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List of works by Vincent Giguère

4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related (ERR) nuclear receptors beta and gamma

scientific article published in October 2001

A frequent regulatory variant of the estrogen-related receptor alpha gene associated with BMD in French-Canadian premenopausal women

scientific article

A polymorphic autoregulatory hormone response element in the human estrogen-related receptor alpha (ERRalpha) promoter dictates peroxisome proliferator-activated receptor gamma coactivator-1alpha control of ERRalpha expression

scientific article published on 20 February 2004

A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters

scientific article

Absence of ERRalpha in female mice confers resistance to bone loss induced by age or estrogen-deficiency

scientific article

Additive effects of epinephrine and corticotropin-releasing factor (CRF) on adrenocorticotropin release in rat anterior pituitary cells

scientific article published on 01 January 1983

Alveolarization in retinoic acid receptor-beta-deficient mice

scientific article published on 5 January 2005

An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis

scientific article published on 01 July 2019

An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha

scientific article

An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression

scientific article

Androgen-Dependent Repression of ERRγ Reprograms Metabolism in Prostate Cancer

scientific article published on 7 November 2016

Androgens decrease LHRH binding sites in rat anterior pituitary cells in culture

scientific article published on 01 January 1981

CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant

scientific article

Characteristics of the alpha-adrenergic stimulation of adrenocorticotropin secretion in rat anterior pituitary cells

scientific article published on 01 September 1981

Chromosomal localization of the human Thy-1 gene

scientific article published on September 1985

Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene

scientific article

Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα.

scientific article published on May 2016

Chronicle of a discovery: the retinoic acid receptor

Chronicle of a discovery: the retinoic acid receptor

scientific article published in November 2022

Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element

scientific article

Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta

scientific journal article

Close linkage of retinoic acid receptor genes with homeobox- and keratin-encoding genes on paralogous segments of mouse chromosomes 11 and 15.

scientific article

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

scientific article published on 01 April 1987

Compound mutants for retinoic acid receptor (RAR) beta and RAR alpha 1 reveal developmental functions for multiple RAR beta isoforms.

scientific article published in March 1996

Contribution of steroid receptor coactivator-1 and CREB binding protein in ligand-independent activity of estrogen receptor beta

scientific article published on April 2001

Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation

scientific article published on 15 December 2005

Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2

scientific article published on 24 October 2016

Coregulators of estrogen receptor action

scientific article

Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta

scientific article

Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors

scientific article

ELF3 is a repressor of androgen receptor action in prostate cancer cells

scientific article published on 25 February 2013

EM-652 (SCH57068), a pure SERM having complete antiestrogenic activity in the mammary gland and endometrium

scientific article

EM-800, a novel antiestrogen, acts as a pure antagonist of the transcriptional functions of estrogen receptors alpha and beta

scientific article published on 01 January 1998

ERBB2 deficiency alters an E2F-1-dependent adaptive stress response and leads to cardiac dysfunction.

scientific article published on 22 September 2014

ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart

scientific article published in July 2007

ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer

scientific article published on 12 July 2016

ESRRA (estrogen-related receptor α) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense.

scientific article

Editorial: What's in a Name, or the Impact of Misnomers in Endocrine Research.

scientific article published on June 2015

Epidermal growth factor-induced signaling in breast cancer cells results in selective target gene activation by orphan nuclear receptor estrogen-related receptor alpha

scientific article published on July 2005

Estrogen receptor alpha-mediated adiposity-lowering and hypocholesterolemic actions of the selective estrogen receptor modulator acolbifene

scientific article published in October 2005

Estrogen receptor beta: re-evaluation of estrogen and antiestrogen signaling

scientific article published in May 1998

Estrogen receptor mutations in breast cancer-an anticipated "rediscovery?"

scientific article published on April 2014

Estrogen related receptor-alpha enhances surfactant protein-A gene expression in fetal lung type II cells.

scientific article

Estrogen related receptors (ERRs): a new dawn in transcriptional control of mitochondrial gene networks

scientific article published on 07 April 2011

Estrogen-related receptor alpha (ERRalpha) is a transcriptional regulator of apolipoprotein A-IV and controls lipid handling in the intestine

scientific article

Estrogen-related receptor alpha (ERRα) is a key regulator of intestinal homeostasis and protects against colitis

scientific article published on 23 July 2021

Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle

scientific article

Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription.

scientific article published on 2 November 2005

Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function

scientific article

Estrogen-related receptor α decreases RHOA stability to induce orientated cell migration

scientific article

Estrogen-related receptor α, the molecular clock, and transcriptional control of metabolic outputs

scientific article published on 16 December 2011

Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness.

scientific article

Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation

scientific article published on 31 October 2011

Estrogen-related receptors are targetable ROS sensors

scientific article published on 20 February 2020

From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response

scientific article

Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease

scientific article

Functional genomics identifies a mechanism for estrogen activation of the retinoic acid receptor alpha1 gene in breast cancer cells

scientific article

Genome-wide computational prediction of transcriptional regulatory modules reveals new insights into human gene expression

scientific article published on 10 April 2006

Genome-wide identification of direct target genes implicates estrogen-related receptor alpha as a determinant of breast cancer heterogeneity.

scientific article

Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma

scientific article published in May 2007

Genomic convergence among ERRα, PROX1, and BMAL1 in the control of metabolic clock outputs

scientific article published in June 2011

Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis

scientific article published on 29 March 2019

Heterodimeric interaction of the retinoic acid and thyroid hormone receptors in transcriptional regulation on the gamma F-crystallin everted retinoic acid response element

scientific article published on 01 November 1994

Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator

scientific journal article

Identification of a chromatin-bound ERRα interactome network in mouse liver

scientific article published in 2024

Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis

scientific article

Identification of receptors for retinoids as members of the steroid and thyroid hormone receptor family.

