List of works by Patrice Dubreuil

A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection

scientific article published on 27 March 2014

A randomized, placebo-controlled phase III trial of masitinib plus gemcitabine in the treatment of advanced pancreatic cancer

scientific article published on 9 April 2015

ASXL1 but not TET2 mutations adversely impact overall survival of patients suffering systemic mastocytosis with associated clonal hematologic non-mast-cell diseases.

scientific article published on 21 January 2014

Absence of circulating mast cell precursors in paediatric mastocytosis: could it reflect a different pathophysiology between adults and children with mastocytosis?

scientific article published on 14 June 2013

Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia

scientific article published on 12 November 2009

Activation of KIT modulates the function of tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) in mast cells.

scientific article published on 16 April 2015

Adult T cell leukemia aggressivenness correlates with loss of both 5-hydroxymethylcytosine and TET2 expression

scientific article published on 26 November 2016

Affinity and inhibitory capacity of T-cell proliferation of monoclonal anti-Ia antibodies

scientific article published on 01 September 1982

An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia ⬇️

scientific article published on 13 June 2016

Anti-CD2 (sheep red blood cell receptor) monoclonal antibodies and T cell activation. I. Pairs of anti-T11.1 and T11.2 (CD2 subgroups) are strongly mitogenic for T cells in presence of 12-O-tetradecanoylphorbol 13-acetate

scientific article published on 01 September 1986

Blood CD34-c-Kit+ cell rate correlates with aggressive forms of systemic mastocytosis and behaves like a mast cell precursor

scientific article published on 30 August 2011

Bone marrow tryptase as a possible diagnostic criterion for adult systemic mastocytosis.

scientific article published on January 2016

Case-control cohort study of patients' perceptions of disability in mastocytosis

scientific article published in 2008

Cell surface fixation of alloantigen bearing plasma vesicles in the presence of polyethylene glycol

scientific article published on 01 January 1981

Cell-to-cell spread of wild-type herpes simplex virus type 1, but not of syncytial strains, is mediated by the immunoglobulin-like receptors that mediate virion entry, nectin1 (PRR1/HveC/HIgR) and nectin2 (PRR2/HveB)

scientific article

Characterization of S628N: a novel KIT mutation found in a metastatic melanoma.

scientific article published in December 2014

Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma

scientific article published on 2 May 2017

Comparison of murine and human nectin1 binding to herpes simplex virus glycoprotein D (gD) reveals a weak interaction of murine nectin1 to gD and a gD-dependent pathway of entry.

scientific article published on April 2001

Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene

scholarly article

Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer.

scientific article

Current concepts and treatment advances in systemic mastocytosis

scientific article published on 10 April 2008

DNAM-1 and PVR regulate monocyte migration through endothelial junctions

scientific article

DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

scientific article published on 15 February 2016

Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms

scientific article published on 24 December 2015

Desmoid-type fibromatosis

scientific article published on 01 August 2007

Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells

scientific article

Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.

scientific article published on 10 November 2017

Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasms

scientific article published on February 2003

Evidence for mast cells contributing to neuromuscular pathology in an inherited model of ALS.

scientific article published on 19 October 2017

FES kinase participates in KIT-ligand induced chemotaxis

scientific article

Familial hematological malignancies: new IDH2 mutation.

scientific article published on 3 September 2016

Gain-of-function mutations in the extracellular domain of KIT are common in canine mast cell tumors

scientific article

Gastrointestinal involvement and manifestations in systemic mastocytosis

scientific article published on July 2010

Gastrointestinal manifestations in mastocytosis: a study of 83 patients

scientific article published on 26 July 2013

Hotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivity

scientific article (publication date: July 2014)

Human erythroleukemia: is the two-hit model of mouse leukemogenesis valid in human disease?

scientific article published on 31 May 2007

Identification on I-Ak molecules of a functional site recognized by proliferating T-lymphocytes

scientific article published on 01 January 1982

Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors

scientific article

In aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells

scientific article published on 16 October 2012

Isolated flushes without permanent, fixed or other skin lesions in patients with systemic mastocytosis: a case series of 9 patients.

scientific article

KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis

scientific article

KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570.

scientific article published on 18 February 2013

KLH-specific, I-E/C-restricted clones of proliferating T lymphocytes

scientific article published on 01 December 1981

Kit-activating mutations cooperate with Spi-1/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice.

scientific article published on December 2005

Leukocyte telomere length in mastocytosis: correlations with depression and perceived stress

scientific article published in August 2013

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells

scientific article

Long-term efficacy and safety of cladribine (2-CdA) in adult patients with mastocytosis.

scientific article published on 22 May 2015

Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth.

scientific article published on 11 April 2011

Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT

scientific article

Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trial

scientific article published on 19 April 2011

Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model

scientific article (publication date: 4 March 2010)

Masitinib decreases signs of canine atopic dermatitis: a multicentre, randomized, double-blind, placebo-controlled phase 3 trial.

