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List of works by Maddy Parsons

A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration.

scientific article

A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility

scientific article published in June 2002

A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability.

scientific article

A small-molecule activator of kinesin-1 drives remodeling of the microtubule network

scientific article published on 11 December 2017

ADAM8 as a drug target in pancreatic cancer.

scientific article

ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis

scientific article published on 27 December 2013

Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42

scientific article

Adhesion dynamics: mechanisms and measurements

scientific article published on 14 April 2008

Advances in imaging cell-matrix adhesions

scientific article

Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration

scientific article

Alternative mechanisms for talin to mediate integrin function

scientific article

An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration

scientific article published on 27 February 2014

An open access microfluidic device for the study of the physical limits of cancer cell deformation during migration in confined environments

scientific article

Analysis of the interaction between RGD-expressing adenovirus type 5 fiber knob domains and alphavbeta3 integrin reveals distinct binding profiles and intracellular trafficking.

scientific article published on September 2006

Aquaporins differentially regulate cell-cell adhesion in MDCK cells

scientific article published on 06 March 2019

Autosomal Recessive Epidermolysis Bullosa Simplex Due to Loss of BPAG1-e Expression

article

BPAG1-e Restricts Keratinocyte Migration through Control of Adhesion Stability

scholarly article by Magdalene Michael published in June 2014

BPAG1-e restricts keratinocyte migration through control of adhesion stability.

scientific article published on 11 September 2013

Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion

scientific article published on 04 April 2024

CAR Co-Operates With Integrins to Promote Lung Cancer Cell Adhesion and Invasion

scientific article published on 14 February 2022

CAR modulates E-cadherin dynamics in the presence of adenovirus type 5.

scientific article

CAR regulates epithelial cell junction stability through control of E-cadherin trafficking

scientific article

CAR: A key regulator of adhesion and inflammation

scientific article published on 22 May 2017

Cadherin Switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces

scientific article

Coagulation Factor XIII-A Subunit Missense Mutation in the Pathobiology of Autosomal Dominant Multiple Dermatofibromas

scientific article published on 04 September 2019

Collective chemotaxis requires contact-dependent cell polarity.

scientific article published on July 2010

Complement fragment C3a controls mutual cell attraction during collective cell migration

scientific article published on 24 November 2011

Contact inhibition of locomotion in vivo controls neural crest directional migration

scientific article

Control of nuclear organization by F-actin binding proteins

scientific article published on 6 January 2017

Corrigendum to "Metabolic perturbations in fibrosis disease" [Int. J. Biochem. Cell Biol. 139 (2021) 106073]

scientific article published on 30 October 2021

Corrigendum to “Fascin: A key regulator of cytoskeletal dynamics” [Int. J. Biochem. Cell Biol. 42 (10) (2010) 1614–1617]

article

Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK.

scientific article

Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G.

scientific article published on 20 November 2017

Defects in cell spreading and ERK1/2 activation in fibroblasts with lamin A/C mutations

scientific article

Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCalpha

scientific article published on 30 August 2006

Differential regulation of adhesion complex turnover by ROCK1 and ROCK2

scientific article (publication date: 2012)

Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase.

scientific article

Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA.

scientific article published on 9 April 2008

Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain- and dynamin-dependent endocytosis and lysosomal targeting.

scientific article

Dissecting cell adhesion architecture using advanced imaging techniques

scientific article

Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion.

scientific article

Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of Rac and contribute to metastasis

scientific article

Endothelial FAK is required for tumour angiogenesis

scientific article

Endothelial FAK is required for tumour angiogenesis.

scientific article

Epithelial inflammation resulting from an inherited loss-of-function mutation in EGFR

scientific article

Erratum: MyosinV controls PTEN function and neuronal cell size

scholarly article published in Nature Cell Biology

Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility

scientific article

FAK-heterozygous mice display enhanced tumour angiogenesis

scientific article published on January 2013

FMNL2 regulates dynamics of fascin in filopodia

scientific article published on 01 May 2020

Fascin Regulates Nuclear Movement and Deformation in Migrating Cells

scientific article published on August 2016

Fascin promotes filopodia formation independent of its role in actin bundling

scientific article

Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain

scientific article published on July 2013

Fascin: a key regulator of cytoskeletal dynamics

scientific article

Flexible and stable optical parametric oscillator based laser system for coherent anti-Stokes Raman scattering microscopy

scientific article

Germline Mutation in EXPH5 Implicates the Rab27B Effector Protein Slac2-b in Inherited Skin Fragility

scientific article

Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer

scientific article published on May 2017

Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration

scientific article

HS1-Associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion via Clathrin-Mediated Endocytosis of Integrin αvβ6

article

Homozygous acceptor splice site mutation in DSG1 disrupts plakoglobin localization and results in keratoderma and skin fragility.

