List of works by Marie-Pierre Dubé

A Discrete Event Simulation Model to Assess the Economic Value of a Hypothetical Pharmacogenomics Test for Statin-Induced Myopathy in Patients Initiating a Statin in Secondary Cardiovascular Prevention.

scientific article published on 12 April 2018

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura

scientific article

A genetic model of ivabradine recapitulates results from randomized clinical trials

scientific article published on 21 July 2020

A model to assess the cost-effectiveness of pharmacogenomics tests in chronic heart failure: the case of ivabradine

scientific article published on 10 October 2016

A new locus for autosomal dominant intracranial aneurysm, ANIB4, maps to chromosome 5p15.2-14.3.

scientific article published in June 2006

A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13.

scientific article

A novel locus for idiopathic generalized epilepsy in French-Canadian families maps to 10p11

article

A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials

scientific article published on March 2016

A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors

scientific article

Additive Effects of Obesity and TCF7L2 Variants on Risk for Type 2 Diabetes Among Cardiac Patients

scientific article published on 10 March 2007

An expanded pharmacogenomics warfarin dosing table with utility in generalised dosing guidance.

scientific article published on 28 April 2016

AnALS2gene mutation causes hereditary spastic paraplegia in a Pakistani kindred

article

Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region

article

Application of homozygosity haplotype analysis to genetic mapping with high-density SNP genotype data

scientific article

Application of principal component analysis to pharmacogenomic studies in Canada

article

Association between cervical and intracranial dimensions and syringomyelia in the cavalier King Charles spaniel

scientific article published on 01 August 2009

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events

scientific article published on 21 March 2019

Autism spectrum disorders associated with X chromosome markers in French-Canadian males

scientific article published in February 2006

Autosomal-dominant locus for Restless Legs Syndrome in French-Canadians on chromosome 16p12.1.

scientific article

Avoidance of Vitamin K-Rich Foods Is Common among Warfarin Users and Translates into Lower Usual Vitamin K Intakes

scientific article published on 24 February 2016

CETP: Pharmacogenomics-Based Response to the CETP Inhibitor Dalcetrapib

scientific article published on 26 January 2017

CKM and LILRB5 are associated with serum levels of creatine kinase

scientific article published on 11 September 2014

Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease

scientific article

Cardiovascular pharmacogenomics; state of current knowledge and implementation in practice

scientific article published on 25 February 2015

Chromosome 11-q24 region in Tourette syndrome: Association and linkage disequilibrium study in the French Canadian population

article

Clouston hidrotic ectodermal dysplasia (HED): genetic homogeneity, presence of a founder effect in the French Canadian population and fine genetic mapping

scientific article

Common genetic vulnerability to depressive symptoms and coronary artery disease: a review and development of candidate genes related to inflammation and serotonin

scientific article

Comparison of genotype clustering tools with rare variants

scientific article

Comparison of sequencing based CNV discovery methods using monozygotic twin quartets

scientific article published on 26 March 2015

Correction: Rare Copy Number Variants Contribute to Congenital Left-Sided Heart Disease

Cuckoo search epistasis: a new method for exploring significant genetic interactions

scientific article published on 19 February 2014

DNA methylation signature of human fetal alcohol spectrum disorder.

scientific article published on 29 June 2016

DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions

scientific article

De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia

scientific article

Design and rationale of a genetic cohort study on congenital cardiac disease: experiences from a multi-institutional platform in Quebec

Development of a broad-based ADME panel for use in pharmacogenomic studies

scientific article published on June 2014

Diagnosis, Prevalence, Awareness, Treatment, Prevention, and Control of Hypertension in Cameroon: Protocol for a Systematic Review and Meta-Analysis of Clinic-Based and Community-Based Studies

scientific article

Different models and single-nucleotide polymorphisms signal the simulated weak gene-gene interaction for a quantitative trait using haplotype-based and mixed models testing

scientific article

Direct measure of the de novo mutation rate in autism and schizophrenia cohorts

scientific article

Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan

scientific article published in July 2008

Erratum: Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy

scholarly article published in Nature Genetics

Evaluation of links between high-density lipoprotein genetics, functionality, and aortic valve stenosis risk in humans

scientific article published on 12 December 2013

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits

scientific article

Familial ventricular aneurysms and septal defects map to chromosome 10p15

scientific article published on 18 December 2010

Family study of restless legs syndrome in Quebec, Canada: clinical characterization of 671 familial cases

scientific article

Fetal alcohol spectrum disorders: gene-environment interactions, predictive biomarkers, and the relationship between structural alterations in the brain and functional outcomes

scientific article published on March 2011

Fine mapping the candidate region for peripheral neuropathy with or without agenesis of the corpus callosum in the French Canadian population.

