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List of works by Reedik Mägi

1A.11: ASSOCIATION OF KIF6 AND HMGCR LOCI WITH CARDIOMETABOLIC PHENOTYPES AND RESPONSE TO STATIN THERAPY IN THE BRISIGHELLA COHORT.

scientific article published in June 2015

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

scientific article

A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations

scientific article

A catalog of genetic loci associated with kidney function from analyses of a million individuals

scientific article published on 31 May 2019

A central role for GRB10 in regulation of islet function in man.

scientific article published on 3 April 2014

A common biological basis of obesity and nicotine addiction

scientific article

A first-generation linkage disequilibrium map of human chromosome 22

scientific article published in Nature

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

scientific article published on 13 May 2012

A genome-wide association meta-analysis identifies new childhood obesity loci

scientific article

A genome-wide association search for type 2 diabetes genes in African Americans

scientific article published on 4 January 2012

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

scientific article published on 10 April 2019

A parallel SNP array study of genomic aberrations associated with mental retardation in patients and general population in Estonia

scientific article published on 26 November 2010

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

scientific article published on 23 November 2016

A recent bottleneck of Y chromosome diversity coincides with a global change in culture

scientific article

A whole-blood transcriptome meta-analysis identifies gene expression signatures of cigarette smoking

scientific article

Adiposity as a cause of cardiovascular disease: a Mendelian randomization study

scientific article

Age- and sex-specific causal effects of adiposity on cardiovascular risk factors

scientific article published on 23 February 2015

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

scientific article published on 31 May 2017

An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population

scientific article

Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals

scientific article published on 02 April 2020

Assessing the impact of missing genotype data in rare variant association analysis

scientific article

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

scientific article (publication date: November 2010)

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

scientific article published on 14 January 2019

Associations between milk performance traits in Holstein cows and 16 candidate SNPs identified by arrayed primer extension (APEX) microarray.

scientific article published in January 2006

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability

scientific article published on 01 July 2019

Biological interpretation of genome-wide association studies using predicted gene functions

scientific article published on 19 January 2015

Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons

scientific article

CUBN is a gene locus for albuminuria

scientific article

Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

scientific article (publication date: 2013)

Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes

scientific article

Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu

scientific article

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

scientific article

Common variants in Mendelian kidney disease genes and their association with renal function

scientific article published on 12 September 2013

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

scientific article published on 28 December 2016

Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery

scientific article

Copy Number Variations and Cognitive Phenotypes in Unselected Populations

Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases

scientific article published on 14 June 2016

Copy number variations and cognitive phenotypes in unselected populations

scientific article

Correction: Genetic Structure of Europeans: A View from the North–East.

scientific article

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 23 August 2017

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Corrigendum: Rare coding variants and X-linked loci associated with age at menarche

scientific article published on 17 December 2015

DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to receptive phase

scientific article

DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns

scientific article

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

scientific article published on 26 August 2021

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

scientific article

Development of a single tube 640-plex genotyping method for detection of nucleic acid variations on microarrays

scientific article published on 5 June 2008

Differences in local population history at the finest level: the case of the Estonian population

scientific article published on 25 July 2020

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

scientific article published on 23 November 2020

Distribution and medical impact of loss-of-function variants in the Finnish founder population

scientific article

Dominance genetic variation contributes little to the missing heritability for human complex traits

scientific article

Erratum to: DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns.

scientific article published on November 2016

Erratum: Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

scientific article published in October 2016

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article published in November 2011

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article published in May 2010

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 23 January 2018

Evaluating the performance of commercial whole-genome marker sets for capturing common genetic variation

scientific article

Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations

scientific article published on 12 October 2017

Evolution of the pygmy phenotype: evidence of positive selection fro genome-wide scans in African, Asian, and Melanesian pygmies

scientific article

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits

scientific article

Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017

Extent, causes, and consequences of small RNA expression variation in human adipose tissue

scientific article

FTO genotype is associated with phenotypic variability of body mass index

scientific article published on 16 September 2012

GWAMA: software for genome-wide association meta-analysis

scientific article

GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

scientific article published on 27 August 2018

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

scientific article published on 05 May 2020

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

scientific article

Genetic evidence of assortative mating in humans

article

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

scientific article

Genetic insights into biological mechanisms governing human ovarian ageing

scientific article

Genetic structure of Europeans: a view from the North-East

scientific article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

scientific article

Genetic variants linked to education predict longevity

scientific article (publication date: 22 November 2016)

