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List of works by Georg Krupitza

12(S)-HETE increases intracellular Ca(2+) in lymph-endothelial cells disrupting their barrier function in vitro; stabilization by clinical drugs impairing calcium supply

scientific article published on 4 July 2016

5-FdUrd-araC heterodinucleoside re-establishes sensitivity in 5-FdUrd- and AraC-resistant MCF-7 breast cancer cells overexpressing ErbB2.

scientific article published in December 2006

A eudesmane-type sesquiterpene isolated from Pluchea odorata (L.) Cass. combats three hallmarks of cancer cells: Unrestricted proliferation, escape from apoptosis and early metastatic outgrowth in vitro

scientific article published on 5 May 2015

A novel N-hydroxy-N'-aminoguanidine derivative inhibits ribonucleotide reductase activity: Effects in human HL-60 promyelocytic leukemia cells and synergism with arabinofuranosylcytosine (Ara-C).

scientific article published on 16 September 2010

A polar extract of the Maya healing plant Anthurium schlechtendalii (Aracea) exhibits strong in vitro anticancer activity

scientific article

ADP-ribosylation of ADPR-transferase and topoisomerase I in intact mouse epidermal cells JB6.

scientific article

AHR/CYP1A1 interplay triggers lymphatic barrier breaching in breast cancer spheroids by inducing 12(S)-HETE synthesis

scientific article published in November 2016

Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinoma

scientific article published on 13 September 2008

An apolar extract of Critonia morifolia inhibits c-Myc, cyclin D1, Cdc25A, Cdc25B, Cdc25C and Akt and induces apoptosis.

scientific article

Analysis of mechanisms contributing to AraC-mediated chemoresistance and re-establishment of drug sensitivity by the novel heterodinucleoside phosphate 5-FdUrd-araC.

scientific article published on March 2006

Anti-leukaemic effects of two extract types of Lactuca sativa correlate with the activation of Chk2, induction of p21, downregulation of cyclin D1 and acetylation of alpha-tubulin.

scientific article

Antiproliferative effects of some novel synthetic solanidine analogs on HL-60 human leukemia cells in vitro.

scientific article

Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells.

scientific article published on 8 October 2008

Apoptosis-inducing cleavage of caspases by trimidox, an inhibitor of ribonucleotide reductase

scientific article published on 01 January 2000

Autocrine self-elimination of cultured ovarian cancer cells by tumour necrosis factor alpha (TNF-alpha).

scientific article

Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis.

scientific article

Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells

Bay11-7082 inhibits the disintegration of the lymphendothelial barrier triggered by MCF-7 breast cancer spheroids; the role of ICAM-1 and adhesion ⬇️

scientific article published on October 23, 2012

Benzamide riboside induces apoptosis independent of Cdc25A expression in human ovarian carcinoma N.1 cells

scientific article published on August 1999

Berberine and a Berberis lycium extract inactivate Cdc25A and induce alpha-tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis

scientific article published in January 2010

Bidirectional interactions between the estrogen receptor and the cerbB-2 signaling pathways: heregulin inhibits estrogenic effects in breast cancer cells

scientific article published on 01 November 1995

Cancer cell-derived 12(S)-HETE signals via 12-HETE receptor, RHO, ROCK and MLC2 to induce lymph endothelial barrier breaching.

scientific article published on 30 June 2016

Cdc25A phosphatase suppresses apoptosis induced by serum deprivation

scientific article

Characterization of glucocerebrosides and the active metabolite 4,8-sphingadienine from Arisaema amurense and Pinellia ternata by NMR and CD spectroscopy and ESI-MS/CID-MS.

scientific article

Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling

scientific article

Colorectal cancer cell-derived microRNA200 modulates the resistance of adjacent blood endothelial barriers in vitro

scientific article published on 20 September 2016

Combination effects of digalloylresveratrol with arabinofuranosylcytosine and difluorodeoxycytidine in human leukemia and pancreatic cancer cells

scientific article

Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses

scientific article published on 23 September 2016

Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis

scientific article

Cytotoxic and apoptotic effects of novel heterodinucleoside phosphates consisting of 5-fluorodeoxyuridine and Ara-C in human cancer cell lines

scientific article

Cytotoxic and biochemical effects of 3,3′,4,4′,5,5′-hexahydroxystilbene, a novel resveratrol analog in HL-60 human promyelocytic leukemia cells

scientific article published on 01 October 2006

Cytotoxic constituents from Lobaria scrobiculata and a comparison of two bioassays for their evaluation

scientific article

Cytotoxic effects of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine in cross-resistant H9 human lymphoma cells.

