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List of works by Leopold Eckhart

'Don't be so over-protective!'

scientific article

2,3,7,8-tetrachlorodibenzo-p-dioxin impairs differentiation of normal human epidermal keratinocytes in a skin equivalent model

scientific article published in January 2005

A Stress Response Program at the Origin of Evolutionary Innovation in the Skin

scientific article published on 03 July 2019

A basement membrane-like matrix formed by cell-released proteins at the medium/air interface supports growth of keratinocytes

scientific article published in November 2003

ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging

scientific article published on 03 January 2020

Against the rules: human keratin K80: two functional alternative splice variants, K80 and K80.1, with special cellular localization in a wide range of epithelia

scientific article

Aldehyde dehydrogenase 1A3 is transcriptionally activated by all-trans-retinoic acid in human epidermal keratinocytes

scientific article published on 13 August 2010

Alternative splicing of caspase-8 mRNA during differentiation of human leukocytes

scientific article published in December 2001

Author Correction: Dense sampling of bird diversity increases power of comparative genomics

Autophagy - how to control your intracellular diet

article by E. Tschachler & Leopold Eckhart published June 2017 in British Journal of Dermatology

Autophagy in epithelial homeostasis and defense.

scientific article published on June 2013

Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model

scientific article

Autophagy is induced by UVA and promotes removal of oxidized phospholipids and protein aggregates in epidermal keratinocytes

scientific article published on 22 January 2013

Caspase-14 but not caspase-3 is processed during the development of fetal mouse epidermis

article

Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner

scientific article (publication date: November 2002)

Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation

scientific article (publication date: 2 November 2000)

Caspase-15 is autoprocessed at two sites that contain an aspartate residue in the P1' position

scientific article published in 2006

Cell death by cornification

scientific article

Comparative Genomics Identifies Epidermal Proteins Associated with the Evolution of the Turtle Shell

scientific article published on 24 November 2015

Comparative analysis of epidermal differentiation genes of crocodilians suggests new models for the evolutionary origin of avian feather proteins

scientific article published on 12 February 2018

Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins

scientific article published on May 2015

Comparative genomics suggests loss of keratin K24 in three evolutionary lineages of mammals

scientific article published on 29 July 2019

Control of cell death-associated danger signals during cornification prevents autoinflammation of the skin

scientific article published on 01 August 2018

Convergent evolution of cysteine-rich proteins in feathers and hair

scientific article

Cornification of nail keratinocytes requires autophagy for bulk degradation of intracellular proteins while sparing components of the cytoskeleton

scientific article published on 01 February 2019

Cuts by caspase-14 control the proteolysis of filaggrin ⬇️

scientific article published on November 1, 2011

Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins

scientific article published on 12 June 2020

DNase 2 is the main DNA-degrading enzyme of the stratum corneum

scientific article

DNase1L2 degrades nuclear DNA during corneocyte formation

scientific article

DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus

Degradation by stratum corneum proteases prevents endogenous RNase inhibitor from blocking antimicrobial activities of RNase 5 and RNase 7.

scientific article published on 5 March 2009

Deleterious mutations of a claw keratin in multiple taxa of reptiles

scientific article published on 23 December 2010

Dense sampling of bird diversity increases power of comparative genomics

scientific article published on 11 November 2020

Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals.

scientific article published in February 2019

Distribution of caspase-14 in epidermis and hair follicles is evolutionarily conserved among mammals

scientific journal article

Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses

scientific article published on 19 September 2017

Duplication of the caspase-12 prodomain and inactivation of NLRC4/IPAF in the dog.

scientific article

Epidermal cornification is preceded by the expression of a keratinocyte-specific set of pyroptosis-related genes

scientific article published on 12 December 2017

Epidermal keratinocytes form a functional skin barrier in the absence of Atg7 dependent autophagy

scientific article published on 19 April 2013

Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails

scientific journal article

Evidence that caspase-13 is not a human but a bovine gene

scientific article (publication date: 3 August 2001)

