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List of works by Jeannie T. Lee

A boundary element between Tsix and Xist binds the chromatin insulator Ctcf and contributes to initiation of X-chromosome inactivation ⬇️

scientific article

A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation

scientific article

A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis

scientific journal article

A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders.

scientific article

A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization

scientific article published on March 2006

ALKBH1 is a histone H2A dioxygenase involved in neural differentiation

scientific article published on December 2012

ATRX Directs Binding of PRC2 to Xist RNA and Polycomb Targets

scientific article published on 20 November 2014

ATRX Directs Binding of PRC2 to Xist RNA and Polycomb Targets

ATRX directs binding of PRC2 to Xist RNA and Polycomb targets

scientific article

Aberrant mitochondrial function in patient-derived neural cells from CDKL5 deficiency disorder and Rett syndrome

scientific article published on 01 November 2019

Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome.

scientific article published on 9 April 2015

An ex vivo model for imprinting: mutually exclusive binding of Cdx2 and Oct4 as a switch for imprinted and random X-inactivation

scientific article

Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus

scientific article

B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2

scientific article published on 23 December 2019

BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis

scientific article

Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci.

scientific article published on 5 April 2013

Building the Connectivity Map of epigenetics: chromatin profiling by quantitative targeted mass spectrometry.

scientific article published on 6 November 2014

CTCF, a candidate trans-acting factor for X-inactivation choice

scientific article (publication date: 11 January 2002)

Characterization and quantitation of differential Tsix transcripts: implications for Tsix function

scientific article published on January 2003

Characterization of X-chromosome inactivation status in human pluripotent stem cells.

scientific article published on February 2010

Characterization of two Mst1-deficient mouse models

scientific article published in November 2008

Characterization ofXpr (Xpct)reveals instability but no effects on X-chromosome pairing orXistexpression ⬇️

scientific article published on July 1, 2010

Chromosomes. A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation

scientific article

Complicity of gene and pseudogene ⬇️

scientific article published on May 1, 2003

Coupling of X-chromosome reactivation with the pluripotent stem cell state

scientific article

Denaturing CLIP, dCLIP, Pipeline Identifies Discrete RNA Footprints on Chromatin-Associated Proteins and Reveals that CBX7 Targets 3' UTRs to Regulate mRNA Expression

scientific article published in October 2017

Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.

scientific article published on 13 May 2010

Destabilization of B2 RNA by EZH2 Activates the Stress Response.

scientific article published on December 2016

Detection of nascent RNA, single-copy DNA and protein localization by immunoFISH in mouse germ cells and preimplantation embryos ⬇️

scientific article published on February 10, 2011

Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice

scientific article

Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes

scientific article

En bloc and segmental deletions of human XIST reveal X chromosome inactivation-involving RNA elements

scientific article published on 01 May 2019

Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo

scientific article published on 4 October 2006

Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein

scientific article published on 21 October 2007

Extending the frontiers of epigenetic regulation

scientific article published on 09 April 2010

Female mice lacking Xist RNA show partial dosage compensation and survive to term

scientific article published on August 2016

Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator

scientific article published on 13 February 2015

Functional intergenic transcription: a case study of the X–inactivation centre ⬇️

scientific article published on August 29, 2003

Genetic Intersection of Tsix and Hedgehog Signaling during the Initiation of X-Chromosome Inactivation

scientific article

Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences

scientific article

Genome-wide Identification of Polycomb-Associated RNAs by RIP-seq ⬇️

scientific article published on December 22, 2010

Genome-wide identification of autosomal genes with allelic imbalance of chromatin state.

scientific article

Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control ⬇️

scientific article published on November 23, 2011

Guided by RNAs: X-inactivation as a model for lncRNA function.

scientific article published on 28 June 2013

High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation.

scientific article published on 27 October 2013

Higher order chromatin structure at the X-inactivation center via looping DNA.

scientific article published on 18 April 2008

Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation

scientific article

Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch.

scientific article published in January 2007

Identification of developmentally specific enhancers for Tsix in the regulation of X chromosome inactivation

scientific article

Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos

scientific article published on 7 December 2003

Intersection of the RNA interference and X-inactivation pathways

scientific article

Is X-chromosome inactivation a homology effect?

scientific article

Jpx RNA activates Xist by evicting CTCF.

scientific article published on June 2013

LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint

scientific article published on 22 May 2014

Locked nucleic acids (LNAs) reveal sequence requirements and kinetics of Xist RNA localization to the X chromosome

scientific article

Locus-specific targeting to the X chromosome revealed by the RNA interactome of CTCF.

