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List of works by Benedikt Brors

150 years of Johann Gregor Mendel's "Versuche über Pflanzen-Hybriden".

scientific article published on 11 October 2016

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

scientific article

A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

A cut-off based approach for gene expression analysis of formalin-fixed and paraffin-embedded tissue samples

scientific article published on 19 May 2008

A highly standardized, robust, and cost-effective method for genome-wide transcriptome analysis of peripheral blood applicable to large-scale clinical trials

article

A reductase/isomerase subunit of mitochondrial NADH:ubiquinone oxidoreductase (complex I) carries an NADPH and is involved in the biogenesis of the complex

scientific article published in September 1999

A systems biology approach to identify the combination effects of human herpesvirus 8 genes on NF-kappaB activation

scientific article

Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature

scientific article

Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles

scientific article

Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin

scientific article published on 15 October 2020

Alterations of microRNA and microRNA-regulated messenger RNA expression in germinal center B-cell lymphomas determined by integrative sequencing analysis

scientific article

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome

scientific article published on 24 February 2021

An integrated genome research network for studying the genetics of alcohol addiction

scientific article published on October 2010

Argonaute--a database for gene regulation by mammalian microRNAs

scientific article

Author Correction: The landscape of genomic alterations across childhood cancers

scientific article published in Nature

Autoantibodies against the exocrine pancreas in autoimmune pancreatitis: gene and protein expression profiling and immunoassays identify pancreatic enzymes as a major target of the inflammatory process.

scientific article

Automated universal BRAF state detection within the activation segment in skin metastases by pyrosequencing-based assay U-BRAF(V600)

scientific article

Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation

scientific article published on 30 January 2013

BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence

scientific article

BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia

scientific article

Between-species differences in gene copy number are enriched among functions critical for adaptive evolution in Arabidopsis halleri

scientific article

Braf Mutations Initiate the Development of Rat Gliomas Induced by Postnatal Exposure to N-Ethyl-N-Nitrosourea

scientific article published in October 2016

Bronchoalveolar lavage fluid of lung cancer patients: Mapping the uncharted waters using proteomics technology

CCM2 mediates death signaling by the TrkA receptor tyrosine kinase

scientific article published on September 2009

CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site.

scientific article published on 11 February 2010

Cell competition is a tumour suppressor mechanism in the thymus

scientific article published on 14 May 2014

Characterization of two novel redox groups in the respiratory NADH:ubiquinone oxidoreductase (complex I).

scientific article

Classification of neuroblastoma patients by published gene-expression markers reveals a low sensitivity for unfavorable courses of MYCN non-amplified disease

article

Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction

scientific article

Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex

scientific article

Comparison of RNA-seq and microarray-based models for clinical endpoint prediction

scientific article published on 25 June 2015

Comparison of normalization methods for Illumina BeadChip HumanHT-12 v3.

scientific article

Comparison of performance of one-color and two-color gene-expression analyses in predicting clinical endpoints of neuroblastoma patients

scientific article

Comprehensive genomic characterization of gene therapy-induced T-cell acute lymphoblastic leukemia

scientific article published on 03 March 2020

Computational identification of signalling pathways in Plasmodium falciparum

scientific article published on 26 November 2010

Cooperation of BRAF(F595L) and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling

scientific article published on 19 November 2015

Corrigendum: Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues

scientific article published in November 2017

Coverage bias and sensitivity of variant calling for four whole-genome sequencing technologies

scientific article

Cross-platform analysis of cancer microarray data improves gene expression based classification of phenotypes

scientific article

Cross-study analysis of gene expression data for intermediate neuroblastoma identifies two biological subtypes

scientific article

Customized Oligonucleotide Microarray Gene Expression–Based Classification of Neuroblastoma Patients Outperforms Current Clinical Risk Stratification

article

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia

scientific article published on 18 January 2016

DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats.

scientific article

Decision-tree based model analysis for efficient identification of parameter relations leading to different signaling states

scientific article (publication date: 2013)

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

scientific article

Decreased contractility due to energy deprivation in a transgenic rat model of hypertrophic cardiomyopathy

scientific article published on 3 February 2009

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma

scientific article published on 09 April 2019

Differential expression of neuronal genes defines subtypes of disseminated neuroblastoma with favorable and unfavorable outcome

scientific article published on September 2006

Discovery of transcriptional programs in cerebral ischemia by in silico promoter analysis

scientific article

Dissecting the genomic complexity underlying medulloblastoma

scientific article

Distinct gene expression patterns associated with FLT3- and NRAS-activating mutations in acute myeloid leukemia with normal karyotype

scientific article

Distinct human circulating NKp30FcεRIγCD8 T cell population exhibiting high natural killer-like antitumor potential

article published in the Proceedings of the National Academy of Sciences of the United States of America

