Search filters

List of works by Véronique Frémeaux-Bacchi

A Clinicopathologic Study of Thrombotic Microangiopathy in IgA Nephropathy ⬇️

scientific article published on November 3, 2011

A Familial C3GN Secondary to Defective C3 Regulation by Complement Receptor 1 and Complement Factor H

scientific article published on 15 October 2015

A case of C3 glomerulonephritis successfully treated with eculizumab

scientific article published on 22 March 2015

A large family with a gain-of-function mutation of complement C3 predisposing to atypical hemolytic uremic syndrome, microhematuria, hypertension and chronic renal failure

scientific article

A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation

scientific article

A mutation in factor I that is strongly associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation

A nationwide study of acquired C1-inhibitor deficiency in France: Characteristics and treatment responses in 92 patients

scientific article published on August 2016

A new type of acquired C1 inhibitor deficiency associated with systemic lupus erythematosus

scientific article published on 01 August 2001

A novel C3 mutation causing increased formation of the C3 convertase in familial atypical hemolytic uremic syndrome

scientific article

A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.

scientific article published on 17 July 2017

A novel non-synonymous polymorphism (p.Arg240His) in C4b-binding protein is associated with atypical hemolytic uremic syndrome and leads to impaired alternative pathway cofactor activity

scientific article

A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function

scientific article

Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies

scientific article published on 28 March 2012

Acute presentation and persistent glomerulonephritis following streptococcal infection in a patient with heterozygous complement factor H-related protein 5 deficiency

scientific article

Alternative complement pathway assessment in patients with atypical HUS.

scientific article

An international consensus approach to the management of atypical hemolytic uremic syndrome in children

scientific article

Analysis of genes coding for CD46, CD55, and C4b-binding protein in patients with idiopathic, recurrent, spontaneous pregnancy loss

scientific article published on 23 April 2013

Analysis of protein missense alterations by combining sequence- and structure-based methods

scientific article published on 25 February 2020

Anti-C5 antibody treatment for delayed hemolytic transfusion reactions in sickle cell disease

scientific article published on 02 July 2020

Anti-Factor B Antibodies and Acute Postinfectious GN in Children

scientific article published on 07 February 2020

Anti-Factor B and Anti-C3b Autoantibodies in C3 Glomerulopathy and Ig-Associated Membranoproliferative GN.

scientific article published on 17 January 2017

Anti-Factor H autoantibodies associated with atypical hemolytic uremic syndrome

scientific article

Anti-factor H autoantibodies assay

scientific article

Anti-factor H autoantibody-associated hemolytic uremic syndrome: the earlier diagnosed and treated, the better

scientific article

Assessing complement blockade in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab

scientific article published on 4 December 2014

Association of hereditary angioneurotic edema with spondylarthropathy: report of a case

scientific article published on 31 August 2007

Atypical Hemolytic Uremic Syndrome Recurrence after Renal Transplantation: C3-Glomerulonephritis as an Initial Presentation

scientific article published on 26 March 2015

Atypical aHUS: State of the art.

scientific article

Atypical and secondary hemolytic uremic syndromes have a distinct presentation and no common genetic risk factors

scientific article published on 15 March 2019

Atypical haemolytic uraemic syndrome and mutations in complement regulator genes

scientific article

Atypical haemolytic uraemic syndrome and pregnancy: outcome with ongoing eculizumab

scientific article published in September 2016

Atypical hemolytic and uremic syndrome due to C3 mutation in pancreatic islet transplantation: a case report

scientific article published on 19 September 2020

Atypical hemolytic uremic syndrome

scientific article published in September 2011

Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference.

scientific article published on 15 December 2016

Atypical hemolytic uremic syndrome and hypertensive crisis

scientific article published on 01 November 2019

Atypical hemolytic uremic syndrome associated with mutations in complement regulator genes

scientific article

Atypical hemolytic uremic syndrome: From the rediscovery of complement to targeted therapy ⬇️

scientific article published on June 5, 2013

Autoantibodies Against C3b-Functional Consequences and Disease Relevance

scientific article published on 29 January 2019

Autoantibodies in haemolytic uraemic syndrome (HUS).

scientific article

Blockade of C5 in Severe Acute Postinfectious Glomerulonephritis Associated With Anti-Factor H Autoantibody

scientific article published on 24 September 2016

Blockade of alternative complement pathway in dense deposit disease

scientific article published on 6 February 2014

C3 glomerulonephritis in a patient treated with anti-PD-1 antibody

scientific article published on 12 December 2019

C3 glomerulopathy

scientific article published on 08 May 2013

C3 glomerulopathy: a new classification

scientific article published on 06 July 2010

C3 glomerulopathy: consensus report

scientific article published on 30 October 2013

C3 nephritic factor associated with C3 glomerulopathy in children

scientific article published on 26 September 2013

C3 nephritic factor can be associated with membranous glomerulonephritis

scientific article

C4 Nephritic Factors in C3 Glomerulopathy: A Case Series.

scientific article published on 22 August 2017

C5 nephritic factors drive the biological phenotype of C3 glomerulopathies

scientific article published on 14 July 2017

C5b9 Deposition in Glomerular Capillaries Is Associated With Poor Kidney Allograft Survival in Antibody-Mediated Rejection

scientific article published on 08 March 2019

CD46-induced human Treg enhance B-cell responses

scientific article

CFH gene mutation in a case of Shiga toxin-associated hemolytic uremic syndrome (STEC-HUS).

scientific article

Characterization of a New DGKE Intronic Mutation in Genetically Unsolved Cases of Familial Atypical Hemolytic Uremic Syndrome

scientific article

Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome

scientific article

Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome

Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis

scientific article published on 07 August 2020

Clinical and Genetic Spectrum of a Large Cohort With Total and Sub-total Complement Deficiencies

scientific article published on 08 August 2019

Clinical and genetic predictors of atypical hemolytic uremic syndrome phenotype and outcome

scientific article published on 19 June 2018

Clinical features of anti-factor H autoantibody-associated hemolytic uremic syndrome

scientific article

Combined complement gene mutations in atypical hemolytic uremic syndrome influence clinical phenotype

scientific article

Common genetic variants in complement genes other than CFH, CD46 and the CFHRs are not associated with aHUS.

scientific article

Complement C3 is a novel modulator of the anti-FVIII immune response

scientific article published on 16 November 2017

Complement C5 inhibition in patients with COVID-19 - a promising target?

scientific article published on 23 July 2020

Complement Gene Variants and Shiga Toxin-Producing Escherichia coli-Associated Hemolytic Uremic Syndrome: Retrospective Genetic and Clinical Study

scientific article published on 23 January 2019

Complement System Part I - Molecular Mechanisms of Activation and Regulation

scientific article

Complement System Part II: Role in Immunity

scientific article

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

scientific article

Complement activation in sickle cell disease: Dependence on cell density, hemolysis and modulation by hydroxyurea therapy

scientific article published on 28 January 2020

Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis

scientific article published on 30 October 2020

Complement alternative pathway acts as a positive feedback amplification of neutrophil activation

scientific article published on 09 November 2010

Complement and the atypical hemolytic uremic syndrome in children.

scientific article

Complement deficiencies and human diseases

scientific article published in May 2014

Complement factor B mutations in atypical hemolytic uremic syndrome-disease-relevant or benign?

scientific article

Complement factor H deficiency and posttransplantation glomerulonephritis with isolated C3 deposits

scientific article

Complement factor H related proteins (CFHRs) ⬇️

scientific article published on July 3, 2013

Complement factor I in health and disease

scientific article

Complement gene variants determine the risk of immunoglobulin-associated MPGN and C3 glomerulopathy and predict long-term renal outcome

scientific article

Complement receptor CD46 co-stimulates optimal human CD8 T cell effector function via fatty acid metabolism

scientific article published in Nature Communications

Complement-binding anti-HLA antibodies and kidney-allograft survival

scientific article published in September 2013

Current Understanding of the Role of Complement in IgA Nephropathy

scientific article

Defining the genetics of thrombotic microangiopathies

scientific article

Detection of Autoantibodies to Complement Components by Surface Plasmon Resonance-Based Technology

scientific article published on 01 January 2019

Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome

scientific article

Distal Angiopathy and Atypical Hemolytic Uremic Syndrome: Clinical and Functional Properties of an Anti-Factor H IgAλ Antibody

scientific article

Does hemolytic uremic syndrome differ from thrombotic thrombocytopenic purpura?