scientific article

Long Noncoding RNA Functionality Beyond Sequence: The Jpx Model: Commentary on "Functional Conservation of lncRNA JPX Despite Sequence and Structural Divergence" by Karner et al. (2019)

scientific article published on 30 November 2019

Long noncoding RNAs: fresh perspectives into the RNA world

scientific article

Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development

scientific article published on 19 July 2018

Mapping of DNA replication origins to noncoding genes of the X-inactivation center

scientific article

Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects

scientific article

Molecular links between X-inactivation and autosomal imprinting: X-inactivation as a driving force for the evolution of imprinting?

scientific article

Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes

scientific article published on July 2012

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene

scientific article published on November 2009

New and Xisting regulatory mechanisms of X chromosome inactivation

scientific article

New twists in X-chromosome inactivation.

scientific article published on 26 May 2008

Perinucleolar targeting of the inactive X during S phase: evidence for a role in the maintenance of silencing.

scientific article published on May 2007

Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation

scientific article published in February 2017

Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation

scientific article published on 01 July 2018

Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome

scientific article (publication date: 31 October 2008)

Postmeiotic sex chromatin in the male germline of mice

scientific article published on 01 April 2006

Practical murine hematopathology: a comparative review and implications for research

scientific article published on April 2015

Regulation of X-chromosome counting by Tsix and Xite sequences

scientific article

Regulatory interactions between RNA and polycomb repressive complex 2.

scientific article

Repeat E anchors Xist RNA to the inactive X chromosomal compartment through CDKN1A-interacting protein (CIZ1).

scientific article published on 18 September 2017

Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient.

scientific article

SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X

scientific article published on 07 June 2018

Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression.

scientific article

Sex chromosome inactivation: the importance of pairing

scientific article

Sex chromosome silencing in the marsupial male germ line

scholarly article

Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes

scientific article published on 12 May 2015

Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations

scientific article

TERRA RNA Antagonizes ATRX and Protects Telomeres

scientific article published in June 2017

Targeting RNA with Small Molecules: Identification of Selective, RNA-Binding Small Molecules Occupying Drug-Like Chemical Space

scientific article published on 08 November 2019

Telomeric RNAs mark sex chromosomes in stem cells.

scientific article published on 20 April 2009

The DXPas34 repeat regulates random and imprinted X inactivation

scientific article published in January 2007

The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation ⬇️

scientific article published on October 29, 2010

The X as model for RNA's niche in epigenomic regulation ⬇️

scientific article published on March 31, 2010

The X chromosome in space

scientific article published on 8 May 2017

The Xist RNA-PRC2 complex at 20-nm resolution reveals a low Xist stoichiometry and suggests a hit-and-run mechanism in mouse cells

scientific article

The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting

scientific article published on 17 June 2009

The roles of long noncoding RNA in epigenetic regulation.

scientific article published on 18 March 2013

The search for a marsupial XIC reveals a break with vertebrate synteny.

scientific article published on 5 March 2007

Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA.

scientific article

Transient homologous chromosome pairing marks the onset of X inactivation

scientific article

Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming

scientific article

Tsix transcription- versus RNA-based mechanisms in Xist repression and epigenetic choice.

scientific article published in October 2004

Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function

article published in the Proceedings of the National Academy of Sciences of the United States of America

Tsx Produces a Long Noncoding RNA and Has General Functions in the Germline, Stem Cells, and Brain ⬇️

scientific article (publication date: September 2011)

Two-step imprinted X inactivation: repeat versus genic silencing in the mouse

scientific article

Widespread organ tolerance to Xist loss and X reactivation except under chronic stress in the gut

scientific article published on 10 February 2020

X Chromosome Inactivation and Epigenetic Responses to Cellular Reprogramming ⬇️

scientific article published on 06 May 2013

X chromosome dosage compensation: how mammals keep the balance

scientific article

X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease ⬇️

scientific article published on March 14, 2013

X-chromosome epigenetic reprogramming in pluripotent stem cells via noncoding genes ⬇️

scientific article published on March 3, 2011

X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription ⬇️

scientific article published on 04 December 2011

X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells

scholarly article

X-chromosome inactivation and the search for chromosome-wide silencers

scientific article

X-chromosome inactivation: a hypothesis linking ontogeny and phylogeny

scientific article

X-chromosome inactivation: a multi-disciplinary approach

scientific article published on 01 December 2003

X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells

scientific article published on 12 June 2011

X-linked genes in female embryonic stem cells carry an epigenetic mark prior to the onset of X inactivation

scientific article published in August 2003

XY and ZW: is meiotic sex chromosome inactivation the rule in evolution?

scientific article

Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X

scientific article published on 28 February 2019

Xist RNA is a potent suppressor of hematologic cancer in mice

scientific article published on February 2013

Xist Repeats A and B Account for Two Distinct Phases of X Inactivation Establishment

scientific article published on 10 June 2020

Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line

scientific article

Xite, X-inactivation intergenic transcription elements that regulate the probability of choice

scientific article published in March 2003

YY1 tethers Xist RNA to the inactive X nucleation center

scientific article

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