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List of works by James C. Eisenach

2007 in review: a dozen steps forward in Anesthesiology

scientific article published on January 2008

A Randomized Controlled Trial Comparing Two Multimodal Analgesic Techniques in Patients Predicted to Have Severe Pain After Cesarean Delivery

scientific article published on 24 March 2015

A pain model after gynecologic surgery: the effect of intrathecal and systemic morphine

scientific article published in November 2006

A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury

scientific article

Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain

scientific article published in September 2005

Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats

scientific article

Adenosine reduces glutamate release in rat spinal synaptosomes

scientific article

Age-dependent responses to nerve injury-induced mechanical allodynia

scientific article published in February 2006

Age-dependent responses to thermal hyperalgesia and mechanical allodynia in a rat model of acute postoperative pain

scientific article published in August 2003

Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism

scientific article published on 20 February 2003

Allosteric modulation of adenosine A1 receptor coupling to G-proteins in brain

scientific article published in May 2005

Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain.

scientific article

An Isobolographic Study of Epidural Clonidine and Fentanyl After Cesarean Section ⬇️

scientific article published on August 1, 1994

Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis

scientific article published on January 2003

Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards

scientific article published on 23 September 2008

Assessment of Behavioral Disruption in Rats with Abdominal Inflammation Using Visual Cue Titration and the Five-choice Serial-reaction Time Task

scientific article published on 25 May 2017

Assessment of attention threshold in rats by titration of visual cue duration during the five choice serial reaction time task

scientific article

Assessment of behavior during labor in rats and effect of intrathecal morphine

scientific article published on June 2008

Blood pressure, but not cerebrospinal fluid fentanyl concentration, predicts duration of labor analgesia from spinal fentanyl

scientific article published in January 2010

Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats

scientific article published on 5 September 2007

Can a Blood Test of Immune Responsiveness Predict Speed of Recovery from Pain and Dysfunction after Surgery?

scientific article

Case reports are leaving Anesthesiology, but not the specialty

scientific article published in March 2013

Cephalad movement of morphine and fentanyl in humans after intrathecal injection

scientific article

Chronic constriction injury of sciatic nerve induces the up-regulation of descending inhibitory noradrenergic innervation to the lumbar dorsal horn of mice

scientific article

Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation

scientific article published on 27 June 2006

Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis

scientific article

Clonidine-induced neuronal activation in the spinal cord is altered after peripheral nerve injury

scientific article published in March 2003

Consent contraindicated?

scientific article published in April 2010

Contribution of the chemokine (C-C motif) ligand 2 (CCL2) to mechanical hypersensitivity after surgical incision in rats

scientific article

Curiosity, discipline, and joy; and the greatest of these is joy.

scientific article

Cyclooxygenase-1 in the Spinal Cord Is Altered after Peripheral Nerve Injury ⬇️

scientific article published on November 1, 2003

Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain

scientific article

Cystatin C in cerebrospinal fluid is not a diagnostic test for pain in humans

scientific article

Data fabrication and article retraction: how not to get lost in the woods.

scientific article published in May 2009

Day-to-day experience in resolution of pain after surgery

scientific article published on 11 July 2017

Depletion of Endogenous Noradrenaline Does Not Prevent Spinal Cord Plasticity Following Peripheral Nerve Injury ⬇️

scientific article published on December 11, 2011

Descending Noradrenergic Inhibition: An Important Mechanism of Gabapentin Analgesia in Neuropathic Pain

scientific article published on 01 January 2018

Developmental differences in peripheral glabrous skin mechanosensory nerve receptive field and intracellular electrophysiologic properties: phenotypic characterization in infant and juvenile rats

scientific article

Developmental differences in spinal cyclooxygenase 1 expression after surgical incision

scientific article published in March 2006

Did experimenter bias conceal the efficacy of spinal opioids in previous studies with the spinal nerve ligation model of neuropathic pain?

scientific article published in April 2004

Differing neurophysiologic mechanosensory input from glabrous and hairy skin in juvenile rats

scientific article

Dose response of intrathecal adenosine in experimental pain and allodynia

scientific article

Down-regulation of astroglial glutamate transporter-1 in the locus coeruleus impairs pain-evoked endogenous analgesia in rats

scientific article

Effect of Dexmedetomidine on Lumbar Cerebrospinal Fluid Pressure in Humans ⬇️

scientific article published on August 1, 1997

Effect of Prior Anesthetic Solution on Epidural Morphine Analgesia ⬇️

scientific article published on August 1, 1991

Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats

scientific article

Effects of intrathecal ketorolac on human experimental pain

scientific article

Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain

scientific article

Electrical field stimulation to study inhibitory mechanisms in individual sensory neurons in culture

scientific article published in March 2004

Electrophysiologic characteristics of large neurons in dorsal root ganglia during development and after hind paw incision in the rat.

