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List of works by Cynthia Wolberger

A Hoogsteen base pair embedded in undistorted B-DNA.

scientific article

A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity

scientific article

A Tunable Brake for HECT Ubiquitin Ligases

scientific article published in May 2017

A conserved asparagine has a structural role in ubiquitin-conjugating enzymes

scientific article

A conserved catalytic residue in the ubiquitin-conjugating enzyme family.

scientific article published on October 2003

A conserved catalytic residue in the ubiquitin-conjugating enzyme family.

scientific article published in September 2007

A conserved catalytic residue in the ubiquitin-conjugating enzyme family.

scientific article published in December 2004

A core nucleosome surface crucial for transcriptional silencing.

scientific article published on 16 September 2002

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation

scientific article published on 21 May 2015

A new DUB makes linear ubiquitin a party to its own destruction.

scientific article published in June 2013

A new RING tossed into an old HAT.

scientific article published on September 2013

A new chapter in the transcription SAGA.

scientific article published on 18 October 2011

A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

scientific article

A quantitative analysis of histone methylation and acetylation isoforms from their deuteroacetylated derivatives: application to a series of knockout mutants

scientific article published on May 2013

A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins.

scientific article

A standard reference frame for the description of nucleic acid base-pair geometry.

scientific article

A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.

scientific article published on 8 November 2017

Activation and regulation of H2B-Ubiquitin-dependent histone methyltransferases

scientific article published on 21 June 2019

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins

scientific article published on 27 August 2018

Active site alanine substitutions can convert deubiquitinating enzymes into avid ubiquitin-binding domains

Altered DNA Recognition and Bending by Insertions in the alpha2 Tail of the Yeast a1/alpha2 Homeodomai n Heterodimer

scientific article published in Science

Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2.

scientific article published on October 2014

Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase.

scientific article published on 17 September 2013

Arm-domain interactions can provide high binding cooperativity.

scientific article published in October 2004

Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2

scientific article

Characterization of the N-terminal Domain of the Yeast Transcriptional Repressor Tup1

scientific article published in Journal of Biological Chemistry

Characterization of the SUMO-binding activity of the myeloproliferative and mental retardation (MYM)-type zinc fingers in ZNF261 and ZNF198

scientific article

Characterization of the oligomeric states of wild type and mutant AraC.

scientific article

Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module.

scientific article published on 09 March 2016

Combinatorial transcription factors.

scientific article

Comparison of Cross-Regulation by Different OTUB1:E2 Complexes

scientific article published on 24 February 2020

Competition Assay for Measuring Deubiquitinating Enzyme Substrate Affinity

scientific article published on 01 January 2018

Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH

scientific article

Crystal structure of the MATa1/MATalpha2 homeodomain heterodimer in complex with DNA containing an A-tract

scientific article

Crystallization and X-ray diffraction studies of a 434 Cro-DNA complex

scientific article published on 01 August 1987

Crystallization and preliminary X-ray diffraction studies of a MATα2-DNA complex

scientific article published on 01 January 1991

Crystallization and preliminary X-ray diffraction studies of an a1/α2/DNA ternary complex

scientific article published on 01 February 1995

E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1

scientific article

Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases

scientific article published on 13 June 2016

Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1

scientific article

Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism.

scientific article published on 21 October 2008

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia

scientific article published on 3 November 2014

FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics

FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics

scientific article published on 25 January 2019

Getting a grip on O-acetyl-ADP-ribose

scientific article published on 01 July 2005

Highly cooperative recruitment of Ets-1 and release of autoinhibition by Pax5.

scientific article published on 17 July 2009

How does the histone code work?

scientific article

Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action

scientific article published on 24 July 2018

Identification of a new nicotinamide binding site in a sirtuin: a reassessment

scientific article published in December 2007

Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera

scientific article

Insights into nonspecific binding of homeodomains from a structure of MATα2 bound to DNA

scientific article published on 01 June 2003

Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD+ and Acetylated Peptide

scientific article published on 01 August 2006

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L

scientific article published on 11 February 2019

Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme

scientific article (publication date: 18 March 2005)

