List of works by Nabeel Bardeesy

A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

scientific article

A mouse plasma peptide atlas as a resource for disease proteomics

scientific article published on 3 June 2008

A mouse to human search for plasma proteome changes associated with pancreatic tumor development

scientific article

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

scientific article

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

scientific article

Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway

scientific article published on 28 February 2009

Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression

scientific article published on 16 December 2013

Amplification-free digital gene expression profiling from minute cell quantities

scientific article

An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis

scientific article

Biliary Tract Cancers: Finding Better Ways to Lump and Split

scientific article published on 20 July 2015

Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

scholarly article

CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers

scientific article

CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice

scientific article published on 20 March 2015

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

scientific article

Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma

scientific article

Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer

scientific article published on 27 October 2014

Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure

scientific article published on July 2014

Corrigendum: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

scholarly article published in Genes & Development

DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer

scientific article published on 2 October 2013

Deletion of Smad4 in fibroblasts leads to defective chondrocyte maturation and cartilage production in a TGFβ type II receptor independent manner

scientific article published on 3 March 2011

Diversity of Precursor Lesions For Pancreatic Cancer: The Genetics and Biology of Intraductal Papillary Mucinous Neoplasm

scientific article

Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium

scientific article

Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein

scientific article

Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma

scientific article

Erratum: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

scientific article published on 12 June 2013

Genetics and biology of pancreatic ductal adenocarcinoma.

scientific article

Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas

scientific article published on February 2014

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

scientific article published on 27 March 2013

Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells

scientific article

High-resolution characterization of the pancreatic adenocarcinoma genome

scholarly article

Hippo signaling regulates differentiation and maintenance in the exocrine pancreas

scientific article published on 27 February 2013

IDH mutations in liver cell plasticity and biliary cancer

scientific article published on January 2014

Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer

scientific article published on January 2009

In vivo quantitative microvasculature phenotype imaging of healthy and malignant tissues using a fiber-optic confocal laser microprobe

scientific article

Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas

scientific article published on 24 July 2009

Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma

scientific article

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles

scientific article

Intra-pancreatic Distal Bile Duct Carcinoma is Morphologically, Genetically, and Clinically Distinct from Pancreatic Ductal Adenocarcinoma

scientific article published on 8 March 2016

Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma

scientific article

KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs

scientific article

Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma

scientific article

LKB1 (XEEK1) regulates Wnt signalling in vertebrate development

scientific article

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis

scientific article published on January 2008

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis

scientific article published on 31 October 2016

LKB1 regulates pancreatic beta cell size, polarity, and function

scientific article published on October 2009

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis

scientific article

LKB1 specifies neural crest cell fates through pyruvate-alanine cycling

scientific article published on 17 July 2019

LKB1-AMPK axis revisited

scientific article

Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy

scientific article

Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects

scientific article

Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice

scientific article published in October 2009

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

scientific article

Macrophages in pancreatic cancer: starting things off on the wrong track

scientific article published on August 2013

Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer

scientific article published on 28 May 2013

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

scientific article

Modeling INK4/ARF tumor suppression in the mouse

scientific article published on February 2007

Molecular imaging agents: impact on diagnosis and therapeutics in oncology

scientific article

Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model

scientific article

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene

scientific article published on November 2009

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism

scientific article published on 25 June 2018

Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

scientific article published on 2 July 2014

Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma

scientific article

NRF2: Translating the Redox Code

scientific article published on 20 August 2016

Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia

scientific article

On oncogenes and tumor suppressor genes in the mammary gland

scientific article published on June 2012

Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors

scientific article published on 09 March 2017

PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network

scientific article published on 23 May 2011

Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up

scientific article

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms

scientific article published on 28 January 2008

Pancreatic cancer biology and genetics

scientific article

Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinoma

scientific article published on 3 November 2014

Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma

scientific article published on 29 December 2016

Prognosis and Clinicopathologic Features of Patients With Advanced Stage Isocitrate Dehydrogenase (IDH) Mutant and IDH Wild-Type Intrahepatic Cholangiocarcinoma

scientific article

Protein kinases of the Hippo pathway: regulation and substrates

scientific article

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

scientific article

Pten constrains centroacinar cell expansion and malignant transformation in the pancreas

scientific article published in September 2005

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

scientific article

Ready, set, go: the EGF receptor at the pancreatic cancer starting line

scientific article published on September 2012

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

scientific article published on July 2004

Reprogramming Enhancers to Drive Metastasis

scientific article published in August 2017

Role of epidermal growth factor receptor signaling in RAS-driven melanoma

scientific article

Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation

scientific article

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

scientific article published on 11 May 2016

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

scientific article published on 02 February 2011

STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines

scientific article published on 11 September 2017

Sin3B expression is required for cellular senescence and is up-regulated upon oncogenic stress

scientific article published on 4 August 2009

Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer

scientific article

Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

scientific article published on November 2006

Somatic LKB1 mutations promote cervical cancer progression

scientific article

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

scientific article

Stromal response to Hedgehog signaling restrains pancreatic cancer progression

scientific article

TGF-β and αvβ6 integrin act in a common pathway to suppress pancreatic cancer progression

scientific article published on 11 July 2012

Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma

scientific article

Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection

scientific article published on July 2013

Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis

scientific article

Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer

scientific article published on 17 February 2008

Telomere induced senescence: end game signaling

scientific article

Temporal dissection of K-ras(G12D) mutant in vitro and in vivo using a regulatable K-ras(G12D) mouse allele

scientific article

The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss

scientific article published on 16 October 2012

The LKB1 tumor suppressor as a biomarker in mouse and human tissues

scientific article

The LKB1 tumor suppressor negatively regulates mTOR signaling

scientific article

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

scientific article

The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis

scientific article

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

scientific article

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

scientific article

Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway

scientific article

Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

scientific article published on 13 July 2015

Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors

scientific article

Tumor engraftment in patient-derived xenografts of pancreatic ductal adenocarcinoma is associated with adverse clinicopathological features and poor survival

scientific article published on 30 August 2017

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

scientific article published on 17 May 2021

Uncapping NF-κB activity in pancreatic cancer

scientific article published on January 2011

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression

scientific article

YAP oncogene overexpression supercharges colon cancer proliferation

scientific article published on 15 March 2012

mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer

scientific article published on 6 October 2016

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