scientific article published on 2 December 2017

Imaging cells within 3D cell-derived matrix

scientific article published in January 2011

Imaging of Human Cancer Cells in 3D Collagen Matrices

scientific article published on 20 January 2021

Imaging of cell adhesion events in 3D matrix environments.

scientific article published on 16 June 2012

Imaging protein-protein interactions in cell motility using fluorescence resonance energy transfer (FRET).

scientific article published on June 2004

In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin

scientific article published on 07 January 2009

In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity

scientific article

In vivo topology converts competition for cell-matrix adhesion into directional migration

article

Integrin α3β1-CD151 complex regulates dimerization of ErbB2 via RhoA.

scientific article published on 24 June 2013

Integrin-specific control of focal adhesion kinase and RhoA regulates membrane protrusion and invasion

scientific article

Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility

scientific article

Intracellular coupling of adhesion receptors: molecular proximity measurements

scientific article published on January 2002

Invad_2019—Mechano-chemical signals in invasion

scientific article published on 05 April 2021

KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation.

scientific article

Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics

scientific article published on 28 October 2013

Kindlin-1 Regulates Epidermal Growth Factor Receptor Signaling

scientific article published on 21 September 2018

Kindlin-1 Regulates Keratinocyte Electrotaxis.

scientific article published on 14 July 2016

L-selectin regulates human neutrophil transendothelial migration

scientific article published on 06 January 2021

L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro

scientific article

Lamellipodia are crucial for haptotactic sensing and response

scientific article published on 12 May 2016

Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23.

scientific article

Large Intragenic KRT1 Deletion Underlying Atypical Autosomal Dominant Keratinopathic Ichthyosis

scientific article published on 25 June 2016

Live cell imaging analysis of receptor function

scientific article

Live imaging of ERK signalling dynamics in differentiating mouse embryonic stem cells

scientific article published on 03 June 2019

Local dimensionality determines imaging speed in localization microscopy.

scientific article published on 12 January 2017

Loss of Cannabinoid CB 1 Receptors Induces Cortical Migration Malformations and Increases Seizure Susceptibility

scientific article published on 5 October 2016

Loss-of-function FERMT1 mutations in kindler syndrome implicate a role for fermitin family homolog-1 in integrin activation.

scientific article published on 17 September 2009

Measuring FRET using time-resolved FLIM.

scientific article published on January 2011

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

scientific article

Mechanical Load Enhances Procollagen Processing in Dermal Fibroblasts by Regulating Levels of Procollagen C-Proteinase

scientific article published on 01 November 1999

Metabolic perturbations in fibrosis disease

scientific article published on 27 August 2021

Microfluidic Devices for Examining the Physical Limits of Migration in Confined Environments

scientific article published in January 2018

Multifocal multiphoton volumetric imaging approach for high-speed time-resolved Förster resonance energy transfer imaging in vivo

scientific article published on 01 December 2018

Mutations in EXPH5 result in autosomal recessive inherited skin fragility.

scientific article published in January 2014

Mutations in GRHL2 result in an autosomal-recessive ectodermal Dysplasia syndrome

scientific article

Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling

scientific article published on 23 November 2015

MyosinV controls PTEN function and neuronal cell size.

scientific article published on 20 September 2009

NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription.

scientific article published on 30 November 2017

New Editor in Chief

scientific article

New insights into the dynamics of cell adhesions

scientific article published on January 2010

New perspectives on integrin-dependent adhesions

scientific article published on 13 January 2020

Nox4 regulates InsP3 receptor-dependent Ca2+ release into mitochondria to promote cell survival

scientific article published on 10 August 2020

Optical parametric oscillator system for CARS microscopy

scholarly article published June 2009

Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans

scientific article published on 28 March 2022

PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells.

scientific article published on 27 September 2016

PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion

scientific article

Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion

scientific article

Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth

scientific article published on 04 June 2020

Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN

scientific article

Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability

scientific article (publication date: 20 August 2015)

Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling

scientific article

Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architecture

scientific article

Quantification of integrin receptor agonism by fluorescence lifetime imaging

scientific article published on February 2008

Quantitative real-time imaging of intracellular FRET biosensor dynamics using rapid multi-beam confocal FLIM

scientific article published on 20 March 2020

R-Ras regulates beta1-integrin trafficking via effects on membrane ruffling and endocytosis ⬇️

scientific article

REMBI: Recommended Metadata for Biological Images—enabling reuse of microscopy data in biology

scientific article published on 21 May 2021

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments

scientific article

Rac regulates the interaction of fascin with protein kinase C in cell migration

scientific article

Redistribution of Adhesive Forces through Src/FAK Drives Contact Inhibition of Locomotion in Neural Crest.

scientific article

Regulation of cell migration by α4 and α9 integrins

scientific article published on 28 February 2019

Revertant Mosaicism in Kindler Syndrome

article

SHARPIN is an endogenous inhibitor of β1-integrin activation

scientific article

Scanning total internal reflection fluorescence imaging

article

Semidominant GPNMB Mutations in Amyloidosis Cutis Dyschromica

scientific article published on 19 June 2019

Sequential binding of ezrin and moesin to L-selectin regulates monocyte protrusive behaviour during transendothelial migration

scientific article published on 04 July 2018

Serine Phosphorylation of L-Selectin Regulates ERM Binding, Clustering, and Monocyte Protrusion in Transendothelial Migration

scientific article published on 25 September 2019

Simultaneous FRAP, FLIM and FAIM for measurements of protein mobility and interaction in living cells

scientific article

Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis.

scientific article

Slac2-b co-ordinates extracellular vesicle secretion to regulate keratinocyte adhesion and migration

scientific article published on 02 September 2020

Spatial activation of ezrin by epidermal growth factor receptor and focal adhesion kinase co-ordinates epithelial cell migration

scientific article published on 11 August 2021

Spatial and temporal regulation of integrin signalling during cell migration

scientific article published on 21 June 2011

Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells

scientific article published on March 2005

Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism

scientific article published on 22 October 2019

Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth

scientific article published in 2013

Sub-diffraction error mapping for localisation microscopy images

scientific article published on 23 September 2021

TNFR1 membrane reorganization promotes distinct modes of TNFα signaling

scientific article published on 30 July 2019

TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers.

scientific article published on 19 May 2016

Targeted fluorescence lifetime probes reveal responsive organelle viscosity and membrane fluidity

scientific article published on 14 February 2019

Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling

scientific article published on 7 January 2016

Targeting of the F-actin-binding protein drebrin by the microtubule plus-tip protein EB3 is required for neuritogenesis

scientific article published on 21 September 2008

The Na+ /H+ exchanger NHE1 localizes as clusters to cryptic lamellipodia and accelerates collective epithelial cell migration

scientific article published on 17 December 2018

The first World Cell Race

The light chains of kinesin-1 are autoinhibited.

scientific article published on 16 February 2016

The manganese(III) porphyrin MnTnHex-2-PyP modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells

The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: impact in doxorubicin-treated cells

article published in 2018

The role of kindlins in cell biology and relevance to human disease

scientific article

The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis

scientific article published on 23 November 2011

The β3-integrin endothelial adhesome regulates microtubule-dependent cell migration.

scientific article published on 24 May 2018

Time-resolved multifocal multiphoton microscope for high speed FRET imaging in vivo.

scientific article

Transmigration of Leukocytes Across Epithelial Monolayers

scientific article published in January 2018

Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861

scientific article published on 12 June 2019

Two-Color, Two-Photon Imaging at Long Excitation Wavelengths Using a Diamond Raman Laser

scientific article

Using FRET to analyse signals controlling cell adhesion and migration

scientific article

hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2

scientific article

α2β1 integrins spatially restrict Cdc42 activity to stabilise adherens junctions

scientific article published on 23 June 2021

α3β1 integrins regulate CD151 complex assembly and membrane dynamics in carcinoma cells within 3D environments

scientific article

α4/α9 Integrins Coordinate Epithelial Cell Migration Through Local Suppression of MAP Kinase Signaling Pathways

scientific article published on 01 December 2021

β1 integrins regulate fibroblast chemotaxis through control of N-WASP stability

scientific article

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