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List of works by James Broach

A dynamic interplay of nucleosome and Msn2 binding regulates kinetics of gene activation and repression following stress

scientific article

A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size

scientific article

A novel clustering approach and prediction of optimal number of clusters: global optimum search with enhanced positioning

A novel clustering approach: Global optimum search with enhanced positioning

A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists

scientific article published on 28 March 2002

A rapid technique for the visualization of live immobilized yeast cells

scientific article published on 9 November 2006

ATP-dependent specific binding of Tn3 transposase to Tn3 inverted repeats

scientific article published in Nature

Acylation and prenylation of proteins

scientific article published on December 1990

Altered molecular profile in thyroid cancers from patients affected by the Three Mile Island nuclear accident

scientific article published on 29 May 2017

Assay for adhesion and agar invasion in S. cerevisiae

scientific article published on 8 November 2006

Autoregulation of 2 micron circle gene expression provides a model for maintenance of stable plasmid copy levels

scientific article published in January 1988

CAC3(MSI1) suppression of RAS2(G19V) is independent of chromatin assembly factor I and mediated by NPR1

scientific article

CD4 T cells control development and maintenance of brain-resident CD8 T cells during polyomavirus infection

article

Cell fates in C. elegans: in medias ras.

scientific article published on December 1990

Chromatin remodelers clear nucleosomes from intrinsically unfavorable sites to establish nucleosome-depleted regions at promoters

scientific article

Chromatin-dependent transcription factor accessibility rather than nucleosome remodeling predominates during global transcriptional restructuring in Saccharomyces cerevisiae

scientific article published on 03 June 2009

Chromosomal boundaries in S. cerevisiae.

scientific article

Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma.

scientific article published on 13 July 2017

Cloning genes by complementation in yeast

scientific article (publication date: 1991)

Complete Genome Sequences of the Human Pathogen Paenibacillus thiaminolyticus Mbale and Type Strain P. thiaminolyticus NRRL B-4156

scientific article published on 09 April 2020

Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2.

scientific article

Correspondence of yeast UAA suppressors to cloned tRNASerUCA genes

scientific article published in August 1981

Creation of GPCR-based chemical sensors by directed evolution in yeast

article by Addison D Ault & James Broach published January 2006 in Protein Engineering Design and Selection

Cross-talk and decision making in MAP kinase pathways

article by Megan N. McClean et al published 28 January 2007 in Nature Genetics

Decoding complex chemical mixtures with a physical model of a sensor array

scientific article

Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity

scientific article published on 18 October 2005

Direct simulation of yeast 2-microns circle plasmid amplification

scientific article

Directional bias during mating type switching in Saccharomyces is independent of chromosomal architecture

scientific article published on May 2002

Do cells think?

scientific article published on July 2007

Erratum: Corrigendum: Cross-talk and decision making in MAP kinase pathways

scholarly article published in Nature Genetics

Evaluation of normalization and pre-clustering issues in a novel clustering approach: global optimum search with enhanced positioning

scientific article published on August 2007

Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus

scientific article published on 19 October 2020

Expansion of C9ORF72 in amyotrophic lateral sclerosis correlates with brain-computer interface performance.

scientific article published on 21 August 2017

Expression of CXCR4, a G-protein-coupled receptor for CXCL12 in yeast identification of new-generation inverse agonists

scientific article published in January 2009

Functional homology of mammalian and yeast RAS genes.

scientific article

Galactose regulation in Saccharomyces cerevisiae. The enzymes encoded by the GAL7, 10, 1 cluster are co-ordinately controlled and separately translated

scientific article published on June 1979

Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins.

scientific article

Genetic analysis of yeast RAS1 and RAS2 genes.

scientific article

Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research

scientific article

Genetic properties of chromosomally integrated 2μ plasmid DNA in yeast

scientific article published on 01 June 1982

Genetic selection in Saccharomyces of mutant mammalian adenylyl cyclases with elevated basal activities

scientific article published in August 2001

Glucose regulates transcription in yeast through a network of signaling pathways

scientific article published on 17 February 2009

High hydrostatic pressure activates gene expression that leads to ethanol production enhancement in a Saccharomyces cerevisiae distillery strain

scientific article

High hydrostatic pressure activates transcription factors involved in Saccharomyces cerevisiae stress tolerance

scientific article

Histidine regulation in Salmonella typhimurium. XVI. A sensitive radiochemical assay for histidinol dehydrogenase

scientific article published in January 1975

How Saccharomyces responds to nutrients

scientific article published on January 2008

Identification and mapping of the transcriptional and translational products of the yeast plasmid, 2mu circle

scientific article

Identification of a rare LAMB4 variant associated with familial diverticulitis through exome sequencing

scientific article published on 8 June 2017

Identification of sites required for repression of a silent mating type locus in yeast

scientific article published on 01 October 1984

Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast.

scientific article

Immunological analysis of yeast chromatin

article

In yeast, RAS proteins are controlling elements of adenylate cyclase.

scientific article

Inhibition of the Platelet-activating factor receptor for the treatment of Amyotrophic Lateral Sclerosis?

Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway

scientific article

Isolation and analysis of recombinant DNA molecules containing yeast DNA.

scientific article published on September 1978

Making good neighbors: The right fence for the right job

Making the right choice--long-range chromosomal interactions in development

scientific article

Mediator binds to boundaries of chromosomal interaction domains and to proteins involved in DNA looping, RNA metabolism, chromatin remodeling, and actin assembly.

scientific article published on 30 May 2017

Metastin and its variant forms suppress migration of pancreatic cancer cells

scientific article published on February 2004

Microarray data mining: a novel optimization-based approach to uncover biologically coherent structures

scientific article

Microarray profiling of phage-display selections for rapid mapping of transcription factor-DNA interactions

scientific article

Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries

scientific article published in July 2003

Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast

scientific article

Mutations in the nucleosome core enhance transcriptional silencing

scientific article

Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses.

scientific article published on 24 April 2013

Nucleotide degradation and ribose salvage in yeast

scientific article

Nutritional Control of Growth and Development in Yeast ⬇️

scientific article published on September 1, 2012

Oncogenes and cell proliferation

scientific article published on 01 February 1995

PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p

scientific article published on October 2004

Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants

scientific article published on 01 September 2020

Ph.D. Training in Cancer Biology

scientific article published on 01 November 2008

Phosphorylation and nuclear transit modulate the balance between normal function and terminal aggregation of the yeast RNA-binding protein Ssd1.

scientific article

Predicting cellular growth from gene expression signatures

scientific article

Propagation and expression of cloned genes in yeast: 2-microns circle-based vectors

scientific article published on January 1990

Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae

scientific article

Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6.

scientific article

RAS genes in Saccharomyces cerevisiae: signal transduction in search of a pathway.

scientific article published on January 1991

Rap1p and other transcriptional regulators can function in defining distinct domains of gene expression

scientific article

Ras and Gpa2 mediate one branch of a redundant glucose signaling pathway in yeast

scientific article

Ras-regulated signaling processes in Saccharomyces cerevisiae

scientific article

Recombination within the yeast plasmid 2mu circle is site-specific

scientific article

Regulation of transcription in expressed and unexpressed mating type cassettes of yeast

scientific article published in Nature

Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation

scientific article published on 16 August 2012

SRV2, a gene required for RAS activation of adenylate cyclase in yeast

scientific article

Sch9 is a major target of TORC1 in Saccharomyces cerevisiae

scientific article

Sense and sensibility: nutritional response and signal integration in yeast

scientific article

Sensitivity of wild type and mutant ras alleles to Ras specific exchange factors: Identification of factor specific requirements

scientific article published on April 2001

Single-Cell Observations Reveal Intermediate Transcriptional Silencing States

article by Eugenia Y. Xu et al published July 2006 in Molecular Cell

Site-specific recombination promotes plasmid amplification in yeast

scientific article

Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response.

scientific article published on January 1998

Systems Biology and TOR

article published in 2010

The Ras/protein kinase A pathway acts in parallel with the Mob2/Cbk1 pathway to effect cell cycle progression and proper bud site selection

scientific article published on February 2004

The Saccharomyces cerevisiae recombination enhancer biases recombination during interchromosomal mating-type switching but not in interchromosomal homologous recombination

scientific article

The dynamics of homologous pairing during mating type interconversion in budding yeast

scientific article published on 23 June 2006

The origin recognition complex interacts with a subset of metabolic genes tightly linked to origins of replication

scientific article

The yeast HML I silencer defines a heterochromatin domain boundary by directional establishment of silencing.

scientific article published on October 1999

The yeast environmental stress response regulates mutagenesis induced by proteotoxic stress

scientific article (publication date: 2013)

The yeast genome undergoes significant topological reorganization in quiescence

scientific article published on 21 July 2015

The yeast plasmid 2μ circle encodes components required for its high copy propagation

scientific article published on 01 August 1983

Theoretical and computational studies of the glucose signaling pathways in yeast using global gene expression data

scientific article

Transformation in yeast: development of a hybrid cloning vector and isolation of the CAN1 gene

scientific article (publication date: December 1979)

Vaginal microbiome topic modeling of laboring Ugandan women with and without fever

scientific article published on 10 September 2021

Web alert Oncogenes and cell proliferation

scientific article published on 01 February 1997

Yeast cells can access distinct quiescent states

scientific article published on 2 February 2011

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