy Older Adults: The NU-AGE Study

scientific article published on 12 November 2020

Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project

scientific article published on 19 July 2017

Author Correction: Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes

scientific article published on 21 February 2020

Autoantibodies to poly(ADP-ribose) polymerase in centenarians: a reappraisal of Grabar's hypothesis

scientific article published on 16 April 2009

Bacterial DNAemia in Older Participants and Nonagenarian Offspring and Association With Redox Biomarkers: Results From MARK-AGE Study

scientific article published in 2022

Beneficial Effects of Elderly Tailored Mediterranean Diet on the Proteasomal Proteolysis.

scientific article published in May 2018

Beneficial Role of Replacing Dietary Saturated Fatty Acids with Polyunsaturated Fatty Acids in the Prevention of Sarcopenia: Findings from the NU-AGE Cohort

scientific article published on 09 October 2020

Biological age of transplanted livers

scientific article published in February 2018

Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load

scientific article (publication date: December 1999)

Both objective and paradoxical insomnia elicit a stress response involving mitokine production

scientific article published on 17 May 2020

Brain aging and garbage cleaning : Modelling the role of sleep, glymphatic system, and microglia senescence in the propagation of inflammaging

scientific article published on 09 October 2020

COVID-19 mortality in Lombardy: the vulnerability of the oldest old and the resilience of male centenarians

scientific article published on 12 August 2020

Calcium metabolism and vitamin D in the extreme longevity

scientific article published on 4 July 2007

Call for articles on neglected topics

scientific article published on 15 July 2019

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

scientific article published on 05 June 2013

Capturing Degeneracy in the Immune System

Cell-free DNA as a biomarker of aging

scientific article published on 20 December 2018

Centenarians as a 21st century healthy aging model: A legacy of humanity and the need for a world-wide consortium (WWC100+).

scientific article published on 23 June 2017

Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases

scientific article published on 24 February 2017

Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes

scientific article published on May 2013

Centenarians' offspring as a model of healthy aging: a reappraisal of the data on Italian subjects and a comprehensive overview

scientific article

Chagas disease: serological and electrocardiographic studies in Wichi and Creole communities of Misión Nueva Pompeya, Chaco, Argentina ⬇️

scientific article published on August 1, 2010

Changes in Dietary Intake and Adherence to the NU-AGE Diet Following a One-Year Dietary Intervention among European Older Adults-Results of the NU-AGE Randomized Trial

scientific article published on 04 December 2018

Changing from a Western to a Mediterranean-style diet does not affect iron or selenium status: results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) 1-year randomized clini

scientific article published on 01 January 2020

Charting the NF-κB pathway interactome map

scientific article published in 2012

Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians

article

Chronic antigenic load and apoptosis in immunosenescence

scientific article published on 01 February 2005

Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases

scientific article

Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons

scientific article published on 05 November 2002

Chronic inflammation in the etiology of disease across the life span

scientific article published on 05 December 2019

Chronic renal impairment and DDAH2-1151 A/C polymorphism determine ADMA levels in type 2 diabetic subjects.

scientific article

Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects

scientific article

Circulating miR-21, miR-146a and Fas ligand respond to postmenopausal estrogen-based hormone replacement therapy--a study with monozygotic twin pairs

scientific article

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

scientific article published on 13 February 2014

Cloning of differentially expressed genes in skin fibroblasts from centenarians

scientific article

Cognitive status in the oldest old and centenarians: a condition crucial for quality of life methodologically difficult to assess

scientific article

Colorectal Cancer Microenvironment: Among Nutrition, Gut Microbiota, Inflammation and Epigenetics

scientific article published on January 1, 2013

Combating inflammaging through a Mediterranean whole diet approach: the NU-AGE project's conceptual framework and design

scientific article published on 14 December 2013

Combination of biomarkers to predict mortality in elderly patients with myocardial infarction

scientific article

Common evolutionary origin of the immune and neuroendocrine systems: from morphological and functional evidence to in silico approaches

scientific article published on 24 October 2007

Complex interplay between neutral and adaptive evolution shaped differential genomic background and disease susceptibility along the Italian peninsula

scientific article published on September 2016

Complex patterns of gene expression in human T cells during in vivo aging

scientific article

Complexity of anti-immunosenescence strategies in humans

scientific article published on October 2006

Conserved and species-specific molecular denominators in mammalian skeletal muscle aging

scientific article

Continuous remodeling as a key to aging and survival: an interview with Claudio Franceschi. Interview by Suresh I S Rattan

scientific article published on January 1, 2003

Convergent adaptation of cellular machineries in the evolution of large body masses and long life spans

scientific article published on June 2017

Correction to: A new cognitive clock matching phenotypic and epigenetic ages

scientific article published in 2022

Correction: Analysis of Population Substructure in Two Sympatric Populations of Gran Chaco, Argentina.