scientific article

Genetic Modulation of Brugada Syndrome by a Common Polymorphism

scientific article published on 22 June 2009

Genetic control of high density lipoprotein-cholesterol in AcB/BcA recombinant congenic strains of mice

scientific article

Genetic determinants of blood pressure reduction following potassium supplementation: and the candidates are…

scientific article published on 01 April 2010

Genetic markers associated with cutaneous adverse drug reactions to allopurinol: a systematic review

scientific article published on 12 May 2015

Genetic markers of cisplatin-induced hearing loss in children

scientific article published in September 2014

Genetic predictors of depressive symptoms in cardiac patients

scientific article published on April 2009

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy

scientific article

Genetics of bronchopulmonary dysplasia in the age of genomics.

scientific article published on April 2010

Genome-wide TDT analysis in French-Canadian families with Tourette syndrome

scientific article published in January 2010

Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3.

scientific article

Genotype-Dependent Effects of Dalcetrapib on Cholesterol Efflux and Inflammation: Concordance With Clinical Outcomes

scientific article

Génome Québec & Montreal Heart Institute Pharmacogenomics Centre: a translational pharmacogenomics platform--from R&D to the clinic

scientific article published on October 2008

Human monogenic disorders - a source of novel drug targets

scientific article

Identification of the genetic determinants responsible for retinal degeneration in families of Mexican descent

scientific article

Impact of regular physical activity on weekly warfarin dose requirement

scientific article published on 4 August 2015

Institutional profile: the Beaulieu-Saucier Université de Montréal Pharmacogenomics Centre at the Montreal Heart Institute

scientific article published in January 2013

Loss-of-function genetic diseases and the concept of pharmaceutical targets

Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations

scientific article published on April 2007

Maximal expected benefits from lowering cholesterol in primary prevention for a high-risk population

scientific article published on 20 September 2016

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

scientific article

Methylomic changes in individuals with psychosis, prenatally exposed to endocrine disrupting compounds: Lessons from diethylstilbestrol

scientific article

Modifiers of (CAG)(n) instability in Machado-Joseph disease (MJD/SCA3) transmissions: an association study with DNA replication, repair and recombination genes

scientific article

Molecular genetic studies of DMT1 on 12q in French-Canadian restless legs syndrome patients and families

scientific article

Multistage designs in the genomic era: providing balance in complex disease studies

scientific article published on January 2007

Multitrait GWAS to connect disease variants and biological mechanisms

scientific article published on 30 August 2021

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

scientific article

Mutation burden of rare variants in schizophrenia candidate genes

scientific article published on 3 June 2015

Mutation in pyrroline-5-carboxylate reductase 1 gene in families with cutis laxa type 2

scientific article published on 02 July 2009

Mutations in DCC cause congenital mirror movements.

scientific article

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

scientific article (publication date: 2004)

Mutations in a novel serine protease PRSS56 in families with nanophthalmos.

scientific article

Mutations in the UBIAD1 gene, encoding a potential prenyltransferase, are causal for Schnyder crystalline corneal dystrophy

scientific article published in 2007

Mutations in the calcium-related gene IL1RAPL1 are associated with autism

scientific article published on 18 September 2008

No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans

scientific article

Novel mutations in the amyloid precursor protein gene within Moroccan patients with Alzheimer's disease

scientific article

Novel mutations in the sacsin gene in ataxia patients from Maritime Canada

article

Novel presenilin mutations within Moroccan patients with Early-Onset Alzheimer's Disease

scientific article

Nuclear receptor gene polymorphisms and warfarin dose requirements in the Quebec Warfarin Cohort.

