List of works by Hubert Schorle

A mouse model for cystic biliary dysgenesis in autosomal recessive polycystic kidney disease (ARPKD)

article

A subtractive gene expression screen suggests a role of transcription factor AP-2 alpha in control of proliferation and differentiation

scientific article

AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase

scientific journal article

AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex

scientific journal article

Abrogation of Gap Junctional Communication in ES Cells Results in a Disruption of Primitive Endoderm Formation in Embryoid Bodies.

scientific article published on 21 November 2016

An activating mutation in the PDGF receptor alpha results in embryonic lethality caused by malformation of the vascular system.

scientific article published in May 2009

Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.

scientific article

Anthrax. The growing danger

scientific article published in May 2002

Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4.

scientific article published in August 1995

Are testicular mast cells involved in the regulation of germ cells in man?

scientific article

Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation.

scientific article

BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma

scientific article published on 30 July 2015

Breaking the first lineage barrier - many roads to trophoblast stem cell fate

scientific article published on 23 December 2016

Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation

scientific article published in March 2004

Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth.

scientific article

Cloning, expression and characterization of the murine Efemp1, a gene mutated in Doyne-Honeycomb retinal dystrophy.

scientific article

Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71.

scientific article published on 9 June 2015

Conditional inactivation of transcription factor AP-2gamma by using the Cre/loxP recombination system.

scientific article published in February 2002

Connexin 31 (GJB3) Deficiency in Mouse Trophoblast Stem Cells Alters Giant Cell Differentiation and Leads to Loss of Oxygen Sensing1

scientific article published on 23 August 2012

Correction: Transcription Factor TFAP2C Regulates Major Programs Required for Murine Fetal Germ Cell Maintenance and Haploinsufficiency Predisposes to Teratomas in Male Mice.

scientific article published on 29 August 2013

Critical function of AP-2 gamma/TCFAP2C in mouse embryonic germ cell maintenance

scientific article

Deficiency in the LIM-only protein Fhl2 impairs skin wound healing

scientific article

Derivation and maintenance of murine trophoblast stem cells under defined conditions

scientific article published on 30 January 2014

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting ⬇️

scientific article published on August 15, 1991

Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4

article

Diagnostic value of markers M2A, OCT3/4, AP-2gamma, PLAP and c-KIT in the detection of extragonadal seminomas.

scientific article published in September 2006

Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5

scientific journal article

Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts

scientific article published on 22 September 2015

Distinct spatial expression patterns of AP-2alpha and AP-2gamma in non-neoplastic human breast and breast cancer

scientific article published on 01 March 2005

Dual role of AP-2? in ErbB-2-induced mammary tumorigenesis

article

Dynamic expression of Krüppel-like factor 4 (Klf4), a target of transcription factor AP-2alpha during murine mid-embryogenesis.

scientific article published in August 2003

Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse embryonic stem cells

scientific article published in August 2007

Epigenetic drugs and their molecular targets in testicular germ cell tumours

scientific article published on 01 April 2019

Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo

scientific article published on 23 April 2007

Establishment and controlled differentiation of neural crest stem cell lines using conditional transgenesis

scientific article published on 23 March 2007

Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cells.

scientific article

Exencephaly in a subset of animals heterozygous for AP-2alpha mutation

scientific article published in May 2002

Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors

scientific article

Expression of Cdcrel-1 (Pnutl1), a gene frequently deleted in velo-cardio-facial syndrome/DiGeorge syndrome

article

Fetuin-B, a liver-derived plasma protein is essential for fertilization

scientific journal article

Filamin A Orchestrates Cytoskeletal Structure, Cell Migration and Stem Cell Characteristics in Human Seminoma TCam-2 Cells

scientific article published on 30 November 2020

Gene expression profiling identifies new biological markers of neoplastic germ cells

article

Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

scientific article

Immune responses in interleukin-2-deficient mice

scientific article published in Science

Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs

scientific article published on 16 December 2021

Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics

scientific article published on 30 April 2015

Interference with activator protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells

scientific article

Kit transduced signals counteract erythroid maturation by MAPK-dependent modulation of erythropoietin signaling and apoptosis induction in mouse fetal liver

scientific article published on 17 October 2014

Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes

scientific article

Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes

article

Lineage conversion of murine extraembryonic trophoblast stem cells to pluripotent stem cells.

