List of works - Frauke Neff

A Five-Year Report on the conception and establishment of the MSc Radiation Biology at the Technical University of Munich

scientific article published on 19 November 2020

A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease Rats.

scientific article published on 23 December 2018

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

scientific article

A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes

scientific article published on 14 February 2020

A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease.

scientific article published on 6 July 2006

A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue

scientific article published on 13 September 2017

APP transgenic mice: the effect of active and passive immunotherapy in cognitive tasks

scientific article published on 24 October 2009

An ENU mutagenesis-derived mouse model with a dominant Jak1 mutation resembling phenotypes of systemic autoimmune disease

scientific article

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

scientific article

Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice

scientific article published on 9 June 2016

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice

scientific article published on 06 January 2017

CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection

scientific article (publication date: 2016)

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

scientific article

Cardioprotection and lifespan extension by the natural polyamine spermidine.

scientific article

Centrosome abnormalities in head and neck squamous cell carcinoma (HNSCC).

scientific article

Characterization of neuroendocrine tumors in heterozygous mutant MENX rats: a novel model of invasive medullary thyroid carcinoma.

scientific article published on 15 November 2017

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

scientific article published on 6 October 2016

Chronic low-dose-rate ionising radiation affects the hippocampal phosphoproteome in the ApoE-/- Alzheimer's mouse model

scientific article published on 30 September 2016

Comment on "One health, one literature: Weaving together veterinary and medical research".

scientific article published in December 2015

Correction to: Dose-responses for mortality from cerebrovascular and heart diseases in atomic bomb survivors: 1950-2003

scientific article published on 01 May 2019

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

scientific article

Cytosolic Hsp70 as a biomarker to predict clinical outcome in patients with glioblastoma

scientific article published on 20 August 2019

Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.

scientific article published on 13 April 2018

Dexamethasone treatment alters insulin, leptin, and adiponectin levels in male mice as observed in DIO but does not lead to alterations of metabolic phenotypes in the offspring

scientific article published on 11 December 2015

Dose-dependent long-term effects of a single radiation event on behaviour and glial cells

scientific article published on 02 December 2020

Dose-responses for mortality from cerebrovascular and heart diseases in atomic bomb survivors: 1950-2003.

scientific article published on 8 December 2017

Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice

scientific article

Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice.

scientific article published on 21 February 2018

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

scientific article

Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression

scientific article

Gene expression profiles derived from single cells in human postmortem brain

scientific article published in April 2004

Gene expression profiling of Lewy body-bearing neurons in Parkinson's disease

scientific article published in September 2005

Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

scientific article published on 14 May 2015

Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis

scientific article published on 27 June 2019

Heterotopic Cervical Heart Transplantation in Mice

scientific article published on 25 August 2015

Immunization as treatment for Parkinson's disease.

scientific article published on January 2009

Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders

scientific article published on May 2008

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

scientific article

Innovations in phenotyping of mouse models in the German Mouse Clinic

scientific article

Intravenous Immunoglobulins as a Treatment for Alzheimerʼs Disease

scientific article

Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation

scientific article

Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.

scientific article

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system

scientific article

Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk

scientific article

Long-Term Cold Adaptation Does Not Require FGF21 or UCP1.

scientific article published in August 2017

Loss of Roquin induces early death and immune deregulation but not autoimmunity ⬇️

scientific article published on August 15, 2011

Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase (TPI) deficiency

scientific article published on 11 June 2019

MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy

scientific article

Methanobactin reverses acute liver failure in a rat model of Wilson disease

scientific article published on 20 June 2016

MiR-34a deficiency accelerates medulloblastoma formation in vivo

scientific article

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

scientific article

Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice

scientific article

Morphology, Biochemistry, and Pathophysiology of MENX-Related Pheochromocytoma Recapitulate the Clinical Features.

scientific article

Mouse Genetics and Metabolic Mouse Phenotyping

article

Mouse phenotyping

scientific article

Multimodality multiparametric imaging of early tumor response to a novel antiangiogenic therapy based on anticalins

scientific article

Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality

scientific article published on 05 September 2019

Naturally Occurring Autoantibodies against β-Amyloid: Investigating Their Role in Transgenic Animal andIn VitroModels of Alzheimer's Disease ⬇️

scientific article published on April 13, 2011

Neonatal Irradiation Leads to Persistent Proteome Alterations Involved in Synaptic Plasticity in the Mouse Hippocampus and Cortex

scientific article

Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma

scientific article

Pleiotropic functions for transcription factor zscan10.

scientific article

Rapamycin extends murine lifespan but has limited effects on aging

scientific article

Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation

scientific article published on 01 August 2011

Regional vulnerability of mesencephalic dopaminergic neurons prone to degenerate in Parkinson's disease: a post-mortem study in human control subjects

scientific article

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

scientific journal article

STEAP1 is associated with the invasive and oxidative stress phenotype of Ewing tumors

scientific article

Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease

scientific article

Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice

scientific article

Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes

scientific article published on 20 July 2012

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

scientific article published on 17 August 2017

Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma

scientific article published on 25 November 2015

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

scientific article

The German Mouse Clinic – Running an Open Access Platform

article

The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth

scientific article published on 18 September 2013

The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation

scientific article published on 16 December 2014

The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma

scientific article

The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?

article

The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma

scientific article published on 30 May 2016

The role of macrophage migration inhibitory factor in Alzheimer's disease

scientific article

Therapy of Alzheimer's disease: current status and future development

scientific article published in January 2008

Validation of preclinical multiparametric imaging for prediction of necrosis in hepatocellular carcinoma after embolization

scientific article published on 24 February 2011

List of works by Frauke Neff

A Five-Year Report on the conception and establishment of the MSc Radiation Biology at the Technical University of Munich

A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease Rats.

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes

A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease.

A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue

APP transgenic mice: the effect of active and passive immunotherapy in cognitive tasks

An ENU mutagenesis-derived mouse model with a dominant Jak1 mutation resembling phenotypes of systemic autoimmune disease

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice

CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

Cardioprotection and lifespan extension by the natural polyamine spermidine.

Centrosome abnormalities in head and neck squamous cell carcinoma (HNSCC).

Characterization of neuroendocrine tumors in heterozygous mutant MENX rats: a novel model of invasive medullary thyroid carcinoma.

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

Chronic low-dose-rate ionising radiation affects the hippocampal phosphoproteome in the ApoE-/- Alzheimer's mouse model

Comment on "One health, one literature: Weaving together veterinary and medical research".

Correction to: Dose-responses for mortality from cerebrovascular and heart diseases in atomic bomb survivors: 1950-2003

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

Cytosolic Hsp70 as a biomarker to predict clinical outcome in patients with glioblastoma

Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.

Dexamethasone treatment alters insulin, leptin, and adiponectin levels in male mice as observed in DIO but does not lead to alterations of metabolic phenotypes in the offspring

Dose-dependent long-term effects of a single radiation event on behaviour and glial cells

Dose-responses for mortality from cerebrovascular and heart diseases in atomic bomb survivors: 1950-2003.

Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice

Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice.

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression

Gene expression profiles derived from single cells in human postmortem brain

Gene expression profiling of Lewy body-bearing neurons in Parkinson's disease

Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis

Heterotopic Cervical Heart Transplantation in Mice

Immunization as treatment for Parkinson's disease.

Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Innovations in phenotyping of mouse models in the German Mouse Clinic

Intravenous Immunoglobulins as a Treatment for Alzheimerʼs Disease

Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation

Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system

Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk

Long-Term Cold Adaptation Does Not Require FGF21 or UCP1.

Loss of Roquin induces early death and immune deregulation but not autoimmunity ⬇️

Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase (TPI) deficiency

MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy

Methanobactin reverses acute liver failure in a rat model of Wilson disease

MiR-34a deficiency accelerates medulloblastoma formation in vivo

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice

Morphology, Biochemistry, and Pathophysiology of MENX-Related Pheochromocytoma Recapitulate the Clinical Features.

Mouse Genetics and Metabolic Mouse Phenotyping

Mouse phenotyping

Multimodality multiparametric imaging of early tumor response to a novel antiangiogenic therapy based on anticalins

Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality

Naturally Occurring Autoantibodies against β-Amyloid: Investigating Their Role in Transgenic Animal andIn VitroModels of Alzheimer's Disease ⬇️

Neonatal Irradiation Leads to Persistent Proteome Alterations Involved in Synaptic Plasticity in the Mouse Hippocampus and Cortex

Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma

Pleiotropic functions for transcription factor zscan10.

Rapamycin extends murine lifespan but has limited effects on aging

Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation

Regional vulnerability of mesencephalic dopaminergic neurons prone to degenerate in Parkinson's disease: a post-mortem study in human control subjects

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

STEAP1 is associated with the invasive and oxidative stress phenotype of Ewing tumors

Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease

Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice

Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

The German Mouse Clinic – Running an Open Access Platform

The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth

The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation

The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma

The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?

The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma

The role of macrophage migration inhibitory factor in Alzheimer's disease