List of works by Karolien De Bosscher

A Dissociated Glucocorticoid Receptor Modulator Reduces Airway Hyperresponsiveness and Inflammation in a Mouse Model of Asthma

scientific article published on 05 March 2012

A fully dissociated compound of plant origin for inflammatory gene repression

scientific article

A paradigm for gene regulation: inflammation, NF-kappaB and PPAR.

scientific article published on January 2003

A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis

scientific article published on February 2008

Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound a.

scientific article

Activation of the Glucocorticoid Receptor in Acute Inflammation: the SEDIGRAM Concept

scientific article

Adrenal hormones mediate disease tolerance in malaria

scientific article published in Nature Communications

Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition

scientific article

An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation

scientific article published on 13 January 2011

Analysis of Smad nucleocytoplasmic shuttling in living cells

scientific article published on 27 July 2004

Antiinflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor modulator in experimental autoimmune encephalomyelitis

scientific article

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα.

scientific article

Circumventing glucocorticoid-mediated hyperinsulinemia via the activation of PPARalpha.

scientific article published on 15 August 2009

Classic glucocorticoids versus non-steroidal glucocorticoid receptor modulators: survival of the fittest regulator of the immune system?

scientific article published on 25 June 2010

Co-activation of GR and PPARγ in murine skin prevents worsening of atopic march

scientific article published on 27 December 2017

Cofactor profiling of the glucocorticoid receptor from a cellular environment

scientific article published in January 2014

Colon cancer-derived myofibroblasts increase endothelial cell migration by glucocorticoid-sensitive secretion of a pro-migratory factor

scientific article published on 04 October 2016

Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

scientific article published in September 2021

Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells

scientific article

Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation

scientific article (publication date: 2013)

Coregulator profiling of the glucocorticoid receptor in lymphoid malignancies

scientific article published on 30 November 2017

Correction: Compound A, a Dissociated Glucocorticoid Receptor Modulator, Inhibits T-bet (Th1) and Induces GATA-3 (Th2) Activity in Immune Cells

scientific article (publication date: 23 May 2012)

Critical Roles of Endogenous Glucocorticoids for Disease Tolerance in Malaria

scientific article published on 09 October 2019

Crosstalk between TNF and glucocorticoid receptor signaling pathways

scientific article published on 24 April 2010

Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases

scientific article

DNA Binding-Independent Induction of IκBα Gene Transcription by PPARα

scientific article published in May 2002

Daucane esters from laserwort (Laserpitium latifolium L.) inhibit cytokine and chemokine production in human lung epithelial cells

scientific article published on 5 January 2017

Delayed development of the protective IL-17A response following a Giardia muris infection in neonatal mice.

scientific article published on 20 June 2019

Differential cytokine profiles upon comparing selective versus classic glucocorticoid receptor modulation in human peripheral blood mononuclear cells and inferior turbinate tissue

scientific article

Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts

scientific article published in November 2009

Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound A, in human bone marrow stromal cells.

scientific article published on 17 November 2010

Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies.

scientific article published on 8 May 2018

Epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells

scientific article published on 09 February 2017

GR-independent down-modulation on GM-CSF bone marrow-derived dendritic cells by the selective glucocorticoid receptor modulator Compound A.

scientific article

Giardia muris infection in mice is associated with a protective interleukin 17A response and induction of peroxisome proliferator-activated receptor alpha

scientific article

Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor

scientific article published on 21 August 2017

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

scientific article published on 25 June 2018

Glucocorticoid receptor mutants: man-made tools for functional research

scientific article published on 05 May 2011

Glucocorticoid receptors: finding the middle ground

scientific article published on 20 March 2017

Glucocorticoids and mitogen- and stress-activated protein kinase 1 inhibitors: possible partners in the combat against inflammation

scientific article published on 27 December 2008

Glucocorticoids limit lipopolysaccharide-induced lethal inflammation by a double control system

scientific article published on 08 May 2020

Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds ⬇️

scientific article published on June 2009

Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma.