scientific article

Masitinib demonstrates anti-proliferative and pro-apoptotic activity in primary and metastatic feline injection-site sarcoma cells

scientific article published on 25 August 2011

Masitinib for the treatment of systemic and cutaneous mastocytosis with handicap: a phase 2a study

scientific article published on December 2010

Masitinib for treatment of severely symptomatic indolent systemic mastocytosis: a randomised, placebo-controlled, phase 3 study.

scientific article published on 6 January 2017

Masitinib in advanced gastrointestinal stromal tumor (GIST) after failure of imatinib: a randomized controlled open-label trial

scientific article

Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study

scientific article published on 23 June 2009

Masitinib is safe and effective for the treatment of canine mast cell tumors

scientific article published on 24 September 2008

Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study

scientific article

Mast cell leukemia

scientific article published on 14 December 2012

Mast cell leukemia: identification of a new c-Kit mutation, dup(501-502), and response to masitinib, a c-Kit tyrosine kinase inhibitor.

scientific article published on 28 April 2012

Mast cell sarcoma: a rare and aggressive entity--report of two cases and review of the literature

scientific article

Mast cell sarcoma: new cases and literature review

scientific article

Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis.

scientific article

Mastocytosis among elderly patients: A multicenter retrospective French study on 53 patients

scientific article

Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells

scientific article

Midostaurin in Advanced Systemic Mastocytosis

Molecular basis of mast cell disease.

scientific article published on 24 April 2014

Molecular defects in mastocytosis: KIT and beyond KIT.

scientific article

Mouse monoclonal anti-Ia antibodies recognize cross-reacting determinants expressed on distinct subsets of human Ia-like cell-surface molecules

scientific article published on 01 May 1983

Mutational Hotspot of TET2, IDH1, IDH2, SRSF2, SF3B1, KRAS, and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast Cell Tumors

scientific article published on 12 November 2015

Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration

scientific article

Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17.

scientific article

Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction

scientific journal article

Neuroprotective effect of masitinib in rats with postischemic stroke

scientific article published on 26 October 2014

Novel, soluble isoform of the herpes simplex virus (HSV) receptor nectin1 (or PRR1-HIgR-HveC) modulates positively and negatively susceptibility to HSV infection

scientific article

Oncogenic tyrosine kinase of malignant hemopathy targets the centrosome.

scientific article published in August 2005

PICK-1: a scaffold protein that interacts with Nectins and JAMs at cell junctions

scientific article

Paediatric mastocytosis: a systematic review of 1747 cases

scientific article published on 08 February 2015

Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations.

scientific article

Pediatric mastocytosis-associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KIT-phosphotransferase domain mutations.

scientific article published on 18 May 2010

Phenotypic and genotypic characteristics of mastocytosis according to the age of onset

scientific article

Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

scientific article published on 11 July 2016

Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain

scientific article (publication date: 26 July 2002)

Rapamycin inhibits growth and survival of D816V-mutated c-kit mast cells.

scientific article

Rapid and clinically significant response to masitinib in the treatment of mucosal primary esophageal melanoma with somatic KIT exon 11 mutation involving brain metastases: A case report

scientific article published on 27 November 2015

Relocalization of KIT D816V to cell surface after dasatinib treatment: potential clinical implications

scientific article

Response of a KIT-positive extra-abdominal fibromatosis to imatinib mesylate and KIT genetic analysis

scientific article published on 01 April 2006

SRSF2-p95 hotspot mutation is highly associated with advanced forms of mastocytosis and mutations in epigenetic regulator genes

scientific article published on 3 January 2014

Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models.

scientific article

Semaxinib (SU5416) as a therapeutic agent targeting oncogenic Kit mutants resistant to imatinib mesylate

scientific article published on 18 December 2006

Signal transduction by several KIT juxtamembrane domain mutations

scientific article published in July 2003

Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal

scientific article (publication date: 22 June 2001)

Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling

scientific article (publication date: 26 March 2004)

Systemic mastocytosis and bone involvement in a cohort of 75 patients

Telangiectasia macularis eruptiva perstans (TMEP): A form of cutaneous mastocytosis with potential systemic involvement

scientific article

Thalidomide in systemic mastocytosis: results from an open-label, multicentre, phase II study

scientific article

The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins

scientific article

The Mouse W/c-kit Locus

scientific article published on 01 January 1990

The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D

scientific article

The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice.

scientific article published on March 1991

The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene

scientific article

The murine homolog of human Nectin1delta serves as a species nonspecific mediator for entry of human and animal alpha herpesviruses in a pathway independent of a detectable binding to gD

scientific article published on April 2000

The tumor suppressor activity of SOCS-1.

scientific article

Trans-inhibition of activation and proliferation signals by Fc receptors in mast cells and basophils.

scientific article published on 20 December 2016

Transformation of LMTK? cells with purified HLA class I genes

article

Two distinct TL-like molecular subsets defined by monoclonal antibodies on the surface of human thymocytes with different expression on leukemia lines

scientific article published on 01 January 1984

Tyrosine kinase inhibitors (TKI), a concept and acronym of the future

scientific article published in February 2003

Tyrosine kinase inhibitors induce down-regulation of c-Kit by targeting the ATP pocket

scientific article

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