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List of works by Robbie Loewith

A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction

scientific article

A brief history of TOR ⬇️

scientific article published on April 1, 2011

A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast

scientific article (publication date: 2014)

A pathway of targeted autophagy is induced by DNA damage in budding yeast

scientific article published on 02 February 2017

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

scientific article

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

scientific article

Amino Acid Signaling in High Definition ⬇️

scholarly article by Christl Gaubitz published in December 2012

Arsenic toxicity to Saccharomyces cerevisiae is a consequence of inhibition of the TORC1 kinase combined with a chronic stress response

scientific article

Caffeine extends yeast lifespan by targeting TORC1.

scientific article

Cell growth control: little eukaryotes make big contributions.

scientific article

Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis

scientific article

Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9

scientific article published on 26 February 2020

Chemical biology approaches to membrane homeostasis and function

scientific article published on January 2011

Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2

scientific article published on 27 August 2018

Dual action antifungal small molecule modulates multidrug efflux and TOR signaling

scientific article

Dynamic metabolome profiling uncovers potential TOR signaling genes

scientific article published on 4 January 2023

Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology

scientific article published on 18 February 2009

Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.

scientific article

Growth control: function follows form

scientific article published in July 2013

Human ING1 proteins differentially regulate histone acetylation

scientific article (publication date: 16 August 2002)

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry

scientific article published in February 2012

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

scientific article

Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae.

scientific article

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.

scientific article

Molecular organization of target of rapamycin complex 2.

scientific article

Mutual antagonism of target of rapamycin and calcineurin signaling

scientific article published on 07 September 2006

Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae

scientific article published on 16 April 2001

Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast

scientific article

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis.

scientific article

Reciprocal Regulation of Target of Rapamycin Complex 1 and Potassium Accumulation

scientific article published on 28 November 2016

Roles for PI(3,5)P2 in nutrient sensing through TORC1.

scientific article published on 29 January 2014

Sch9 is a major target of TORC1 in Saccharomyces cerevisiae

scientific article

Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L.

scientific article

Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling

scientific article

Skh1, the MEK component of the mkh1 signaling pathway in Schizosaccharomyces pombe

scientific article published in January 2000

Structural Insights into TOR Signaling

scientific article published on 04 August 2020

Systematic analysis of complex genetic interactions.

scientific article

Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis

scientific article

TOR Complexes and the Maintenance of Cellular Homeostasis

scientific article

TOR complex 2 (TORC2) signaling and the ESCRT machinery cooperate in the protection of plasma membrane integrity in yeast

scientific article published on 01 July 2020

TOR signaling in growth and metabolism

scientific article (publication date: 10 February 2006)

TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae

scientific article

TORC2 Structure and Function

scientific article published on 5 May 2016

TORC2 controls endocytosis through plasma membrane tension

scientific article published on 23 May 2019

TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.

scientific article

Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways

scientific article published on 16 April 2015

Target of rapamycin (TOR) in nutrient signaling and growth control

scientific article published on December 2011

Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae

scientific article published on 12 June 2018

Tensing Up for Lipid Droplet Formation

scientific article published in June 2017

The TOR signalling network from yeast to man.

scientific article

The Vam6 GEF controls TORC1 by activating the EGO complex

scientific article

The flipside of the TOR coin - TORC2 and plasma membrane homeostasis at a glance

scientific article published on 11 May 2020

Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities.

scientific article

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

scientific article

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

scientific article

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