scientific article

Correction: Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism.

scientific article published on 13 August 2013

Correction: Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians.

scientific article published on 8 June 2010

Correction: X-chromosome-linked miR548am-5p is a key regulator of sex disparity in the susceptibility to mitochondria-mediated apoptosis

scientific article published on 04 November 2019

Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation

scientific article

Corrigendum to “What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?” [Mechanisms of Ageing and Development 126 (2005) 421–429]

article

Cross-Sectional Analysis of the Correlation Between Daily Nutrient Intake Assessed by 7-Day Food Records and Biomarkers of Dietary Intake Among Participants of the NU-AGE Study

article by Rita Ostan et al published 1 October 2018 in Frontiers in Physiology

Cytomegalovirus infection: a driving force in human T cell immunosenescence

scientific article published on October 2007

DNA hydroxymethylation levels are altered in blood cells from Down syndrome persons enrolled in the MARK-AGE project

scientific article published on 21 October 2017

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring

scientific article

Demographic characteristics of Sardinian centenarian genealogies: Preliminary results of the AKeA2 study

article published in 2015

Demographic, genetic and phenotypic characteristics of centenarians in Italy: Focus on gender differences

scientific article published on 28 April 2017

Detrimental links between physical inactivity, metabolic risk and N-glycomic biomarkers of aging

scientific article published on 31 May 2019

Development of a pilot project on data sharing among partners of the Italian Hub of Population Biobanks (HIBP): association between lipid profile and socio-demographic variables

scientific article

Dietary Fibre May Mitigate Sarcopenia Risk: Findings from the NU-AGE Cohort of Older European Adults

scientific article published on 13 April 2020

Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells

scientific article published on 01 August 2004

Different types of cell death in organismal aging and longevity: state of the art and possible systems biology approach

scientific article published on January 2008

Differential course of HIV-1 infection and APOE polymorphism

scholarly article

Differential course of HIV-1 infection and apolipoprotein E polymorphism

scientific article published in January 2007

Differential expression of perilipin 2 and 5 in human skeletal muscle during aging and their association with atrophy-related genes

scientific article published on 6 January 2015

Discovery of novel and selective SIRT6 inhibitors

scientific article

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging

scientific article published on 31 October 2020

Dissecting the Pre-Columbian Genomic Ancestry of Native Americans along the Andes-Amazonia Divide

scientific article published on 01 June 2019

Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly

scientific article published in March 2004

Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

article

Down Syndrome, Ageing and Epigenetics

scientific article published on 01 January 2019

Down syndrome, accelerated aging and immunosenescence

scientific article published on 23 July 2020

Ecoimmunology: is there any room for the neuroendocrine system?

scientific article published in September 2008

Ecological Sensing Through Taste and Chemosensation Mediates Inflammation: A Biological Anthropological Approach

scientific article published on 10 July 2020

Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis

scientific article published on 27 September 2008

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

scientific article

Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults: A Randomized Controlled Trial.

scientific article

Effects of Pulsed Electromagnetic Fields on the Proliferation of Lymphocytes from Aids Patients, HIV-Seropositive Subjects, and Seronegative Drug Users

scientific article published in January 1989

Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational study

scientific article published in February 2010

Encoding the states of interacting proteins to facilitate biological pathways reconstruction.

scientific article published on 13 August 2010

Epigenetic DNA methylation changes in episodic and chronic migraine

article by Rossana Terlizzi et al published June 2018 in Neurological Sciences

Epigenetic Variability across Human Populations: A Focus on DNA Methylation Profiles of the KRTCAP3, MAD1L1 and BRSK2 Genes

scientific article published on 8 August 2016

Epigenetic up-regulation of ribosome biogenesis and more aggressive phenotype triggered by the lack of the histone demethylase JHDM1B in mammary epithelial cells

scientific article published on 14 March 2017

Epigenome-wide association study in hepatocellular carcinoma: Identification of stochastic epigenetic mutations through an innovative statistical approach.

scientific article published on 27 April 2017

Erratum to: Differential expression of perilipin 2 and 5 in human skeletal muscle during aging and their association with atrophy-related genes

article

Erratum: A meta-analysis on age-associated changes in blood DNA methylation: results from an original analysis pipeline for Infinium 450k data ⬇️

scientific article

Erratum: Author Correction: Sarcolab pilot study into skeletal muscle's adaptation to longterm spaceflight

scientific article published on 24 October 2018

Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes

scientific article published on 17 July 2019

Estrogen Containing Hormone Replacement Therapy Affects MicroRNAs And Fas/FasL In Genetically Identical Female Twin Pairs

article by Reeta Kangas et al published May 2014 in Medicine and Science in Sports and Exercise

Ethical aspects of aging research

scientific article published on 22 May 2011

Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring.