Distinct molecular phenotype of malignant CD34(+) hematopoietic stem and progenitor cells in chronic myelogenous leukemia

scientific article

Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

scientific article published on 13 October 2008

Distributed Ledger Technology in genomics: a call for Europe

scientific article published on 16 September 2019

Drug-based perturbation screen uncovers synergistic drug combinations in Burkitt lymphoma

scientific article published in Scientific Reports

Durable remission under dual HER2 blockade with Trastuzumab and Pertuzumab in a patient with metastatic gallbladder cancer

scientific article published on 12 May 2016

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

scientific article

Epigenetic dynamics of monocyte-to-macrophage differentiation

scientific article published on 29 July 2016

Epigenomic Profiling of Human CD4(+) T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

scientific article published on November 2016

Evolutionary conserved gene co-expression drives generation of self-antigen diversity in medullary thymic epithelial cells

scientific article published on 15 October 2015

FGFR2 is overexpressed in myxoid liposarcoma and inhibition of FGFR signaling impairs tumor growth in vitro

scientific article published on 8 May 2015

Feasibility of real-time molecular profiling for patients with newly diagnosed glioblastoma without MGMT promoter-hypermethylation - the NCT Neuro Master Match (N2M2) pilot study

scientific article published on 18 November 2017

From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards.

scientific article published on 15 March 2018

Gene expression pattern in biomechanically stretched cardiomyocytes: evidence for a stretch-specific gene program

scientific article published on 24 December 2007

Gene expression signature predicting pathologic complete response with gemcitabine, epirubicin, and docetaxel in primary breast cancer

scientific article published in April 2006

Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis

scientific article published on 17 July 2017

Genetic and epigenetic profiling of a solitary Peutz-Jeghers colon polyp.

scientific article published on May 2017

Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer.

scientific article published in June 2017

Genetic variants in apoptosis-related genes associated with colorectal hyperplasia

scientific article

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

scientific article

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

scientific article

Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues.

scientific article published on 7 August 2017

Genome-wide association study of pathological gambling

scientific article published on 14 June 2016

Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression

scientific article

Genome-wide transcriptional analysis of the human cell cycle identifies genes differentially regulated in normal and cancer cells

scholarly article

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

scientific article published on 29 March 2019

Genomic footprints of activated telomere maintenance mechanisms in cancer

scientific article published on 05 February 2020

Group testing for pathway analysis improves comparability of different microarray datasets

scientific article published on 7 August 2006

HiGHmed – An Open Platform Approach to Enhance Care and Research across Institutional Boundaries

scientific article published on 17 July 2018

High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma

scientific article

Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma

scientific article published on 11 April 2013

Hypermutation of the inactive X chromosome is a frequent event in cancer

scientific article published on 17 October 2013

ICGC PedBrain - dissecting the genomic complexity underlying medulloblastoma using whole-genome sequencing.

scientific article

Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains

scientific article published on 26 September 2019

Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing

scientific article

Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.

scientific article published on 21 August 2014

Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation

scientific article

Identification of two tetranuclear FeS clusters on the ferredoxin-type subunit of NADH:ubiquinone oxidoreductase (complex I).

scientific article

In Silico Gene Regulatory Network of the Maurer's Cleft Pathway in Plasmodium falciparum

scientific article published on 22 October 2015

Initiation of an inflammatory response in resident intestinal lamina propria cells -use of a human organ culture model

scientific article

Integrated genomic profiling identifies two distinct molecular subtypes with divergent outcome in neuroblastoma with loss of chromosome 11q

Integrated pathway-based approach identifies association between genomic regions at CTCF and CACNB2 and schizophrenia

scientific article

Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification

scientific article

Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas

scientific article published on 17 December 2013

Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer

scientific article

Integrative genomic and transcriptomic analysis of leiomyosarcoma.

scientific article published on 10 January 2018

International network of cancer genome projects

scientific article

Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer.

scientific article published on 24 July 2014

Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer-Specific Immune Responses and Their Correlation to Prognosis

article

Investigation of manic and euthymic episodes identifies state- and trait-specific gene expression and STAB1 as a new candidate gene for bipolar disorder

scientific article

Iroquois homeobox 2 suppresses cellular motility and chemokine expression in breast cancer cells

scientific article

KIT-Dependent and KIT-Independent Genomic Heterogeneity of Resistance in Gastrointestinal Stromal Tumors - TORC1/2 Inhibition as Salvage Strategy

scientific article published on 15 July 2019

MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma

scientific article

Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters

scientific article

MetaboDiff: an R package for differential metabolomic analysis

scholarly article by Andreas Mock published in October 2018

Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin.