Evolution of Trichocyte Keratins

Evolutionary origin and diversification of epidermal barrier proteins in amniotes

scientific article

Filaggrin has evolved from an "S100 fused-type protein" (SFTP) gene present in a common ancestor of amphibians and mammals

scientific article published on 13 February 2017

Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7.

scientific article published on 17 March 2018

Flagellin is the principal inducer of the antimicrobial peptide S100A7c (psoriasin) in human epidermal keratinocytes exposed to Escherichia coli

scientific article

Genome sequence comparison reveals independent inactivation of the caspase-15 gene in different evolutionary lineages of mammals

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Hepatocyte growth factor/scatter factor inhibits UVB induced apoptosis of human keratinocytes via the PI-3-kinase pathway

scientific article published on 01 December 1999

Hepatocyte growth factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the phosphatidylinositol 3-kinase/AKT pathway

scientific article published on 30 January 2002

Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model

scientific article published on 15 November 2012

Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid

scientific article

Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death

scientific article published on 19 October 2016

Human caspase 12 has acquired deleterious mutations

scientific article

Identification and characterization of a novel mammalian caspase with proapoptotic activity

scientific article published on 24 August 2005

Identification and comparative analysis of the epidermal differentiation complex in snakes

scientific article published on 27 March 2017

Identification of Novel Mammalian Caspases Reveals an Important Role of Gene Loss in Shaping the Human Caspase Repertoire

article

Identification of a homozygous PSTPIP1 mutation in a patient with a PAPA-like syndrome responding to canakinumab treatment

scientific article published on February 2013

Identification of a human cDNA encoding a novel Bcl-x isoform.

scientific article published on July 1998

Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants

scientific article published in 2006

Identification of reptilian genes encoding hair keratin-like proteins suggests a new scenario for the evolutionary origin of hair

scientific article

Immunogenic presentation of a conserved gp41 epitope of human immunodeficiency virus type 1 on recombinant surface antigen of hepatitis B virus.

scientific article published on September 1996

Immunolocalization and phylogenetic profiling of the feather protein with the highest cysteine content

scientific article published on 29 April 2019

Immunolocalization of a Histidine-Rich Epidermal Differentiation Protein in the Chicken Supports the Hypothesis of an Evolutionary Developmental Link between the Embryonic Subperiderm and Feather Barbs and Barbules

scientific article

Immunolocalization of loricrin in the maturing α-layer of normal and regenerating epidermis of the lizard Anolis carolinensis

scientific article published on 17 February 2015

Immunolocalization of scaffoldin, a trichohyalin-like protein, in the epidermis of the chicken embryo

article published in 2015

Impact of filaggrin mutations on Raman spectra and biophysical properties of the stratum corneum in mild to moderate atopic dermatitis

In situ labeling of DNA reveals interindividual variation in nuclear DNA breakdown in hair and may be useful to predict success of forensic genotyping of hair

scientific article

Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis

scientific article published on 25 July 2017

Inactivation of autophagy leads to changes in sebaceous gland morphology and function

scientific article published on 20 August 2018

Increased Sensitivity of Histidinemic Mice to UVB Radiation Suggests a Crucial Role of Endogenous Urocanic Acid in Photoprotection

Infection with human immunodeficiency virus-1 increases expression of vascular endothelial cell growth factor in T cells: implications for acquired immunodeficiency syndrome-associated vasculopathy.

scientific article published on June 1999

Is the filaggrin-histidine-urocanic acid pathway essential for stratum corneum acidification?

scientific article

Keratins K2 and K10 are essential for the epidermal integrity of plantar skin

scientific article published on 22 October 2015

Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model

scientific article published on 6 May 2010

Localisation of keratin K78 in the basal layer and first suprabasal layers of stratified epithelia completes expression catalogue of type II keratins and provides new insights into sequential keratin expression

scientific article published on 4 September 2015

Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation

scientific journal article

MCPIP1 contributes to the inflammatory response of UVB-treated keratinocytes.

