List of works - Mark Shlomchik

A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data

scientific article

A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells

scientific article published on 18 July 2011

Activating systemic autoimmunity: B's, T's, and tolls.

scientific article published on 30 September 2009

Activation of Rheumatoid Factor (RF) B Cells and Somatic Hypermutation Outside of Germinal Centers in Autoimmune‐Prone MRL/lpr Mice ⬇️

scientific article published on April 1, 2003

Activation of rheumatoid factor-specific B cells is antigen dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse model

scientific article

Antibody effector functions mediated by Fcγ-receptors are compromised during persistent viral infection

scientific article

Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice

scientific article

Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells

scientific article

Autoimmunity

scientific article published on 17 November 2010

Autoimmunity: The genes and phenotypes of autoimmunity

scientific article published on 01 December 2004

B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus.

scientific article

B cell primary immune responses

scientific article published on 01 March 2019

B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity

scientific article (publication date: June 2012)

B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice

scientific article published on 9 December 2011

CD73 expression is dynamically regulated in the germinal center and bone marrow plasma cells are diminished in its absence

scientific article

CD80 Expression on B Cells Regulates Murine T Follicular Helper Development, Germinal Center B Cell Survival, and Plasma Cell Generation ⬇️

scientific article published on March 26, 2012

CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype.

scientific article

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

scientific article (publication date: 11 April 2002)

Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 Vκ8 B Cells

scientific article published on 18 September 2019

Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell Subsets ⬇️

scientific article published on November 15, 2010

Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage

scientific article

Detecting selection in immunoglobulin sequences

scientific article

Differences in potential for amino acid change after mutation reveals distinct strategies for kappa and lambda light-chain variation

scholarly article

Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides

scientific article

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

scientific article published on 9 November 2011

Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells

scientific article published on 19 February 2008

Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4+ effector memory T cells ⬇️

scientific article published on August 18, 2011

Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity

scientific article

Estimating Hypermutation Rates from Clonal Tree Data ⬇️

scientific article published on November 1, 2003

Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo.

scientific article

Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis

scientific article published on 17 February 2020

Germinal center selection and the development of memory B and plasma cells

scientific article

Germinal centers

scientific article published on 01 May 2012

Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted

scientific article published on 24 September 2018

Langerhans cells are not required for efficient skin graft rejection

scientific article published on 13 March 2008

Langerhans cells are not required for graft-versus-host disease ⬇️

scientific article published on October 13, 2010

Linking signaling and selection in the germinal center

scientific article published on 01 March 2019

Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus

scientific article published on March 2015

Lupus and proliferative nephritis are PAD4 independent in murine models.

scientific article

Memory CD4+ T cells do not induce graft-versus-host disease

scientific article

Memory T cells in GVHD and GVL.

scientific article published on January 2008

Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop

scientific article

Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model

scientific article published on 03 April 2020

NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus.

scientific article published on October 2012

New markers for murine memory B cells that define mutated and unmutated subsets

scientific article

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

scientific article

PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease

scientific article

PIRs mediate innate myeloid cell memory to nonself MHC molecules

scientific article published on 07 May 2020

Reassessing the function of immune-complex retention by follicular dendritic cells

scientific article

Recipient B cells are not required for graft-versus-host disease induction

scientific article

Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease

scientific article published on 18 May 2004

Rheumatoid factors in health and disease: structure, function, induction and regulation

scientific article

Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation.

scientific article published on 14 July 2015

Sites and stages of autoreactive B cell activation and regulation.

scientific article published on January 2008

Suppression of systemic autoimmunity by the innate immune adaptor STING.

scientific article

Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities

scientific article published on July 2008

TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus

scientific article

Target antigens determine graft-versus-host disease phenotype

scientific article published on 01 November 2004

The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells

scientific article published on 22 April 2019

The Type II anti-CD20 Antibody Obinutuzumab (GA101) is More Effective than Rituximab at Depleting B Cells and Treating Disease in a Murine Lupus Model

scientific article published on 05 December 2020

The role of B cells in mouse hepatitis virus infection and pathology.

scientific article published in January 2001

The role of antibodies and B cells in the pathogenesis of lupus nephritis

scientific article

Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

scientific article

Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

scientific article

Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice

scientific article

Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced

scientific article

List of works by Mark Shlomchik

A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data

A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells

Activating systemic autoimmunity: B's, T's, and tolls.

Activation of Rheumatoid Factor (RF) B Cells and Somatic Hypermutation Outside of Germinal Centers in Autoimmune‐Prone MRL/lpr Mice ⬇️

Activation of rheumatoid factor-specific B cells is antigen dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse model

Antibody effector functions mediated by Fcγ-receptors are compromised during persistent viral infection

Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice

Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells

Autoimmunity

Autoimmunity: The genes and phenotypes of autoimmunity

B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus.

B cell primary immune responses

B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity

B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice

CD73 expression is dynamically regulated in the germinal center and bone marrow plasma cells are diminished in its absence

CD80 Expression on B Cells Regulates Murine T Follicular Helper Development, Germinal Center B Cell Survival, and Plasma Cell Generation ⬇️

CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype.

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 Vκ8 B Cells

Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell Subsets ⬇️

Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage

Detecting selection in immunoglobulin sequences

Differences in potential for amino acid change after mutation reveals distinct strategies for kappa and lambda light-chain variation

Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells

Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4+ effector memory T cells ⬇️

Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity

Estimating Hypermutation Rates from Clonal Tree Data ⬇️

Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo.

Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis

Germinal center selection and the development of memory B and plasma cells

Germinal centers

Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted

Langerhans cells are not required for efficient skin graft rejection

Langerhans cells are not required for graft-versus-host disease ⬇️

Linking signaling and selection in the germinal center

Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus

Lupus and proliferative nephritis are PAD4 independent in murine models.

Memory CD4+ T cells do not induce graft-versus-host disease

Memory T cells in GVHD and GVL.

Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop

Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model

NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus.

New markers for murine memory B cells that define mutated and unmutated subsets

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease

PIRs mediate innate myeloid cell memory to nonself MHC molecules

Reassessing the function of immune-complex retention by follicular dendritic cells

Recipient B cells are not required for graft-versus-host disease induction

Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease

Rheumatoid factors in health and disease: structure, function, induction and regulation

Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation.

Sites and stages of autoreactive B cell activation and regulation.

Suppression of systemic autoimmunity by the innate immune adaptor STING.

Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities

TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus

Target antigens determine graft-versus-host disease phenotype

The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells

The Type II anti-CD20 Antibody Obinutuzumab (GA101) is More Effective than Rituximab at Depleting B Cells and Treating Disease in a Murine Lupus Model

The role of B cells in mouse hepatitis virus infection and pathology.

The role of antibodies and B cells in the pathogenesis of lupus nephritis

Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice

Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced