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List of works by Thirumala-Devi Kanneganti

A comprehensive guide to studying inflammasome activation and cell death

scientific article published on 07 September 2020

A functional genetic assay for nuclear trafficking in plants

article

A20 is a regulator of necroptosis

scientific article published in June 2015

AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity

scientific article published on 2 December 2015

ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming

scientific article published on 15 January 2018

ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis

scientific article published on 9 April 2018

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

scientific article published on January 2014

Acute IL-4 Governs Pathogenic T Cell Responses during Leishmania major Infection

scientific article published on 18 September 2020

Addendum: defective Dock2 expression in a subset of ASC-deficient mouse lines.

scientific article published on July 2012

Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice

scientific article published on 16 October 2013

An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis

scientific article

Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages

scientific article

Autoinflammatory Skin Disorders: The Inflammasomme in Focus

scientific article published on 03 June 2016

Autophagy is redundant for the host defense against systemic Candida albicans infections.

scientific article

Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1β (IL-1β)

scientific article published on 5 February 2013

Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease

scientific article

Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism

scientific article published on 09 December 2010

Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation.

scientific article published on 4 December 2017

Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans

scientific article published in April 2009

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4.

scientific article published in December 2017

Caspase-1 inflammasomes in infection and inflammation

scientific article published on 18 April 2007

Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis

scientific article

Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection

scientific article

Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival.

scientific article published on 23 January 2009

Caspase-7: a protease involved in apoptosis and inflammation

scientific article published on 25 September 2009

Cell death-mediated cytokine release and its therapeutic implications

scientific article published on 11 June 2019

Central roles of NLRs and inflammasomes in viral infection ⬇️

scientific article published on September 17, 2010

Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation

scientific article

Computational and comparative analyses of 150 full-length cDNA sequences from the oomycete plant pathogen Phytophthora infestans

scientific article published on 27 December 2005

Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection

scientific article

Converging roles of caspases in inflammasome activation, cell death and innate immunity

scientific article

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

scientific article published on 18 June 2015

Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA

scientific journal article

Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation

scientific article

Critical role for inflammasome-independent IL-1β production in osteomyelitis

scientific article published on 06 January 2014

Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis

scientific article published on 23 March 2016

Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β.

scientific article

Cutting Edge: Dysregulated CARD9 Signaling in Neutrophils Drives Inflammation in a Mouse Model of Neutrophilic Dermatoses

scholarly article by Sarang Tartey et al published 15 September 2018 in Journal of Immunology

Cutting edge: SHARPIN is required for optimal NLRP3 inflammasome activation

scientific article

Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation

scientific article

Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis

scientific article

Cutting edge: proteolytic inactivation of poly(ADP-ribose) polymerase 1 by the Nlrp3 and Nlrc4 inflammasomes

scientific article

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

scientific journal article

DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota

scientific article

DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection

scientific article published on 13 June 2016

Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8+ T Cell Function and Impaired Viral Clearance

scientific article published on 14 June 2017

Deregulated inflammasome signaling in disease

scientific article

Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection

article

Dietary modulation of the microbiome affects autoinflammatory disease

scientific article

Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria

scientific article published on 9 May 2007

Differential roles of caspase-1 and caspase-11 in infection and inflammation

scientific article published on 27 March 2017

Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes

scientific article published in April 2006

Diverging inflammasome signals in tumorigenesis and potential targeting

scientific article published on 01 April 2019

Drak2 is not required for tumor surveillance and suppression

scientific article

Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

scientific article

FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.

scientific article published on 22 January 2014

Fat Chance: Not Much against NKT Cells

article

Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

scientific article

Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

scientific article

Food for Training-Western Diet and Inflammatory Memory

scientific article published in March 2018

Function and regulation of IL-1α in inflammatory diseases and cancer

scientific article published in January 2018

Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation.

scientific article

Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection

scientific article published on 03 December 2018

Fungal zymosan and mannan activate the cryopyrin inflammasome

scientific article published on 09 June 2009

Galactosaminogalactan activates the inflammasome to provide host protection

scientific article published on 02 December 2020

Gasdermin D Flashes an Exit Signal for IL-1.

scientific article published in January 2018

Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against

Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against Francisella novicida

scholarly article by Qifan Zhu et al published 7 November 2018 in Journal of Immunology

Gasdermin D: the long-awaited executioner of pyroptosis

scientific article published on 20 October 2015

Guanylate Binding Proteins regulate inflammasome activation in response to hyper-injected Yersinia translocon components