scientific article

Evidence for reduction of pro-atherosclerotic properties in platelets from healthy centenarians.

scientific article published in April 2003

Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease

scientific article

Evidences of +896 A/G TLR4 polymorphism as an indicative of prevalence of complications in T2DM patients

scientific article published on 02 April 2014

Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients

scientific article

Family clustering in Sardinian longevity: a genealogical approach

scientific article published on 21 June 2006

Fighting Sarcopenia in Ageing European Adults: The Importance of the Amount and Source of Dietary Proteins

scientific article published on 24 November 2020

Fine Dissection of Human Mitochondrial DNA Haplogroup HV Lineages Reveals Paleolithic Signatures from European Glacial Refugia

scientific article published on 7 December 2015

From lifetime to evolution: timescales of human gut microbiota adaptation

scientific article

Functional metagenomic profiling of intestinal microbiome in extreme ageing

scientific article published on December 2013

GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness

scientific article published on 12 May 2020

Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity

scientific article published in July 2004

Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study

scientific article published on 04 February 2019

Gene expression changes in human cells after exposure to mobile phone microwaves

scientific article published on September 2006

Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines.

scientific article published on August 2006

Gene polymorphism affecting α1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk

scientific article published in September 2000

Genes associated with Type 2 Diabetes and vascular complications

scientific article published on 4 February 2018

Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians

scientific article

Genes of human longevity: an endless quest?

scientific article

Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians

scientific article published in May 2002

Genetic polymorphisms of inflammatory cytokines and myocardial infarction in the elderly

scientific article

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework

article

Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging).

scientific article published on April 2007

Genetics of neurodegenerative disorders

scientific article

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity

scientific article published on 17 December 2015

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

scientific article published on 06 February 2013

Genomic history of the Italian population recapitulates key evolutionary dynamics of both Continental and Southern Europeans

scientific article published on 22 May 2020

Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians

scientific article published on 08 January 2019

Genomics and epigenomics

scientific article published on December 2015

Genotype of inflammatory cytokines in limbal stem cell graft in Italian patients

article

Geroscience: linking aging to chronic disease

scientific article

Gut Microbiota and Extreme Longevity

scientific article

Gut microbiome in Down syndrome

scientific article

Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)

scientific article published on 19 August 2019

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

scientific article published on 14 October 2017

Gut microbiota ecology: Biodiversity estimated from hybrid neutral-niche model increases with health status and aging

scientific article published on 30 October 2020

HAPLOFIND: a new method for high-throughput mtDNA haplogroup assignment

scientific article published on 12 June 2013

Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition

scientific article published on 9 September 2017

Healthy ageing in 2016: Obesity in geroscience - is cellular senescence the culprit?

scientific article published on 6 January 2017

Heat shock response by EBV-immortalized B-lymphocytes from centenarians and control subjects: a model to study the relevance of stress response in longevity

scientific article published on January 2004

Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality

scientific article published on 01 May 2019

High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid

High-resolution quantitative metabolome analysis of urine by automated flow injection NMR.

scientific article published on 29 May 2013

History of Research into Ageing/Senescence

Hormetic approaches to the treatment of Parkinson's disease: Perspectives and possibilities

scholarly article by Vittorio Calabrese et al published 11 August 2018 in Journal of Neuroscience Research

Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-223 expressions: a study on postmenopausal monozygotic twin pairs

scientific article

How to classify the oldest old according to their health status: a study on 1160 subjects belonging to 552 90+ Italian sib-ships characterized by familial longevity recruited within the GEHA EU Project

scientific article published on 20 November 2013

Human aging and longevity are characterized by high levels of mitokines

scientific article published on 01 April 2019

Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer

scientific article published on 29 September 2010

Human longevity and 11p15.5: a study in 1321 centenarians

scientific article

Human longevity within an evolutionary perspective: the peculiar paradigm of a post-reproductive genetics

scientific article published on July 2007

Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population

scientific article published on 12 March 2020

Identification of Pre-frailty Sub-Phenotypes in Elderly Using Metabolomics

article published in 2018

Identification of a DNA methylation signature in blood cells from persons with Down Syndrome

scientific article

Identification of a T cell gene expression clock obtained by exploiting a MZ twin design

scientific article

Identification of a geographic area characterized by extreme longevity in the Sardinia island: the AKEA study ⬇️

scientific article

Identification of miR-31-5p, miR-141-3p, miR-200c-3p, and GLT1 as human liver aging markers sensitive to donor-recipient age-mismatch in transplants

scientific article published on 20 December 2016

Identification of novel plasma glycosylation-associated markers of aging

scientific article published on 28 January 2016

Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population

scientific article

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges

scientific article published on 19 February 2013

Immune system, cell senescence, aging and longevity--inflamm-aging reappraised

scientific article published on January 2013

Immune therapy for age-related diseases

scientific article published on 21 June 2009

Immunity, Inflammation and infections during aging

Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity

scientific article

Immunogenetics, gender, and longevity.

