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List of works by Dagmar Ringe

"Sleeping beauty": quiescence in Saccharomyces cerevisiae

scientific article

1-Butaneboronic acid binding to Aeromonas proteolytica aminopeptidase: a case of arrested development

scientific article

2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor

scientific article (publication date: 10 June 2003)

A Phenylalanine Clamp Controls Substrate Specificity in the Quorum-Quenching Metallo-γ-lactonase from Bacillus thuringiensis ⬇️

scientific article published on February 20, 2013

A Side Reaction of Alanine Racemase: Transamination of Cycloserine, ⬇️

scientific article (publication date: 20 May 2003)

A Tale of Two Isomerases: Compact versus Extended Active Sites in Ketosteroid Isomerase and Phosphoglucose Isomerase ⬇️

scientific article published on October 4, 2011

A preliminary neutron diffraction study of gamma-chymotrypsin

scientific article published on 26 February 2009

A soluble α-synuclein construct forms a dynamic tetramer

scientific article published on 17 October 2011

A transport problem?

scientific article published in Nature

A yeast model of FUS/TLS-dependent cytotoxicity

scientific article

Active Site Analysis of the Potential Antimicrobial Target Aspartate Semialdehyde Dehydrogenase ⬇️

scientific article published on December 4, 2001

Active-site engineering of benzaldehyde lyase shows that a point mutation can confer both new reactivity and susceptibility to mechanism-based inhibition

scientific article

Activity and structure of the active-site mutants R386Y and R386F of Escherichia coli aspartate aminotransferase

scientific article

Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.

scientific article published on 8 June 2015

An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate

scientific article

Analogous inhibitors of elastase do not always bind analogously ⬇️

scientific article published on January 1, 1994

Anchoring a cationic ligand: the structure of the Fab fragment of the anti-morphine antibody 9B1 and its complex with morphine

scientific article published in March 2004

Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation

scientific article published on 17 April 2014

Behind the Movement ⬇️

scientific article published on September 14, 2012

Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein

scientific article published on August 2016

Chiral discrimination among aminotransferases: inactivation by 4-amino-4,5-dihydrothiophenecarboxylic acid

scientific article

Comparison of anionic and cationic trypsinogens: The anionic activation domain is more flexible in solution and differs in its mode of BPTI binding in the crystal structure

scientific article

Correction to Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover

scientific article

Crystal Cryocooling Distorts Conformational Heterogeneity in a Model Michaelis Complex of DHFR

scientific article

Crystal structure at 1.8 A resolution of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis

scientific article published on March 2004

Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6

scientific article

Crystal structure of 3-carboxy-cis,cis-muconate lactonizing enzyme from Pseudomonas putida, a fumarase class II type cycloisomerase: enzyme evolution in parallel pathways

scientific article

Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT

scientific article

Crystal structure of a D-amino acid aminotransferase: how the protein controls stereoselectivity

scientific article

Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator

scientific article

Crystal structure of recombinant chicken triosephosphate isomerase-phosphoglycolohydroxamate complex at 1.8-A resolution

scientific article

Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites

scientific article published on 10 October 2016

Crystal structure of the proenzyme domain of plasminogen

scientific article

Crystal structures of Escherichia coli and Salmonella typhimurium 3-isopropylmalate dehydrogenase and comparison with their thermophilic counterpart from Thermus thermophilus

scientific article

Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins

scientific article

Crystal structures of L201A mutant of D-amino acid aminotransferase at 2.0 A resolution: implication of the structural role of Leu201 in transamination ⬇️

scientific article published on August 1, 1998

Crystalline ribonuclease A loses function below the dynamical transition at 220 K

scientific article published in Nature

Crystallographic Study of Steps along the Reaction Pathway of d-Amino Acid Aminotransferase, ⬇️

scientific article published on April 7, 1998

Decreased sensitivity to changes in the concentration of metal ions as the basis for the hyperactivity of DtxR(E175K)

scientific article

Design, synthesis, and characterization of a potent xylose isomerase inhibitor, D-threonohydroxamic acid, and high-resolution X-ray crystallographic structure of the enzyme-inhibitor complex

scientific article

Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase

scientific article

Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase

scientific article

Determinants of the Src Homology Domain 3-Like Fold

scientific article

Determination of the structure of alanine racemase from Bacillus stearothermophilus at 1.9-A resolution

scientific article

Direct crystallographic observation of an acyl-enzyme intermediate in the elastase-catalyzed hydrolysis of a peptidyl ester substrate: Exploiting the "glass transition" in protein dynamics

scientific article published on 2 November 2006

Direct structural observation of an acyl-enzyme intermediate in the hydrolysis of an ester substrate by elastase

scientific article

Diversity in hapten recognition: structural study of an anti-cocaine antibody M82G2.

scientific article published on 21 April 2005

Dual chemistry catalyzed by human acireductone dioxygenase

scientific article published on 5 January 2017

Effect of a Y265F mutant on the transamination-based cycloserine inactivation of alanine racemase

scientific article

Effects of pH and Iminosugar Pharmacological Chaperones on Lysosomal Glycosidase Structure and Stability

scientific article

Effects of the E177K mutation in D-amino acid transaminase. Studies on an essential coenzyme anchoring group that contributes to stereochemical fidelity

scientific article

Enzyme crystal structure in a neat organic solvent

scientific article

Evidence of the Participation of Remote Residues in the Catalytic Activity of Co-Type Nitrile Hydratase from Pseudomonas putida

scientific article

Evolution of an enzyme active site: The structure of a new crystal form of muconate lactonizing enzyme compared with mandelate racemase and enolase ⬇️

scientific article published on September 1, 1998

Expression, crystallization and preliminary crystallographic analysis of human carbonyl reductase

scientific article published in December 1994

Function by serendipity

scientific article published in January 2002

Functional Genomics with YBL036c.

scientific article

Galactose Mutarotase: pH Dependence of Enzymatic Mutarotation ⬇️

scientific article published on April 22, 2003

Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme

scientific article

Hydrogen Bond Coupling in the Ketosteroid Isomerase Active Site

scientific article

Identification of functional subclasses in the DJ-1 superfamily proteins

scientific article

Identification of structural and catalytic classes of highly conserved amino acid residues in lysine 2,3-aminomutase

scientific article published on October 2006

Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms"

scientific article

Inactivation of subtilisin Carlsberg by N-((tert-butoxycarbonyl)alanylprolylphenylalanyl)-O-benzoylhydroxyl- amine: formation of a covalent enzyme-inhibitor linkage in the form of a carbamate derivative

scientific article

Inhibition of Chymotrypsin by a Complex of Ortho-Vanadate and Benzohydroxamic Acid:  Structure of the Inert Complex and Its Mechanistic Interpretation †

scientific article

Inhibition of the aminopeptidase from Aeromonas proteolytica by L-leucinephosphonic acid. Spectroscopic and crystallographic characterization of the transition state of peptide hydrolysis

scientific article

Interaction of a Peptidomimetic Aminimide Inhibitor with Elastase ⬇️

scientific article published on July 7, 1995

Kinetic, spectroscopic, and X-ray crystallographic characterization of the functional E151H aminopeptidase from Aeromonas proteolytica.

scientific article published in September 2005

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

scientific article published on 31 July 2012

Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain ⬇️

scientific article published on August 7, 2012

Malonate: a versatile cryoprotectant and stabilizing solution for salt-grown macromolecular crystals

scientific article

Mass spectrometry tools for analysis of intermolecular interactions

scientific article

Mechanism of Inactivation of Escherichia coli Aspartate Aminotransferase by ( S )-4-Amino-4,5-dihydro-2-furancarboxylic Acid,

scientific article

Mechanism of metal ion activation of the diphtheria toxin repressor DtxR.