scientific article

Eculizumab and drug-induced haemolytic-uraemic syndrome

scientific article published on 5 September 2013

Eculizumab as an emergency treatment for adult patients with severe COVID-19 in the intensive care unit: A proof-of-concept study

scientific article published on 05 November 2020

Eculizumab discontinuation in children and adults with atypical haemolytic uremic syndrome: a prospective multicentric study

scientific article published on 03 December 2020

Eculizumab for treatment of rapidly progressive C3 glomerulopathy

scientific article published on 17 December 2014

Eculizumab in an anephric patient with atypical haemolytic uraemic syndrome and advanced vascular lesions

scientific article

Eculizumab in severe Shiga-toxin-associated HUS

scientific article (publication date: 30 June 2011)

Eculizumab treatment in severe pediatric STEC-HUS: a multicenter retrospective study.

scientific article published on 23 March 2018

Efficacy of eculizumab in a patient with factor-H-associated atypical hemolytic uremic syndrome ⬇️

scientific article published on December 15, 2010

Efficacy of plasma therapy in atypical hemolytic uremic syndrome with complement factor H mutations

scientific article

Endothelial cells: source, barrier, and target of defensive mediators

scientific article

Endothelium structure and function in kidney health and disease

scientific article published on 01 February 2019

Erratum: Post-partum atypical haemolytic-uraemic syndrome treated with eculizumab: terminal complement activity assessment in clinical practice

scientific article published on August 2013

Factor H, membrane cofactor protein, and factor I mutations in patients with hemolysis, elevated liver enzymes, and low platelet count syndrome

scientific article published on 24 July 2008

Functional Characterization of Autoantibodies against Complement Component C3 in Patients with Lupus Nephritis.

scientific article

Functional analysis of splicing mutations and of an exon 2 polymorphic variant of SERPING1/C1NH

scientific article published on 01 March 2006

Functional and structural insight into properdin control of complement alternative pathway amplification.

scientific article published on 6 March 2017

Functional characterization of the recombinant human C1 inhibitor serpin domain: insights into heparin binding.

scientific article published on 29 March 2010

Functional complement C1q abnormality leads to impaired immune complexes and apoptotic cell clearance

scientific article

Functional evaluation of factor H genetic and acquired abnormalities: application for atypical hemolytic uremic syndrome (aHUS).

scientific article

Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome

scientific article

Genotype-phenotype correlations for exudative age-related macular degeneration associated with homozygous HTRA1 and CFH genotypes

scientific article

Glomerulonephritis With Isolated C3 Deposits as a Manifestation of Subtotal Factor I Deficiency

scientific article published on 31 May 2019

Glomerulonephritis with isolated C3 deposits and monoclonal gammopathy: a fortuitous association?

scientific article

Haemolytic uraemic syndrome

scientific article published on 25 February 2017

Haemolytic uraemic syndrome associated with non shiga toxin-producing Escherichia coli bacteraemia: a case report

scientific article published on 07 May 2019

Haemolytic uraemic syndrome caused by factor H mutation: is single kidney transplantation under intensive plasmatherapy an option?

scientific article

Heme Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1

scientific article published on 20 December 2018

Heme interacts with c1q and inhibits the classical complement pathway

scientific article

Hemolytic Uremic Syndrome in Pregnancy and Postpartum

scientific article published on 8 June 2017

Hemolytic uremic syndrome associated with Bordetella pertussis infection in a 2-month-old infant carrying a pathogenic variant in complement factor H

scientific article published on 17 December 2018

Hemolytic uremic syndrome recurrence after renal transplantation

scientific article published on 10 May 2008

Hemolytic-uremic syndrome: what is the mechanism?

scientific article

Hereditary and acquired complement dysregulation in membranoproliferative glomerulonephritis

scientific article

Hereditary and acquired complement dysregulation in membranoproliferative glomerulonephritis

scientific article (publication date: 17 January 2009)

Hereditary hemolytic uremic syndromes and thrombotic thrombocytopenic purpura

scientific article

Heterogeneous histologic and clinical evolution in 3 cases of dense deposit disease with long-term follow-up

scientific article published on 16 August 2014

Heterogeneous pattern of renal disease associated with homozygous Factor H deficiency

scientific article published on 10 March 2011

Heterozygous and homozygous factor h deficiencies associated with hemolytic uremic syndrome or membranoproliferative glomerulonephritis: report and genetic analysis of 16 cases

scientific article

High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis

scientific article published on 28 July 2006

Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome

scientific article

Identification of Jagged1 as a novel ligand for CD46: An interaction required for normal induction and regulation of human TH1 responses

