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List of works by Reto Brun

1,2-substituted 4-(1H)-quinolones: synthesis, antimalarial and antitrypanosomal activities in vitro.

scientific article published on 10 September 2014

1-Aryl-1,2,3,4-tetrahydroisoquinolines as potential antimalarials: synthesis, in vitro antiplasmodial activity and in silico pharmacokinetics evaluation

scholarly article in RSC Advances, vol. 4 no. 44, 2014

1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis

article published in 2011

2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design

scientific article published on 06 April 2018

2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities

scientific article

2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections ⬇️

scientific article published on September 18, 2010

2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile.

scientific article published on 3 August 2015

4-Aminobicyclo[2.2.2]octan-2-ones and -ols via Enamine Intermediates

article

4-Aminobicyclo[2.2.2]octan-2-yl 4-aminobutanoates with antiprotozoal activity

8,8-Dialkyldihydroberberines with Potent Antiprotozoal Activity

9β-hydroxyparthenolide esters from Inula montbretiana and their antiprotozoal activity

scientific article

A Near-Complete Series of Four Atropisomeric Jozimine A2-Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from Ancistrocladus abbreviatus

scientific article published on 23 October 2019

A protocol for HPLC-based activity profiling for natural products with activities against tropical parasites

scientific article

Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi.

scientific article published on 5 February 2016

Activities of psilostachyin A and cynaropicrin against Trypanosoma cruzi in vitro and in vivo

scientific article

Acyclic Nucleoside Analogues as Inhibitors ofPlasmodiumfalciparumdUTPase

scientific article published on 01 July 2006

Acyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes

article

Adenosine Kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics

scientific article

Advancing drug innovation for neglected diseases-criteria for lead progression

scientific article

Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease

scientific article

Alkamides from Anacyclus pyrethrum L. and Their in Vitro Antiprotozoal Activity.

scientific article published on 12 May 2017

Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents.

scientific article published on 19 April 2016

Alkyl and dialkylaminoethyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes and their antiplasmodial and antitrypanosomal activities

scientific article published on 30 September 2009

An Unusually Broad Series of Seven Cyclombandakamines, Bridged Dimeric Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ealaensis

scientific article published on 08 July 2019

An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatoriumperfoliatum

scientific article published on 15 February 2011

Analogues of thiolactomycin as potential antimalarial agents

scientific article published on September 2005

Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity.

scientific article

Ancistectorine D, a naphthylisoquinoline alkaloid with antiprotozoal and antileukemic activities, and further 5,8'- and 7,1'-linked metabolites from the Chinese liana Ancistrocladus tectorius.

scientific article published on 16 September 2016

Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana Ancistrocladus abbreviatus with inhibitory activities against Plasmodium falciparum and PANC-1 human pancreatic cancer cells

scientific article published on 09 November 2018

Ancistrocladinium A and B, the First N,C-Coupled Naphthyldihydroisoquinoline Alkaloids, from a CongoleseAncistrocladusSpecies¶

scientific article published on 01 December 2006

Anthecularin: A Novel Sesquiterpene Lactone from Anthemis auriculata with Antiprotozoal Activity

scientific article published in October 2007

Anti-Protozoal Activities of Cembrane-Type Diterpenes from Vietnamese Soft Corals.

scientific article published on 8 July 2015

Anti-Trypanosomatid Elemanolide Sesquiterpene Lactones from Vernonia lasiopus O. Hoffm.

scientific article

Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots

scientific article

Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones

scientific article (publication date: August 2002)

Anti-trypanosomal cadinanes synthesized by transannular cyclization of the natural sesquiterpene lactone nobilin

scientific article published on 13 February 2015

Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides

scientific article published on 3 May 2006

Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae)

scientific article published in 2014

Antileukemic ancistrobenomine B and related 5,1'-coupled naphthylisoquinoline alkaloids from the Chinese liana Ancistrocladus tectorius.

scientific article

Antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation

scientific article published on 11 January 2010

Antiparasitic agents: new drugs on the horizon

scientific article published on 29 May 2012

Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense

scientific article published on 25 March 2011

Antiplasmodial Ealapasamines A-C,'Mixed' Naphthylisoquinoline Dimers from the Central African Liana Ancistrocladus ealaensis.