scientific article published on 25 March 2017

Mechanisms and emerging functions of DNA degradation in the epidermis

scientific article published on June 2012

Melanin Binds Reversibly to Thermostable DNA Polymerase and Inhibits Its Activity

scientific article published in 2000

Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis

scientific article published on 15 June 2015

New facets of keratin K77: interspecies variations of expression and different intracellular location in embryonic and adult skin of humans and mice

scientific article

Phylogenetic profiling and gene expression studies implicate a primary role of PSORS1C2 in terminal differentiation of keratinocytes

scientific article

Phylogenomics of caspase-activated DNA fragmentation factor

scientific article

Psoriasin (S100A7) is a major Escherichia coli-cidal factor of the female genital tract

scientific article

Retinoic acid increases the expression of p53 and proapoptotic caspases and sensitizes keratinocytes to apoptosis: a possible explanation for tumor preventive action of retinoids

scientific article published in September 2004

Reverse transcription-polymerase chain reaction products of alternatively spliced mRNAs form DNA heteroduplexes and heteroduplex complexes

scientific article published on January 1999

Review: Evolution and diversification of corneous beta-proteins, the characteristic epidermal proteins of reptiles and birds

scientific article published on 01 December 2018

Stratum corneum-derived caspase-14 is catalytically active

scientific article published in November 2004

Suppression of autophagy dysregulates the antioxidant response and causes premature senescence of melanocytes

scientific article published on 7 October 2014

Suppression of autophagy perturbs turnover of sequestosome-1/p62 in Merkel cells but not in keratinocytes

scientific article published on 29 January 2018

Suppression of epithelial autophagy compromises the homeostasis of sweat glands during aging

scientific article published on 20 March 2018

TINCR is not a non-coding RNA but encodes a protein component of cornified epidermal keratinocytes

scientific article published on 03 February 2020

Targeted deletion of Atg5 reveals differential roles of autophagy in keratin K5-expressing epithelia

scientific article published on 2 December 2012

Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation

scientific article (publication date: December 2000)

Terminal differentiation of nail matrix keratinocytes involves up-regulation of DNase1L2 but is independent of caspase-14 expression

scientific article

The Differentiation-Associated Keratinocyte Protein Cornifelin Contributes to Cell-Cell Adhesion of Epidermal and Mucosal Keratinocytes

scientific article published on 24 May 2019

The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.

scientific article

The anatomy and development of the claws of Xenopus laevis (Lissamphibia: Anura) reveal alternate pathways of structural evolution in the integument of tetrapods

scientific article

The antimicrobial heterodimer S100A8/S100A9 (calprotectin) is upregulated by bacterial flagellin in human epidermal keratinocytes

scientific article published on 17 June 2010

The caspase-1 inhibitor CARD18 is specifically expressed during late differentiation of keratinocytes and its expression is lost in lichen planus

scientific article published in May 2017

The molecular organization of the beta-sheet region in Corneous beta-proteins (beta-keratins) of sauropsids explains its stability and polymerization into filaments

scientific article published on 7 March 2016

The skin barrier: Epidermis vs environment

scientific article published on 01 August 2018

The tail domains of keratins contain conserved amino acid sequence motifs

scientific article published on 7 February 2009

Transcription of the caspase-14 gene in human epidermal keratinocytes requires AP-1 and NFkappaB.

scientific article published on 18 April 2008

Trichohyalin-like proteins have evolutionarily conserved roles in the morphogenesis of skin appendages

scientific article

Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice

scientific article

Ultrastructural characterization of an artificial basement membrane produced by cultured keratinocytes

scientific article

Ultrastructural localization of caspase-14 in human epidermis

scientific article published on December 2004

Ultrastructural localization of hair keratin homologs in the claw of the lizard Anolis carolinensis

scientific article published on 15 December 2010

Urocanic Acid: An Endogenous Regulator of Langerhans Cells

scientific article published on 14 May 2016

miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging

scientific article

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