scientific article

Inactivation of RARβ inhibits Wnt1-induced mammary tumorigenesis by suppressing epithelial-mesenchymal transitions.

scientific article

Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4

scientific article published on 27 August 2020

Interactions between CRF, epinephrine, vasopressin and glucocorticoids in the control of ACTH secretion.

scientific article published on January 1984

Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis

scientific article

International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors

scientific article

International Union of Pharmacology. LXVI. Orphan nuclear receptors

scientific article

Inverse Regulation of DHT Synthesis Enzymes 5α-Reductase Types 1 and 2 by the Androgen Receptor in Prostate Cancer.

scientific article

Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells

scientific article

Isolation of a novel retinoic acid-responsive gene by selection of genomic fragments derived from CpG-island-enriched DNA.

scientific article published on August 1996

Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation

scientific article (publication date: June 2003)

Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1

scientific article published on 01 April 1999

Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos

scientific article published in March 2004

Loss of estrogen-related receptor α promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances.

scientific article published on 14 October 2013

MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα

scientific article published on 22 May 2017

Measurement of subnanomolar retinoic acid binding affinities for cellular retinoic acid binding proteins by fluorometric titration

scientific article published in November 1994

Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway

scientific article published in 2008

Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid

scientific article published on 01 September 1995

Modulation of the far-upstream enhancer of the rat alpha-fetoprotein gene by members of the ROR alpha, Rev-erb alpha, and Rev-erb beta groups of monomeric orphan nuclear receptors

scientific article

Modulation of the retinoic acid and retinoid X receptor signaling pathways in P19 embryonal carcinoma cells by calreticulin

scientific article published on January 1997

Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver

scientific article published in April 2013

Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein

scientific article

Multiple factors involved in the control of ACTH secretion.

scientific article published in June 1984

Novel mechanism of nuclear receptor corepressor interaction dictated by activation function 2 helix determinants

scientific article

Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis

scientific article published on 18 April 2011

Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense

scientific article published in August 2007

Nuclear receptor location analyses in mammalian genomes: from gene regulation to regulatory networks

scientific article published on 21 February 2008

Nuclear receptor target gene discovery using high-throughput chromatin immunoprecipitation

scientific article published on January 2003

Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond

scientific article

Ordered binding of retinoic acid and retinoid-X receptors to asymmetric response elements involves determinants adjacent to the DNA-binding domain.

scientific article published on January 1994

Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation.

scientific article published on July 2015

Orphan nuclear receptor ROR alpha-deficient mice display the cerebellar defects of staggerer

scientific article published in January 1998

Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis

scientific article

PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism

scientific article

PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer.

scientific article published on 26 January 2012

Parallel stimulation of ACTH, beta-LPH + beta-endorphin and alpha-MSH release by alpha-adrenergic agents in rat anterior pituitary cells in culture

scientific article published on 01 June 1981

Phosphatases at the heart of FoxO metabolic control

scientific article published on February 2008

Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif

scientific article

Physiological genomics identifies estrogen-related receptor alpha as a regulator of renal sodium and potassium homeostasis and the renin-angiotensin pathway

scientific article

Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta

scientific journal article

Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors.

scientific article published on 30 December 2013

RARbeta mediates the response of Hoxd4 and Hoxb4 to exogenous retinoic acid

scientific article published in June 1999

Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha

scientific article

Reprogramming clinical outcome

journal article; published in Nature on 2012-01-18

Requirement of Ras-dependent pathways for activation of the transforming growth factor beta3 promoter by estradiol

scientific article

Retinoic acid receptors and cellular retinoid binding proteins: complex interplay in retinoid signaling

scientific article published on February 1994

Retinoic acid-dependent transgene expression is regulated by RARbeta expression in the retina

scientific article published in August 2001

Role of extracellular cysteine residues in dimerization/oligomerization of the human prostacyclin receptor.

scientific article published on June 2004

SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer

scientific article published on 21 May 2018

Site of calcium requirement for stimulation of ACTH release in rat anterior pituitary cells in culture by synthetic ovine corticotropin-releasing factor

scientific article published in December 1982

Stimulation of cyclic AMP accumulation and corticotropin release by synthetic ovine corticotropin-releasing factor in rat anterior pituitary cells: site of glucocorticoid action

scientific article

Stromal retinoic acid receptor beta promotes mammary gland tumorigenesis

scientific article

Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program.

scientific article published on 29 June 2018

The PGC-1/ERR signaling axis in cancer

scientific article published on 03 December 2012

The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer.

scientific article published on 19 January 2016

The co-repressor hairless protects RORalpha orphan nuclear receptor from proteasome-mediated degradation

scientific article published on 21 October 2003

The functional domains of the murine Thy-1 gene promoter ⬇️

scientific article published on April 1, 1991

The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functions

scientific article published on March 2010

The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseases.

scientific article

The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload.

scientific article

The orphan nuclear receptor ROR alpha (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9.

scientific article

There and back again: The journey of the estrogen-related receptors in the cancer realm.

scientific article published on 04 July 2015

Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

scientific article published on 26 June 2018

To ERR in the estrogen pathway

scientific article

Transcriptional control of energy homeostasis by the estrogen-related receptors

scientific article published on 29 July 2008

Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesis

scientific article published on 20 October 2010

miR-378(∗) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway

scientific article published on October 2010

β-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression.

scientific article published on 29 May 2013

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