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List of works by Kai Johnsson

A Caged, Localizable Rhodamine Derivative for Superresolution Microscopy

scientific article published on 04 November 2011

A Chemogenetic Approach for the Optical Monitoring of Voltage in Neurons

scientific article published on 25 January 2019

A Fluorescent Sensor for GABA and Synthetic GABAB Receptor Ligands

scientific article published on 05 November 2012

A General Strategy for the Semisynthesis of Ratiometric Fluorescent Sensor Proteins with Increased Dynamic Range

scientific article published on 12 April 2016

A New Fluorogenic Small-Molecule Labeling Tool for Surface Diffusion Analysis and Advanced Fluorescence Imaging of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Based on Silicone Rhodamine: SiR-BACE1

scientific article published on 10 July 2018

A Semisynthetic Fluorescent Sensor Protein for Glutamate

scientific article published on 25 April 2012

A biosensor for measuring NAD+ levels at the point of care

scientific article published on 13 December 2019

A covalent chemical genotype-phenotype linkage for in vitro protein evolution

scientific article

A designed protein for the specific and covalent heteroconjugation of biomolecules

scientific article published on 28 August 2008

A discontinuous epitope on p36, the major substrate of src tyrosine-protein-kinase, brings the phosphorylation site into the neighbourhood of a consensus sequence for Ca2+/lipid-binding proteins

scientific article

A fluorogenic probe for SNAP-tagged plasma membrane proteins based on the solvatochromic molecule Nile Red.

scientific article published on 29 January 2014

A fusion of disciplines: chemical approaches to exploit fusion proteins for functional genomics

scientific article

A general method for the covalent labeling of fusion proteins with small molecules in vivo

scientific article published on 9 December 2002

A general strategy to develop cell permeable and fluorogenic probes for multicolour nanoscopy

scientific article published on 02 December 2019

A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins

scientific article published on 6 January 2013

A split-protein sensor for studying protein-protein interaction in mycobacteria

scientific article published on 21 February 2008

A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis.

scientific article

Adding value to fusion proteins through covalent labelling

scientific article

An engineered protein tag for multiprotein labeling in living cells

scientific article

Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

scientific article published on 09 October 2020

Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1.

scientific article

Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-β-D-ribose 2'-epimerase DprE1 of Mycobacterium tuberculosis

scientific article published on October 2010

Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring.

scientific article published on 08 June 2014

Caged substrates for protein labeling and immobilization

scientific article published in January 2008

Changing the substrate specificity of cytochrome c peroxidase using directed evolution.

scientific article published in August 2001

Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number

scientific article

Chemical biology approaches to membrane homeostasis and function

scientific article published on January 2011

Chemical probes shed light on protein function

scientific article published on August 2007

Chemogenetic Control of Nanobodies

scientific article published on 17 February 2020

Chimeric streptavidins with reduced valencies

scientific article published in April 2006

Commercial Cdk1 antibodies recognize the centrosomal protein Cep152.

scientific article published in September 2013

Computational design of ligand-binding proteins with high affinity and selectivity

scientific article

Correction: NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro.

scientific article published on 28 October 2015

Corrigendum: Modulating protein activity using tethered ligands with mutually exclusive binding sites

scientific article published on 15 February 2016

Covalent and selective immobilization of fusion proteins

scientific article

Covalent labeling of cell-surface proteins for in-vivo FRET studies

scientific article published on 17 February 2006

DNA repair protein O6-methylguanine-DNA methyltransferase in testis and testicular tumors as determined by a novel nonradioactive assay

scientific article published on October 2003

Development of SNAP-tag fluorogenic probes for wash-free fluorescence imaging.

scientific article published on 26 July 2011

Differences in cisplatin distribution in sensitive and resistant ovarian cancer cells: a TEM/NanoSIMS study.

scientific article

Directed evolution of O6-alkylguanine-DNA alkyltransferase for applications in protein labeling.

scientific article published on 25 April 2006

Directed evolution of O6-alkylguanine-DNA alkyltransferase for efficient labeling of fusion proteins with small molecules in vivo

scientific article

Directed evolution of the suicide protein O⁶-alkylguanine-DNA alkyltransferase for increased reactivity results in an alkylated protein with exceptional stability

scientific article

Engineered HaloTag variants for fluorescence lifetime multiplexing

scientific article published on 16 December 2021

Engineering substrate specificity of O6-alkylguanine-DNA alkyltransferase for specific protein labeling in living cells

scientific article

Evaluating Cellular Drug Uptake with Fluorescent Sensor Proteins.

scientific article published on 2 August 2017

Evolving the substrate specificity of O6-alkylguanine-DNA alkyltransferase through loop insertion for applications in molecular imaging.

scientific article published in October 2006

Examining reactivity and specificity of cytochrome c peroxidase by using combinatorial mutagenesis

scientific article

Exploiting ligand-protein conjugates to monitor ligand-receptor interactions

scientific article

FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells

scholarly article

Fast directed evolution of non-immunoglobulin proteins by somatic hypermutation in immune cells

scientific article published in May 2005

Fluorescence microscopy: strategic blinking.

scientific article published in August 2014

Fluorescent labeling of SNAP-tagged proteins in cells.

scientific article

Fluorogenic Probes for Multicolor Imaging in Living Cells

scientific article published on 15 July 2016

Fluorogenic probes for live-cell imaging of the cytoskeleton

scientific article

Fura-2FF-based calcium indicator for protein labeling

scientific article published on 16 June 2010

Genetic targeting of chemical indicators in vivo.

