List of works - Eddy Arnold

2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants

scientific article

3-Hydroxyquinolin-2(1 H )-ones As Inhibitors of Influenza A Endonuclease

scientific article

A Bactericidal Guanidinomethyl Biaryl That Alters the Dynamics of Bacterial FtsZ Polymerization ⬇️

scientific article published on October 26, 2012

A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain

scientific article

A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants

scientific article

Advantages of crystallographic fragment screening: functional and mechanistic insights from a powerful platform for efficient drug discovery

scientific article published on 10 August 2014

Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics

scientific article

Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase

scientific article

Antigenic characteristics of rhinovirus chimeras designed in silico for enhanced presentation of HIV-1 gp41 epitopes [corrected].

scientific article

Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease

scientific article published on 14 May 2019

Broad neutralization of human immunodeficiency virus type 1 (HIV-1) elicited from human rhinoviruses that display the HIV-1 gp41 ELDKWA epitope

scientific article

Chimeric rhinoviruses displaying MPER epitopes elicit anti-HIV neutralizing responses

scientific article

Crystal Structure of D-Hydantoinase from Burkholderia pickettii at a Resolution of 2.7 Angstroms: Insights into the Molecular Basis of Enzyme Thermostability

scientific article

Crystal Structure of tert -Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket

scientific article

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design

scientific article

Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site.

scientific article

Crystal structure of a human rhinovirus that displays part of the HIV-1 V3 loop and induces neutralizing antibodies against HIV-1

scientific article

Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity

scientific article

Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097.

scientific article

Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors

scientific article

Crystallographic Study of a Novel Subnanomolar Inhibitor Provides Insight on the Binding Interactions of Alkenyldiarylmethanes with Human Immunodeficiency Virus-1 Reverse Transcriptase

scientific article

Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article

Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model

scientific article published on 28 March 2024

Designing anti-AIDS drugs targeting the major mechanism of HIV-1 RT resistance to nucleoside analog drugs

scientific article published on September 2004

Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening

scientific article

Differential isotopic enrichment to facilitate characterization of asymmetric multimeric proteins using hydrogen/deuterium exchange mass spectrometry

scientific article published on 25 March 2015

Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel

scientific article published on 24 January 2020

Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors

scientific article

Effects of mutations in the polymerase domain on the polymerase, RNase H and strand transfer activities of human immunodeficiency virus type 1 reverse transcriptase 1 1Edited By J.Karn ⬇️

scientific article published on April 3, 1998

Exploring structural variability in X-ray crystallographic models using protein local optimization by torsion-angle sampling

scientific article

Extension into the entrance channel of HIV-1 reverse transcriptase—Crystallography and enhanced solubility

scientific article

Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries

scientific article

Fragment screening and HIV therapeutics

scientific article

GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides

scientific article published in 2014

HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

scientific article

HIV-1 reverse transcriptase and antiviral drug resistance. Part 1.

scientific article

HIV-1 reverse transcriptase and antiviral drug resistance. Part 2.

scientific article

HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism

scientific article

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations

scientific article

Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies

scientific article

In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

scientific article

Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation

scientific article

Molecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutations

scientific article

Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design

scientific article

Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication

scientific article

On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data

scientific article

Phenyl substituted 3-hydroxypyridin-2(1H)-ones: inhibitors of influenza A endonuclease

scientific article

Phenyl substituted 4-hydroxypyridazin-3(2H)-ones and 5-hydroxypyrimidin-4(3H)-ones: inhibitors of influenza A endonuclease.

scientific article

Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates

scientific article published on 09 October 2015

RNase H Cleavage of the 5′ End of the Human Immunodeficiency Virus Type 1 Genome ⬇️

scientific article published on December 1, 2001

Rapid experimental SAD phasing and hot-spot identification with halogenated fragments

scientific article

Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase

scientific article

Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance

scientific article

Structural Basis of HIV-1 Inhibition by Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1

scientific article published on 25 October 2019

Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.

scientific article

Structural and molecular interactions of CCR5 inhibitors with CCR5.

scientific article

Structural basis for suppression of a host antiviral response by influenza A virus

scientific article

Structural basis for the unique biological function of small GTPase RHEB

scientific journal article

Structural basis of BLyS receptor recognition

scientific article

Structural basis of HIV-1 resistance to AZT by excision

scientific article

Structural basis of transcription initiation

scientific article

Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition

scientific article

Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site

scientific article

Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure–Activity Analysis of Inhibitor Analogs

scientific article

Structure of the guanylyltransferase domain of human mRNA capping enzyme

scientific article

Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage

scientific article

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

scientific article

Structures of RNA polymerase-antibiotic complexes

scientific article

Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity

scientific journal article

Structures of influenza A proteins and insights into antiviral drug targets.

