List of works - Walter Marcotti

AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness

scientific article published on 31 July 2022

Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice

scientific article

Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells

scientific article published on 01 July 2020

An allosteric gating model recapitulates the biophysical properties of IK,L expressed in mouse vestibular type I hair cells

scientific article published in September 2017

Auditory function in the Tc1 mouse model of down syndrome suggests a limited region of human chromosome 21 involved in otitis media

scientific article

Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea

scientific article published on 14 October 2020

Burst activity and ultrafast activation kinetics of CaV1.3 Ca²⁺ channels support presynaptic activity in adult gerbil hair cell ribbon synapses

scientific article

Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells

scientific journal article

Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells

scientific article

Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses

scientific article

Clarin-2 is essential for hearing by maintaining stereocilia integrity and function

scientific article published on 26 August 2019

Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea

scientific article published on January 2017

Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea

article

Coordinated calcium signalling in cochlear sensory and non-sensory cells refines afferent innervation of outer hair cells

scientific article published on 25 February 2019

Enlargement of Ribbons in Zebrafish Hair Cells Increases Calcium Currents But Disrupts Afferent Spontaneous Activity and Timing of Stimulus Onset

scientific article

Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells

scientific article

Fine Tuning of CaV1.3 Ca2+ channel properties in adult inner hair cells positioned in the most sensitive region of the Gerbil Cochlea

scientific article

Functional assembly of mammalian cochlear hair cells

scientific article

Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea

scientific article published on 28 May 2019

Generation of Otic Lineages from Integration-Free Human-Induced Pluripotent Stem Cells Reprogrammed by mRNAs

scientific article published on 01 March 2020

Genetic deletion of SK2 channels in mouse inner hair cells prevents the developmental linearization in the Ca2+ dependence of exocytosis

scientific article

Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea

scientific article published on 21 December 2019

Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt).

scientific article

Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness

scientific article published on 05 November 2020

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

scientific article published in Nature Communications

Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells

scientific article

Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing

scientific article published in 2022

Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells

scientific journal article

Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea

scientific article published on 25 July 2020

Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells

scientific article

Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity

scientific article

Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.

scientific article

Restoration of auditory evoked responses by human ES-cell-derived otic progenitors

scientific article

Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses

scientific article

The Coupling between Ca2+ Channels and the Exocytotic Ca2+ Sensor at Hair Cell Ribbon Synapses Varies Tonotopically along the Mature Cochlea

scientific article published on 02 February 2017

Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing.

scientific article

miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells

scientific article

List of works by Walter Marcotti

AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness

Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice

Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells

An allosteric gating model recapitulates the biophysical properties of IK,L expressed in mouse vestibular type I hair cells

Auditory function in the Tc1 mouse model of down syndrome suggests a limited region of human chromosome 21 involved in otitis media

Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea

Burst activity and ultrafast activation kinetics of CaV1.3 Ca²⁺ channels support presynaptic activity in adult gerbil hair cell ribbon synapses

Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells

Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells

Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses

Clarin-2 is essential for hearing by maintaining stereocilia integrity and function

Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea

Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea

Coordinated calcium signalling in cochlear sensory and non-sensory cells refines afferent innervation of outer hair cells

Enlargement of Ribbons in Zebrafish Hair Cells Increases Calcium Currents But Disrupts Afferent Spontaneous Activity and Timing of Stimulus Onset

Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells

Fine Tuning of CaV1.3 Ca2+ channel properties in adult inner hair cells positioned in the most sensitive region of the Gerbil Cochlea

Functional assembly of mammalian cochlear hair cells

Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea

Generation of Otic Lineages from Integration-Free Human-Induced Pluripotent Stem Cells Reprogrammed by mRNAs

Genetic deletion of SK2 channels in mouse inner hair cells prevents the developmental linearization in the Ca2+ dependence of exocytosis

Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea

Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt).

Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells

Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing

Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells

Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea

Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells

Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity

Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.

Restoration of auditory evoked responses by human ES-cell-derived otic progenitors

Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses

The Coupling between Ca2+ Channels and the Exocytotic Ca2+ Sensor at Hair Cell Ribbon Synapses Varies Tonotopically along the Mature Cochlea

Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing.

miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells