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List of works by David Warburton

A Grhl2-dependent gene network controls trophoblast branching morphogenesis

scientific journal article

A Modified Technique for Partial Pneumonectomy in the Mouse ⬇️

scientific article published on January 1, 2011

A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis

scientific article published in June 2005

A novel profibrotic mechanism mediated by TGFβ-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells

scientific article published on 8 April 2015

A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma

scientific article

Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema

scientific article published on 10 December 2004

Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling

scientific article published on 26 July 2013

Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation

scientific article (publication date: 2012)

Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation

Amniotic fluid stem cells inhibit the progression of bleomycin-induced pulmonary fibrosis via CCL2 modulation in bronchoalveolar lavage

scientific article

BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction

scientific article published on 31 July 2006

Bcr and Abr cooperate in negatively regulating acute inflammatory responses

scientific journal article

Burkholderia cepacia-induced IL-8 gene expression in an alveolar epithelial cell line: signaling through CD14 and mitogen-activated protein kinase

scientific article published on 21 May 2003

Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes

scientific article

Cell-based therapies for lung disease ⬇️

scientific article published on January 25, 2012

Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis inSmad3knockout mice ⬇️

scientific article published on July 8, 2011

Colonic atresia without mesenteric vascular occlusion. The role of the fibroblast growth factor 10 signaling pathway

scientific article published in February 2005

Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair.

scientific article

Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung

scientific article published in January 2005

Differential epithelial growth in tissue-engineered larynx and trachea generated from postnatal and fetal progenitor cells

scientific article published on 25 January 2019

Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung

scientific article published on 21 February 2006

Discordant roles for FGF ligands in lung branching morphogenesis between human and mouse

Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-alpha

scientific article published on 17 August 2008

Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner.

scientific article

Entrained pulmonary clocks: epithelium and vasculature keeping pace ⬇️

scientific article published on 06 August 2010

Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease

scientific article

Explant culture of mouse embryonic whole lung, isolated epithelium, or mesenchyme under chemically defined conditions as a system to evaluate the molecular mechanism of branching morphogenesis and cellular differentiation

scientific article

Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium ⬇️

scientific article published on April 1, 2011

Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium ⬇️

scientific article published on June 8, 2012

Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung ⬇️

scientific article published on February 1, 2011

FGF10 controls the patterning of the tracheal cartilage rings via Shh ⬇️

scientific article published on December 9, 2010

FGF9-Pitx2-FGF10 signaling controls cecal formation in mice.

scientific article published on 20 July 2012

Failure to Down-Regulate miR-154 Expression in Early Postnatal Mouse Lung Epithelium Suppresses Alveologenesis, with Changes in Tgf-β Signaling Similar to those Induced by Exposure to Hyperoxia

scientific article published on 02 April 2020

Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development

scientific journal article

Fibroblast growth factor 10 (Fgf10) invalidation results in anorectal malformation in mice

scientific journal article

Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development

scientific journal article

Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome

scientific article published on October 2009

Fibroblast growth factor receptor 2 IIIb invalidation--a potential cause of familial duodenal atresia

scientific article published in June 2004

Fibroblast growth factor-10 serves a regulatory role in duodenal development

scientific article

Functional analysis of the human Sprouty2 gene promoter

scientific article published on December 2003

Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis

scientific article

Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis.

scientific article published on 27 December 2013

Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry

scientific article

Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications.

scientific article published on 22 January 2010

Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages

scientific article

Human lung branching morphogenesis is orchestrated by the spatio-temporal distribution of ACTA2, SOX2 and SOX9.

scientific article published on 28 September 2017

Impact of Seasonal Winter Air Pollution on Health across the Lifespan in Mongolia and Some Putative Solutions.

scientific article published in April 2018

Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization

scientific article published on 18 October 2016

Increased alveolar soluble annexin V promotes lung inflammation and fibrosis

scientific article published on 9 July 2015

Infection-induced kinin B1 receptors in human pulmonary fibroblasts: role of intact pathogens and p38 mitogen-activated protein kinase-dependent signaling

scientific article published on 2 March 2005

Inhaled resveratrol treatments slow ageing-related degenerative changes in mouse lung

scientific article published on 9 January 2017

Injection of amniotic fluid stem cells delays progression of renal fibrosis.

scientific article published on 2 February 2012

Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung

scientific article published on 03 July 2019

Isolation and Characterization of Distal Lung Progenitor Cells ⬇️

scientific article published on January 1, 2012

Isolation of a putative progenitor subpopulation of alveolar epithelial type 2 cells

scientific article published on 15 August 2003

Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung

scientific journal article

Lo, and the niche is knit: lysyl oxidase activity and maintenance of lung, aorta, and skin integrity

scientific article published on October 2005

Lung development and adult lung diseases

scientific article published on August 2007

Lung development and susceptibility to chronic obstructive pulmonary disease

scientific article published on November 2006

Lung mesenchymal expression of Sox9 plays a critical role in tracheal development.

scientific article

Lung organogenesis

scientific article published in January 2010

LungMAP: The Molecular Atlas of Lung Development Program.

scientific article published on 10 August 2017

MIR-99a and MIR-99b Modulate TGF-β Induced Epithelial to Mesenchymal Plasticity in Normal Murine Mammary Gland Cells ⬇️

scientific article published on January 27, 2012

Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-alpha

scientific article published on 23 February 2009

Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development

scientific article published on 20 June 2015

Mesenchymal-Specific Inhibition of Vascular Endothelial Growth Factor (VEGF) Attenuates Growth in Neonatal Mice ⬇️

scientific article published on May 17, 2011

Mesenchyme-specific deletion of Tgf-β1 in the embryonic lung disrupts branching morphogenesis and induces lung hypoplasia

scientific article published on 25 April 2019

Modulating the Alveolar Milieu to Enhance Resolution of Fibrotic Lung Injury ⬇️

scientific article published on July 1, 2012

Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice ⬇️

scientific article published on May 18, 2012

Molecular mechanisms of early lung specification and branching morphogenesis

scientific article

Morphogenetic Implications of Peristalsis-Driven Fluid Flow in the Embryonic Lung

scientific article

Morphogenetic implications of peristaltic fluid-tissue dynamics in the embryonic lung

scientific article published on 9 July 2015

Murine nitrofen-induced pulmonary hypoplasia does not involve induction of TGF-beta signaling

scientific article published in August 2002

Nitrofen inhibition of pulmonary growth and development occurs in the early embryonic mouse

scientific article published in September 2002

Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins

scientific article published on February 2004

Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice.

scientific article published on 04 June 2009

Partial pneumonectomy of telomerase null mice carrying shortened telomeres initiates cell growth arrest resulting in a limited compensatory growth response ⬇️

scientific article published on April 1, 2011

Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation

scientific article

Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3

scientific article published on 6 September 2007

Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis

scientific article

Quantifying cellular and subcellular stretches in embryonic lung epithelia under peristalsis: where to look for mechanosensing

scientific article published on October 2016

Quantifying stretch and secretion in the embryonic lung: Implications for morphogenesis.

scientific article published on 16 July 2015

Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR.

scientific article

Retraction: Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development doi: 10.1242/dev.058479.

scientific article published in October 2017

Retraction: Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J. Cell. Sci. doi: 10.1242/102848.

scientific article published on 2 October 2017

Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung ⬇️

scientific article published on March 6, 2011

Smad1 expression and function during mouse embryonic lung branching morphogenesis

scientific article

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

scientific article published in March 2002

Smad3 signaling involved in pulmonary fibrosis and emphysema

scientific article published on November 2006

Spatial and temporal changes in extracellular elastin and laminin distribution during lung alveolar development.

scientific article published on 29 May 2018

Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4 enhancer

scientific article (publication date: 13 November 2013)

Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells

scientific article published on September 2007

Stem cells and cell therapies in lung biology and lung diseases

scientific article published on 01 June 2011

Stem/progenitor cells in lung development, injury repair, and regeneration

scientific article published on August 2008

Stem/progenitor cells in lung morphogenesis, repair, and regeneration

scientific article published in January 2004

Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin α6β1-ADAM17/tumor necrosis factor-α-converting enzyme (TACE) signaling pathway

scientific article published on 25 July 2013

TACE is required for fetal murine cardiac development and modeling ⬇️

scientific article published on September 15, 2003

TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA

scientific journal article

TGF-β-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development? ⬇️

scientific article published on November 16, 2012

TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells

scientific article

The Transcription Factors Grainyhead-like 2 and NK2-Homeobox 1 Form a Regulatory Loop That Coordinates Lung Epithelial Cell Morphogenesis and Differentiation ⬇️

scientific article published on September 6, 2012

The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

scientific article published on 30 August 2007

The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR.

scientific article

The fibroblast growth factor pathway serves a regulatory role in proliferation and apoptosis in the pathogenesis of intestinal atresia

scientific article published in January 2006

The human gamma-glutamyltransferase gene family

scientific article

The milieu of damaged alveolar epithelial type 2 cells stimulates alveolar wound repair by endogenous and exogenous progenitors

scientific article published on 23 June 2011

The molecular genetics of lung morphogenesis and injury repair

scientific article published on January 2004

Tracheal occlusion increases the rate of epithelial branching of embryonic mouse lung via the FGF10-FGFR2b-Sprouty2 pathway

scientific article published on 7 November 2007

Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia

scientific article published on December 2003

Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs

scientific article

VEGF Optimizes the Formation of Tissue-Engineered Small Intestine ⬇️

scientific article published on September 1, 2011

VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis

scientific journal article

miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution

scientific article

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