scientific article

How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer

scientific article published on 16 August 2021

How the venom from the ectoparasitoid Wasp nasonia vitripennis exhibits anti-inflammatory properties on mammalian cell lines

scientific article

Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion

scientific article

Improved Glucocorticoid Receptor Ligands: Fantastic Beasts, but How to Find Them?

scientific article published on 24 September 2020

In vitro inhibition of the transcription factor NF-κB and cyclooxygenase by bamboo extracts

scientific article published on 5 April 2013

Inhibition of cytokine production by the herbicide atrazine. Search for nuclear receptor targets

scientific article

Interleukin-17 receptor A (IL-17RA) as a central regulator of the protective immune response against Giardia

scientific article

Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin

scientific article published on July 2017

Involvement of the Glucocorticoid Receptor in Pro-inflammatory Transcription Factor Inhibition by Daucane Esters from Laserpitium zernyi

scientific article published on 10 May 2017

Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies

scientific article published on 17 September 2020

MAPPIT: a protein interaction toolbox built on insights in cytokine receptor signaling

scientific article published on October 2011

Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses

scientific article published on 09 August 2019

Minireview: latest perspectives on antiinflammatory actions of glucocorticoids

scientific article

Mitogen- and stress-activated protein kinase 1 MSK1 regulates glucocorticoid response element promoter activity in a glucocorticoid concentration-dependent manner

scientific article published on 4 July 2013

Modulation of Protein-Protein Interactions for the Development of Novel Therapeutics

scientific article

Molecular Actions of PPARα in Lipid Metabolism and Inflammation

scientific article published on 01 October 2018

Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells

scientific article published on April 2004

Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation

scientific article published on 17 April 2020

Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2.

scientific article published on 28 September 2011

PPARalpha blocks glucocorticoid receptor alpha-mediated transactivation but cooperates with the activated glucocorticoid receptor alpha for transrepression on NF-kappaB

scholarly article

Pharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells

scientific article published on 03 February 2014

Plasmodium berghei NK65 in Combination with IFN-γ Induces Endothelial Glucocorticoid Resistance via Sustained Activation of p38 and JNK.

scientific article published on 28 September 2017

Proteome-scale Binary Interactomics in Human Cells

scientific article

Recurrent mutation in the first zinc finger of the orphan nuclear receptor NR2E3 causes autosomal dominant retinitis pigmentosa

scientific article

Risks and benefits of corticosteroids in arthritic diseases in the clinic

scientific article published on 10 April 2019

Role of glucocorticoids in dopamine-related neuropsychiatric disorders

scientific article

Selective Glucocorticoid Receptor modulators

scientific article published on 04 March 2010

Selective Modulation of the Human Glucocorticoid Receptor Compromises GR Chromatin Occupancy and Recruitment of p300/CBP and the Mediator Complex

scientific article published in 2024

Selective glucocorticoid receptor modulation maintains bone mineral density in mice

scientific article

Selective glucocorticoid receptor modulation: New directions with non-steroidal scaffolds

scientific article

Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1.

scientific article published on 20 June 2013

Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems

scientific article published on 31 January 2008

Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors

scientific article published on June 2015

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

scientific article published on 10 June 2019

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity

scientific article

Targeting inflammation using selective glucocorticoid receptor modulators

scientific article published on 20 May 2010

The HAT/HDAC interplay: multilevel control of STAT signaling

scientific article published on 16 September 2012

The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious Diseases

scientific article published on 11 May 2016

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

scientific article

The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages

scientific article published on 14 September 2018

The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression

scientific article

The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice

article

The versatile role of MSKs in transcriptional regulation.

scientific article published on 21 May 2009

Therapeutic implications of the nuclear factor-kappaB/nuclear receptor cross-talk

scientific article published on May 2008

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

scientific article published on 28 June 2021

Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium

scientific article published on 11 September 2020

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