List of works by Melanie Waldenberger

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

scientific article

16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy

scientific article published on 16 June 2014

52 Genetic Loci Influencing Myocardial Mass

scientific article

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

scientific article

A catalog of genetic loci associated with kidney function from analyses of a million individuals

scientific article published on 31 May 2019

A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure

scientific article published on 27 March 2015

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

scientific article

A meta-analysis of gene expression signatures of blood pressure and hypertension

scientific article (publication date: March 2015)

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

scientific article published on 20 August 2019

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

scientific article published on 10 April 2019

Activated immune-inflammatory pathways are associated with long-standing depressive symptoms: Evidence from gene-set enrichment analyses in the Young Finns Study

scientific article

An atlas of genetic influences on human blood metabolites

scientific article

Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction

Anxiety Associated Increased CpG Methylation In The Promoter of Asb1: A Translational Approach Evidenced By Epidemiological And Clinical Studies And A Murine Model

scientific article published on 25 May 2017

Are Epigenetic Factors Implicated in Chronic Widespread Pain?

scientific article

Arsenic and gallbladder cancer risk: Mendelian randomization analysis of European prospective data

scientific article published on 31 December 2019

Association between DNA Methylation in Whole Blood and Measures of Glucose Metabolism: KORA F4 Study

scientific article

Association between Usual Dietary Intake of Food Groups and DNA Methylation and Effect Modification by Metabotype in the KORA FF4 Cohort

scientific article published in 2022

Association of Methylation Signals With Incident Coronary Heart Disease in an Epigenome-Wide Assessment of Circulating Tumor Necrosis Factor α.

scientific article

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

scientific article published in Nature Communications

Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism-The Young Finns Study

scientific article published on 05 December 2016

Blood pathway analyses reveal differences between prediabetic subjects with or without dyslipidaemia. The Cardiovascular Risk in Young Finns Study

scientific article published on 13 June 2017

Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: a cross-sectional analysis in population-based data

scientific article

Characterization of whole-genome autosomal differences of DNA methylation between men and women

scientific article

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

scientific article published on 2 March 2016

Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval

Common coding variant in SERPINA1 increases the risk for large artery stroke

scientific article

Compound heterozygosity of low-frequency promoter deletions and rare loss-of-function mutations in TXNL4A causes Burn-McKeown syndrome

scientific article

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

scientific article published on 26 May 2017

Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

scientific article published on 30 March 2015

DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies

article published in 2018

DNA methylation and body-mass index: a genome-wide analysis

scientific article

DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures

scientific article published on 07 January 2021

DNA methylation of lipid-related genes affects blood lipid levels

scientific article published on 12 January 2015

DNA methylation signatures in peripheral blood strongly predict all-cause mortality

scientific article published on 17 March 2017

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

scientific article published on 12 December 2016

DNA methylation-based measures of biological age: meta-analysis predicting time to death

scientific article

DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

scientific article published on 19 December 2013

Data harmonization and federated analysis of population-based studies: the BioSHaRE project

scientific article

DataSHIELD: taking the analysis to the data, not the data to the analysis

scientific article

Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation.

scientific article published on 8 January 2018

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Discovery and fine mapping of serum protein loci through transethnic meta-analysis

scientific article

Discovery of novel heart rate-associated loci using the Exome Chip

scientific article

Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals

scientific article published on 01 June 2019

Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues

scientific article

Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB-driven inflammation and cardiovascular risk.

scientific article published on 21 May 2019

Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits

scientific article published on 06 September 2013

Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits

scientific article published on 03 January 2020

Epigenome-wide analysis of methylation changes in the sequence of gallstone disease, dysplasia, and gallbladder cancer

scientific article published on 05 October 2020

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

scientific article published on 21 December 2016

Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk

scientific article published on 2 August 2017

Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

scientific article published in July 2017

Evidence for Stress-like Alterations in the HPA-Axis in Women Taking Oral Contraceptives

scientific article published on 26 October 2017

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017

ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals

FTO, obesity and the adolescent brain

scientific article published on 30 November 2012

Fifteen Genetic Loci Associated With the Electrocardiographic P Wave

scientific article

Gallstones, Body Mass Index, C-reactive Protein and Gallbladder Cancer - Mendelian Randomization Analysis of Chilean and European Genotype Data

scientific article published on 06 September 2020

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

scientific article published on 05 May 2020

Gene-gene Interaction Analyses for Atrial Fibrillation

scientific article

Genetic Determinants of Electrocardiographic P-wave Duration and Relation to Atrial Fibrillation

scientific article published on 21 August 2020

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium

scientific article published on 12 September 2017

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

scientific article

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

scientific article

Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes

scientific article

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

scientific article published on 30 October 2017

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

scientific article published in November 2018

Genome-Wide Analysis of DNA Methylation and Fine Particulate Matter Air Pollution in Three Study Populations: KORA F3, KORA F4, and the Normative Aging Study

scientific article published on 05 January 2016

Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality

scientific article published on 9 September 2015

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.

scientific article

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

scientific article published in February 2013

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

scientific article published on 11 September 2019

Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

scientific article published on 24 January 2019

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

scientific article

Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.

scientific article

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

scientific article

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

scientific article

Genome-wide methylation data mirror ancestry information

scientific article

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

scientific article published on 23 March 2016

Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research

scientific article

Improvement of myocardial infarction risk prediction via inflammation-associated metabolite biomarkers

scientific article published on 2 March 2017

Influence of Storage and Inter- and Intra-Assay Variability on the Measurement of Inflammatory Biomarkers in Population-Based Biobanking

scientific article published on 13 November 2017

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

scientific article

Layered genetic control of DNA methylation and gene expression: a locus of multiple sclerosis in healthy individuals

scientific article

Ldlr and ApoE mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease

MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study

scientific article published on 25 June 2016

Mapping the genetic architecture of gene regulation in whole blood

scientific article

Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects

scientific article

Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease

scientific article published on 10 May 2019

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

scientific article

Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

scientific article published on 30 October 2020

Metabolite profiling reveals new insights into the regulation of serum urate in humans

scientific article published on 20 July 2013

Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism

scientific article

Mitochondrial GWA Analysis of Lipid Profile Identifies Genetic Variants to Be Associated with HDL Cholesterol and Triglyceride Levels

scientific article published on 6 May 2015

Mitochondrial genetic variants identified to be associated with BMI in adults

scientific article published in 2014

Modulation of genetic associations with serum urate levels by body-mass-index in humans

scientific article

Molecular Characterization of the NLRC4 Expression in Relation to Interleukin-18 Levels

scientific article

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

scientific article published on 21 May 2020

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

article

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

scientific article published in Nature Communications

Multi-omic signature of body weight change: results from a population-based cohort study

scientific article

No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects

scientific article

Novel DNA Methylation Sites Influence Expression in Relation to Smoking

scientific article published on 20 August 2018

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

scientific article published on 18 June 2018

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

scientific article

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation

scientific article published on 17 June 2016

On the potential of models for location and scale for genome-wide DNA methylation data

scientific article

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

scientific article published in Nature Communications

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

scientific article

Pre-analytical sample quality: metabolite ratios as an intrinsic marker for prolonged room temperature exposure of serum samples

scientific article published on 30 March 2015

Predicting sudden cardiac death using common genetic risk variants for coronary artery disease

scientific article published on 23 April 2015

Prenatal and early life influences on epigenetic age in children: a study of mother-offspring pairs from two cohort studies

scientific article published on 5 November 2015

Prenatal exposure to maternal cigarette smoking and DNA methylation: epigenome-wide association in a discovery sample of adolescents and replication in an independent cohort at birth through 17 years of age.

scientific article

Protein markers and risk of type 2 diabetes and prediabetes: a targeted proteomics approach in the KORA F4/FF4 study

scientific article published on 31 December 2018

RL-SKAT: An Exact and Efficient Score Test for Heritability and Set Tests.

scientific article published on 12 October 2017

Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF

scientific article

Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon

scientific journal article

SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

scientific article published on 5 December 2016

Selected single-nucleotide polymorphisms in FOXE1, SERPINA5, FTO, EVPL, TICAM1 and SCARB1 are associated with papillary and follicular thyroid cancer risk: replication study in a German population

scientific article published on 28 April 2016

Successful Replication of GWAS Hits for Multiple Sclerosis in 10,000 Germans Using the Exome Array

scientific article published on 26 October 2015

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease ⬇️

scientific article published on February 2017

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

scientific article published on 02 October 2019

Telomere length in circulating leukocytes is associated with lung function and disease.

scientific article published on 5 December 2013

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers

scientific article published on 03 October 2016

The Pharmacogenetic Footprint of ACE Inhibition: A Population-Based Metabolomics Study

scientific article

The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies

scientific article

The transcriptional landscape of age in human peripheral blood

scientific article

Tobacco smoking leads to extensive genome-wide changes in DNA methylation

scientific article

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

scientific article

Vitamin E supplementation is associated with lower levels of C-reactive protein only in higher dosages and combined with other antioxidants: The Cooperative Health Research in the Region of Augsburg (KORA) F4 study

scientific article published on 21 April 2015

pulver: an R package for parallel ultra-rapid p-value computation for linear regression interaction terms

scientific article published on 29 September 2017

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