scientific article

Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 1. Product-bound structures

scientific article

Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 2. Substrate modeling and active site mutations

scientific article

Metal stoichiometry and functional studies of the diphtheria toxin repressor

scientific article

Metal-Dependent Function of a Mammalian Acireductone Dioxygenase

scientific article

Methyl groups of thymine bases are important for nucleic acid recognition by DtxR

scientific article

Molecular metamorphosis

scientific article published in Nature

Multiple solvent crystal structures: probing binding sites, plasticity and hydration

scientific article published on 30 January 2006

Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2

scientific article (publication date: May 2014)

Nature of the inactivation of elastase by N-peptidyl-O-aroyl hydroxylamine as a function of pH

scientific article

Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease

scientific article published on 29 June 2015

Open questions - in brief: Beyond -omics, missing motor proteins, and getting from molecules to organisms ⬇️

scientific article published on January 31, 2013

PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation

scientific article published on 27 March 2017

Pharmacological chaperones stabilize retromer to limit APP processing

scientific article

Photolysis and deacylation of inhibited chymotrypsin

scientific article

Polyamine pathway contributes to the pathogenesis of Parkinson disease ⬇️

scientific article published on September 13, 2010

Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage

scientific article published on 26 August 2013

Prediction of interaction sites from apo 3D structures when the holo conformation is different

scientific article

Probing the Active Center of Benzaldehyde Lyase with Substitutions and the Pseudosubstrate Analogue Benzoylphosphonic Acid Methyl Ester †

scientific article

Proteases: to each his own

scientific article published in Nature

Proteostasis and Movement Disorders: Parkinson's Disease and Amyotrophic Lateral Sclerosis ⬇️

scientific article published on October 1, 2011

Purification and crystallization of benzoylformate decarboxylase ⬇️

scientific article published on May 1, 1995

Purification, crystallization and molecular symmetry of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis

scientific article published on 24 January 2002

Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site

scientific article

Reaction of Alanine Racemase with 1-Aminoethylphosphonic Acid Forms a Stable External Aldimine, ⬇️

scientific article published on July 21, 1998

Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy

scientific article published on August 2016

Role of the N-terminal helix in the metal ion-induced activation of the diphtheria toxin repressor DtxR

scientific article

Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid

scientific article

Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.

scientific article published on 17 August 2017

Snapshot of a Reaction Intermediate: Analysis of Benzoylformate Decarboxylase in Complex with a Benzoylphosphonate Inhibitor †

scientific article

Spectroscopic and X-ray crystallographic characterization of bestatin bound to the aminopeptidase from Aeromonas (Vibrio) proteolytica

scientific article

Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis

scientific article

Structural Consequences of Cysteinylation of Cu/Zn-Superoxide Dismutase

scientific article

Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal structures of complexes with trifluoroacetyl-dipeptide-anilide inhibitors

scientific article

Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1

scholarly article

Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases

scientific article published in March 2004

Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).

scientific article published on 27 March 2017

Structure and activity of two photoreversible cinnamates bound to chymotrypsin

scientific article

Structure and mechanism of benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633, a member of the Class 3 aldehyde dehydrogenase superfamily

scientific article published on 9 March 2017

Structure and specificity of a quorum-quenching lactonase (AiiB) from Agrobacterium tumefaciens

scientific article

Structure of a Michaelis complex analogue: propionate binds in the substrate carboxylate site of alanine racemase

scientific article

Structure of a eukaryotic thiaminase I

scientific article

Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease

scientific article

Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis

scientific article

Structure of the Mg(2+)-bound form of CheY and mechanism of phosphoryl transfer in bacterial chemotaxis

scientific article

Structure of the metal-ion-activated diphtheria toxin repressor/ tox operator complex ⬇️

scientific article published on July 30, 1998

Structure of the triosephosphate isomerase-phosphoglycolohydroxamate complex: an analogue of the intermediate on the reaction pathway

scientific article

Structures of the apo- and the metal ion-activated forms of the diphtheria tox repressor from Corynebacterium diphtheriae

scientific article

Substrate Inhibition of d-Amino Acid Transaminase and Protection by Salts and by Reduced Nicotinamide Adenine Dinucleotide: Isolation and Initial Characterization of a Pyridoxo Intermediate Related to Inactivation ⬇️

scientific article published on March 3, 1998

Testing Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole

scientific article

Testing electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion hole

scientific article

The 'glass transition' in protein dynamics: what it is, why it occurs, and how to exploit it.

