List of works - Valeriya Lyssenko

40 EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004 ⬇️

article

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

scientific article published on 27 April 2018

A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells

scientific article (publication date: 2016)

A central role for GRB10 in regulation of islet function in man.

scientific article published on 3 April 2014

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

scientific article published on January 2011

A common variant of HMGA2 is associated with adult and childhood height in the general population

scientific article

A common variant upstream of the PAX6 gene influences islet function in man.

scientific article published on 16 September 2011

A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study

scientific article published on 8 May 2010

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

scientific article published on 13 May 2012

A genome-wide association search for type 2 diabetes genes in African Americans

scientific article published on 4 January 2012

A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes

article

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

scientific article published on 23 November 2016

A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets

scientific article

A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion

scientific article published on 07 July 2009

Age- and sex-specific causal effects of adiposity on cardiovascular risk factors

scientific article published on 23 February 2015

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

scientific article published on 31 May 2017

Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults

scientific article published on 17 April 2009

Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes

scientific article

Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies

scientific article

Atrial Natriuretic Peptide in the High Normal Range Is Associated With Lower Prevalence of Insulin Resistance.

scientific article published on 27 January 2016

Authors' Reply

article published 28 February 2006

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.

scientific article published on 23 June 2016

Characteristics and prognosis of healthy severe obesity (HSO) subjects - The Malmo Preventive Project

Clinical risk factors, DNA variants, and the development of type 2 diabetes

scientific article

Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time

scientific article

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

scientific article

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

scientific article

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

scientific article

Common variants in HNF-1 alpha and risk of type 2 diabetes

scientific article published on 11 October 2006

Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes

scientific article

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

scholarly article published in Nature Genetics

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

scientific article

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

scientific article

Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance

scientific article

Effect of a common variant of the PCSK2 gene on reduced insulin secretion

scientific article published on 26 September 2012

Effects of common genetic variants associated with type 2 diabetes and glycemic traits on α- and β-cell function and insulin action in humans

scientific article published on 4 April 2013

Erratum. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019;68:441-456

scientific article published on 27 April 2020

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article published in May 2010

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 23 January 2018

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

article by Jason Flannick et al published 22 May 2019 in Nature

FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies

scientific article published on 11 March 2011

Fasting versus postload plasma glucose concentration and the risk for future type 2 diabetes: results from the Botnia Study

scientific article

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Functional variant disrupts insulin induction of USF1: mechanism for USF1-associated dyslipidemias

scientific article published on 12 June 2009

GAD antibody positivity predicts type 2 diabetes in an adult population

scientific article

Genetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmö Diet and Cancer Cohort

Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study).

scientific article published on 24 April 2008

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

scientific article published on 18 November 2009

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

scientific article

Genetic prediction of future type 2 diabetes

scientific article

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

scientific article published on 21 March 2016

Genetic screening for the risk of type 2 diabetes: worthless or valuable?

scientific article

Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes

scientific article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes

scientific article published on February 2013

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

scientific journal article

Genetics of type 2 diabetes. An overview

scientific article published on December 2009

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

scientific article (publication date: June 2007)

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

scientific article

Genome-wide association study for type 2 diabetes: clinical applications

scientific article published on April 2009

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

scientific article

Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

scientific article published on 22 September 2015

Glucose-dependent insulinotropic polypeptide (GIP) and GIP receptor (GIPR) genes: An association analysis of polymorphisms and bone in young and elderly women

scientific article

Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study

article by Peter Almgren et al published 9 August 2011 in Diabetologia

IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies

scientific article

Identification of ten loci associated with height highlights new biological pathways in human growth

scientific article

Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia

scientific article published on 10 October 2016

Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes

scientific article published on 19 February 2009

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index

scientific article

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

scientific article

Link between GIP and osteopontin in adipose tissue and insulin resistance

scientific article published on 24 January 2013

Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes

scientific article published on 14 July 2020

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

scientific article published in August 2007

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

scientific article published on 18 April 2009

Minimal contribution of fasting hyperglycemia to the incidence of type 2 diabetes in subjects with normal 2-h plasma glucose

scientific article

Modelling of OGTT curve identifies 1 h plasma glucose level as a strong predictor of incident type 2 diabetes: results from two prospective cohorts

scientific article published on 8 October 2014

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

scientific article published on 28 November 2018

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes

scientific article

Pleiotropic effects of GIP on islet function involve osteopontin

scientific article

Polymorphisms in the gene encoding the voltage-dependent Ca(2+) channel Ca (V)2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretion

scientific article

Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants

Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes

scientific article published in January 2005

Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults

scientific article published on 26 March 2009

Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus

scientific article

Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

scientific article

Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes--a role for the transcription factor NFAT and phosphodiesterase 3B.