scientific article published on 18 July 2017

Antiplasmodial and antitrypanosomal activities of aminobicyclo[2.2.2]octyl omega-aminoalkanoates

scientific article published on 10 May 2008

Antiplasmodial and antitrypanosomal activity of bicyclic amides and esters of dialkylamino acids

article

Antiplasmodial and antitrypanosomal activity of new esters and ethers of 4-dialkylaminobicyclo[2.2.2]octan-2-ols

scientific article published on 18 April 2006

Antiplasmodial lanostanes from the Ganoderma lucidum mushroom

scientific article published in May 2010

Antiprotozoal Activities of Epimeric Aminobicycles

Antiprotozoal Activities of Epimeric Aminobicycles

Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning

scientific article

Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata.

scientific article published on 15 December 2017

Antiprotozoal Spirombandakamines A1 and A2, Fused Naphthylisoquinoline Dimers from a Congolese Ancistrocladus Plant.

scientific article published on 30 November 2017

Antiprotozoal activities of new bicyclo[2.2.2]octan-2-imines and esters of bicyclo[2.2.2]octan-2-ols

scientific article published on 29 December 2004

Antiprotozoal activities of new bis-chlorophenyl derivatives of bicyclic octanes and aza-nonanes

scientific article published on 2 August 2006

Antiprotozoal activities of traditional medicinal plants from the Garhwal region of North West Himalaya, India

scientific article published on 16 April 2011

Antiprotozoal activity of (E)-cinnamic N-acylhydrazone derivatives

scientific article published on 5 December 2014

Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives

scientific article published on 29 June 2009

Antiprotozoal activity of Achillea ptarmica (Asteraceae) and its main alkamide constituents. ⬇️

scientific article published on 20 May 2014

Antiprotozoal activity of Buxus sempervirens and activity-guided isolation of O-tigloylcyclovirobuxeine-B as the main constituent active against Plasmodium falciparum.

scientific article published on 15 May 2014

Antiprotozoal activity of Melampyrum arvense and its metabolites

scientific article published on 01 January 2011

Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead.

scientific article published on 14 June 2016

Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atom

scientific article published on 2 July 2013

Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania donovani and Trypanosoma cruzi

Antiprotozoal isoflavan quinones from Abrus precatorius ssp. africanus

scientific article

Antiprotozoal screening of 60 South African plants, and the identification of the antitrypanosomal germacranolides schkuhrin I and II.

scientific article

Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness

scientific article published on 12 September 2011

Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies

scientific article

Antitrypanosomal isoflavan quinones from Abrus precatorius

scientific article published on 29 December 2013

Antitrypanosomal isothiocyanate and thiocarbamate glycosides from Moringa peregrina

scientific article

Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives

scientific article published on 2 January 2014

Antitumoral and antileishmanial dioncoquinones and ancistroquinones from cell cultures of Triphyophyllum peltatum (Dioncophyllaceae) and Ancistrocladus abbreviatus (Ancistrocladaceae).

scientific article

Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol

scientific article (publication date: 2013)

Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis

scientific article

Balgacyclamides, antiplasmodial heterocyclic peptides from Microcystis aeruguinosa EAWAG 251. ⬇️

scientific article published on 6 January 2014

Betraying the parasite's redox system: diaryl sulfide-based inhibitors of trypanothione reductase: subversive substrates and antitrypanosomal properties

scientific article

Bicyclic amido compounds with antiprotozoal activity

Bicyclo[2.2.2]octyl esters of dialkylamino acids as antiprotozoals

scientific article published on 23 May 2007

Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase

scientific article

Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents

scientific article published on 28 June 2018

Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents.

scientific article

Bisguanidine, bis(2-aminoimidazoline), and polyamine derivatives as potent and selective chemotherapeutic agents against Trypanosoma brucei rhodesiense. Synthesis and in vitro evaluation

scientific article published in April 2004

Bottlenecks and the maintenance of minor genotypes during the life cycle of Trypanosoma brucei.

scientific article

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling

scientific article

Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis

scientific article

Characterization of a novel DNA minor-groove complex

scientific article

ChemInform Abstract: Anthecularin (I): A Novel Sesquiterpene Lactone from Anthemis auriculata with Antiprotozoal Activity

scientific article published on 31 January 2008

ChemInform Abstract: Diarylcyclohexanones: Synthons for New Bicyclic Compounds

article

ChemInform Abstract: Epimers of Bicyclo[2.2.2]octan-2-ol Derivatives with Antiprotozoal Activity

article

ChemInform Abstract: Potent and Selective Antiplasmodial Activity of the Cyanobacterial Alkaloid Nostocarboline and Its Dimers

ChemInform Abstract: Synthesis and Antiprotozoal Activities of Simplified Analogues of Naphthylisoquinoline Alkaloids

ChemInform Abstract: Synthesis and Evaluation of 2-Pyridyl Pyrimidines with in vitro Antiplasmodial and Antileishmanial Activity

Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys

scientific article (publication date: February 2015)