scientific article

Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations

scientific article

Epidural Clonidine after Cesarean Section Appropriate Dose and Effect of Prior Local Anesthetic ⬇️

scientific article published on February 1, 1992

Epidural Fentanyl Produces Labor Analgesia by a Spinal Mechanism ⬇️

scientific article published on June 1, 1998

Epidural Neostigmine versus Fentanyl to Decrease Bupivacaine Use in Patient-controlled Epidural Analgesia during Labor: A Randomized, Double-blind, Controlled Study

scientific article published on 5 May 2017

Epidural ketamine in healthy children--what's the point?

scientific article published in February 2003

Epidural neostigmine produces analgesia but also sedation in women after cesarean delivery

scientific article published on February 2004

Estrogen reduces efficacy of mu- but Not kappa-opioid agonist inhibition in response to uterine cervical distension

scientific article published in February 2002

Ethical Concerns Regarding Human Study

scientific article published on 31 August 2016

Failure of intrathecal ketorolac to reduce remifentanil-induced postinfusion hyperalgesia in humans

scientific article published on January 2015

Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats

scientific article

Fishing for genes: practical ways to study genetic polymorphisms for pain

scientific article published in June 2004

Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation

scientific article published in October 2003

Future Directions for Intrathecal Pain Management: A Review and Update From the Interdisciplinary Polyanalgesic Consensus Conference 2007 ⬇️

scientific article published on April 1, 2008

Gabapentin Inhibits γ-Amino Butyric Acid Release in the Locus Coeruleus but Not in the Spinal Dorsal Horn after Peripheral Nerve Injury in Rats ⬇️

scientific article published on June 1, 2012

Gabapentin acts within the locus coeruleus to alleviate neuropathic pain

scientific article

Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms

scientific article published on February 2014

Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus

scientific article published on 9 May 2016

Gestational Obstructive Sleep Apnea: Biomarker Screening Models and Lack of Postpartum Resolution

scientific article published on 30 March 2018

Hyperexcitability of axotomized and neighboring unaxotomized sensory neurons is reduced days after perineural clonidine at the site of injury

scientific article

Immunocytochemical localization of the α3, α4, α5, α7, β2, β3 and β4 nicotinic acetylcholine receptor subunits in the locus coeruleus of the rat ⬇️

scientific article published on June 6, 2003

Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat.

scientific article

Intraspinal adenosine induces spinal cord norepinephrine release in spinal nerve-ligated rats but not in normal or sham controls

scientific article published in June 2003

Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding

scientific article published in January 2002

Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats

scientific article published in September 2006

Intrathecal but not intravenous opioids release adenosine from the spinal cord

scientific article published in February 2004

Intrathecal clonidine and adenosine: effects on pain and sensory processing in patients with chronic regional pain syndrome

scientific article published on January 2015

Intrathecal clonidine and the response to hemorrhage

scientific article published on September 1, 1992

Intrathecal clonidine for postoperative analgesia in elderly patients: the influence of baricity on hemodynamic and analgesic effects

scientific article

Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors

scientific article published in May 2003

Intrathecal injection of cAMP response element binding protein (CREB) antisense oligonucleotide attenuates tactile allodynia caused by partial sciatic nerve ligation

scientific article published on October 2003

Intrathecal ketorolac does not improve acute or chronic pain after hip arthroplasty: a randomized controlled trial

scientific article

Intrathecal ketorolac enhances antinociception from clonidine

scientific article

Intrathecal ketorolac in dogs and rats

scientific article

Intrathecal ketorolac reverses hypersensitivity following acute fentanyl exposure

scientific article published in December 2002

Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac

scientific article

Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats

scientific article published in February 2005

Intrathecal morphine reduces allodynia after peripheral nerve injury in rats via activation of a spinal A1 adenosine receptor

scientific article

Intrathecal morphine reduces the visceromotor response to acute uterine cervical distension in an estrogen-independent manner

scientific article published in June 2003

Intrathecal sufentanil and epidural bupivacaine for labor analgesia: Dose-response of individual agents and in combination ⬇️

scientific article published on September 1, 1998

Intrathecal, but not intravenous adenosine reduces allodynia in patients with neuropathic pain ⬇️

scientific article published on September 1, 2003

Intravenous butorphanol, meperidine, and their combination relieve pain and distress in women in labor

scientific article

Intravenous remifentanil produces withdrawal hyperalgesia in volunteers with capsaicin-induced hyperalgesia

scientific article published in September 2003

Journal-related and other special activities at the 2008 American Society of Anesthesiologists Annual Meeting

scientific article published in September 2008

Ketamine fails to prevent postoperative delirium

scientific article

Knock down of the alpha 5 nicotinic acetylcholine receptor in spinal nerve-ligated rats alleviates mechanical allodynia

scientific article

Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat.