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HMGB1 release by inflammasomes ⬇️

scientific article published on March 1, 2011

IL-1 family cytokines trigger sterile inflammatory disease

scientific article

IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis

scientific article

IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation

scientific article

IL-1β and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1α or Caspase-8 in a Mouse Model of Familial Mediterranean Fever

scientific article

IL-33 regulates the IgA-microbiota axis to restrain IL-1α-dependent colitis and tumorigenesis

scientific article published on 24 October 2016

IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection

scientific article published on 10 January 2018

IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death

scientific article published on 23 March 2020

IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation

scientific article published on 22 March 2018

Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors

scientific article published on 31 March 2016

Immunological complications of obesity

scientific article published on 19 July 2012

Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins

scientific article published on 3 October 2017

Inflammasome activation and assembly at a glance

scientific article published in December 2017

Inflammasome activation by nucleic acids and nucleosomes in sterile inflammation… or is it sterile?

scientific article published on 04 April 2017

Inflammasome activation in obesity-related inflammatory diseases and autoimmunity ⬇️

scientific article published on July 1, 2011

Inflammasome control of viral infection

scientific article

Inflammasome is a central player in the induction of obesity and insulin resistance

scientific article

Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia

scientific article

Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4(+) T cells and γδ T cells

scientific article published on 17 February 2012

Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis

scientific article

Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59.

scientific article

Inflammasomes and Cancer

scientific article published on 16 January 2017

Inflammasomes and Intestinal Tumorigenesis

scientific article published in January 2011

Inflammasomes and autoimmunity

scientific article

Inflammasomes in the pathophysiology of autoinflammatory syndromes

scientific article published on 14 October 2019

Inflammatory Bowel Disease and the NLRP3 Inflammasome

scientific article published in August 2017

Inflammatory cell death in intestinal pathologies

scientific article published in November 2017

Innate immune pathways in host defense

scientific article published on 30 December 2012

Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

scientific article published on 01 March 2020

Innate immune recognition of mtDNA--an undercover signal?

scientific article published on June 2015

Innate immunity against Leishmania infections

scientific article

Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion

scientific article published on 09 March 2020

Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation.

scientific article published on 14 July 2016

Intracellular NOD-like receptors in host defense and disease

scientific article published on October 2007

Intracellular innate immune receptors: Life inside the cell

scientific article published on 01 September 2020

K⁺ drops tilt the NLRP3 inflammasome

scientific article published in June 2013

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

article

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4.

scientific article

Mechanisms and Consequences of Inflammasome Activation

scientific article published on 13 December 2017

Mechanisms governing inflammasome activation, assembly and pyroptosis induction

scientific article published in May 2017

Membrane Damage during Listeria monocytogenes Infection Triggers a Caspase-7 Dependent Cytoprotective Response ⬇️

scientific article published on July 12, 2012

MiR-155 Induction by Microbes/Microbial Ligands Requires NF-κB-Dependent de novo Protein Synthesis ⬇️

scientific article published on January 1, 2012

MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response

scientific article

Microbiota and caspase-1/caspase-8 regulate IL-1β-mediated bone disease

scientific article published on 5 May 2016

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

scientific article

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

scientific article

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases.

scientific article

Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3.

scientific article published on 13 November 2012

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

scientific article published on 4 May 2015

NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer

scientific article

NLRP12 in autoimmune diseases

scientific article published in August 2015

NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β-mediated osteomyelitis

scientific article published on 6 April 2016

NLRP6 in infection and inflammation

scientific article

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

scientific journal article

NOD-like receptor (NLR) signaling beyond the inflammasome

scientific article published on March 2010

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

scientific article

Nlrp3: an immune sensor of cellular stress and infection

scientific article

Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells.

scientific article published in July 2007

Novel roles for caspase-8 in IL-1β and inflammasome regulation

scientific article

Nucleotide oligomerization and binding domain 2-dependent dendritic cell activation is necessary for innate immunity and optimal CD8+ T Cell responses to influenza A virus infection

scientific article

Nucleotide-binding oligomerization domain-like receptors: intracellular pattern recognition molecules for pathogen detection and host defense

scientific article published on September 2006

On the Road to Discovering the Elusive Executioner of Pyroptosis

scientific article published on 01 April 2019

Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9

scientific article

Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling

article by Thirumala-Devi Kanneganti et al published April 2007 in Immunity

Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor.

scientific article published on 25 September 2017

Protective roles for caspase-8 and cFLIP in adult homeostasis.