scientific article published on 8 February 2018

MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival

scientific article

MicroRNA profiling of primary high-grade soft tissue sarcomas

scientific article

Microarray data warehouse allowing for inclusion of experiment annotations in statistical analysis

scientific article

Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease

scientific article

Mining quasi-bicliques from HIV-1-human protein interaction network: a multiobjective biclustering approach

scientific article published on March 2013

Mitochondrial fatty acid synthesis: a relic of endosymbiontic origin and a specialized means for respiration

scientific article published on May 1997

Modelling p-value distributions to improve theme-driven survival analysis of cancer transcriptome datasets

scientific article

Molecular Classification Substitutes for the Prognostic Variables Stage, Age, and MYCN Status in Neuroblastoma Risk Assessment

scientific article published on 26 October 2017

Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain

scientific article published on May 2015

Molekularpathologie von Sarkomen

Monitoring CSF proteome alterations in amyotrophic lateral sclerosis: obstacles and perspectives in translating a novel marker panel to the clinic

scientific article

Multi-parametric analysis and modeling of relationships between mitochondrial morphology and apoptosis

scientific article

Multiple myeloma-related deregulation of bone marrow-derived CD34(+) hematopoietic stem and progenitor cells

scientific article

Mutant KIT as imatinib-sensitive target in metastatic sinonasal carcinoma.

scientific article published on 29 September 2016

NRG1 Fusions in KRAS Wild-type Pancreatic Cancer.

scientific article

New Insights into the Genetic Regulation of Plasmodium Falciparum Obtained by Bayesian Modeling

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study

scientific article published on 28 July 2016

Ontological Analysis and Pathway Modelling in Drug Discovery

Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity

scientific article published on 26 August 2013

PD-L1 (CD274) copy number gain, expression, and immune cell infiltration as candidate predictors for response to immune checkpoint inhibitors in soft-tissue sarcoma

scientific article published on 27 January 2017

Pathways of urothelial cancer progression suggested by Bayesian network analysis of allelotyping data

scientific article

Patient-derived xenografts of gastrointestinal cancers are susceptible to rapid and delayed B-lymphoproliferation

scientific article

Precision oncology based on omics data: The NCT Heidelberg experience

scientific article

Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling

scientific article published in November 2005

Prognostic impact of gene expression-based classification for neuroblastoma.

scientific article published on 21 June 2010

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

scientific article

Proteomic bronchiolitis obliterans syndrome risk monitoring in lung transplant recipients

scientific article

Recurrent CDKN1B (p27) mutations in hairy cell leukemia

scientific article

Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing

scientific article

Recurrent mutations within the amino-terminal region of β-catenin are probable key molecular driver events in sinonasal hemangiopericytoma

scientific article published on 4 December 2014

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

scientific article

Redox components and structure of the respiratory NADH:ubiquinone oxidoreductase (complex I).

scientific article published in June 1998

Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients

scientific article

Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers

scientific article published on 17 September 2014

Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation.

scientific article published on 9 October 2017

Sarcoma classification by DNA methylation profiling

scientific article published on 21 January 2021

Search for novel redox groups in mitochondrial NADH:ubiquinone oxidoreductase (complex I) by diode array UV/VIS spectroscopy

scientific article published on 01 January 1998

Selective elimination of immunosuppressive T cells in patients with multiple myeloma

scientific article published on 17 February 2021

Seromic profiling of ovarian and pancreatic cancer

scientific article

Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features

scientific article

Subclassification and individual survival time prediction from gene expression data of neuroblastoma patients by using CASPAR.

scientific article

Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts

scientific article

Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2.

scientific article

TMPRSS2-ERG fusions are strongly linked to young patient age in low-grade prostate cancer

scientific article published on 9 July 2014

Targeting Fibroblast Growth Factor Receptor 1 for Treatment of Soft-Tissue Sarcoma

scientific article

Temporal transcriptomic analysis of the Listeria monocytogenes EGD-e sigmaB regulon

scientific article

The Forkhead factor FoxQ1 influences epithelial differentiation.

scientific article

The hematopoietic stem cell in chronic phase CML is characterized by a transcriptional profile resembling normal myeloid progenitor cells and reflecting loss of quiescence

scientific article published on 22 January 2009

The landscape of chromothripsis across adult cancer types

scientific article published on 08 May 2020

The landscape of genomic alterations across childhood cancers

scientific article published on 28 February 2018

The whole-genome landscape of medulloblastoma subtypes

scientific article published in July 2017

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction

scientific article published on 9 June 2015

Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation

scientific article published on 24 January 2006

Translating expression profiling into a clinically feasible test to predict neuroblastoma outcome

scientific article published in March 2007

Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae

scientific article

Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer

scientific article published in Nature Communications

Whole-exome sequencing in eccrine porocarcinoma indicates promising therapeutic strategies

scientific article published on 27 May 2021

Whole-genome analysis of gene expression associates the ubiquitin-proteasome system with the cardiomyopathy phenotype in disease-sensitized congenic mouse strains

article

XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans

scientific article

circlize Implements and enhances circular visualization in R.

scientific article

qPCR in gastrointestinal stromal tumors: Evaluation of reference genes and expression analysis of KIT and the alternative receptor tyrosine kinases FLT3, CSF1-R, PDGFRB, MET and AXL.

scientific article

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