Chloropupukeanolides C-E: cytotoxic pupukeanane chlorides with a spiroketal skeleton from Pestalotiopsis fici.

scientific article published on 8 February 2011

Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity

scientific article published on 18 November 2008

Complete structural assignment of serratol, a cembrane-type diterpene from Boswellia serrata, and evaluation of its antiprotozoal activity

scientific article published on 14 December 2010

Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile

scientific article

Cyclombandakamines A1 and A2, Oxygen-Bridged Naphthylisoquinoline Dimers from a Congolese Ancistrocladus Liana.

scientific article published on 23 February 2017

Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei

scientific article published on 5 September 2013

Cynaropicrin: the first plant natural product with in vivo activity against Trypanosoma brucei

scientific article

DNA Binding Affinity of Bisguanidine and Bis(2-aminoimidazoline) Derivatives with in Vivo Antitrypanosomal Activity

scientific article published on 01 June 2006

Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target

scientific article published in September 2005

Design and preparation of sterol mimetics as potential antiparasitics

scientific article published on 9 August 2010

Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents

scientific article

Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents

scientific article published on 23 January 2019

Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.

scientific article

Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase.

scientific article published on 10 July 2008

Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase.

scientific article published on 3 May 2006

Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI)

scientific article

Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase

scientific article

Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test

scientific article

Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections.

scientific article published on 16 February 2018

Dialkylaminoalkyl derivatives of bicyclic compounds with antiplasmodial activity

article

Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities

scientific article

Diarylcyclohexanones: synthons for new bicyclic compounds

Dioncophyllines C2, D2, and F and Related Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ileboensis with Potent Activities against Plasmodium falciparum and against Multiple Myeloma and Leukemia Cell Lines.

scientific article published on 25 January 2017

Directed Synthesis of All Four Pure Stereoisomers of the N,C-Coupled Naphthylisoquinoline Alkaloid Ancistrocladinium A.

scientific article

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

scientific article published on 18 September 2015

Discovery of Novel Benzo[a]phenoxazine SSJ-183 as a Drug Candidate for Malaria

scientific article

Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis

scientific article

Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8'-Coupling Site, from the Congolese Liana Ancistrocladus ealaensis, Targeting Pancreatic Cancer Cells

scientific article published on 20 October 2019

Efficacy study of novel diamidine compounds in a Trypanosoma evansi goat model

scientific article

Eflornithine for the treatment of human African trypanosomiasis

scientific article

Encecalol angelate, an unstable chromene from Ageratum conyzoides L.: total synthesis and investigation of its antiprotozoal activity

scientific article published on 17 June 2011

Epimers of bicyclo[2.2.2]octan-2-ol derivatives with antiprotozoal activity

scientific article

Epithelial innate immunity. A novel antimicrobial peptide with antiparasitic activity in the blood-sucking insect Stomoxys calcitrans

scientific article

Evaluation of Alkanediamide-Linked Bisbenzamidines as Potential Antiparasitic Agents

Evaluation of the in vitro trypanocidal activity of methylated flavonoid constituents of Vitex simplicifolia leaves

scientific article published on 26 March 2015

Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness

scientific article

Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL).

scientific article

Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma

scientific article

Global metabolic responses of mice to Trypanosoma brucei brucei infection

scientific article

HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant Carica papaya L.

scientific article

HPLC-profiling for antiplasmodial compounds—3-Methoxycarpachromene from Pistacia atlantica

article published in 2009

Highly antiplasmodial non-natural oxidative products of dioncophylline A: synthesis, absolute configuration, and conformational stability

scientific article published on 13 August 2015

Hydrazones and new Oximes of 4-Aminobicyclo[2.2.2]octanones and their Antiprotozoal Activities

Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties

scientific article

Identification of 1,3-diiminoisoindoline carbohydrazides as potential antimalarial candidates

scientific article

Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

scientific article

Identification of a new chemical class of antimalarials

scientific article

Identification of an antimalarial synthetic trioxolane drug development candidate

scientific article

Identification of two new phenathrenones and a saponin as antiprotozoal constituents of Drypetes gerrardii

Imidazolopiperazines: lead optimization of the second-generation antimalarial agents

scientific article

Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities

scientific article published on 16 December 2010

In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase.

scientific article published on 3 September 2015

In Silico prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against Trypanosoma brucei rhodesiense

scientific article

In pursuit of natural product leads: synthesis and biological evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4-carboxylic acid (A-33853) and its analogues: discovery of N-(2-benzoxazol-2-ylphenyl)benzamides as n

scientific article

In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness

scientific article

In vitro screening of traditional South African malaria remedies against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum

scientific article published on 16 March 2011

Inhibiting activities of the secondary metabolites of Phlomis brunneogaleata against parasitic protozoa and plasmodial enoyl-ACP Reductase, a crucial enzyme in fatty acid biosynthesis

scientific article published on August 2004

Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids

scientific article published in June 2006

Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5'-amino-5'-deoxyadenosines.

