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List of works by David J. Beech

(-)-Englerin A-evoked Cytotoxicity Is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase ⬇️

scientific article published on 14 November 2016

(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels

scientific article

A differential role of macrophage TRPM2 channels in Ca²⁺ signaling and cell death in early responses to H₂O₂.

scientific article published on 17 April 2013

A diffusible second messenger mediates one of the pathways coupling receptors to calcium channels in rat sympathetic neurons

scientific article published in June 1991

A method for direct patch-clamp recording from smooth muscle cells embedded in functional brain microvessels.

scientific article published in March 1998

A residue in the TRPM2 channel outer pore is crucial in determining species-dependent sensitivity to extracellular acidic pH

article

A simple method of fast extracellular solution exchange for the study of whole-cell or single channel currents using patch-clamp technique.

scientific article

A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility

scientific article published on 4 May 2006

AZD1775 Induces Toxicity Through Double-Stranded DNA Breaks Independently of Chemotherapeutic Agents in p53-Mutated Colorectal Cancer Cells. ⬇️

scientific article published on 15 March 2017

Action of nifedipine of BAY K8644 is dependent on calcium channel state in single smooth muscle cells from rabbit ear artery

scientific article published on 01 May 1988

Actions of neurotransmitters and other messengers on Ca2+ channels and K+ channels in smooth muscle cells

scientific article published on January 1997

Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory ⬇️

scientific article published on 14 September 2018

Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor

scientific article

Activation thresholds of K(V), BK andCl(Ca) channels in smooth muscle cells in pial precapillary arterioles.

scientific article

Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice

scientific journal article

Bipolar phospholipid sensing by TRPC5 calcium channel.

scientific article

Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect

scientific article

Calcium-sensing mechanism in TRPC5 channels contributing to retardation of neurite outgrowth

scientific article

Canonical transient receptor potential 5.

scientific article

Channel regulation by extracellular redox protein.

scientific article published on November 2007

Characteristics of Transient Receptor Potential Canonical Calcium-Permeable Channels and Their Relevance to Vascular Physiology and Disease ⬇️

scientific article published on February 14, 2013

Characterization of a voltage-gated K+ channel that accelerates the rod response to dim light

scientific article

Cholesterol depletion impairs vascular reactivity to endothelin-1 by reducing store-operated Ca2+ entry dependent on TRPC1.

scientific article published on 9 October 2003

Cis‐isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels ⬇️

scientific article published on September 1, 2010

Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin

scientific article published on 5 June 2012

Correspondence: Challenging a proposed role for TRPC5 in aortic baroreceptor pressure-sensing ⬇️

scientific article published on 23 March 2018

Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation

scientific article published on 15 January 2003

Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation

scientific article published on October 2005

E3-targeted anti-TRPC5 antibody inhibits store-operated calcium entry in freshly isolated pial arterioles

scientific article published on 21 July 2006

Electrophysiological and other aspects of the relaxant action of isoprenaline in guinea-pig isolated trachealis

scientific article published in December 1985

Emerging functions of 10 types of TRP cationic channel in vascular smooth muscle

scientific article

Endothelial Piezo1 channels as sensors of exercise ⬇️

scientific article published in December 2017

Endothelial Piezo1: life depends on it.

scientific article

Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction and Systemic Insulin Resistance. ⬇️

scientific article

Expression of a long variant of CRACR2A that belongs to the Rab GTPase protein family in endothelial cells. ⬇️

scientific article published on 2 December 2014

Functional up-regulation of KCNA gene family expression in murine mesenteric resistance artery smooth muscle. ⬇️

scientific article published on 23 January 2004

Functions of large conductance Ca2+‐activated (BKCa), delayed rectifier (KV) and background K+ channels in the control of membrane potential in rabbit renal arcuate artery ⬇️

scientific article published on August 15, 1998

GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels.

scientific article published on 13 July 2011

Generation of antibodies that are externally acting isoform-specific inhibitors of ion channels

scientific article published in January 2013

Generation of functional ion-channel tools by E3 targeting

scientific article published on 18 September 2005

Harmony and discord in endothelial calcium entry

scientific article published on January 2009

Homotypic endothelial nanotubes induced by wheat germ agglutinin and thrombin. ⬇️

scientific article

Human TRPC5 channel activated by a multiplicity of signals in a single cell

scientific article published on 14 July 2004

Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

scientific article published on 23 November 2020

Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release

scientific article published on 26 July 2012

Identification of an (-)-Englerin A analogue which antagonizes (-)-Englerin A at TRPC1/4/5 channels. ⬇️

scientific article

Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel 2.