scientific article published on 7 August 2012

Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes

scientific article

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 19 December 2017

The Genetic Landscape of Renal Complications in Type 1 Diabetes

scientific article

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.

scientific article published on 14 March 2009

The association of mitochondrial content with prevalent and incident type 2 diabetes.

scientific article published on 11 February 2010

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

The human L-type calcium channel Cav1.3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes

scientific article published on 15 November 2012

The impact of low-frequency and rare variants on lipid levels

scientific article published on 11 May 2015

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

scientific article (publication date: 2013)

The search for putative unifying genetic factors for components of the metabolic syndrome

scientific article published on 14 October 2008

The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes

scientific article published on May 2010

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

scientific article

Underlying genetic models of inheritance in established type 2 diabetes associations

scientific article published on 14 July 2009

Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes

scientific article published on 6 May 2015

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

scientific article published in September 2008

Variants in MTNR1B influence fasting glucose levels

scientific article

Variants in the FFAR1 gene are associated with beta cell function

scientific article

Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality

scientific article

Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in mice and humans

scientific article published on 26 February 2015

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels

scientific article

List of works by Valeriya Lyssenko

40 EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004 ⬇️

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells

A central role for GRB10 in regulation of islet function in man.

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

A common variant of HMGA2 is associated with adult and childhood height in the general population

A common variant upstream of the PAX6 gene influences islet function in man.

A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

A genome-wide association search for type 2 diabetes genes in African Americans

A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets

A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion

Age- and sex-specific causal effects of adiposity on cardiovascular risk factors

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults

Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes

Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies

Atrial Natriuretic Peptide in the High Normal Range Is Associated With Lower Prevalence of Insulin Resistance.

Authors' Reply

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.

Characteristics and prognosis of healthy severe obesity (HSO) subjects - The Malmo Preventive Project

Clinical risk factors, DNA variants, and the development of type 2 diabetes

Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

Common variants in HNF-1 alpha and risk of type 2 diabetes

Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Defining the role of common variation in the genomic and biological architecture of adult human height

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance

Effect of a common variant of the PCSK2 gene on reduced insulin secretion

Effects of common genetic variants associated with type 2 diabetes and glycemic traits on α- and β-cell function and insulin action in humans

Erratum. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019;68:441-456

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies

Fasting versus postload plasma glucose concentration and the risk for future type 2 diabetes: results from the Botnia Study

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Functional variant disrupts insulin induction of USF1: mechanism for USF1-associated dyslipidemias

GAD antibody positivity predicts type 2 diabetes in an adult population

Genetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmö Diet and Cancer Cohort

Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study).

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Genetic prediction of future type 2 diabetes

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

Genetic screening for the risk of type 2 diabetes: worthless or valuable?

Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes

Genetic studies of body mass index yield new insights for obesity biology

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

Genetics of type 2 diabetes. An overview

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Genome-wide association study for type 2 diabetes: clinical applications

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

Glucose-dependent insulinotropic polypeptide (GIP) and GIP receptor (GIPR) genes: An association analysis of polymorphisms and bone in young and elderly women

Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study

IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies

Identification of ten loci associated with height highlights new biological pathways in human growth

Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia

Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Link between GIP and osteopontin in adipose tissue and insulin resistance

Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

Minimal contribution of fasting hyperglycemia to the incidence of type 2 diabetes in subjects with normal 2-h plasma glucose

Modelling of OGTT curve identifies 1 h plasma glucose level as a strong predictor of incident type 2 diabetes: results from two prospective cohorts

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control