article

Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis

scientific article

Impact of hypertensive emergency and rare complement variants on the presentation and outcome of atypical hemolytic uremic syndrome

scientific article published on 19 March 2019

Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome

scientific article

In Reply to 'Benefit of Eculizumab Compared to Standard of Care Still Unproven in C3 Glomerulopathy'

scientific article published on 17 September 2018

Inherited deficiency of membrane cofactor protein expression and varying manifestations of recurrent atypical hemolytic uremic syndrome in a sibling pair

scientific article

Insights from the use in clinical practice of eculizumab in adult patients with atypical hemolytic uremic syndrome affecting the native kidneys: an analysis of 19 cases

scientific article

Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles

scientific article published on 21 June 2018

Invasive pneumococcal disease in children can reveal a primary immunodeficiency

scientific article

Investigation of the complement system in clinical practice

scientific article

Late-onset thrombocytic microangiopathy caused by cblC disease: association with a factor H mutation

scientific article

Long-term remission of atypical HUS with anti-factor H antibodies after cyclophosphamide pulses

scientific article

Long-term successful liver-kidney transplantation in a child with atypical hemolytic uremic syndrome caused by homozygous factor H deficiency.

scientific article

Loss of DGKε induces endothelial cell activation and death independently of complement activation

scientific article published on 10 December 2014

Lupus nephritis associated with complete C1s deficiency efficiently treated with rituximab: A case report

scientific article published on 01 September 2010

Malignant hypertension and thrombotic microangiopathy: complement as a usual suspect

scientific article published on 10 December 2020

Management of thrombotic microangiopathy in pregnancy and postpartum: report from an international working group

scientific article published on 17 August 2020

Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome

scientific article

Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome

scientific article

Midterm Outcomes of 12 Renal Transplant Recipients Treated With Eculizumab to Prevent Atypical Hemolytic Syndrome Recurrence

scientific article published on 25 August 2017

Molecular and functional analysis of complement factor I mutations in atypical haemolytic uraemic syndrome patients

scholarly article by Sara C. Nilsson et al published October 2008 in Molecular Immunology

Monitoring Complement Activation: The New Conundrum in Thrombotic Microangiopathies

scientific article published on 06 November 2019

Mutations in complement factor I as found in atypical hemolytic uremic syndrome lead to either altered secretion or altered function of factor I

scientific article

Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort

scientific article (publication date: March 2011)

Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome

scientific article

Myocardial infarction is a complication of factor H-associated atypical HUS.

scientific article

Neisseria meningitidis inside neutrophils, revealing properdin deficiency

scientific article published on 24 July 2020

Neurological involvement in a child with atypical hemolytic uremic syndrome

scientific article

New insights into postrenal transplant hemolytic uremic syndrome.

scientific article

No lupus nephritis in the absence of antiC1q autoantibodies?

scientific article published on 01 December 2002

Obstetric nephrology: AKI and thrombotic microangiopathies in pregnancy

scientific article

Obstetrical Complications and Outcome in Two Families with Hereditary Angioedema due to Mutation in the F12 Gene.

scientific article

Ockham's razor defeated: about two atypical cases of hemolytic uremic syndrome

scientific article published on 11 July 2020

Ocular involvement in hemolytic uremic syndrome due to factor H deficiency--are there therapeutic consequences?

scientific article

Overall neutralization of complement factor H by autoantibodies in the acute phase of the autoimmune form of atypical hemolytic uremic syndrome

scientific article

P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner

scientific article published on 08 March 2019

Pathogenic Variants in Complement Genes and Risk of Atypical Hemolytic Uremic Syndrome Relapse after Eculizumab Discontinuation

scientific article published on 31 October 2016

Pathophysiology of atypical hemolytic uremic syndrome. Ten years of progress, from laboratory to patient

scientific article

Pathophysiology of thrombotic microangiopathies: current understanding

scientific article

Patterns of Clinical Response to Eculizumab in Patients With C3 Glomerulopathy.