scientific article published on 26 June 2009

Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5'-amido-5'-deoxyadenosine derivatives

scientific article published on 20 January 2009

Inhibitory activity of marine sponge-derived natural products against parasitic protozoa

scientific article

Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter

scientific article

Isolation of aerucyclamides C and D and structure revision of microcyclamide 7806A: heterocyclic ribosomal peptides from Microcystis aeruginosa PCC 7806 and their antiparasite evaluation

scientific article

Isomerization of 4-Amino-6,7-diphenylbicyclo[2.2.2]octan-2-ones

article

Isomerization of 4-amino-6,7-diphenylbicyclo[2.2.2]octan-2-ones

Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound

scientific article published on May 2005

Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum

scientific article

Jacaranone-derived glucosidic esters from Jacaranda glabra and their activity against Plasmodium falciparum

scientific article published in April 2010

Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana Ancistrocladus ileboensis, with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line.

scientific article

Jozimine A2: the first dimeric Dioncophyllaceae-type naphthylisoquinoline alkaloid, with three chiral axes and high antiplasmodial activity

scientific article published on 5 December 2012

Kinetoplastids: related protozoan pathogens, different diseases

scientific article published on April 2008

Larrea tridentata—Absolute configuration of its epoxylignans and investigations on its antiprotozoal activity

Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles

scientific article

Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus ekstrelerinin antiprotozoal aktivitesi ve sitotoksisitesi

Major surface glycoproteins of insect forms of Trypanosoma brucei are not essential for cyclical transmission by tsetse

scientific article

Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli

scientific article published on 22 August 2007

Mbandakamine-Type Naphthylisoquinoline Dimers and Related Alkaloids from the Central African Liana Ancistrocladus ealaensis with Antiparasitic and Antileukemic Activities.

scientific article published on 21 March 2018

Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei

scientific article

Modified 5'-trityl nucleosides as inhibitors of Plasmodium falciparum dUTPase

scientific article published on 18 January 2011

Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.

scientific article published on January 2010

Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism

scientific article

New 4-Amino-2-azabicyclo[3.2.2]nonane Derivatives and Their Antiprotozoal Potencies

article

New 4-Amino-2-azabicyclo[3.2.2]nonane Derivatives and their Antiprotozoal Potencies

New N-methylpiperazinyl derivatives of bicyclic antiprotozoal compounds

scientific article published on 18 November 2011

New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi

scientific article published on 7 May 2013

New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity

scientific article published on 5 February 2008

New derivatives of bicyclic diamines with antiprotozoal activity

Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents

scientific article

Novel azabicyclo[3.2.2]nonane derivatives and their activities against Plasmodium falciparum K1 and Trypanosoma brucei rhodesiense

scientific article published on 7 May 2008

Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites

scientific article

Novel nucleoside-based antimalarial compounds

scientific article published on 23 April 2016

Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).

scientific article published on 26 March 2013

Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models.

scientific article published on 8 October 2010

Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei

scientific article published on 23 May 2013

PLS-Prediction and Confirmation of Hydrojuglone Glucoside as the Antitrypanosomal Constituent of Juglans Spp.

scientific article

Parallel synthesis and antileishmanial activity of ether-linked phospholipids

scientific article published on 10 July 2008

Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites.

scientific article published on 30 May 2009

Pentafluorosulfanyl as a novel building block for enzyme inhibitors: trypanothione reductase inhibition and antiprotozoal activities of diarylamines

scientific article

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

scientific article published on 11 June 2007

Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis

scientific article

Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis

scientific article

Phenolic analogs of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A, from Ancistrocladus cochinchinensis (Ancistrocladaceae), with improved antiprotozoal activities ⬇️

scientific article published on 01 November 2010

Potent and selective antiplasmodial activity of the cyanobacterial alkaloid nostocarboline and its dimers

scientific article published on 19 June 2008

Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N'6'-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate

scientific article

QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids

scientific article

Quantitative structure--antiprotozoal activity relationships of sesquiterpene lactones

scientific article published on 8 June 2009

Quinuclidine derivatives as potential antiparasitics

scientific article

Rapid One-Pot Synthesis of Antiparasitic Quinolines Based upon the Microwave-Assisted Coupling-Isomerization Reaction (MACIR)