scientific article

In pursuit of small molecule chemistry for calcium‐permeable non‐selective TRPC channels – mirage or pot of gold? ⬇️

scientific article published on October 1, 2013

Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands ⬇️

scientific article published on March 2013

Inhibitors of spasmogen-induced Ca2+ channel suppression in smooth muscle cells from small intestine.

scientific article published in October 1998

Inhibitory effects of histamine and bradykinin on calcium current in smooth muscle cells isolated from guinea-pig ileum.

scientific article

Integration of transient receptor potential canonical channels with lipids.

scientific article published on 27 May 2011

Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells

scientific article published on 18 September 2008

Intracellular Ca2+ buffers disrupt muscarinic suppression of Ca2+ current and M current in rat sympathetic neurons.

scientific article published on January 1991

Intracellular coiled-coil domain engaged in subunit interaction and assembly of melastatin-related transient receptor potential channel 2.

scientific article published on 23 October 2006

Ion channel switching and activation in smooth-muscle cells of occlusive vascular diseases

scientific article published on November 2007

Ions in smooth muscle, now and then

article by David J. Beech published 1 January 2006 in Journal of Physiology

K(+)-induced dilation of a small renal artery: no role for inward rectifier K+ channels

scientific article published in March 1998

K(v)1.5 potassium channel gene regulation by Sp1 transcription factor and oxidative stress

scientific article

Less REST, more vascular disease? Regulation of cell cycle and migration of vascular smooth muscle cells

scientific article

Mechanical sensing in placental vascular endothelium

scholarly article by Lara Morley et al published September 2017 in Placenta

Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion

scientific article published on 04 October 2019

Mechanism of calcium channel block by D600 in single smooth muscle cells from rabbit ear artery

scientific article published on May 1989

Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons.

scientific article

Na+ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells ⬇️

scientific article

Nanomolar potency and selectivity of a Ca²⁺ release-activated Ca²⁺ channel inhibitor against store-operated Ca²⁺ entry and migration of vascular smooth muscle cells

scientific article published on September 2011

Natural and synthetic flavonoid modulation of TRPC5 channels ⬇️

scientific article published on 13 November 2015

Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells

scientific article published on June 2010

Non-selective cationic channels in chemical and physical stress

scientific article

Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP.

scientific article published on 22 July 2004

Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice ⬇️

scientific article

Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction

scientific article published on 24 January 2013

ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension ⬇️

scientific article published on 01 July 2018

Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation

scientific article published on 24 March 2011

Orai1 calcium channels in the vasculature ⬇️

scientific article published on March 9, 2012

Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor ⬇️

scientific article published on 9 July 2015

Pertussis toxin and voltage dependence distinguish multiple pathways modulating calcium channels of rat sympathetic neurons

scientific article published on 01 January 1992

Pharmacological profile of store-operated channels in cerebral arteriolar smooth muscle cells.

scientific article published on July 2003

Pico145 - powerful new tool for TRPC1/4/5 channels

scientific article published on 11 April 2017

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels ⬇️

scientific article published on 21 March 2017

Piezo channel mechanisms in health and disease. ⬇️

scientific article published in March 2018

Piezo1 Channels in Vascular Development and the Sensing of Shear Stress

scientific article

Piezo1 channel activation mimics high glucose as a stimulator of insulin release

scientific article published on 14 November 2019

Piezo1 channel agonist mimics high glucose as a stimulator of insulin release

scientific article published on 29 October 2018

Piezo1 channels are mechanosensors in human fetoplacental endothelial cells ⬇️

scientific article published on 01 October 2018

Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance ⬇️

scientific article published on 24 August 2017

Piezo1 integration of vascular architecture with physiological force. ⬇️

scientific article

Plasticity of TRPC expression in arterial smooth muscle: correlation with store-operated Ca2+ entry

scientific article published on 23 November 2004

Platelet-derived growth factor maintains stored calcium through a nonclustering Orai1 mechanism but evokes clustering if the endoplasmic reticulum is stressed by store depletion

scientific article

Positive and negative coupling of the endothelin ETA receptor to Ca2+-permeable channels in rabbit cerebral cortex arterioles.

