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List of works by Dyann Wirth

A High-Throughput Screen Targeting Malaria Transmission Stages Opens New Avenues for Drug Development ⬇️

scientific article published on May 15, 2011

A Novel Methodology for Bioenergetic Analysis of Plasmodium falciparum Reveals a Glucose-Regulated Metabolic Shift and Enables Mode of Action Analyses of Mitochondrial Inhibitors

scientific article

A broad analysis of resistance development in the malaria parasite

scientific article published on 15 June 2016

A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity

scientific article published on September 2010

A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking

scientific article published on 29 October 2008

A genome-wide map of diversity in Plasmodium falciparum

scientific article published on 10 December 2006

A genomic and evolutionary approach reveals non-genetic drug resistance in malaria

scientific article (publication date: 2014)

A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs

scientific article published on 20 June 2011

A new reporter gene for transient transfection of Plasmodium falciparum

scientific article

A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal

scientific article

A systematic map of genetic variation in Plasmodium falciparum

scientific article

Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt

scientific article

Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model

scientific article published on 16 February 2016

Aminoazabenzimidazoles, a novel class of orally active antimalarial agents

scientific article

Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum

scientific article

An adjustable gas-mixing device to increase feasibility of in vitro culture of Plasmodium falciparum parasites in the field

scientific article (publication date: 2014)

Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests

scientific article published on 29 January 2014

Analysis of the genetic diversity of the Plasmodium falciparum multidrug resistance gene 5' upstream region.

scientific article

Application of genomics to field investigations of malaria by the international centers of excellence for malaria research

scientific article

Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia

scientific article

Biological revelations

scientific article published in October 2002

Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection.

scientific article

COIL: a methodology for evaluating malarial complexity of infection using likelihood from single nucleotide polymorphism data

scientific article

Case report of Plasmodium ovale curtisi malaria in Sri Lanka: relevance for the maintenance of elimination status

scientific article

Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal

scientific article published on 06 December 2013

Characterization of Plasmodium falciparum structure in Nigeria with malaria SNPs barcode

scholarly article published by Pardis C. Sabeti in 2018

Clonal outbreak of Plasmodium falciparum infection in eastern Panama

scientific article

Colorimetric high-throughput screen for detection of heme crystallization inhibitors

scientific article published on 23 March 2009

Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa

scientific article published on 04 October 2006

Conformation-guided analogue design identifies potential antimalarial compounds through inhibition of mitochondrial respiration

Correction: A Systematic Map of Genetic Variation in Plasmodium falciparum.

scientific article

De Novo Mutations Resolve Disease Transmission Pathways in Clonal Malaria.

scientific article

Development of a fluorescence polarization based assay for histone deacetylase ligand discovery

scientific article published on 07 April 2008

Development of a single nucleotide polymorphism barcode to genotype Plasmodium vivax infections

scientific article

Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression

scientific article

Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal ⬇️

scientific article published on October 19, 2012

Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006.

scientific article published in November 2011

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria

scientific article

Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors

scientific article

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

scientific article (publication date: 7 September 2016)

Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents

scientific article

Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance

scientific article published on 9 January 2018

Drug‐induced alterations in gene expression of the asexual blood forms of Plasmodium falciparum ⬇️

scientific article published on November 1, 2003

Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum

scientific article (publication date: November 2006)

Enrichment of reticulocytes from whole blood using aqueous multiphase systems of polymers

scientific article published on 18 October 2014

Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients

scientific article published on 26 February 2016

Evidence of non-Plasmodium falciparum malaria infection in Kédougou, Sénégal

scientific article published on 03 January 2017

Evolution of the pfcrt T76 and pfmdr1 Y86 markers and chloroquine susceptibility 8 years after cessation of chloroquine use in Pikine, Senegal ⬇️

scientific article published on June 17, 2012

Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity

scientific article published on 26 October 2017

Excess Polymorphisms in Genes for Membrane Proteins in Plasmodium falciparum

scientific article published in Science

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

scientific article published on 31 July 2015

Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax

scientific article published on 15 January 2008

Fetuin-A, a hepatocyte-specific protein that binds Plasmodium berghei thrombospondin-related adhesive protein: a potential role in infectivity