scientific article published on November 2006

Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population

scientific article

Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains

scientific article

Immunoproteasome expression is induced in mesial temporal lobe epilepsy

scientific article published on 30 March 2011

Immunoproteasome in Macaca fascicularis: no age-dependent modification of abundance and activity in the brain and insight into an in silico structural model

scientific article published in February 2008

Immunoproteasome in cancer and neuropathologies: a new therapeutic target?

scientific article published on January 2013

Immunoproteasomes and immunosenescence

scientific article published on October 2003

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

scientific article published in January 2017

Immunosupportive therapies in aging

scientific article published on January 2007

Impact of demography and population dynamics on the genetic architecture of human longevity

scholarly article by Cristina Giuliani et al published 8 August 2018 in Aging

Impact of personalized diet and probiotic supplementation on inflammation, nutritional parameters and intestinal microbiota - The "RISTOMED project": Randomized controlled trial in healthy older people

scientific article

In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging

scientific article published on April 2003

In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies of proliferation, apoptosis and mitochondrial membrane potential

scientific article published in August 2004

Increased Plin2 expression in human skeletal muscle is associated with sarcopenia and muscle weakness

scientific article

Increased brain-predicted aging in treated HIV disease

scientific article

Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity?

scientific article published on 01 June 2003

Inferring chronological age from DNA methylation patterns of human teeth

scientific article

Inferring the genetic history of lactase persistence along the Italian peninsula from a large genomic interval surrounding the LCT gene

scientific article

Inflamm-ageing

scientific article published on January 2013

Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity.

scientific article published in April 2005

Inflamm-aging of the stem cell niche: breast cancer as a paradigmatic example: breakdown of the multi-shell cytokine network fuels cancer in aged people

scientific article

Inflammaging 2018: An update and a model

scientific article published on 02 November 2018

Inflammaging and 'Garb-aging'.

scientific article

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

scientific article published on 20 November 2006

Inflammaging and cancer: a challenge for the Mediterranean diet

scientific article published on 9 April 2015

Inflammaging and human longevity in the omics era.

scientific article published on 27 December 2016

Inflammaging as a major characteristic of old people: can it be prevented or cured?

scientific article published on December 2007

Inflammaging in Endemic Areas for Infectious Diseases

scientific article published on 12 November 2020

Inflammaging, hormesis and the rationale for anti-aging strategies

scientific article published on 16 August 2020

Inflammaging: a new immune-metabolic viewpoint for age-related diseases

Inflammation and life-span

scientific article

Inflammation markers predicting frailty and mortality in the elderly.

scientific article

Influence of f-MLP, ACTH(1-24) and CRH on in vitro chemotaxis of monocytes from centenarians

scientific article

Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

scientific article

Innate immunity and inflammation in ageing: a key for understanding age-related diseases

scientific article

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans

scientific article published on November 2003

Integrating Omics data for signaling pathways, interactome reconstruction, and functional analysis

scientific article

Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status

scientific article published on 19 February 2010

Interdisciplinary views on Molecular Anthropology in the Genomic Era

scientific article published on January 1, 2010

Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain

scientific article published in November 2003

Interventions to Slow Aging in Humans: Are We Ready?

scientific article

Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis

scientific article published on 2 May 2017

Invecchiamento, infiammazione sistemica e malattie croniche complesse

Investigating Mitonuclear Genetic Interactions Through Machine Learning: A Case Study on Cold Adaptation Genes in Human Populations From Different European Climate Regions

scientific article published on 11 November 2020

Is chronic inflammation a determinant of blood pressure in the elderly?

scientific article published in July 2003

Karyotype instability and anchorage-independent growth in telomerase-immortalized fibroblasts from two centenarian individuals

scientific article published in September 2003

LL-paraoxonase genotype is associated with a more severe degree of homeostasis model assessment IR in healthy subjects

scientific article published in January 2002

Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework

scientific article published on 18 July 2020

Lamin A involvement in ageing processes

scientific article published on 21 May 2020

Lamins are rapamycin targets that impact human longevity: a study in centenarians

scientific article published on 23 October 2013

Life expectancy in the immune recovery era: the evolving scenario of the HIV epidemic in northern Italy

scientific article published on February 2014

Lifelong calorie restriction affects indicators of colonic health in aging C57Bl/6J mice.

scientific article published on 20 March 2018

Lifelong maintenance of composition, function and cellular/subcellular distribution of proteasomes in human liver

scientific article

Long-term effects of vaccination on attentional performance

article by Roberto Nicoletti et al published 28 September 2004 in Vaccine

Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood

scientific article

Low Vitamin D Status, High Bone Turnover, and Bone Fractures in Centenarians ⬇️

scientific article published on November 1, 2003

Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians' offspring.