scientific article published on 8 February 2018

Phenotypic expansion of DGKE-associated diseases

scientific article

Physiological and therapeutic complement regulators in kidney transplantation ⬇️

scientific article published on August 1, 2013

Post-partum acute kidney injury: sorting placental and non-placental thrombotic microangiopathies using the trajectory of biomarkers

scientific article published on 25 February 2019

Post-partum atypical haemolytic-uraemic syndrome treated with eculizumab: terminal complement activity assessment in clinical practice

scientific article published on April 2013

Practical management of C3 glomerulopathy and immunoglobulin-mediated MPGN: facts and uncertainties

scientific article published on 02 July 2020

Prevalence of monoclonal gammopathy in patients presenting with acquired angioedema type 2

scientific article published on 01 August 2002

Primary glomerulonephritis with isolated C3 deposits: a new entity which shares common genetic risk factors with haemolytic uraemic syndrome

scientific article

Pulse cyclophosphamide therapy and clinical remission in atypical hemolytic uremic syndrome with anti-complement factor H autoantibodies

scientific article

Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome

scientific article

Recurrent Hemolytic and Uremic Syndrome Induced by Escherichia Coli

scientific article

Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome

scientific article

Secondary failure of plasma therapy in factor H deficiency

scientific article

Severe ADAMTS13 deficiency in adult idiopathic thrombotic microangiopathies defines a subset of patients characterized by various autoimmune manifestations, lower platelet count, and mild renal involvement

scientific article

Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome in solid organ transplant recipients

scientific article published on 01 December 2019

Spectrum of complement-mediated thrombotic microangiopathies: pathogenetic insights identifying novel treatment approaches

scientific article

Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.

scientific article published on 2 March 2018

Strains Responsible for Invasive Meningococcal Disease in Patients With Terminal Complement Pathway Deficiencies

scientific article published on 25 March 2017

Successful pre-transplant management of a patient with anti-factor H autoantibodies-associated haemolytic uraemic syndrome

scientific article

Successful treatment of a Streptococcus pneumoniae-associated haemolytic uraemic syndrome by eculizumab

scientific article published on 20 March 2018

Successful treatment of acute thrombotic microangiopathy by eculizumab after combined lung and kidney transplantation

scientific article published in October 2013

Successful use of eculizumab in a patient with post‐transplant thrombotic microangiopathy ⬇️

scientific article published on January 7, 2013

Systemic and kidney toxicity of intraocular administration of vascular endothelial growth factor inhibitors

scientific article

Targeted strategies in the prevention and management of atypical HUS recurrence after kidney transplantation.

scientific article

The CD46-Jagged1 interaction is critical for human TH1 immunity

scientific article

The Phenotypic Spectrum of Nephropathies Associated with Mutations in Diacylglycerol Kinase ε.

scientific article published on 19 May 2017

The authors reply

The clinical spectrum and therapeutic management of hypocomplementemic urticarial vasculitis: data from a French nationwide study of fifty-seven patients

scientific article

The complement factor H R1210C mutation is associated with atypical hemolytic uremic syndrome

scientific article

The emerging role of complement inhibitors in transplantation

scientific article published on 16 September 2015

The global aHUS registry: methodology and initial patient characteristics

scientific article

The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status

scientific article published on 6 September 2013

The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models

scientific article

The role of complement in C3 glomerulopathy

scientific article

Thrombotic microangiopathy associated with Gemcitabine use: presentation and outcome in a national French retrospective cohort

article

Thrombotic microangiopathy: eculizumab for atypical haemolytic uraemic syndrome: what next?

scientific article

Treatment of B-cell disorder improves renal outcome of patients with monoclonal gammopathy-associated C3 glomerulopathy

scientific article

Treatment of atypical uraemic syndrome in the era of eculizumab

scientific article published on February 2012

Unusual clinical severity of complement membrane cofactor protein-associated hemolytic-uremic syndrome and uniparental isodisomy

scientific article

Use of Eculizumab in Patients With Allogeneic Stem Cell Transplant-Associated Thrombotic Microangiopathy: A Study From the SFGM-TC.

scientific article

Use of Highly Individualized Complement Blockade Has Revolutionized Clinical Outcomes after Kidney Transplantation and Renal Epidemiology of Atypical Hemolytic Uremic Syndrome

scientific article published on 01 October 2019

Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies

scientific article

Varicella as a trigger of atypical haemolytic uraemic syndrome associated with complement dysfunction: two cases

scientific article

Where next with atypical hemolytic uremic syndrome?

scientific article

Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population

article

[C3 glomerulopathy]

scientific article published on 04 February 2014

[Combined-heterozygous deficiency of complement C7 in a patient with recurrent meningitis]

scientific article published on 01 August 2006

Paulina is supported by:

About Paulina

Help