scientific article

Gene conversion as a source of nucleotide diversity in Plasmodium falciparum

scientific article published on 2 April 2003

Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum

scientific article published on 28 December 2020

Genetic diversity and selection at the Plasmodium vivax apical membrane antigen-1 (PvAMA-1) locus in a Sri Lankan population

scientific article published on 22 January 2007

Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal

scientific article published on 24 January 2017

Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal

scientific article

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence

scientific article published on 15 December 2008

Genomic heterogeneity in the density of noncoding single-nucleotide and microsatellite polymorphisms in Plasmodium falciparum

scientific article published on 14 August 2006

Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population

scientific article

Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia

scientific article published in February 2010

Global action for training in malaria elimination

scientific article published on 25 January 2018

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

scientific article

Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance

scientific article

Harnessing genomics and genome biology to understand malaria biology

scientific article published on 12 April 2012

High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations

scientific article

High-throughput Plasmodium falciparum growth assay for malaria drug discovery

scientific article

Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections.

scientific article published on 11 April 2018

Human cerebral malaria and Plasmodium falciparum genotypes in Malawi

scientific article published on 7 February 2012

Hybrid selection for sequencing pathogen genomes from clinical samples

scientific article published on 11 August 2011

Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

scientific article published on 8 October 2008

Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum

scientific article (publication date: 23 April 2009)

Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum

scientific article

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors

scientific article

Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum

scientific article published on 16 January 2018

Identification of regulatory elements in the Plasmodium falciparum genome

scientific article published in March 2004

Immune characterization of Plasmodium falciparum parasites with a shared genetic signature in a region of decreasing transmission

scientific article

Improving malaria control in West Africa: interruption of transmission as a paradigm shift

scientific article published on 28 November 2011

In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth

scientific article

In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from Senegal

scientific article published on May 2002

In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model

scientific article published on 01 December 2019

In vitro-reduced susceptibility to artemether in P. falciparum and its association with polymorphisms on transporter genes

scientific article

In vivo and in vitro analysis of chloroquine resistance in Plasmodium falciparum isolates from Senegal

scientific article published on 29 June 2005

In vivo profiles in malaria are consistent with a novel physiological state

scientific article published in July 2009

In vivo transcriptional profiling of Plasmodium falciparum

scientific article

In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins

scientific article

Inactivation of Plasmepsin 2 and 3 sensitizes Plasmodium falciparum to the antimalarial drug piperaquine

scientific article published on 12 February 2018

Inferring developmental stage composition from gene expression in human malaria

scientific article (publication date: 2013)

Intramolecular Diaza-Diels-Alder Protocol: A New Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks

scientific article

Linkage disequilibrium between two distinct loci in chromosomes 5 and 7 of Plasmodium falciparum and in vivo chloroquine resistance in Southwest Nigeria

scientific article published on 28 July 2006

Linker scanning mutagenesis of the Plasmodium gallinaceum sexual stage specific gene pgs28 reveals a novel downstream cis-control element

scientific article published in July 2003

Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites

scientific article published on March 2004

Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome

scientific article

Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum

scientific article published on 2 November 2017

ML238: An Antimalarial Small Molecule of a Unique Structural Class

Malaria life cycle intensifies both natural selection and random genetic drift

scientific article

Mapping of the Plasmodium falciparum multidrug resistance gene 5'-upstream region, and evidence of induction of transcript levels by antimalarial drugs in chloroquine sensitive parasites

scientific article published on August 2003

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

scientific article published in January 2018

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria

scientific article

Modeling malaria genomics reveals transmission decline and rebound in Senegal

scientific article published on 4 May 2015

Modeling the genetic relatedness of Plasmodium falciparum parasites following meiotic recombination and cotransmission

scientific article published on 9 January 2018

Modulation of PF10_0355 (MSPDBL2) alters Plasmodium falciparum response to antimalarial drugs

scientific article (publication date: July 2013)

Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria

scientific article published on January 2004

Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal ⬇️

scientific article published on 30 April 2007

Mutations in PFCRT K76T do not correlate with sulfadoxine-pyrimethamine-amodiaquine failure in Pikine, Senegal

scientific article published on 05 June 2008

Mutations in actin-binding protein coronin confer reduced artemisinin susceptibility

article published in the Proceedings of the National Academy of Sciences of the United States of America