scientific article

Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.

scientific article published on 18 March 2015

Lower platelet count in healthy centenarians correlates with dispersion of the QT interval

scientific article published on 01 April 2004

MARK-AGE biomarkers of ageing

scientific article

MARK-AGE population: From the human model to new insights

scientific article

MARK-AGE standard operating procedures (SOPs): A successful effort

scientific article published on 26 March 2015

Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing

scientific article published on 2 December 2017

Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence

scientific article published in September 2003

Markers of inflammation, vitamin E and peripheral nervous system function: the InCHIANTI study

scientific article published on 22 August 2005

Massive load of functional effector CD4+ and CD8+ T cells against cytomegalovirus in very old subjects

scientific article published on 01 September 2007

Massive parallel sequencing of human whole mitochondrial genomes with Ion Torrent technology: an optimized workflow for Anthropological and Population Genetics studies

scientific article published on 8 November 2016

Masticatory dysfunction is associated with osteoporosis in older men

scientific article published on 01 November 2007

Maternal longevity is associated with lower infant mortality

Medication Intake Is Associated with Lower Plasma Carotenoids and Higher Fat-Soluble Vitamins in the Cross-Sectional MARK-AGE Study in Older Individuals

scientific article published on 01 July 2020

Mediterranean diet and inflammaging in the elderly: the European project NU-AGE. Preface.

scientific article

Mediterranean diet and inflammaging within the hormesis paradigm

scientific article published on 08 June 2017

Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

scientific article published on 17 February 2020

Mediterranean-Style Diet Improves Systolic Blood Pressure and Arterial Stiffness in Older Adults

article by Amy Jennings et al published March 2019 in Hypertension

Meeting report: mitochondrial DNA and cancer epidemiology

scientific article

Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement

scientific article published on 18 December 2017

Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism

scientific article

Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply

scientific article published on 01 April 2003

Methylation of ELOVL2 gene as a new epigenetic marker of age

article

MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling.

scientific article

MicroRNAs linking inflamm-aging, cellular senescence and cancer

scientific article published on 17 May 2013

Microbiomes other than the gut: inflammaging and age-related diseases

scientific article published on 30 September 2020

Mismatch repair system and aging: microsatellite instability in peripheral blood cells from differently aged participants

article

Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians.

scientific article

Mitochondria, immunosenescence and inflammaging: a role for mitokines?

scientific article published on 05 August 2020

Mitochondrial DNA backgrounds might modulate diabetes complications rather than T2DM as a whole

scientific article published in 2011

Mitochondrial DNA involvement in human longevity

scientific article published on 7 June 2006

Mitochondrial heterogeneity during staurosporine-induced apoptosis in HL60 cells: Analysis at the single cell and single organelle level

scientific article published in 2000

Modeling the in vitro 20S proteasome activity: the effect of PA28-alphabeta and of the sequence and length of polypeptides on the degradation kinetics

scientific article published on 8 February 2008

Models for preclinical studies in aging-related disorders: One is not for all.

scientific article published on December 2015

Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature

scientific article published on 15 March 2018

Molecular remodeling of potassium channels in fibroblasts from centenarians: a marker of longevity?

scientific article published on 19 September 2010

Molecular variation of human HSP90alpha and HSP90beta genes in Caucasians

scientific article

Morpho-functional changes of fat body in bacteria fed Drosophila melanogaster strains

scientific article published on 17 December 2011

Muscle-specific Perilipin2 down-regulation affects lipid metabolism and induces myofiber hypertrophy

scientific article published on 04 October 2018

Musculoskeletal system in the old age and the demand for healthy ageing biomarkers

scientific article

N-glycan profiles as tools in diagnosis of hepatocellular carcinoma and prediction of healthy human ageing

scientific article

N-glycomic biomarkers of biological aging and longevity: a link with inflammaging

scientific article published on 14 February 2012

N-glycomic changes in serum proteins during human aging.

scientific article published in December 2007

N-glycomic changes in serum proteins in type 2 diabetes mellitus correlate with complications and with metabolic syndrome parameters

scientific article

Naïve and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus

scientific article (publication date: April 2014)

Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system

scientific article

New advances in CMV and immunosenescence

scientific article

Novel loci and pathways significantly associated with longevity

scientific article published on 25 February 2016

Numerical and functional alterations of circulating gammadelta T lymphocytes in aged people and centenarians

scientific article published on 01 July 2002

Nutrition and Inflammation: Are Centenarians Similar to Individuals on Calorie-Restricted Diets?

article published in 2018

Nutritional Factors Modulating Alu Methylation in an Italian Sample from The Mark-Age Study Including Offspring of Healthy Nonagenarians

scientific article published on 06 December 2019

One-Year Consumption of a Mediterranean-Like Dietary Pattern With Vitamin D3 Supplements Induced Small Scale but Extensive Changes of Immune Cell Phenotype, Co-receptor Expression and Innate Immune Responses in Healthy Elderly Subjects: Results From

article

One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project

scientific article published on 24 January 2020

Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population.

