List of works - Daniela Ungureanu

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

scientific article

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation

scientific article

Analysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutation

scientific article

Analysis of steady-state Förster resonance energy transfer data by avoiding pitfalls: interaction of JAK2 tyrosine kinase with N-methylanthraniloyl nucleotides.

scientific article

Crosstalk between ROR1 and BCR pathways defines novel treatment strategies in mantle cell lymphoma

scientific article published on 09 November 2017

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

scientific article

Expression Analysis of Platinum Sensitive and Resistant Epithelial Ovarian Cancer Patient Samples Reveals New Candidates for Targeted Therapies

scientific article published on 26 July 2018

Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.

scientific article published on 17 May 2017

Interaction between ROR1 and MuSK activation complex in myogenic cells

scientific article published in January 2018

Interleukin-15 protects from lethal apoptosis in vivo.

scientific article

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

scientific article

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase

scientific article

New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome

scientific article published on 04 May 2022

PIAS proteins promote SUMO-1 conjugation to STAT1

scientific article (publication date: November 2003)

SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.

scientific article

STRN-ALK rearranged pediatric malignant peritoneal mesothelioma - Functional testing of 527 cancer drugs in patient-derived cancer cells

scientific article published on 30 January 2021

SUMO-1 conjugation selectively modulates STAT1-mediated gene responses

article

Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases

scientific article published on 24 June 2020

Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).

scientific article

Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1.

scientific article

Sumoylation of Drosophila transcription factor STAT92E.

scientific article published on 12 July 2010

Targeting ROR1 identifies new treatment strategies in hematological cancers.

scientific article

Targeting Wnt signaling pseudokinases in hematological cancers

scientific article published on 05 September 2018

The JH2 domain and SH2-JH2 linker regulate JAK2 activity: A detailed kinetic analysis of wild type and V617F mutant kinase domains.

scientific article published on 7 August 2014

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling ⬇️

scientific article published on August 14, 2011

List of works by Daniela Ungureanu

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation

Analysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutation

Analysis of steady-state Förster resonance energy transfer data by avoiding pitfalls: interaction of JAK2 tyrosine kinase with N-methylanthraniloyl nucleotides.

Crosstalk between ROR1 and BCR pathways defines novel treatment strategies in mantle cell lymphoma

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

Expression Analysis of Platinum Sensitive and Resistant Epithelial Ovarian Cancer Patient Samples Reveals New Candidates for Targeted Therapies

Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.

Interaction between ROR1 and MuSK activation complex in myogenic cells

Interleukin-15 protects from lethal apoptosis in vivo.

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase

New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome

PIAS proteins promote SUMO-1 conjugation to STAT1

SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.

STRN-ALK rearranged pediatric malignant peritoneal mesothelioma - Functional testing of 527 cancer drugs in patient-derived cancer cells

SUMO-1 conjugation selectively modulates STAT1-mediated gene responses

Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases

Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).

Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1.

Sumoylation of Drosophila transcription factor STAT92E.

Targeting ROR1 identifies new treatment strategies in hematological cancers.

Targeting Wnt signaling pseudokinases in hematological cancers

The JH2 domain and SH2-JH2 linker regulate JAK2 activity: A detailed kinetic analysis of wild type and V617F mutant kinase domains.

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling ⬇️