List of works - Mathias Jucker

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease

scientific article published on 11 March 2020

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

scientific article

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

scientific article

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

scientific article published on 16 November 2020

Age and gender effects on microglia and astrocyte numbers in brains of mice

scientific article published in November 2002

Amyloid by default

scientific article published in June 2011

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease

scientific article published on 20 November 2017

Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice.

scientific article published in January 2002

Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease

scientific article published on 02 December 2019

Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis

scientific article published on 12 July 2017

Aβ seeds and prions: How close the fit?

scientific article published on 28 June 2017

Aβ seeds resist inactivation by formaldehyde

scientific article

BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice

scientific article published in January 2007

BRI2 Protein Regulates β-Amyloid Degradation by Increasing Levels of Secreted Insulin-degrading Enzyme (IDE) ⬇️

scientific article published on August 26, 2011

Blood platelets in the progression of Alzheimer's disease

scientific article

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

scholarly article by Marc Suárez-Calvet et al published December 2018 in EMBO Molecular Medicine

Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease

scientific article

Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist.

scientific article published on July 2008

Cerebral β-Amyloidosis in Mice Investigated by Ultramicroscopy

scientific article

Changes in Amyloid-β and Tau in the Cerebrospinal Fluid of Transgenic Mice Overexpressing Amyloid Precursor Protein ⬇️

scientific article published on July 17, 2013

Changes in extracellular space size and geometry in APP23 transgenic mice: a model of Alzheimer's disease

scientific article published on 3 January 2005

Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis.

scientific article

Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease

scientific article published on 01 May 2019

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

scientific article

Comparison of commissural sprouting in the mouse and rat fascia dentata after entorhinal cortex lesion

scientific article published on January 2003

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue

scientific article published on 29 October 2019

Cystatin C modulates cerebral beta-amyloidosis

scientific article

Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer's disease

scientific article

Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer's Disease: Results of the DIAN Study

scientific article

Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates

scientific article

Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

scientific article published on April 2008

E22Q-mutant Abeta peptide (AbetaDutch) increases vascular but reduces parenchymal Abeta deposition

scientific article published on 13 February 2009

Early Aβ reduction prevents progression of cerebral amyloid angiopathy

scientific article published on 19 August 2019

Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease

scientific article published on 04 March 2019

Emerging prospects for the disease-modifying treatment of Alzheimer's disease

scientific article

Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice

scientific article

Evidence for age-dependent in vivo conformational rearrangement within Aβ amyloid deposits

scientific article

Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice

scientific article published on 20 February 2008

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

scientific article

Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats

scientific article published on 18 November 2011

Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair

scientific article

Extracellular amyloid formation and associated pathology in neural grafts

scientific article published in April 2003

Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts

scientific article published on 4 November 2014

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

scientific article

Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin

scientific article

Highly potent intracellular membrane-associated Aβ seeds

scientific article published on 17 June 2016

Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid

scientific article

Homeostatic and injury‐induced microglia behavior in the aging brain ⬇️

scientific article published on September 18, 2013

Immune receptor for pathogenic α-synuclein

scientific article published in September 2016

Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice

scientific article

Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models

scientific article published on 15 May 2015

Independent effects of intra- and extracellular Abeta on learning-related gene expression

scientific article published on July 2009

Inducible proteopathies

scientific article

Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice.

scientific article published in March 2004

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation

scholarly article

Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice

scientific article

Infectious prions do not induce Aβ deposition in an in vivo seeding model

scientific article published on 16 April 2018

Innate immune memory in the brain shapes neurological disease hallmarks

scientific article published in Nature

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations

scientific article published on 15 June 2007

Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice.

scientific article published in November 2005

Koch's postulates and infectious proteins

scientific article

LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies

scientific article published on 26 July 2021

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease

scientific article published on 15 February 2018

Lesion-induced axonal sprouting in the central nervous system

scientific article published on January 2006

Long-term in vivo imaging of β-amyloid plaque appearance and growth in a mouse model of cerebral β-amyloidosis.

scientific article published in January 2011

Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion

scientific article published on 10 November 2014

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease

scientific article published on 14 September 2018

MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier

scientific article

Mechanism of cerebral beta-amyloid angiopathy: murine and cellular models

scientific article

Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice

scientific article published on 08 September 2020

Membrane-anchored Aβ accelerates amyloid formation and exacerbates amyloid-associated toxicity in mice.

scientific article published in December 2013

Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells

scientific article

Modeling familial British dementia in transgenic mice

scientific article

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

scientific article

Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis.

scientific article published on July 2014

Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice

scientific article published in May 2005

Neurodegeneration: Amyloid-β pathology induced in humans

scientific article published in September 2015

Neurodegenerative diseases: expanding the prion concept

scientific article

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

scientific article published on 9 June 2016

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

scientific article published on 20 July 2016

Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis

scientific article published on 8 May 2008

No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts

scientific article (publication date: 2015)

Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses

scientific article

Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders

scientific article

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis

scientific article published on 21 October 2010

Persistence of Aβ seeds in APP null mouse brain

scientific article published on 9 September 2015

Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition

scientific article published on 14 October 2016

Prion-like aspects of cerebral amyloidosis.

scientific article published on 13 September 2013

Progression of Seed-Induced Aβ Deposition within the Limbic Connectome

scientific article

Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions

scientific article published on 12 August 2020

Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases

scientific article published on 26 September 2018

Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease

scientific article published on 25 September 2018

Repeatable target localization for long-term in vivo imaging of mice with 2-photon microscopy ⬇️

scientific article published on November 6, 2011

Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer's disease

scientific article

Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis

scientific article published on 01 August 2004

Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice

scientific article published on 3 September 2013

Seeds of dementia

scientific article published in May 2013

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

scientific article

Sequence of Alzheimer disease biomarker changes in cognitively normal adults: A cross-sectional study

scientific article published on 01 September 2020

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

scientific article published on 21 January 2019

Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease

scientific article published on 06 June 2020

Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition

scientific article published on October 2011

Spectral discrimination of cerebral amyloid lesions after peripheral application of luminescent conjugated oligothiophenes

scientific article published on 4 October 2012

The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

scientific article published on July 2011

The Exceptional Vulnerability of Humans to Alzheimer's Disease

scientific article published on 5 May 2017

The Malignant Protein Puzzle

scientific article

The Prion-Like Properties of Amyloid-β Assemblies: Implications for Alzheimer's Disease

scientific article

The accessible cerebral vascular proteome in a mouse model of cerebral β-amyloidosis

article

The amyloid state of proteins in human diseases

scientific article published on March 2012

The benefits and limitations of animal models for translational research in neurodegenerative diseases

scientific article published on 21 September 2010

The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain

scientific article published on 20 November 2011

The value of incomplete mouse models of Alzheimer's disease

scientific article published on March 2008

Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy

scientific article published in June 2002

Transmission and spreading of tauopathy in transgenic mouse brain

scientific article

Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage

scientific article published on 20 January 2006

White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease

article by Miguel Ángel Araque Caballero et al published 1 October 2018 in Brain

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

scientific article

List of works by Mathias Jucker

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

Age and gender effects on microglia and astrocyte numbers in brains of mice

Amyloid by default

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease

Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice.

Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease

Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis

Aβ seeds and prions: How close the fit?

Aβ seeds resist inactivation by formaldehyde

BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice

BRI2 Protein Regulates β-Amyloid Degradation by Increasing Levels of Secreted Insulin-degrading Enzyme (IDE) ⬇️

Blood platelets in the progression of Alzheimer's disease

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease

Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist.

Cerebral β-Amyloidosis in Mice Investigated by Ultramicroscopy

Changes in Amyloid-β and Tau in the Cerebrospinal Fluid of Transgenic Mice Overexpressing Amyloid Precursor Protein ⬇️

Changes in extracellular space size and geometry in APP23 transgenic mice: a model of Alzheimer's disease

Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis.

Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

Comparison of commissural sprouting in the mouse and rat fascia dentata after entorhinal cortex lesion

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue

Cystatin C modulates cerebral beta-amyloidosis

Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer's disease

Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer's Disease: Results of the DIAN Study

Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates

Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

E22Q-mutant Abeta peptide (AbetaDutch) increases vascular but reduces parenchymal Abeta deposition

Early Aβ reduction prevents progression of cerebral amyloid angiopathy

Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease

Emerging prospects for the disease-modifying treatment of Alzheimer's disease

Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice

Evidence for age-dependent in vivo conformational rearrangement within Aβ amyloid deposits

Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats

Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair

Extracellular amyloid formation and associated pathology in neural grafts

Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin

Highly potent intracellular membrane-associated Aβ seeds

Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid

Homeostatic and injury‐induced microglia behavior in the aging brain ⬇️

Immune receptor for pathogenic α-synuclein

Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice

Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models

Independent effects of intra- and extracellular Abeta on learning-related gene expression

Inducible proteopathies

Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice.

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation

Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice

Infectious prions do not induce Aβ deposition in an in vivo seeding model

Innate immune memory in the brain shapes neurological disease hallmarks

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations

Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice.

Koch's postulates and infectious proteins

LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease

Lesion-induced axonal sprouting in the central nervous system

Long-term in vivo imaging of β-amyloid plaque appearance and growth in a mouse model of cerebral β-amyloidosis.

Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease

MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier

Mechanism of cerebral beta-amyloid angiopathy: murine and cellular models

Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice

Membrane-anchored Aβ accelerates amyloid formation and exacerbates amyloid-associated toxicity in mice.

Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells

Modeling familial British dementia in transgenic mice

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis.

Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice

Neurodegeneration: Amyloid-β pathology induced in humans

Neurodegenerative diseases: expanding the prion concept

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases