List of works - Wesley C Van Voorhis

A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.

scientific article

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds

scientific article

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

scientific article

BrabA.11339.a: anomalous diffraction and ligand binding guide towards the elucidation of the function of a `putative β-lactamase-like protein' from Brucella melitensis

scientific article

C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins

scientific article published on March 2007

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

scientific article

Chemical genetics of Plasmodium falciparum

scientific article (publication date: 20 May 2010)

Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens

scientific article (publication date: 2014)

Combining functional and structural genomics to sample the essential Burkholderia structome

scientific article

Comparative analysis of glutaredoxin domains from bacterial opportunistic pathogens

scientific article

Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

scientific article

Crystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase

scientific article

Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia

scientific article

Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design

scientific article

Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase

scientific article

Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.

scientific article

Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes

scientific article

Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

scientific article

Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

scientific article

Expression of proteins in Escherichia coli as fusions with maltose-binding protein to rescue non-expressed targets in a high-throughput protein-expression and purification pipeline ⬇️

scientific article published on August 13, 2011

Fragment screening of infectious disease targets in a structural genomics environment

scientific article

Genomic-scale prioritization of drug targets: the TDR Targets database

scientific article

Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy

scientific article published on 21 July 2008

Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes

scientific article published on 18 April 2006

Identification of attractive drug targets in neglected-disease pathogens using an in silico approach

scientific article

In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability

scientific article published on December 2004

Increasing the structural coverage of tuberculosis drug targets

scientific article

Integrated Dataset of Screening Hits against Multiple Neglected Disease Pathogens ⬇️

scientific article published on December 20, 2011

Isothiazole dioxides: synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase.

scientific article

Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1 ⬇️

scientific article published on March 13, 2012

NMR structure of an acyl-carrier protein from Borrelia burgdorferi ⬇️

scientific article published on August 13, 2011

Nanovolume optimization of protein crystal growth using the microcapillary protein crystallization system

scientific article published on 19 August 2010

Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy

scientific article

Novel paradigms for drug discovery: computational multitarget screening

scientific article

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

scientific article (publication date: July 2016)

Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.

scientific article

Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening

scientific article

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

scientific article

Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.

scientific article

Protein farnesyltransferase inhibitors exhibit potent antimalarial activity

scientific article

Protein geranylgeranyltransferase-I of Trypanosoma cruzi

scientific article

Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase

scientific article

Safety and comparability of controlled human Plasmodium falciparum infection by mosquito bite in malaria-naïve subjects at a new facility for sporozoite challenge

scientific article

Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials

scientific article published on 28 August 2007

Solution structure of a putative FKBP-type peptidyl-propyl cis–trans isomerase from Giardia lamblia

scientific article

Solution structure of an arsenate reductase-related protein, YffB, from Brucella melitensis , the etiological agent responsible for brucellosis

scientific article

Solution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis

scientific article

Stabilizing Additives Added during Cell Lysis Aid in the Solubilization of Recombinant Proteins ⬇️

scientific article published on December 20, 2012

Structural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein Farnesyltransferase

scientific article

Structural Basis of the Substrate Specificity of Bifunctional Isocitrate Dehydrogenase Kinase/Phosphatase

scientific article

Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis

scientific article

Structural genomics of pathogenic protozoa: an overview

scientific article

Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites

scientific article published in August 2005

Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.

scientific article published on June 2009

Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites

scientific article published on September 2006

Structure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 Å resolution

scientific article

Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate

scientific article

Structure of a Burkholderia pseudomallei trimeric autotransporter adhesin head

scientific article

Structure of a Nudix hydrolase (MutT) in the Mg 2+ -bound state from Bartonella henselae , the bacterium responsible for cat scratch fever

scientific article

Structure of aTrypanosoma bruceiα/β-hydrolase fold protein with unknown function

scientific article

Structure of fumarate hydratase from Rickettsia prowazekii , the agent of typhus and suspected relative of the mitochondria

scientific article

Structure of the cystathionine γ-synthase MetB from Mycobacterium ulcerans

scientific article

Structure of thymidylate kinase from Ehrlichia chaffeensis ⬇️

scientific article published on August 16, 2011

Structure of triosephosphate isomerase from Cryptosporidium parvum

scientific article

Structures of a putative ζ-class glutathione S -transferase from the pathogenic fungus Coccidioides immitis

scientific article

Structures of phosphopantetheine adenylyltransferase from Burkholderia pseudomallei

scientific article

TDR Targets: a chemogenomics resource for neglected diseases

scientific article published on 23 November 2011

The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase

scientific article

The Role of Medical Structural Genomics in Discovering New Drugs for Infectious Diseases

scientific article

The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix

scientific article

The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs

scientific article

Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation

scientific article

Trypanosoma brucei Glycogen Synthase Kinase-3, A Target for Anti-Trypanosomal Drug Development: A Public-Private Partnership to Identify Novel Leads ⬇️

scientific article published on April 5, 2011

List of works by Wesley C Van Voorhis

A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

BrabA.11339.a: anomalous diffraction and ligand binding guide towards the elucidation of the function of a `putative β-lactamase-like protein' from Brucella melitensis

C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

Chemical genetics of Plasmodium falciparum

Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens

Combining functional and structural genomics to sample the essential Burkholderia structome

Comparative analysis of glutaredoxin domains from bacterial opportunistic pathogens

Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

Crystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase

Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia

Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design

Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase

Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.

Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes

Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

Expression of proteins in Escherichia coli as fusions with maltose-binding protein to rescue non-expressed targets in a high-throughput protein-expression and purification pipeline ⬇️

Fragment screening of infectious disease targets in a structural genomics environment

Genomic-scale prioritization of drug targets: the TDR Targets database

Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy

Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes

Identification of attractive drug targets in neglected-disease pathogens using an in silico approach

In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability

Increasing the structural coverage of tuberculosis drug targets

Integrated Dataset of Screening Hits against Multiple Neglected Disease Pathogens ⬇️

Isothiazole dioxides: synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase.

Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1 ⬇️

NMR structure of an acyl-carrier protein from Borrelia burgdorferi ⬇️

Nanovolume optimization of protein crystal growth using the microcapillary protein crystallization system

Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy

Novel paradigms for drug discovery: computational multitarget screening

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.

Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.

Protein farnesyltransferase inhibitors exhibit potent antimalarial activity

Protein geranylgeranyltransferase-I of Trypanosoma cruzi

Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase

Safety and comparability of controlled human Plasmodium falciparum infection by mosquito bite in malaria-naïve subjects at a new facility for sporozoite challenge

Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials

Solution structure of a putative FKBP-type peptidyl-propyl cis–trans isomerase from Giardia lamblia

Solution structure of an arsenate reductase-related protein, YffB, from Brucella melitensis , the etiological agent responsible for brucellosis

Solution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis

Stabilizing Additives Added during Cell Lysis Aid in the Solubilization of Recombinant Proteins ⬇️

Structural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein Farnesyltransferase

Structural Basis of the Substrate Specificity of Bifunctional Isocitrate Dehydrogenase Kinase/Phosphatase

Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis

Structural genomics of pathogenic protozoa: an overview

Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites

Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.

Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites

Structure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 Å resolution

Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate

Structure of a Burkholderia pseudomallei trimeric autotransporter adhesin head

Structure of a Nudix hydrolase (MutT) in the Mg 2+ -bound state from Bartonella henselae , the bacterium responsible for cat scratch fever

Structure of aTrypanosoma bruceiα/β-hydrolase fold protein with unknown function

Structure of fumarate hydratase from Rickettsia prowazekii , the agent of typhus and suspected relative of the mitochondria

Structure of the cystathionine γ-synthase MetB from Mycobacterium ulcerans

Structure of thymidylate kinase from Ehrlichia chaffeensis ⬇️

Structure of triosephosphate isomerase from Cryptosporidium parvum

Structures of a putative ζ-class glutathione S -transferase from the pathogenic fungus Coccidioides immitis

Structures of phosphopantetheine adenylyltransferase from Burkholderia pseudomallei

TDR Targets: a chemogenomics resource for neglected diseases

The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase

The Role of Medical Structural Genomics in Discovering New Drugs for Infectious Diseases

The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix

The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs

Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation

Trypanosoma brucei Glycogen Synthase Kinase-3, A Target for Anti-Trypanosomal Drug Development: A Public-Private Partnership to Identify Novel Leads ⬇️