scientific article

Potassium channels at the beginnings of cell proliferation

scientific article published on 17 November 2005

Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers

scientific article

Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction

scientific article

Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone

scientific article published on 14 October 2011

Prevention of a hypoxic Ca(2+)(i) response by SERCA inhibitors in cerebral arterioles.

scientific article

Production of a specific extracellular inhibitor of TRPM3 channels.

scientific article

Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1.

scientific article published on May 2011

Properties of the cromakalim-induced potassium conductance in smooth muscle cells isolated from the rabbit portal vein

scientific article published on November 1989

Protein kinase C requirement of Ca2+ channel stimulation by intracellular ATP in guinea-pig basilar artery smooth muscle cells.

scientific article published in April 1997

Quantitative rt-PCR methods for investigation of low copy potassium channel gene expression in native murine arteries

scientific article published in January 2008

RNA and the PIEZO force sensor

scientific article published on 03 September 2020

Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels

scientific article published on 15 March 2011

Regulation of arterial tone by KV1 potassium channels.

scientific article

Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease. ⬇️

scientific article published in June 2018

Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential ⬇️

scientific article published in October 2014

Rho-kinase inhibitors prevent agonist-induced vasospasm in human internal mammary artery

scientific article

Robotic multiwell planar patch-clamp for native and primary mammalian cells

scientific article published in January 2009

Role of K+ channels in A2A adenosine receptor-mediated dilation of the pressurized renal arcuate artery.

scientific article published on January 1999

SOCs - store-operated channels in vascular smooth muscle?

article by David J. Beech published 1 October 2002 in Journal of Physiology

Sar1-GTPase-dependent ER exit of KATP channels revealed by a mutation causing congenital hyperinsulinism

scientific article published on 8 April 2009

Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop ⬇️

scientific article published on 5 December 2016

Sensing of lysophospholipids by TRPC5 calcium channel

scientific article published on 20 December 2005

Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells

scientific article published on 02 June 2020

Short-term stimulation of calcium-permeable transient receptor potential canonical 5-containing channels by oxidized phospholipids

scientific article published on 8 April 2010

State-dependent inhibition of TRPM2 channel by acidic pH.

scientific article published on 26 July 2010

Stereo‐selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids ⬇️

scientific article published on April 1, 2011

Stimulation of TRPC5 cationic channels by low micromolar concentrations of lead ions (Pb2+).

scientific article

TRPC and Orai Channels in Store-Operated Calcium Entry and Vascular Remodelling

scientific article published in 2016

TRPC channel activation by extracellular thioredoxin

scientific article

TRPC channel lipid specificity and mechanisms of lipid regulation

scientific article published on 25 March 2009

TRPC1 store-operated cationic channel subunit.

scientific article

TRPC1 transcript variants, inefficient nonsense-mediated decay and low up-frameshift-1 in vascular smooth muscle cells

scientific article

TRPC1: store-operated channel and more

scientific article

TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A ⬇️

article by Sin Ying Cheung et al published 3 July 2018 in Oncotarget

TRPC5 channel sensitivities to antioxidants and hydroxylated stilbenes

scientific article

TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice

scientific article published in Scientific Reports

TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia ⬇️

scientific article

TRPM2 channel properties, functions and therapeutic potentials

scientific article published on September 2010

TRPM2-mediated intracellular Zn2+ release triggers pancreatic β-cell death

scientific article

TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan

scientific article

The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium

scientific journal article

Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels ⬇️

article by Hussein N Rubaiy et al published 2 June 2018 in British Journal of Pharmacology

Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics ⬇️

scientific article

Translocon closure to Ca2+ leak in proliferating vascular smooth muscle cells

scientific article published on 13 February 2009

TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells.

scientific article

Two components of potassium current activated by depolarization of single smooth muscle cells from the rabbit portal vein.

scientific article

Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases ⬇️

scientific article published on 2 February 2017

Vasorelaxant properties of nicorandil on human radial artery.

scientific article published in March 2000

Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. ⬇️

scientific article published on 2 March 2018

Zinc inactivates melastatin transient receptor potential 2 channels via the outer pore

scientific article published on 20 May 2011

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