Mechanisms for regulating deubiquitinating enzymes

scientific article published on 12 February 2014

Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation

scientific article (publication date: October 2006)

Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer

scientific article

Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.

scientific article

N-lysine propionylation controls the activity of propionyl-CoA synthetase

scientific article

Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme

scientific article

New insights into ubiquitin E3 ligase mechanism

scientific article published on April 2014

New perch for the winged helix

article

Not just Salk

scientific article published in September 2017

Nucleosome competition reveals processive acetylation by the SAGA HAT module.

scientific article

OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination

scientific article published in Journal of Biological Chemistry

Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins

scientific article published in Nature Communications

Preprints for the life sciences ⬇️

scientific article

Proteins: histones and chromatin.

scientific article

Protein–nucleic acid interactions

RAP80, ubiquitin and SUMO in the DNA damage response.

scientific article published on 5 July 2017

RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.

scientific article

Recognition of DNA sequences by the repressor of bacteriophage 434

scientific article published on 01 February 1988

Recognition of specific DNA sequences.

scientific article

Recognition of ubiquitinated nucleosomes.

scientific article published on 3 December 2016

Regulated nucleosome mobility and the histone code.

scientific article

Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination

scientific article

Role of a non-canonical surface of Rad6 in ubiquitin conjugating activity.

scientific article

SIR2 family of NAD(+)-dependent protein deacetylases.

scientific article

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

scientific article

Semisynthesis of ubiquitinated histone H2B with a native or nonhydrolyzable linkage

scientific article published on 26 February 2019

Side chain specificity of ADP-ribosylation by a sirtuin

scientific article

Sirtuin on a high-fat diet

scientific article published in Nature

Structural Insights into Intermediate Steps in the Sir2 Deacetylation Reaction

scientific article

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

scientific article

Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships

scientific article

Structural and Functional Studies of the Rap1 C-Terminus Reveal Novel Separation-of-Function Mutants

scientific article

Structural and thermodynamic characterization of the DNA binding properties of a triple alanine mutant of MATalpha2

scientific article

Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome

scientific article published on 10 January 2020

Structural basis for acyl group discrimination by human Gcn5L2

Structural basis for acyl-group discrimination by human Gcn5L2

scientific article published on 23 June 2016

Structural basis for histone H2B deubiquitination by the SAGA DUB module.

scientific article

Structural basis for the mechanism and regulation of Sir2 enzymes.

scientific article published in March 2004

Structural studies of Ets-1/Pax5 complex formation on DNA

scientific article

Structure and DNA binding of the yeast MAT alpha 2 homeodomain.

scientific article published in January 1993

Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior

scientific article

Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme.

scientific article

Structure of Sir2Tm bound to a propionylated peptide

scientific article

Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation

scientific article

Structure of a Sir2 enzyme bound to an acetylated p53 peptide

scientific article

Structure of a phage 434 Cro/DNA complex

scientific article published in Nature

Structure of the yeast Bre1 RING domain.

scientific article published on 29 April 2015

Structure-based Mechanism of ADP-ribosylation by Sirtuins

scientific article

The 1.6 A crystal structure of the AraC sugar-binding and dimerization domain complexed with D-fucose

scientific article

The Structural Basis of Sirtuin Substrate Affinity†,‡

scientific article published on 01 June 2006

The Structure and Conformation of Lys63-Linked Tetraubiquitin

scientific article

The Substrate Specificity of Sirtuins

scientific article published on 18 April 2016

The biochemistry of sirtuins.

scientific article

The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3

scientific article

The crystal structure of the tumor suppressor protein pp32 (Anp32a): Structural insights into Anp32 family of proteins

scientific article

The mechanism of OTUB1-mediated inhibition of ubiquitination

scientific article

The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA

scientific article

Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags.

scientific article published on 05 April 2017

Transcription factor structure and DNA binding

Uncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity

scientific article

b/HLH without the zip

scientific article published on 01 July 1994

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