scientific article

Letter: Very fast zinc-catalyzed hydrolysis of an anhydride. A model for the rate and mechanism of carboxypeptidase A catalysis

scientific article published on January 8, 1975

Management of intrathecal catheter-tip inflammatory masses: an updated 2007 consensus statement from an expert panel

scientific article published on April 2008

Maternal and Fetal Effects of Labetalol in Pregnant Ewes ⬇️

scientific article published on February 1, 1991

Mechanical sensibility of nociceptive and non-nociceptive fast-conducting afferents is modulated by skin temperature

scientific article published on 18 November 2015

Mechanism of Antiarrhythmic Effect of Dexmedetomidine on Epinephrine-induced Arrhythmias ⬇️

scientific article published on 01 December 1991

Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased alpha2C-adrenoceptor co-expression and functional inhibition by clonidine

scientific article published in February 2005

Mindfulness-Meditation-Based Pain Relief Is Not Mediated by Endogenous Opioids.

scientific article published on March 2016

Modeling individual recovery after peripheral nerve injury in rats and the effects of parturition

scientific article

Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain

scientific article published in March 2002

Multifactorial preoperative predictors for postcesarean section pain and analgesic requirement

scientific article published in March 2006

Multiplicative interactions to enhance gabapentin to treat neuropathic pain

scientific article published on 17 September 2008

Neostigmine decreases bupivacaine use by patient-controlled epidural analgesia during labor: a randomized controlled study

scientific article

Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents

scientific article

Neuronal nitric oxide synthase is upregulated in a subset of primary sensory afferents after nerve injury which are necessary for analgesia from alpha2-adrenoceptor stimulation

scientific article published on 17 November 2006

Nicotinic acetylcholine receptor regulation of spinal norepinephrine release

scientific article

Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats

scientific article published in April 2014

Note of Editorial Concern ⬇️

scientific article published on 01 September 2011

Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of γ-aminobutyric acid in α2-adrenoceptor and 5-HT3 serotonin receptor analgesia

scientific article

Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics

scientific article

Opioid-independent mechanisms supporting offset analgesia and temporal sharpening of nociceptive information ⬇️

scientific article published on April 13, 2012

Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism

scientific article

Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil

scientific article

Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action

scientific article

PAD Study Entrance Questionnaire

Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming

scientific article published on October 2010

Patient safety: anesthesiology contributions and supplements to the American Society of Anesthesiologists' Annual Meeting

scientific article published in October 2013

Patterns of recovery from pain after cesarean delivery

scientific article published on 01 October 2018

Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury

scientific article published in October 2002

Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury

scientific article published in February 2006

Perineural clonidine reduces p38 mitogen-activated protein kinase activation in sensory neurons

Peripheral block of the hyperpolarization-activated cation current (Ih) reduces mechanical allodynia in animal models of postoperative and neuropathic pain

scientific article published in May 2005

Peripheral nerve injury alters the alpha2 adrenoceptor subtype activated by clonidine for analgesia

scientific article published on September 2002

Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain

scientific article

Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran

scientific article published in March 2004

Pharmacology of opioid inhibition to noxious uterine cervical distension

scientific article published in October 2002

Phase 1 safety assessment of intrathecal oxytocin

scientific article

Phase I Human Safety Assessment of Intrathecal Neostigmine Containing Methyl- and Propylparabens ⬇️

scientific article published on October 1, 1997

Phase I safety assessment of intrathecal injection of an American formulation of adenosine in humans

scientific article

Phase I safety assessment of intrathecal ketorolac

scientific article published on October 2002

Plasma concentrations and disposition of clonidine following a constant 14-day epidural infusion in cancer patients ⬇️

scientific article published on September 1, 1997

Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury

scientific article

Plasticity of spinal nicotinic acetylcholine receptors following spinal nerve ligation

scientific article published in February 2004

Polyanalgesic Consensus Conference 2003: an update on the management of pain by intraspinal drug delivery-- report of an expert panel

scientific article published on June 2004

Polyanalgesic Consensus Conference 2007: Recommendations for the Management of Pain by Intrathecal (Intraspinal) Drug Delivery: Report of an Interdisciplinary Expert Panel ⬇️

scientific article published on October 1, 2007

Post-discharge hyperpolarization is an endogenous modulatory factor limiting input from fast-conducting nociceptors (AHTMRs).

scientific article published on January 2017

Preclinical toxicity screening of intrathecal oxytocin in rats and dogs

scientific article

Predicting acute pain after cesarean delivery using three simple questions

scientific article

Predictors of headache before, during, and after pregnancy: a cohort study

scientific article published on 23 January 2012

Pregnancy increases excitability of mechanosensitive afferents innervating the uterine cervix

scientific article published on June 2008

Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans

scientific article

Preoperative inhibition of cyclooxygenase-1 in the spinal cord reduces postoperative pain

scientific article published in May 2005

Preoperative sciatic nerve block decreases mechanical allodynia more in young rats: is preemptive analgesia developmentally modulated?