scientific article

Digalloylresveratrol, a new phenolic acid derivative induces apoptosis and cell cycle arrest in human HT-29 colon cancer cells

scientific article published on 25 October 2008

Digalloylresveratrol, a novel resveratrol analog inhibits the growth of human pancreatic cancer cells.

scientific article published on 14 August 2013

Dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA), two naturally occurring benzoxazinones contained in sprouts of Gramineae are potent aneugens in human-derived liver cells (HepG2).

scientific article published on 27 April 2006

Drug resistance mediated changes in lymphendothelial tumor cell intravasation

scientific article published on January 2014

Effects of Scrophularia extracts on tumor cell proliferation, death and intravasation through lymphoendothelial cell barriers

scientific article

Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine

scientific article published on 15 June 2012

Epigallocatechin gallate, ellagic acid, and rosmarinic acid perturb dNTP pools and inhibit de novo DNA synthesis and proliferation of human HL-60 promyelocytic leukemia cells: Synergism with arabinofuranosylcytosine.

scientific article published on 3 December 2014

FAS (CD95) mutations are rare in gastric MALT lymphoma but occur more frequently in primary gastric diffuse large B-cell lymphoma

scientific article (publication date: March 2004)

Fenofibrate inhibits tumour intravasation by several independent mechanisms in a 3-dimensional co-culture model

scientific article published on 7 April 2017

Ferruginenes A-C from Rhododendron ferrugineum and their cytotoxic evaluation

scientific article

Fibroblast growth factor receptor 4: a putative key driver for the aggressive phenotype of hepatocellular carcinoma.

scientific article

Fractionation of an Extract of Pluchea odorata Separates a Property Indicative for the Induction of Cell Plasticity from One That Inhibits a Neoplastic Phenotype.

scientific article published on 13 March 2012

Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex

scientific article

Gallic acid inhibits ribonucleotide reductase and cyclooxygenases in human HL-60 promyelocytic leukemia cells.

scientific article published on 20 February 2006

Genes related to growth and invasiveness are repressed by sodium butyrate in ovarian carcinoma cells.

scientific article

Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells

scientific journal article

Ikarugamycin induces DNA damage, intracellular calcium increase, p38 MAP kinase activation and apoptosis in HL-60 human promyelocytic leukemia cells.

scientific article published on 12 March 2011

In vitro and in vivo antitumor activity of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine.

scientific article published on August 2004

In vitro anti-cancer activity of two ethno-pharmacological healing plants from Guatemala Pluchea odorata and Phlebodium decumanum

scientific article published on April 2009

In vitro anti-inflammatory and anticancer activities of extracts of Acalypha alopecuroidea (Euphorbiaceae).

scientific article published in October 2009

In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey.

scientific article

In vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey

scientific article

In vitro cell migration and invasion assays

scientific article published on 23 August 2012

In vitro characterisation of the anti-intravasative properties of the marine product heteronemin.

scientific article published on 30 March 2013

In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen.

scientific article published on 8 January 2013

Increased complexity in carcinomas: Analyzing and modeling the interaction of human cancer cells with their microenvironment

scientific article published on 28 August 2015

Induction of nuclear anomalies in exfoliated buccal cells of coca chewers: results of a field study

scientific article published on 06 November 2012

Inhibition of induced chemoresistance by cotreatment with (E)-5-(2-bromovinyl)-2'-deoxyuridine (RP101).

scientific article

Inhibition of tumour spheroid-induced prometastatic intravasation gates in the lymph endothelial cell barrier by carbamazepine: drug testing in a 3D model

scientific article published on 19 December 2013

Initial steps of metastasis: cell invasion and endothelial transmigration

scientific article (publication date: 2011)

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

scientific article

Lobatin B inhibits NPM/ALK and NF-κB attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation

scientific article published on 15 November 2014

Long-term persistence of acquired resistance to 5-fluorouracil in the colon cancer cell line SW620.

scientific article published on 21 September 2010

Loss of miR-200 family in 5-fluorouracil resistant colon cancer drives lymphendothelial invasiveness in vitro

scientific article

Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside

scientific article published in February 2002

Mechanism of c-fos induction by active oxygen

scientific article published on July 1992

Mechanisms of oxidant carcinogenesis

scientific article published on January 1990

Metabolomic analysis of resveratrol-induced effects in the human breast cancer cell lines MCF-7 and MDA-MB-231.