scientific article published on 3 January 2018

Older adults with heart failure treated with carvedilol, bisoprolol, or metoprolol tartrate: risk of mortality

scientific article published on 16 November 2016

Oral Anticoagulant Prescription Trends, Profile Use, and Determinants of Adherence in Patients with Atrial Fibrillation

scientific article published on 17 December 2019

Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

scientific article

PRKCB is associated with calcineurin inhibitor-induced renal dysfunction in heart transplant recipients

scientific article published on 01 May 2012

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

article

Partitioning of copy-number genotypes in pedigrees

scientific article

Paternal Age Explains a Major Portion of De Novo Germline Mutation Rate Variability in Healthy Individuals

scientific article

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

scientific article

Pharmacogenetics of Lipid-Lowering Agents: an Update Review on Genotype-Dependent Effects of HDL-Targetingand Statin Therapies

scientific article

Pharmacogenomic Prediction of Anthracycline-Induced Cardiotoxicity in Children

Pharmacogenomic approaches to lipid-regulating trials

scientific article published on 26 September 2016

Pharmacogenomic determinants of the cardiovascular effects of dalcetrapib

scientific article

Pharmacogenomics to Revive Drug Development in Cardiovascular Disease

scientific article

Pillbox Use and INR Stability in a Prospective Cohort of New Warfarin Users

scientific article

Polygenic Versus Monogenic Causes of Hypercholesterolemia Ascertained Clinically

scientific article published on 20 October 2016

Polygenic determinants in extremes of high-density lipoprotein cholesterol

scientific article published on 4 September 2017

Pooled DNA Resequencing of 68 Myocardial Infarction Candidate Genes in French Canadians

article

Positional cloning of a quantitative trait locus contributing to pain sensitivity: possible mediation by Tyrp1.

scientific article published in November 2010

Progesterone receptor variant increases ovarian cancer risk in BRCA1 and BRCA2 mutation carriers who were never exposed to oral contraceptives

scientific article published in October 2001

Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve

scientific article

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

article

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 01 July 2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

scientific article published on 16 March 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

scientific article

Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits

scientific article (publication date: June 2014)

Rare copy number variants contribute to congenital left-sided heart disease

scientific article

Rationale, design and preliminary results of the Quebec Warfarin Cohort Study.

scientific article published on 15 March 2018

Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutation carriers (United States).

scientific article

Resting heart rate as a predictor of aortic valve stenosis progression

scientific article published on 26 November 2015

Risk of congenital heart defects is influenced by genetic variation in folate metabolism

scientific article

Role of TPMT and COMT genetic variation in cisplatin-induced ototoxicity.

scientific article published on 5 November 2013

Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol

scientific article

Subsequent Event Risk in Individuals With Established Coronary Heart Disease

scientific article published on 21 March 2019

Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain

scientific article published on 30 June 2007

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease ⬇️

scientific article published on February 2017

Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure

scientific article published on 12 February 2008

Testing for Gene-Gene Interaction with AMMI Models

article

Testing the role of predicted gene knockouts in human anthropometric trait variation

scientific article

The 14q restless legs syndrome locus in the French Canadian population

scientific article

The Impact of Partial and Complete Loss-of-Function Mutations in Endothelial Lipase on High-Density Lipoprotein Levels and Functionality in Humans

article

The challenge of detecting epistasis (G x G interactions): Genetic Analysis Workshop 16

scientific article published on January 2009

The genetics of congenital amusia (tone deafness): a family-aggregation study

scientific article

Two-stage strategies to detect gene x gene interactions in case-control data

scientific article

Validation of patient-reported warfarin dose in a prospective incident cohort study

scientific article published on 24 January 2014

Validation of warfarin pharmacogenetic algorithms in clinical practice

scientific article published in January 2012

Whole-genome sequencing in French Canadians from Quebec

scientific article published on 4 July 2016

Will personalized drugs for cardiovascular disease become an option? - Defining 'Evidence-based personalized medicine' for its implementation and future use.

scientific article published on 15 September 2015

genipe: an automated genome-wide imputation pipeline with automatic reporting and statistical tools

scientific article

pyGenClean: efficient tool for genetic data clean up before association testing

scientific article

Paulina is supported by:

About Paulina

Help