scientific article

Preventing chronic pain after surgery: who, how, and when?

scientific article published in January 2006

Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors

scientific article

Psychosocial Stress Delays Recovery of Postoperative Pain Following Incisional Surgery in the Rat

Pupil responses and pain ratings to heat stimuli: Reliability and effects of expectations and a conditioning pain stimulus

scientific article published on 12 January 2017

Regional anesthesia: advancing the practice of medicine; the 2008 Gaston Labat Award lecture

scientific article published on September 2008

Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and γ-aminobutyric acid mechanisms

scientific article published on January 2013

Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain

scientific article

Reporting of Preclinical Research in Anesthesiology: Transparency and Enforcement

scientific article published on 04 February 2016

Resolution of Pain After Childbirth

Resolution of pain after childbirth

scientific article published on January 2013

Retraction: Fospropofol Assay Issues and Impact on Pharmacokinetic and Pharmacodynamic Evaluation

Reversal of Peripheral Nerve Injury-Induced Hypersensitivity in the Postpartum Period

Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin

scientific article published on January 2013

Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes

scientific article published on 21 December 2011

Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury

scientific article published in May 2002

Role of adenosine receptors in spinal G-protein activation after peripheral nerve injury

scientific article published in June 2002

Role of spinal cyclooxygenase in human postoperative and chronic pain

scientific article

Safety in numbers: how do we study toxicity of spinal analgesics?

scientific article published in November 2002

Severe Maternal Hypotension and Fetal Bradycardia after a Combined Spinal Epidural Anesthetic ⬇️

scientific article published on July 1, 1997

Severity of acute pain after childbirth, but not type of delivery, predicts persistent pain and postpartum depression

scientific article published on 24 September 2008

Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat.

scientific article

Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury

scientific article published in May 2004

Spinal adrenergic and cholinergic receptor interactions activated by clonidine in postincisional pain

scientific article

Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function

scientific article

Spinal anesthesia: Mechanisms, agents, methods, and safety*1 ⬇️

scientific article published on July 1, 1998

Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision

scientific article

Spinal nerve ligation increases alpha2-adrenergic receptor G-protein coupling in the spinal cord

scientific article published on March 2005

Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats

scientific article published in February 2005

Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain

scientific article published in May 2002

Spinal norepinephrine release from nitric oxide species is not increased following peripheral nerve injury in rats

scientific article published in August 2002

Studies of the composition of purified Torpedo californica acetylcholine receptor and of its subunits

scientific article published on May 15, 1979

Studies on the Safety of Glucose and Paraben-Containing Neostigmine for Intrathecal Administration ⬇️

scientific article published on August 1, 1997

Systemic, but not intrathecal ketorolac is antinociceptive to uterine cervical distension in rats ⬇️

scientific article published on September 1, 2003

The Need for Perspective

article published in 2009

The antinociceptive effects of spinal cyclooxygenase inhibitors on uterine cervical distension

scientific article published in October 2004

The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor

scientific article published in May 2009

The monoamine reuptake inhibitor milnacipran does not affect nociception to acute visceral distension in rats

scientific article published in May 2004

The need for a journal policy on intrathecal, epidural, and perineural administration of non-approved drugs

scientific article published on 15 March 2010

The puerperium alters spinal cord plasticity following peripheral nerve injury ⬇️

scientific article published on October 25, 2012

The vascular mechanism of ephedrine's beneficial effect on uterine perfusion during pregnancy

scientific article published on May 1, 1992

Toxicology profile of N-methyl-D-aspartate antagonists delivered by intrathecal infusion in the canine model

scientific article published in May 2008

Treating and preventing chronic pain: a view from the spinal cord--Bonica Lecture, ASRA Annual Meeting, 2005.

scientific article published in March 2006

Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury

scientific article

Uterine cervical distension induces cFos expression in deep dorsal horn neurons of the rat spinal cord

scientific article

Valproate prevents dysregulation of spinal glutamate and reduces the development of hypersensitivity in rats after peripheral nerve injury

scientific article published on 07 September 2013

Vasopressin and fetal cerebrovascular regulation

scientific article published on August 1, 1992

Washington University and the Why of Anesthesiology ⬇️

scientific article published on December 1, 2011

Wherefore Gabapentinoids?: Was There Rush Too Soon to Judgment?

scientific article

Why is Karolinska on the cover of an American journal? ⬇️

scientific article published on 01 December 2010

Without Science There Is Little Art in Anesthesiology: 2015 Rovenstine Lecture

scientific article published on 30 March 2016

alpha2-Adrenoceptor activation by clonidine enhances stimulation-evoked acetylcholine release from spinal cord tissue after nerve ligation in rats

scientific article published in March 2005

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