scientific article published on May 2006

Oxidative DNA damage repair and parp 1 and parp 2 expression in Epstein-Barr virus-immortalized B lymphocyte cells from young subjects, old subjects, and centenarians.

scientific article

Oxidative stress and the ageing endocrine system ⬇️

scientific article published on February 26, 2013

PON1 is a longevity gene: results of a meta-analysis

scientific article published on 17 April 2009

Paraoxonase 1: genetics and activities during aging

scientific article published on February 2008

Paraoxonase activity and genotype predispose to successful aging.

scientific article

Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis

scientific article published in April 2004

Paraoxonase-1 55 LL Genotype Is Associated with No ST-Elevation Myocardial Infarction and with High Levels of Myoglobin.

scientific article published on 25 March 2012

Paraoxonase2 C311S polymorphism and low levels of HDL contribute to a higher mortality risk after acute myocardial infarction in elderly patients.

scientific article published on 27 May 2009

Pathological Relevance of the Natural Immune System

Pathophysiology of ageing, longevity and age related diseases

scientific article

Perilipin 2 and Age-Related Metabolic Diseases: A New Perspective

scientific article

Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries

scientific article

Plasma N-Glycome Signature of Down Syndrome

scientific article published on 3 September 2015

Plasminogen activator inhibitor-1 plasma level increases with age in subjects with the 4G allele at position -675 in the promoter region.

scientific article

Plasticity of lifelong calorie-restricted C57BL/6J mice in adapting to a medium-fat diet intervention at old age.

scientific article published on 21 December 2017

Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription

scientific article

Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control

article

Population-specific association of genes for telomere-associated proteins with longevity in an Italian population

scientific article published on 29 January 2015

Postoperative Delirium after elective and emergency surgery: analysis and checking of risk factors. A study protocol

scientific article

Pre-Operative, High-IL-6 Blood Level is a Risk Factor of Post-Operative Delirium Onset in Old Patients

scientific article

Pre-analytical stability of the plasma proteomes based on the storage temperature

scientific article published on 21 March 2013

Present and future of anti-ageing epigenetic diets

scientific article published on 02 January 2014

Prevalence and loads of torquetenovirus (TTV) in the European MARK-AGE Study population

scientific article published on 15 December 2019

Professor Dr. Mark Mattson's special contributions to ageing research and neuroscience

scientific article published on 29 April 2019

Propagation of a transmissible cytotoxic activity on cultures of human peripheral blood lymphocytes.

scientific article published in July 2008

Proteasome Modulation in Brain: A New Target for Anti-Aging Drugs?

Protection against Tetanus and Diphtheria in Europe: The impact of age, gender and country of origin based on data from the MARK-AGE Study

scientific article published on 7 October 2017

Quality control data of physiological and immunological biomarkers measured in serum and plasma

scientific article

Quality of Life: Psychological Symptoms-Effects of a 2-Month Healthy Diet and Nutraceutical Intervention; A Randomized, Open-Label Intervention Trial (RISTOMED)

scientific article published on 18 March 2020

Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics

Reconfiguration of DNA methylation in aging

scientific article

Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting

scientific article published on 08 January 2019

Reduced expression levels of the senescence biomarker clusterin/apolipoprotein j in lymphocytes from healthy centenarians

scientific article published on 01 May 2006

Regulatory T cells from patients with end-stage organ disease can be isolated, expanded and cryopreserved according good manufacturing practice improving their function

scientific article published on 05 August 2019

Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes

scientific article published on 16 December 2011

Reply from Franceschi et al

scientific article published in November 1995

Report from the second cytomegalovirus and immunosenescence workshop

scientific article published on 28 October 2011

Reprint of: A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: design of the NU-AGE dietary intervention study

article by Agnes Berendsen et al published March 2014 in Mechanisms of Ageing and Development

Reprint of: Musculoskeletal system in the old age and the demand for healthy ageing biomarkers.

scientific article published on 21 March 2014

Resistance to apoptosis of HCW-2 cells can be overcome by curcumin- or vincristine-induced mitotic catastrophe

scientific article published on October 2006

Responders and non-responders to influenza vaccination: A DNA methylation approach on blood cells

scientific article published on 19 January 2018

Response by Giuliani et al to Letter Regarding Article, "Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework"

scientific article published on 01 January 2019

Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patients

scientific article published on October 2003

Role of Toll-like receptor 4 in acute myocardial infarction and longevity

scientific article published on 01 November 2004

Role of connectivity in immune and neural network models: memory development and aging

scientific article published on May 1, 2003

Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring.