scientific article

Highly Modular Bioluminescent Sensors for Small Molecules and Proteins

scientific article published on 28 February 2017

How to obtain labeled proteins and what to do with them

scientific article published on 26 October 2010

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

scientific article

Imaging and manipulating proteins in live cells through covalent labeling

scientific article published on 17 November 2015

Indo-1 derivatives for local calcium sensing.

scientific article published on March 2009

Induced protein dimerization in vivo through covalent labeling

scientific article

Inducing and sensing protein--protein interactions in living cells by selective cross-linking

scientific article published on January 2007

Inter- and intramolecular domain interactions of the catalase-peroxidase KatG from M. tuberculosis.

scientific article published in December 2001

Investigating endocytic pathways to the endoplasmic reticulum and to the cytosol using SNAP-trap

scientific article

Investigative Reporters

scientific article published on 01 June 2008

Labeling of fusion proteins of O6-alkylguanine-DNA alkyltransferase with small molecules in vivo and in vitro

scientific article

Labeling of fusion proteins with synthetic fluorophores in live cells

scientific article

Labelling cell structures and tracking cell lineage in zebrafish using SNAP-tag.

scientific article published on 28 February 2011

Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma.

scientific article published on 27 August 2012

Localizable and highly sensitive calcium indicator based on a BODIPY fluorophore

scientific article published in August 2010

Luciferases with Tunable Emission Wavelengths.

scientific article published on 22 September 2017

Measuring In Vivo Protein Half-Life

scientific article published on 01 June 2011

Modulating protein activity using tethered ligands with mutually exclusive binding sites

scientific article published on 22 July 2015

Multicolor imaging of cell surface proteins

scientific article published in September 2005

NCCR Chemical Biology: Interdisciplinary Research Excellence, Outreach, Education, and New Tools for Switzerland.

scientific article published in January 2011

NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro.

scientific article published in October 2015

Overexpression, purification, and characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis

scientific journal article

Phosphopantetheinyl transferase-catalyzed formation of bioactive hydrogels for tissue engineering.

scientific article published in May 2010

Photoactivatable and photoconvertible fluorescent probes for protein labeling

scientific article published in May 2010

Post-translational covalent labeling reveals heterogeneous mobility of individual G protein-coupled receptors in living cells

scientific article

Protein chemistry on the surface of living cells

scientific article

Protein function microarrays based on self-immobilizing and self-labeling fusion proteins

scientific article

Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation

scientific article

Protein-functionalized polymer brushes

scientific article published in May 2005

Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

scientific article published on 01 August 2019

Rational Design and Applications of Semisynthetic Modular Biosensors: SNIFITs and LUCIDs

scientific article published in January 2017

Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling method

scientific article published on 7 April 2011

Recording physiological history of cells with chemical labeling

scientific article published on 22 February 2024

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway

scientific article published on June 2015

Reflections on chemical biology.

scientific article published in January 2011

Regulation of glutamate metabolism by protein kinases in mycobacteria

scientific journal article

SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand

scientific article published on 07 September 2018

Searching for the protein targets of bioactive molecules.

scientific article

Selective chemical crosslinking reveals a Cep57-Cep63-Cep152 centrosomal complex

scientific article published on 17 January 2013

Selective cross-linking of interacting proteins using self-labeling tags

scientific article published in December 2009

Semisynthesis of fluorescent metabolite sensors on cell surfaces

scientific article published on 16 September 2011

Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides.

scientific article

Semisynthetic fluorescent sensor proteins based on self-labeling protein tags

scientific article published in April 2009

Semisynthetic sensor proteins enable metabolic assays at the point of care

scientific article

Sensing Acetylcholine and Anticholinesterase Compounds

scientific article published on 13 December 2013

Small-Molecule Fluorescent Probes for Live-Cell Super-Resolution Microscopy

scientific article published on 29 January 2019

Specific labeling of cell surface proteins with chemically diverse compounds

scientific article

Spontaneous Formation of the Bioactive Form of the Tuberculosis Drug Isoniazid

scientific article published on 01 September 1999

Substrates for improved live-cell fluorescence labeling of SNAP-tag

scientific article published on January 2013

Subunit-specific surface mobility of differentially labeled AMPA receptor subunits

scientific article

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

scientific article published on 24 January 2020

Switchable fluorophores for protein labeling in living cells

scientific article

Synthesis and characterization of bifunctional probes for the specific labeling of fusion proteins

scientific article

Targeted photoswitchable probe for nanoscopy of biological structures

scientific article published on July 2010

Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs

scientific article

The laboratory in a droplet

scientific article

Towards the generation of artificial O6-alkylguanine-DNA alkyltransferases: in vitro selection of antibodies with reactive cysteine residues

scientific article

Triplet Imaging of Oxygen Consumption During the Contraction of a Single Smooth Muscle Cell (A7r5)

Triplet imaging of oxygen consumption during the contraction of a single smooth muscle cell (A7r5)

scientific article published on January 2010

Using peptide loop insertion mutagenesis for the evolution of proteins

scientific article

Visualizing biochemical activities in living cells

scientific article published in February 2009

Visualizing biochemical activities in living cells through chemistry.

scientific article published on January 2011

WhiB5, a transcriptional regulator that contributes to Mycobacterium tuberculosis virulence and reactivation

scientific article

Yeast three-hybrid screening for identifying anti-tuberculosis drug targets

scientific article

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