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

scientific article published in November 2018

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

scientific article published on 30 January 2017

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

scientific article

Genome-wide association analysis of imputed rare variants: application to seven common complex diseases

scientific article published on 5 September 2012

Genome-wide association and functional follow-up reveals new loci for kidney function

scientific article

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women

scientific article

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

scientific article

Genome-wide association study identifies 48 common genetic variants associated with handedness

scientific article published on 28 September 2020

Genome-wide association study identifies 74 loci associated with educational attainment

scientific article published on 11 May 2016

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

scientific article published on 16 October 2011

Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

scientific article

Genome-wide genetic homogeneity between sexes and populations for human height and body mass index

scientific article published on 22 October 2015

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

scientific article published on 13 October 2017

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

scientific article

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 27 April 2017

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

scientific article

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits ⬇️

scientific article published on 21 June 2016

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

scientific article published on 23 September 2016

Genomic analyses inform on migration events during the peopling of Eurasia

scientific article (publication date: 13 October 2016)

Genomic inflation factors under polygenic inheritance

scientific article

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age

article

Hundreds of variants clustered in genomic loci and biological pathways affect human height

scientific article

Identification of seven loci affecting mean telomere length and their association with disease

scientific article published on April 2013

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

scientific article

Imprinted genes and imprinting control regions show predominant intermediate methylation in adult somatic tissues

scientific article published on 23 March 2016

Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel

scientific article

In vitro fertilization does not increase the incidence of de novo copy number alterations in fetal and placental lineages

scientific article published on 04 November 2019

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

scientific article published on 8 September 2012

Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies

scientific article

Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults

scientific article published on 5 March 2015

Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium

scientific article

Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases

scientific article

Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair

scientific article published in December 2015

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

scientific article

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

scientific article published in November 2015

Linkage disequilibrium patterns and tagSNP transferability among European populations

scientific article

MARV: a tool for genome-wide multi-phenotype analysis of rare variants

scientific article

Mapping the genetic architecture of gene regulation in whole blood

scientific article

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

scientific article

Mining the human phenome using allelic scores that index biological intermediates

scientific article

Modulation of genetic associations with serum urate levels by body-mass-index in humans

scientific article

Molecular diagnosis of Down syndrome using quantitative APEX-2 microarrays

scientific article published in December 2010

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

article

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

scientific article published in Nature Communications

Multi-ethnic fine-mapping of 14 central adiposity loci

scientific article

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

scientific article published in October 2017

New gene functions in megakaryopoiesis and platelet formation

scientific article published on 30 November 2011

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

New loci associated with kidney function and chronic kidney disease

scientific article

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

scientific article published on February 2016

Non-syndromic tooth agenesis associated with a nonsense mutation in ectodysplasin-A (EDA).

scientific article published on 19 April 2013

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

scientific article published on 18 June 2018

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

scientific article

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond

scientific article published on 21 May 2016

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

article

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

scientific article

Patterns of genetic connectedness between modern and medieval Estonian genomes reveal the origins of a major ancestry component of the Finnish population

scientific article published on 18 August 2021

Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores

scientific article published on 11 August 2016

Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

scientific article

Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies

scientific article

Population genetic structure in Indian Austroasiatic speakers: the role of landscape barriers and sex-specific admixture

scientific article

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

article

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Quality control and conduct of genome-wide association meta-analyses

scientific article

Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions

scientific article

Rare coding variants and X-linked loci associated with age at menarche

scientific article

Reconstructing recent population history while mapping rare variants using haplotypes

scientific article published on 10 April 2019

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

article

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

scientific article published on 9 April 2018

RegScan: a GWAS tool for quick estimation of allele effects on continuous traits and their combinations

scientific article published on 5 September 2013

Regression and data mining methods for analyses of multiple rare variants in the Genetic Analysis Workshop 17 mini-exome data

scientific article

SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes

scientific article

Selective sweep on human amylase genes postdates the split with Neanderthals

scientific article

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 19 December 2017

Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior

scientific article

Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption

scientific article

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

scientific article

Shared and unique components of human population structure and genome-wide signals of positive selection in South Asia

scientific article

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

scientific article published on 02 October 2019

The Arrival of Siberian Ancestry Connecting the Eastern Baltic to Uralic Speakers further East

scientific article published on 09 May 2019

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The Lin28/let-7 axis regulates glucose metabolism

scientific article

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

The impact of low-frequency and rare variants on lipid levels

scientific article published on 11 May 2015

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

scientific article (publication date: 2013)

The whole genome tagSNP selection and transferability among HapMap populations.

scientific article published on January 2006

Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian population

scientific article

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

scientific article published on 03 October 2016

Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans

scientific article

Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes

scientific article published on 6 May 2015

Using RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta

scientific article

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

scientific article

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk

scientific article

Whole-exome sequencing identifies a polymorphism in the BMP5 gene associated with SSRI treatment response in major depression.

scientific article published on 7 August 2013

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