scientific article published on 25 August 2012

Role of mitochondrial DNA in longevity, aging and age-related diseases in humans: a reappraisal.

scientific article published on December 2007

Role of polymorphisms of CC-chemokine receptor-5 gene in acute myocardial infarction and biological implications for longevity

scientific article published on 01 April 2008

Role of the pyrin M694V (A2080G) allele in acute myocardial infarction and longevity: a study in the Sicilian population.

scientific article

Senescence associated macrophages and "macroph-aging": are they pieces of the same puzzle?

scientific article

Serum IL-1beta levels in health and disease: a population-based study. 'The InCHIANTI study'.

scientific article published in June 2003

Serum N-glycan profile shift during human ageing

scientific article

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

scientific article published on January 2014

Sex Differences in Genetic Associations With Longevity

Sex-Specific Associations of Blood-Based Nutrient Profiling With Body Composition in the Elderly

article

Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population

scientific article published on 06 November 2020

Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults

scientific article published on 10 August 2018

Shotgun Metagenomics of Gut Microbiota in Humans with up to Extreme Longevity and the Increasing Role of Xenobiotic Degradation

scientific article published on 24 March 2020

Slug/β-catenin-dependent proinflammatory phenotype in hypoxic breast cancer stem cells

Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells

scientific article published on 18 February 2020

Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study

scientific article

Space/population and time/age in DNA methylation variability in humans: a study on IGF2/H19 locus in different Italian populations and in mono- and di-zygotic twins of different age.

scientific article

Statistical strategies and stochastic predictive models for the MARK-AGE data

scientific article

Stochastic epigenetic mutations (DNA methylation) increase exponentially in human aging and correlate with X chromosome inactivation skewing in females

scientific article

Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes

scientific article

Structural characterization of p53 isoforms due to the polymorphism at codon 72 by mass spectrometry and circular dichroism

scientific article

Studies on immunoproteasome in human liver. Part I: absence in fetuses, presence in normal subjects, and increased levels in chronic active hepatitis and cirrhosis

scientific article published on 26 May 2010

Study of the association with -330T/G IL-2 in a population of centenarians from centre and south Italy

scientific article published in December 2005

Suggestions from Geroscience for the Genetics of Age-Related Diseases

scientific article

Survival features of EBV-stabilized cells from centenarians: morpho-functional and transcriptomic analyses

scientific article

Systematic review by meta-analyses on the possible role of TNF-alpha polymorphisms in association with Alzheimer's disease

scientific article published on 13 May 2009

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process

scientific article published on 26 September 2016

Systems medicine of inflammaging.

scientific article published on 24 August 2015

T cells and aging, January 2002 update.

scientific article

TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells ⬇️

scientific article published on January 1, 2012

Terminal differentiation of T cells is strongly associated with CMV infection and increased in HIV-positive individuals on ART and lifestyle matched controls

scientific article published on 14 August 2017

The "Oldest Man on the Planet"

scientific article published on 01 December 2002

The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics

scientific article published on 29 March 2018

The -174 C/G locus affects in vitro/in vivo IL-6 production during aging

scientific article published in January 2002

The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing

scientific article published in April 2004

The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective

scientific article published on 01 October 2019

The Contextualized Genetics of Human Longevity: JACC Focus Seminar

scientific article published on 01 March 2020

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

scientific article published on 12 March 2018

The Dual Role of the Pervasive “Fattish” Tissue Remodeling With Age

The Elderly-Nutrient Rich Food Score Is Associated With Biochemical Markers of Nutritional Status in European Older Adults

scientific article published on 11 September 2019

The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians

scientific article published on 01 December 2004

The Genetic Variability of in Different Human Populations and Its Implications for Longevity

article

The Human Body as a Super Network: Digital Methods to Analyze the Propagation of Aging

scientific article published on 25 May 2020

The Impact of Caloric Restriction on the Epigenetic Signatures of Aging

article published in 2019

The MALVA (MAntova LongeVA) study: an investigation on people 98 years of age and over in a province of Northern Italy

scientific article published in October 2003

The New Antigenic Ecospace of the Globalized World and its Impact on the Immune System: The Battleground of Trade-off and Antagonistic Pleiotropy

The PON1192RR genotype is associated with a higher prevalence of arterial hypertension.

scientific article

The Pro/Pro genotype of the p53 codon 72 polymorphism modulates PAI-1 plasma levels in ageing.

scientific article

The Use of Non-Variant Sites to Improve the Clinical Assessment of Whole-Genome Sequence Data

scientific article

The adapter protein CD2AP binds to p53 protein in the cytoplasm and can discriminate its polymorphic variants P72R.