scientific article published on September 2003

The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

scientific article

The 1.20 A resolution crystal structure of the aminopeptidase from Aeromonas proteolytica complexed with tris: a tale of buffer inhibition

scientific article

The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: A member of the DJ-1/ThiJ/PfpI superfamily

scientific article

The 2.1-A resolution structure of iron superoxide dismutase from Pseudomonas ovalis

scientific article

The Alrestatin Double-Decker: Binding of Two Inhibitor Molecules to Human Aldose Reductase Reveals a New Specificity Determinant ⬇️

scientific article published on December 23, 1997

The Crystal Structure of Benzoylformate Decarboxylase at 1.6 Å Resolution: Diversity of Catalytic Residues in Thiamin Diphosphate-Dependent Enzymes, ⬇️

scientific article published on July 14, 1998

The EMBO biocatalysis conference "The biochemistry and chemistry of biocatalysis: from understanding to design".

scientific article published on 24 April 2017

The Metal Drives the Chemistry: Dual Functions of Acireductone Dioxygenase

scientific article

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

scholarly article

The Structural Basis for Pseudoreversion of the E165D Lesion by the Secondary S96P Mutation in Triosephosphate Isomerase Depends on the Positions of Active Site Water Molecules ⬇️

scientific article published on October 17, 1995

The aminopeptidase from Aeromonas proteolytica can function as an esterase

scientific article published on 11 August 2001

The atomic resolution crystal structure of the YajL (ThiJ) protein from Escherichia coli: a close prokaryotic homologue of the Parkinsonism-associated protein DJ-1.

scientific article published on 2 September 2005

The catalytic pathway of cytochrome p450cam at atomic resolution

scientific article

The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)

scientific article

The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity

scientific article

The role of residues outside the active site: structural basis for function of C191 mutants of Escherichia coli aspartate aminotransferase

scientific article

The role of water in the catalytic efficiency of triosephosphate isomerase

scientific article

The sheep in wolfs clothing

scientific article published in Nature

The structural basis for pseudoreversion of the H95N lesion by the secondary S96P mutation in triosephosphate isomerase

scientific article

The structural basis for the altered substrate specificity of the R292D active site mutant of aspartate aminotransferase from E. coli

scientific article

The use of pharmacological retromer chaperones in Alzheimer's disease and other endosomal-related disorders

scientific article

The x-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale

scientific article

Three-dimensional structure of chymotrypsin inactivated with (2S)-N-acetyl-L-alanyl-L-phenylalanyl alpha-chloroethane: implications for the mechanism of inactivation of serine proteases by chloroketones

scientific article

Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis

scientific article

Time-of-flight neutron diffraction study of bovine γ-chymotrypsin at the Protein Crystallography Station

scientific article

Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme

scientific article

What are pharmacological chaperones and why are they interesting?

scientific article published on 13 October 2009

X-ray crystallographic characterization of the Co(II)-substituted Tris-bound form of the aminopeptidase from Aeromonas proteolytica

scientific article

X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis

scientific article

Xylose isomerase in substrate and inhibitor michaelis states: atomic resolution studies of a metal-mediated hydride shift

scientific article

Zinc Coordination Geometry and Ligand Binding Affinity: The Structural and Kinetic Analysis of the Second-Shell Serine 228 Residue and the Methionine 180 Residue of the Aminopeptidase from Vibrio proteolyticus †

scientific article

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