Naturally acquired immunity against immature Plasmodium falciparum gametocytes

scientific article published on 01 June 2019

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections ⬇️

scientific article published on 14 July 2016

Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

scientific article

Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene ⬇️

scientific article

On the road to eliminate malaria in Sri Lanka: lessons from history, challenges, gaps in knowledge and research needs

scientific article

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

scientific article published on 01 December 2018

Patterns of gene-specific and total transcriptional activity during the Plasmodium falciparum intraerythrocytic developmental cycle

scientific article published on 16 January 2009

Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda

scientific article published on 20 May 2016

Plasmepsin II-III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum.

scientific article published on 2 May 2018

Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes

scientific article published on 07 April 2016

Plasmodium falciparum gene expression measured directly from tissue during human infection

scientific article

Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment

scientific article published on 14 March 2007

Polymorphism in dhfr/dhps genes, parasite density and ex vivo response to pyrimethamine in Plasmodium falciparum malaria parasites in Thies, Senegal

scientific article published on 12 August 2013

Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria

scientific article published in September 2005

Population structure and transmission dynamics of Plasmodium vivax in rural Amazonia.

scientific article published on 6 March 2007

Pre-amplification methods for tracking low-grade Plasmodium falciparum populations during scaled-up interventions in Southern Zambia

scientific article

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

scientific article

Quantitative Proteomic Profiling Reveals Novel Plasmodium falciparum Surface Antigens and Possible Vaccine Candidates

scientific article published on 21 November 2017

RDTs as a source of DNA to study Plasmodium falciparum drug resistance in isolates from Senegal and the Comoros Islands

scientific article (publication date: 29 September 2015)

RNA polymerase II synthesizes antisense RNA in Plasmodium falciparum

scientific article published on 9 February 2005

Rapid, Field-Deployable Method for Genotyping and Discovery of Single-Nucleotide Polymorphisms Associated with Drug Resistance in Plasmodium falciparum ⬇️

scientific article published on March 19, 2012

Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum

scientific article published on 18 January 2007

Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae

scientific article

Reply to Velavan et al.: Polymorphisms of pfcoronin in natural populations: Implications for functional significance

scientific article published on 01 June 2019

Responses to Bacteria, Virus, and Malaria Distinguish the Etiology of Pediatric Clinical Pneumonia

scientific article

SNP genotyping identifies new signatures of selection in a deep sample of West African Plasmodium falciparum malaria parasites

scientific article published on 11 June 2012

Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes

scientific article published on 19 November 2011

Secreted antibody is required for immunity to Plasmodium berghei

scientific article published on 10 November 2008

Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria

scientific article published on 15 December 2008

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite

scientific article

Single-nucleotide polymorphism, linkage disequilibrium and geographic structure in the malaria parasite Plasmodium vivax: prospects for genome-wide association studies

scientific article

Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA.

scientific article published on 13 June 2015

The Sri Lankan paradox: high genetic diversity in Plasmodium vivax populations despite decreasing levels of malaria transmission.

scientific article published on 14 February 2014

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

scientific article

The paradoxical population genetics of Plasmodium falciparum

scientific article

The role of DNA mismatch repair in generating genetic diversity and drug resistance in malaria parasites

scientific article (publication date: September 2007)

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

scientific article published on 08 July 2013

Transcriptional Categorization of the Etiology of Pneumonia Syndrome in Pediatric Patients in Malaria-Endemic Areas

scientific article published on 10 November 2016

Transcriptional profiling of Plasmodium falciparum parasites from patients with severe malaria identifies distinct low vs. high parasitemic clusters

scientific article

Transformation-specific secreted phosphoproteins

scientific article published in Nature

Transmission of molecularly undetectable circulating parasite clones leads to high infection complexity in mosquitoes post feeding.

scientific article published on 5 May 2018

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

scientific article

Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors

scientific article published on 24 November 2008

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

scientific article

West Africa International Centers of Excellence for Malaria Research: Drug Resistance Patterns to Artemether-Lumefantrine in Senegal, Mali, and The Gambia

scientific article

Widespread distribution of antisense transcripts in the Plasmodium falciparum genome

scientific article published in July 2004

hmmIBD: software to infer pairwise identity by descent between haploid genotypes.

scientific article published on 15 May 2018

malERA: An updated research agenda for malaria elimination and eradication

scientific article published on 30 November 2017

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