scientific article published on 17 January 2011

Methanol extract of the ethnopharmaceutical remedy Smilax spinosa exhibits anti-neoplastic activity

scientific article

Molecular mechanisms of drug resistance

scientific article published on 01 January 2009

Multifactorial anticancer effects of digalloyl-resveratrol encompass apoptosis, cell-cycle arrest, and inhibition of lymphendothelial gap formation in vitro

scientific article

N-hydroxy-N'-(3,4,5-trimethoxyphenyl)-3,4,5-trimethoxy-benzamidine, a novel resveratrol analog, inhibits ribonucleotide reductase in HL-60 human promyelocytic leukemia cells: synergistic antitumor activity with arabinofuranosylcytosine.

scientific article

NF-κB contributes to MMP1 expression in breast cancer spheroids causing paracrine PAR1 activation and disintegrations in the lymph endothelial barrier in vitro.

scientific article published on 15 October 2015

NF-κB mediates the 12(S)-HETE-induced endothelial to mesenchymal transition of lymphendothelial cells during the intravasation of breast carcinoma cells

scientific article

Oncogenic c-H-ras deregulates survivin expression: an improvement for survival

scientific article

Pharmacological insight into the anti-inflammatory activity of sesquiterpene lactones from Neurolaena lobata (L.) R.Br. ex Cass.

scientific article published on 15 September 2014

Physiological and pathologic effects of oxidants in mouse epidermal cells

scientific article

Poly(ADP-ribosylation) of histones in intact human keratinocytes

scientific article published in May 1989

Pro- and anticarcinogenic mechanisms of piceatannol are activated dose dependently in MCF-7 breast cancer cells.

scientific article

RP101 improves the efficacy of chemotherapy in pancreas carcinoma cell lines and pancreatic cancer patients

scientific article published on October 2006

Regulation of interleukin-8 gene expression by all-trans retinoic acid

scientific article published on May 1995

Retinoic acid induced death of ovarian carcinoma cells correlates with c-myc stimulation

scientific article published on May 1995

Retinoic acid receptors in retinoid responsive ovarian cancer cell lines detected by polymerase chain reaction following reverse transcription

scientific article

Separation of anti-neoplastic activities by fractionation of a Pluchea odorata extract ⬇️

scientific article published on June 1, 2011

Sesquiterpenes from Neurolaena lobata and their antiproliferative and anti-inflammatory activities.

scientific article published on 29 January 2014

Short 42 degrees C heat shock induces phosphorylation and degradation of Cdc25A which depends on p38MAPK, Chk2 and 14.3.3.

scientific article

Sodium butyrate inhibits c-myc splicing and interferes with signal transduction in ovarian carcinoma cells

scientific article published on May 1995

Stilbene analogues affect cell cycle progression and apoptosis independently of each other in an MCF-7 array of clones with distinct genetic and chemoresistant backgrounds

scientific article

Subcellular localisation of Cdc25A determines cell fate

scientific article published on January 2004

Synergistic effects of deuterium oxide and gemcitabine in human pancreatic cancer cell lines

scientific article published on 26 November 2007

TNFalpha-mediated cell death is independent of cdc25A

scientific article published on 01 September 1998

The Effects of Butyrate and the Role of c- mycin N.1 Ovarian Carcinoma Cells Determined by Northern Blotting

scientific article published on January 1, 2001

The Tradescantia micronucleus assay is a highly sensitive tool for the detection of low levels of radioactivity in environmental samples

scientific article published on 7 September 2016

The dichloromethane extract of the ethnomedicinal plant Neurolaena lobata inhibits NPM/ALK expression which is causal for anaplastic large cell lymphomagenesis

scientific article published on 6 November 2012

The effect of organic anion-transporting polypeptides 1B1, 1B3 and 2B1 on the antitumor activity of flavopiridol in breast cancer cells.

scientific article

The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-κB-driven tumour intravasation

scientific article published on 26 June 2015

The major vault protein mediates resistance to epidermal growth factor receptor inhibition in human hepatoma cells

scientific article published on 17 January 2012

The microRNA-200 family: still much to discover

scientific article

Transferrin ensures survival of ovarian carcinoma cells when apoptosis is induced by TNFalpha, FasL, TRAIL, or Myc.

scientific article published in November 2003

Translational activation of GCN4 mRNA in a cell-free system is triggered by uncharged tRNAs

scientific article published in August 1990

Trimidox, an inhibitor of ribonucleotide reductase, induces apoptosis and activates caspases in HL-60 promyelocytic leukemia cells

article

Trimidox, an inhibitor of ribonucleotide reductase, synergistically enhances the inhibition of colony formation by Ara-C in HL-60 human promyelocytic leukemia cells

scientific article published in August 2002

Truncated ALK derived from chromosomal translocation t(2;5)(p23;q35) binds to the SH3 domain of p85-PI3K.

scientific article

Tuberin activates the proapoptotic molecule BAD.

scientific article

Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis

scientific article published on 17 March 2013

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