scientific article

Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

scientific article

Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme

scientific article

Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases

scientific article

The RNA polymerase "switch region" is a target for inhibitors

scientific article

Three-dimensional EM structure of an intact activator-dependent transcription initiation complex

scientific article

Transcription inhibition by the depsipeptide antibiotic salinamide A

scientific article

Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase

scientific article

Why do HIV-1 and HIV-2 use different pathways to develop AZT resistance?

scientific article

List of works by Eddy Arnold

2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants

3-Hydroxyquinolin-2(1 H )-ones As Inhibitors of Influenza A Endonuclease

A Bactericidal Guanidinomethyl Biaryl That Alters the Dynamics of Bacterial FtsZ Polymerization ⬇️

A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain

A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants

Advantages of crystallographic fragment screening: functional and mechanistic insights from a powerful platform for efficient drug discovery

Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics

Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase

Antigenic characteristics of rhinovirus chimeras designed in silico for enhanced presentation of HIV-1 gp41 epitopes [corrected].

Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease

Broad neutralization of human immunodeficiency virus type 1 (HIV-1) elicited from human rhinoviruses that display the HIV-1 gp41 ELDKWA epitope

Chimeric rhinoviruses displaying MPER epitopes elicit anti-HIV neutralizing responses

Crystal Structure of D-Hydantoinase from Burkholderia pickettii at a Resolution of 2.7 Angstroms: Insights into the Molecular Basis of Enzyme Thermostability

Crystal Structure of tert -Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design

Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site.

Crystal structure of a human rhinovirus that displays part of the HIV-1 V3 loop and induces neutralizing antibodies against HIV-1

Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity

Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097.

Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors

Crystallographic Study of a Novel Subnanomolar Inhibitor Provides Insight on the Binding Interactions of Alkenyldiarylmethanes with Human Immunodeficiency Virus-1 Reverse Transcriptase

Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors

Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model

Designing anti-AIDS drugs targeting the major mechanism of HIV-1 RT resistance to nucleoside analog drugs

Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening

Differential isotopic enrichment to facilitate characterization of asymmetric multimeric proteins using hydrogen/deuterium exchange mass spectrometry

Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel

Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors

Effects of mutations in the polymerase domain on the polymerase, RNase H and strand transfer activities of human immunodeficiency virus type 1 reverse transcriptase 1 1Edited By J.Karn ⬇️

Exploring structural variability in X-ray crystallographic models using protein local optimization by torsion-angle sampling

Extension into the entrance channel of HIV-1 reverse transcriptase—Crystallography and enhanced solubility

Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries

Fragment screening and HIV therapeutics

GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides

HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

HIV-1 reverse transcriptase and antiviral drug resistance. Part 1.

HIV-1 reverse transcriptase and antiviral drug resistance. Part 2.

HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations

Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies

In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation

Molecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutations

Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design

Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication

On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data

Phenyl substituted 3-hydroxypyridin-2(1H)-ones: inhibitors of influenza A endonuclease

Phenyl substituted 4-hydroxypyridazin-3(2H)-ones and 5-hydroxypyrimidin-4(3H)-ones: inhibitors of influenza A endonuclease.

Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates

RNase H Cleavage of the 5′ End of the Human Immunodeficiency Virus Type 1 Genome ⬇️

Rapid experimental SAD phasing and hot-spot identification with halogenated fragments

Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase

Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance

Structural Basis of HIV-1 Inhibition by Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1

Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.

Structural and molecular interactions of CCR5 inhibitors with CCR5.

Structural basis for suppression of a host antiviral response by influenza A virus

Structural basis for the unique biological function of small GTPase RHEB

Structural basis of BLyS receptor recognition

Structural basis of HIV-1 resistance to AZT by excision

Structural basis of transcription initiation

Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition

Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site

Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure–Activity Analysis of Inhibitor Analogs

Structure of the guanylyltransferase domain of human mRNA capping enzyme

Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

Structures of RNA polymerase-antibiotic complexes

Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity

Structures of influenza A proteins and insights into antiviral drug targets.

Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme

Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases

The RNA polymerase "switch region" is a target for inhibitors

Three-dimensional EM structure of an intact activator-dependent transcription initiation complex

Transcription inhibition by the depsipeptide antibiotic salinamide A

Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase

Why do HIV-1 and HIV-2 use different pathways to develop AZT resistance?