scientific article

Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice

scientific journal article

Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland

scientific journal article

MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells

scientific article

Mammalian germ cells are determined after PGC colonization of the nascent gonad

scientific article published on 21 November 2019

Mice overexpressing genes from the 22q11 region deleted in velo-cardio-facial syndrome/DiGeorge syndrome have middle and inner ear defects

scientific article published in October 2001

Mice transgenic for NPM-ALK develop non-Hodgkin lymphomas

scientific article published in September 2005

Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15.

scientific article

N6-Methyladenosine detected in RNA of testicular germ cell tumors is controlled by METTL3, ALKBH5, YTHDC1/F1/F2, and HNRNPC as writers, erasers, and readers

scientific article published on 23 March 2019

NANOG promoter methylation and expression correlation during normal and malignant human germ cell development

scientific article published on January 2011

Normal embryonic development and cardiac morphogenesis in mice with Wnt1-Cre-mediated deletion of connexin43

article

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

scientific article

Persistent Human KIT Receptor Signaling Disposes Murine Placenta to Premature Differentiation Resulting in Severely Disrupted Placental Structure and Functionality

scientific article published on 31 July 2020

Production of chick embryo extract for the cultivation of murine neural crest stem cells

scientific article published on 27 November 2010

Reduced Gene Dosage of Tfap2c Impairs Trophoblast Lineage Differentiation and Alters Maternal Blood Spaces in the Mouse Placenta

scientific article published on 10 June 2015

Reference gene validation for RT-qPCR, a note on different available software packages

scientific article published on 31 March 2015

Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control

scientific article (publication date: 30 December 2000)

Spatial expression of germ cell markers during maturation of human fetal male gonads: an immunohistochemical study

scientific article published on 06 October 2005

Starvation response in mouse liver shows strong correlation with life-span-prolonging processes

scientific article published on 13 April 2004

Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway

scientific article published in December 2008

TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome

scientific journal article

TCam-2 Cells Deficient for SOX2 and FOXA2 Are Blocked in Differentiation and Maintain a Seminoma-Like Cell Fate In Vivo.

scientific article published on 25 May 2019

TCam-2 but not JKT-1 cells resemble seminoma in cell culture.

scientific article published on 15 November 2007

TGF-β1, EGF and FGF4 synergistically induce differentiation of the seminoma cell line TCam-2 into a cell type resembling mixed non-seminoma.

scientific article published on 8 June 2011

Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines

scientific article published on 19 May 2020

Terminal renal failure in mice lacking transcription factor AP-2 beta

scientific journal article

The AP-2 family of transcription factors

scientific article

The role of BLIMP1 and its putative downstream target TFAP2C in germ cell development and germ cell tumours.

scientific article published on 12 May 2011

The role of transcription factor Tcfap2c/TFAP2C in trophectoderm development

scientific article published on 03 March 2012

The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expression

scientific article published on 24 August 2011

The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas

scientific article published on 02 August 2021

The transcription factor TCFAP2C/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation

scientific journal article

The transcription factor TCFAP2C/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation.

scientific article published on 23 October 2010

Towards Dissecting The Complexity of The AP-1 (Activator Protein 1) Family

scientific article published on 01 January 2004

Transcription factor AP-2 essential for cranial closure and craniofacial development

scientific journal article

Transcription factor AP-2gamma stimulates proliferation and apoptosis and impairs differentiation in a transgenic model.

scientific article published in October 2003

Transcription factor AP-2gamma, a novel marker of gonocytes and seminomatous germ cell tumors.

scientific article

Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice

scientific article

Transcription factor gene AP-2 gamma essential for early murine development

scientific article

Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia

scientific article

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

scientific journal article

Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumor fate

scientific article published on 01 November 2019

Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach

scientific article

[Embryonal germ cells and germ cell tumors]

scientific article published on 01 January 2007

[Generalized autoimmune diseases in BALB/c mice with a genetically dependent interleukin-2 deficiency]

scientific article published on 01 January 1996

[On the role of transcription factor family AP-2 for development and disease--lessons from mouse models]

scientific article published on 01 January 2007

c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminoma

article

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