scientific article published on 03 October 2013

Publisher Correction: Galactosaminogalactan activates the inflammasome to provide host protection

scientific article published on 21 December 2020

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis

scientific article published in December 2017

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

scientific article published on 26 May 2013

RIPK1 Distinctly Regulates <i>Yersinia</i>-Induced Inflammatory Cell Death, PANoptosis

scientific article published on 11 December 2020

RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3

scientific article

RIPK3 Promotes Mefv Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling

scientific article published on 28 September 2020

Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection

scientific article

Recent advances in inflammasome biology

scientific article published on 9 November 2017

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection

scientific article published on 24 March 2013

Reciprocal regulation of activating and inhibitory Fc{gamma} receptors by TLR7/8 activation: implications for tumor immunotherapy

scientific article

Recognition of Borrelia burgdorferi by NOD2 is central for the induction of an inflammatory reaction

scientific article

Recognition of Coxiella burnetii by toll-like receptors and nucleotide-binding oligomerization domain-like receptors

scientific article published on 22 September 2014

Regulation and functions of NLRP3 inflammasome during influenza virus infection

scientific article published on 3 February 2017

Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.

scientific article

Regulation of immune pathways by the NOD-like receptor NLRC5

scientific article

Regulation of inflammasome activation

scientific article

Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B.

scientific article

Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells

scientific article published on 14 September 2016

Role of AIM2 inflammasome in inflammatory diseases, cancer and infection

scientific article published on 14 August 2019

Role of inflammasomes in host defense against Citrobacter rodentium infection

scientific article

Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury

scientific article

Role of the nlrp3 inflammasome in microbial infection.

scientific article

Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection.

scientific article

SHP-1 and IL-1α conspire to provoke neutrophilic dermatoses

scientific article

Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

scientific article published on 17 December 2013

Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates

scientific article

Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity

scientific article

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

scientific article published on 8 January 2012

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

scientific article

Stressed-out ROS take a silent death route

scientific article published on 18 January 2018

Synergistic interactions of the plant cell death pathways induced by Phytophthora infestans Nepl-like protein PiNPP1.1 and INF1 elicitin

scientific article published in August 2006

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation.

scientific article

TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation

scientific journal article

TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy

scholarly article by Deepika Sharma et al published 2 January 2019 in Journal of Clinical Investigation

Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes

scientific article published on 30 July 2008

Targeting NLRP6 to Enhance Immunity Against Bacterial Infections ⬇️

scientific article published on November 1, 2012

The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression

scientific article published on 13 December 2017

The C-terminal half of Phytophthora infestans RXLR effector AVR3a is sufficient to trigger R3a-mediated hypersensitivity and suppress INF1-induced cell death in Nicotiana benthamiana.

scientific article published on 12 September 2006

The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells

scientific article

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

scientific article

The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.

scientific article

The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence

scientific article published on 26 January 2012

The Nlrp3 inflammasome: contributions to intestinal homeostasis

scientific article

The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation

scientific article published on 26 June 2018

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

scientific article

The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans

scientific article published on 29 April 2011

The expanding role of NLRs in antiviral immunity

scientific article published on September 2013

The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization

scientific journal article

The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis.

scientific article published on 04 July 2011

The inflammasome puts obesity in the danger zone

scientific article published on January 2012

The inflammasome starts rolling

scholarly article by Thirumala-Devi Kanneganti published 1 June 2018 in Nature Reviews Immunology

The inflammasome: a remote control for metabolic syndrome

scientific article

The inflammasome: firing up innate immunity

scientific article

The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1

scientific article

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

scientific article

The malarial host-targeting signal is conserved in the Irish potato famine pathogen

scientific article

The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)

scientific article published on 29 July 2020

The role of inflammasome modulation in virulence

scientific article

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

scientific article published on 16 March 2015

Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens

scientific article

Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

scientific article

Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics

scientific article published on 13 September 2017

Toward targeting inflammasomes: insights into their regulation and activation

scientific article published on 09 March 2020

Type I Interferon Keeps IL-1β in Check

scientific article

Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease

scientific article

Unsolved Mysteries in NLR Biology

scientific article published on 17 September 2013

War on Viruses: LC3 Recruits GTPases

scientific article published on July 2017

ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection

scientific article published on 19 May 2022

ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways

scientific article published on 12 August 2016

ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death.

scientific article published on 20 June 2017

ZBP1: Innate Sensor Regulating Cell Death and Inflammation

scientific article published on 24 November 2017

cGAMP: A tale of two signals

scientific article published on 17 November 2017

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