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors

scientific article published on 13 April 2018

SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents

scientific article published on 3 July 2009

SARs of the antiprotozoal action of 6,7-diaryl-bicyclo[2.2.2]octan-2-ols

article

SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis

scientific article

Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis

scientific article

Search for Antiprotozoal Activity in Herbal Medicinal Preparations; New Natural Leads against Neglected Tropical Diseases.

scientific article published on 4 August 2015

Sesquiterpene Lactones from Vernonia cinerascens Sch. Bip. and Their in Vitro Antitrypanosomal Activity

scientific article

Shuangancistrotectorines A-E, dimeric naphthylisoquinoline alkaloids with three chiral biaryl axes from the Chinese plant Ancistrocladus tectorius

scientific article published in April 2010

Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5'-carboxamidoadenosine analogues

scientific article published on 24 October 2005

Spiroindolones, a potent compound class for the treatment of malaria

scientific article

Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense.

scientific article

Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove

scientific article

Structural Requirements for the Antiprotozoal Activity of 4-Aminobicyclo[2.2.2]octan-2-ols

article

Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues

scientific article published on 3 September 2009

Synthesis and Biological Properties of a Rhodacyanine Derivatives, SSJ-127, Having High Efficacy against Malaria Protozoa

scholarly article by Masataka Ihara et al published 2009 in Heterocycles

Synthesis and Evaluation of the Antitrypanosomal and Antiplasmodial Activities of New 4-Aminobicyclo[2.2.2]octane Derivatives

article

Synthesis and activity of nucleoside-based antiprotozoan compounds.

scientific article published on 16 February 2017

Synthesis and antimalarial efficacy of aza-fused rhodacyanines in vitro and in the P. berghei mouse model

scientific article published on July 2006

Synthesis and antimalarial property of orally active phenoxazinium salts.

scientific article published on 19 April 2007

Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes

scientific article published on 30 November 2014

Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids

scientific article

Synthesis and antiprotozoal activity of N-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with improved human blood-brain barrier permeability

scientific article published on 22 December 2010

Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase

scientific article

Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis

scientific article

Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity

scientific article

Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives

scientific article published on 20 October 2007

Synthesis and evaluation of the antitrypanosomal and antiplasmodial activities of new 4-aminobicyclo[2.2.2]octane derivatives

scientific article

Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives

scientific article published on 5 August 2011

Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives

scientific article published on 14 May 2008

Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive phenothiazinium chlorides

Synthesis and pharmacological evaluation of fluorescent and photoactivatable analogues of antiplasmodial naphthylisoquinolines.

scientific article

Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense.

scientific article published on 25 June 2016

Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities

scientific article

Synthesis of Novel Diazabicycles and their Antiprotozoal Activities

article

Synthesis of a series of N6-substituted adenosines with activity against trypanosomatid parasites

scientific article published on 20 February 2009

Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity

scientific article

Synthesis of antiprotozoal diamines by regioselective insertion of nitrogen into a bicyclic ring system

article

Synthesis of bicyclic amines and their activities against Trypanosoma brucei rhodesiense and Plasmodium falciparum K1.

scientific article published on 19 June 2008

Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities

Synthesis of new tetrahydropyridinylidene ammonium salts and their antiprotozoal potency

Synthesis of three classes of rhodacyanine dyes and evaluation of their in vitro and in vivo antimalarial activity

scientific article published on 12 September 2006

Synthesis, Structure−Activity Relationship, and Mode-of-Action Studies of Antimalarial Reversed Chloroquine Compounds ⬇️

scientific article published on September 9, 2010

Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania

scientific article

Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds

scientific article published in December 2009

Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines

scientific article

Terpenoids from the Oleo-Gum-Resin of Boswellia serrata and Their Antiplasmodial Effects In Vitro.

scientific article published on 24 July 2017

The antiprotozoal activity of methylated flavonoids from Ageratum conyzoides L.

scientific article published on 26 February 2010

The antiprotozoal activity of sixteen asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from Xanthium brasilicum.

scientific article published on 8 May 2009

The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes

scientific article

Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi.

scientific article

Trematocidal activity of praziquantel and artemisinin derivatives: in vitro and in vivo investigations with adult Echinostoma caproni

scientific article

Triclosan is minimally effective in rodent malaria models

scientific article published in January 2011

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity

scientific article published on 13 April 2009

Yucatec Mayan medicinal plants: evaluation based on indigenous uses

scientific article

ent-Pimarane and ent-Kaurane Diterpenes from Aldama discolor (Asteraceae) and Their Antiprotozoal Activity.

scientific article published on 15 September 2016

β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase

scientific article

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