scientific article published on 26 September 2014

The aging gut microbiota: new perspectives

scientific article published on 23 March 2011

The carotid plaque as paradigmatic case of site-specific acceleration of aging process: The microRNAs and the inflammaging contribution

scientific article published on 28 May 2020

The challenges in moving from ageing to successful longevity

scientific article published in January 2014

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

scientific article

The complex relationship between Immunosenescence and Inflammaging: Special issue on the New Biomedical Perspectives

scientific article published on 01 October 2020

The conundrum of human immune system "senescence"

scientific article published on 16 September 2020

The effect on rat thymocytes of the simultaneous in vivo exposure to 50-Hz electric and magnetic field and to continuous light.

scientific article published on 20 October 2004

The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans

scientific article

The epigenetic landscape of age-related diseases: the geroscience perspective

scientific article published on 28 March 2017

The epigenetic side of human adaptation: hypotheses, evidences and theories

scientific article

The evolution of the adipose tissue: a neglected enigma

scientific article published on 14 July 2011

The extreme longevity: The state of the art in Italy

article

The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect

scientific article (publication date: February 2010)

The genetics of human longevity

scientific article published on May 2006

The genetics of human longevity: an intricacy of genes, environment, culture and microbiome

scientific article published on 5 April 2017

The immune system in the elderly: activation-induced and damage-induced apoptosis

scientific article published in January 2004

The impact of mitochondrial DNA on human lifespan: a view from studies on centenarians

scientific article published on June 2008

The impact of phenocopy on the genetic analysis of complex traits

scientific article

The interleukin-6 −174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients

scientific article published on 01 September 2005

The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity

scientific article published on 20 January 2017

The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring

scientific article

The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas

scientific article

The onset of type 2 diabetes: proposal for a multi-scale model.

scientific article published on 31 October 2013

The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study

scientific article published on 27 December 2012

The peculiar aging of human liver: A geroscience perspective within transplant context

scientific article published on 14 February 2019

The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging)

scientific article published on 24 May 2020

The role of IL-1 gene cluster in longevity: a study in Italian population

scientific article published on 01 April 2003

The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

scientific article published on 23 January 2014

The second international conference "genetics of aging and longevity".

scientific article published on May 2012

The smell of longevity: a combination of Volatile Organic Compounds (VOCs) can discriminate centenarians and their offspring from age-matched subjects and young controls

scientific article published on 05 December 2019

The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms

scientific article

The unusual genetics of human longevity

scientific article published on May 2006

Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians

scientific article

Thymic output and functionality of the IL-7/IL-7 receptor system in centenarians: implications for the neolymphogenesis at the limit of human life

scientific article published in April 2006

Thyroid hormones and frailty in persons experiencing extreme longevity

scientific article published on 07 June 2020

Towards a liquid self: how time, geography, and life experiences reshape the biological identity

scientific article published on 09 April 2014

Tracing Behçet's disease origins along the Silk Road: an anthropological evolutionary genetics perspective

scientific article published on 22 September 2015

Transmission from centenarians to their offspring of mtDNA heteroplasmy revealed by ultra-deep sequencing

scientific article

Tumor necrosis factor-alpha gene -308G>A polymorphism is associated with ST-elevation myocardial infarction and with high plasma levels of biochemical ischemia markers

scientific article published in December 2005

Twelve-Week Daily Consumption of <i>ad hoc</i> Fortified Milk with ω-3, D, and Group B Vitamins Has a Positive Impact on Inflammaging Parameters: A Randomized Cross-Over Trial

scientific article published on 22 November 2020

Undulating changes in human plasma proteome profiles across the lifespan

scientific article published on 05 December 2019

Vaccination in the elderly: The challenge of immune changes with aging

scientific article published on 01 December 2018

Variations at the H-strand replication origins of mitochondrial DNA and mitochondrial DNA content in the blood of type 2 diabetes patients

Vitamin E-gene interactions in aging and inflammatory age-related diseases: implications for treatment. A systematic review

scientific article published on 11 January 2014

Von Willebrand factor in Italian centenarians

scientific article published on 01 January 2003

What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

scientific article

What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?

scientific article

What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians

scientific article

Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53.

scientific article published on 13 January 2009

X-chromosome-linked miR548am-5p is a key regulator of sex disparity in the susceptibility to mitochondria-mediated apoptosis

scientific article published on 11 September 2019

Zinc-induced Metallothionein in centenarian offspring from a large European population: the MARK-AGE Project

scientific article

lnterleukin-6 is a determinant of PAI-1 levels in diabetic subjects with the 4G allele at position -675 of the PAI-1 gene

article

mtDNA mutations in human aging and longevity: controversies and new perspectives opened by high-throughput technologies

scientific article published on 05 April 2014

p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1.

scientific article published on 27 September 2005

p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes

scientific article published in December 2002

p66(Shc) gene has a pro-apoptotic role in human cell lines and it is activated by a p53-independent pathway

scientific article published on 9 February 2006

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