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List of works by Jean-Charles Lambert

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

scientific article

17q21.31 duplication causes prominent tau-related dementia with increased MAPT expression.

scientific article published on 13 December 2016

A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease

scientific article

A FE65 polymorphism associated with risk of developing sporadic late-onset alzheimer's disease but not with Abeta loading in brains

scientific article published in October 2000

A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.

scientific article published on 19 June 2017

A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly

scientific article published on 18 February 2014

A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium

scientific article published on 05 May 2013

A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis

scientific article

A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease

scientific article

A new GTP-cyclohydrolase I mutation in an unusual doparesponsive dystonia, familial form

scientific article published on 01 February 1999

A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease.

scientific article published in March 1998

A novel Alzheimer disease locus located near the gene encoding tau protein.

scientific article

A novel presenilin-2 splice variant in human Alzheimer's disease brain tissue

scientific article

A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer's disease

scientific article

A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk

scientific article

A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease.

scientific article

A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer's disease, nor does it influence the extent of tau pathology in the brain.

scientific article published in May 2002

A regulatory variant in CCR6 is associated with susceptibility to antitopoisomerase-positive systemic sclerosis

scientific article published on December 2013

A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease

scientific article

ABCA7 rare variants and Alzheimer disease risk

scientific article published on April 2016

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

scientific article published on 02 June 2016

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

scientific article

APOE promoter polymorphisms and dementia in the elderly

scientific article published in July 2004

Abdominal obesity and lower gray matter volume: a Mendelian randomization study

scientific article published on 31 August 2013

Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells

scientific article published in May 2021

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

scientific article published on 15 March 2011

Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

scientific article published on 03 November 2020

Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

scientific article published on 10 June 2019

Analysis of modular gene co-expression networks reveals molecular pathways underlying Alzheimer's disease and progressive supranuclear palsy

scientific article published on 14 April 2022

Analysis of the APOE alleles impact in Down's syndrome

scientific article published on 01 December 1996

Apolipoprotein E (APOE) ε4 and episodic memory decline in Alzheimer's disease: A review

scientific article published on 10 February 2016

Are the estrogen receptors involved in Alzheimer's disease?

scientific article published in June 2001

Association at LRP gene locus with sporadic late-onset Alzheimer's disease.

scientific article published in June 1998

Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels

scientific article (publication date: 2011)

Association between Parkinson's disease and the HLA-DRB1 locus

scientific article published on 13 July 2012

Association between coding variability in the LRP gene and the risk of late-onset Alzheimer's disease.

scientific article published on May 1999

Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease.

scientific article published in May 1997

Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease

scientific article

Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study

scientific article

Association of ornithine transcarbamylase gene polymorphisms with hypertension and coronary artery vasomotion.

scientific article published on 2 July 2009

Association of plasma Aß peptides with blood pressure in the elderly

scientific article (publication date: 15 April 2011)

Association of plasma amyloid with risk of dementia: The prospective Three-City Study

scientific article published on 01 September 2009

Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease

scientific article

Association study of Notch 4 polymorphisms with Alzheimer's disease

scientific article

Association study of the CFH Y402H polymorphism with Alzheimer's disease

scientific article published on 22 April 2008

Association study of the GAB2 gene with the risk of developing Alzheimer's disease

scientific article published on 5 January 2008

Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease

scientific article

Association study of the PIN1 gene with Alzheimer's disease

scientific article

Association study of the Ubiquilin gene with Alzheimer's disease

scientific article published on 28 February 2006

Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease

scientific article published on 12 July 2007

Association study of the vascular endothelial growth factor gene with the risk of developing Alzheimer's disease

scientific article

Association study of three polymorphisms of TGF-beta1 gene with Alzheimer's disease.

scientific article published on July 2002

Associations of complement factor H and smoking with early age-related macular degeneration: the ALIENOR study

scientific article published on 29 July 2011

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation

scientific article published on 07 May 2019

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

scientific article published on 16 January 2012

Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis

scientific article (publication date: 2012)

Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease

scientific article published in January 2005

Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson Disease

scientific article published in The Journal of the American Medical Association

Common polygenic variation enhances risk prediction for Alzheimer's disease

scientific article published on 21 October 2015

Common variants at 12q14 and 12q24 are associated with hippocampal volume

scientific article

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

scientific article (publication date: May 2011)

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

scientific article published on 7 June 2021

Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls

scientific article published on 14 July 2017

Correction to: Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

scientific article published on 04 January 2021

Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

scientific article published on 21 October 2019

Corrigendum to "Genome-wide association interaction analysis for Alzheimer's disease." [Neurobiol. Aging 35 (2014) 2436-2443].

scientific article

Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

scientific article published on 26 May 2017

Deciphering genetic susceptibility to frontotemporal lobar dementia

scholarly article by Jean-Charles Lambert & Philippe Amouyel published March 2010 in Nature Genetics

Deletion of the progranulin gene in patients with frontotemporal lobar degeneration or Parkinson disease

article

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models

scientific article

Differential transcript usage unravels gene expression alterations in Alzheimer's disease human brains

scientific article published on 04 January 2021

Distortion of allelic expression of apolipoprotein E in Alzheimer's disease.

scientific article published in November 1997

Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease.

scientific article

Epidemiology of dementia in Central Africa (EPIDEMCA): protocol for a multicentre population-based study in rural and urban areas of the Central African Republic and the Republic of Congo.

scientific article

Erratum to: Epidemiology of dementia in Central Africa (EPIDEMCA): protocol for a multicentre population-based study in rural and urban areas of the Central African Republic and the Republic of Congo.

scientific article published on 5 May 2016

Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease

scientific article published on 18 June 2016

Evidence for caveolin-1 as a new susceptibility gene regulating tissue fibrosis in systemic sclerosis

scientific article

Evidence for induction of the ornithine transcarbamylase expression in Alzheimer's disease

scientific article

Evidence of a role for lactadherin in Alzheimer's disease

scientific article published on March 2007

Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations

scientific article

Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population

scientific article

From genetics to dietetics: the contribution of epidemiology to understanding Alzheimer's disease

scientific article published on January 2013

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus

scientific article published on 08 March 2012

Functional complementation in Drosophila to predict the pathogenicity of TARDBP variants: evidence for a loss-of-function mechanism

scientific article published on 28 September 2014

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology.

scientific article

GWAS for executive function and processing speed suggests involvement of the CADM2 gene.

scientific article

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

scientific article

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

scientific article

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).

scientific article

Genetic heterogeneity of Alzheimer's disease: complexity and advances

scientific article (publication date: August 2007)

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Genetics of Alzheimer's disease: new evidences for an old hypothesis? ⬇️

scientific article published on March 1, 2011

Genetics of Alzheimer's disease: where we are, and where we are going

scientific article published on 18 December 2019

Genetics of venous thrombosis: insights from a new genome wide association study

scientific article (publication date: 2011)

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.

scientific article

Genome-wide Association Study Links APOEϵ4 and BACE1 Variants with Plasma Amyloid β Levels

Genome-wide analysis of genetic loci associated with Alzheimer disease

scientific article

Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease

scientific article published on 23 January 2012

Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension

scientific article published on 17 March 2013

Genome-wide association interaction analysis for Alzheimer's disease

scientific article

Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium

scientific article

Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population

scientific article published on 17 November 2010

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

scientific article (publication date: October 2009)

Genome-wide association study of kidney function decline in individuals of European descent

scientific article

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

scientific article published on 20 March 2012

Genome-wide pathway analysis implicates intracellular transmembrane protein transport in Alzheimer disease.

scientific article published on 29 July 2010

Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis

scientific article

Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk

scientific journal article

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism

scientific article

HENA, heterogeneous network-based data set for Alzheimer's disease

scientific article published on 14 August 2019

High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease.

scientific article published on 3 April 2012

High-Content Screening for Protein-Protein Interaction Modulators Using Proximity Ligation Assay in Primary Neurons

scientific article published on 01 March 2020

Implication of the Immune System in Alzheimer's Disease: Evidence from Genome-Wide Pathway Analysis

article

Incidence of and Risk Factors Associated With Age-Related Macular Degeneration: Four-Year Follow-up From the ALIENOR Study

scientific article published on 29 March 2018

Independent and joint effects of the MAPT and SNCA genes in Parkinson disease

scientific article

Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations--the ECTIM Study

article

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

scientific article published on 8 September 2012

Interleukin-6 promoter polymorphism: risk and pathology of Alzheimer's disease

scientific article published in May 2004

Is the LDL receptor-related protein involved in Alzheimer's disease?

scientific article published in April 1999

Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?

scientific article

Is the urea cycle involved in Alzheimer's disease?

scientific article

Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease?

scientific article

KNG1 Ile581Thr and susceptibility to venous thrombosis

scientific article published on 26 January 2011

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease

article

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

scientific article

Meta-analysis of genetic association with diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing

MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms

scientific article

Missense variant in TREML2 protects against Alzheimer's disease

scientific article published on 21 December 2013

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease

scientific article

Mutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy

scientific article published on April 2015

Neuropathological epidemiology of cerebral aging: a study of two genetic polymorphisms.

scientific article published in March 2001

New Insight Into the Association of Apolipoprotein E Genetic Variants With Carotid Plaques and Intima-Media Thickness

scientific article published on 09 November 2006

New insights into the genetic etiology of Alzheimer's disease and related dementias

scientific article published in April 2022

No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease

scientific article published in March 1999

No association of the -48CT polymorphism of the presenilin 1 gene with Alzheimer disease in a late-onset sporadic population.

scientific article published in July 2002

No association of the HLA-A2 allele with Alzheimer's disease

scientific article published on 01 December 2002

Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study

scientific article

PLD3 and sporadic Alzheimer's disease risk

scientific article published in April 2015

Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study

scientific article published in February 2008

Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study

scientific article

Plasma amyloid-β levels and prognosis in incident dementia cases of the 3-City Study

scientific article published on January 2013

Plasma β-amyloid 40 levels are positively associated with mortality risks in the elderly.

scientific article published on 9 July 2014

Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease

scientific article published in September 1998

Pyk2 overexpression in postsynaptic neurons blocks amyloid β<sub>1-42</sub>-induced synaptotoxicity in microfluidic co-cultures

scientific article published on 28 August 2020

Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain

scientific article published on 29 July 2017

Relevance and limitations of public databases for microarray design: a critical approach to gene predictions.

scientific article published on January 2003

Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease

scientific article published on 22 July 2011

SORL1 rare variants: a major risk factor for familial early-onset Alzheimer's disease.

scientific article published on 25 August 2015

Single polymorphism nucleotide rs1333049 on chromosome 9p21 is associated with carotid plaques but not with common carotid intima-media thickness in older adults. A combined analysis of the Three-City and the EVA studies

article

Structural Basis of Tau Interaction With BIN1 and Regulation by Tau Phosphorylation

scholarly article by Alessia Lasorsa published in January 2018

Study of estrogen receptor-α and receptor-β gene polymorphisms on Alzheimer's disease

scientific article published in January 2011

Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease

scientific article

Systematic Analysis of Candidate Genes for Alzheimer's Disease in a French, Genome-Wide Association Study

article

TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila

scientific article published on 17 January 2013

TREM2 Variants in Alzheimer's Disease ⬇️

scientific article published on November 14, 2012

Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain

scientific article published on 23 September 2015

The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain.

scientific article published in June 2001

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study

scientific article

The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism

scientific article published on 13 February 2013

The allelic modulation of apolipoprotein E expression by oestrogen: potential relevance for Alzheimer's disease

scientific article

The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimer's disease

scientific article published in August 2002

The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis?

scientific article published on 13 April 2019

The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects

scientific article published on 18 January 2010

The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels

scientific article published in February 2011

Total ApoE and ApoE4 isoform assays in an Alzheimer's disease case-control study by targeted mass spectrometry (n=669): a pilot assay for methionine-containing proteotypic peptides

scientific article

Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease

scientific article

Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease

scientific article published on 31 January 2019

Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals

Variations in the APP gene promoter region and risk of Alzheimer disease.

scientific article published in February 2007

Voxel-Based Statistical Analysis of 3D Immunostained Tissue Imaging

scientific article published on 15 November 2018

Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

article

miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer's disease

scientific article

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