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List of works by Gert-Jan van Ommen

A 3 months mild functional test regime does not affect disease parameters in young mdx mice.

scientific article published on 21 March 2010

A duplication at chromosome 11q12.2-11q12.3 is associated with spinocerebellar ataxia type 20

scientific article published on 18 September 2008

A high-quality human reference panel reveals the complexity and distribution of genomic structural variants

scientific article published on 06 October 2016

Advances in Duchenne muscular dystrophy gene therapy ⬇️

scientific article published on October 1, 2003

Advances in therapeutic RNA-targeting

scientific article

Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs

scientific article

An immune response network associated with blood lipid levels

scientific article

Antisense oligonucleotide mediated exon skipping as a potential strategy for the treatment of a variety of inflammatory diseases such as rheumatoid arthritis

scientific article published on 01 April 2012

Antisense-induced exon skipping for duplications in Duchenne muscular dystrophy

scientific article

Antisense-induced multiexon skipping for Duchenne muscular dystrophy makes more sense

scientific article published on 16 December 2003

Antisense-mediated exon skipping: a versatile tool with therapeutic and research applications

scientific article

Assessment of the feasibility of exon 45-55 multiexon skipping for Duchenne muscular dystrophy

scientific article

Ataxin-3 protein modification as a treatment strategy for spinocerebellar ataxia type 3: removal of the CAG containing exon

scientific article published on 06 May 2013

BBMRI-ERIC as a resource for pharmaceutical and life science industries: the development of biobank-based Expert Centres

scientific article

Biobanking for Europe

scientific article

CORE_TF: a user-friendly interface to identify evolutionary conserved transcription factor binding sites in sets of co-regulated genes

scientific article

Calling on a million minds for community annotation in WikiProteins

scientific article

Cell-type specific regulation of myostatin signaling

scientific article

Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophy

scientific article (publication date: September 1992)

Chronic disease research in Europe and the need for integrated population cohorts

scientific article published on 6 October 2017

Combined association and linkage analysis applied to the APOE locus

scientific article published in May 2004

Comprehensive catalog of European biobanks

scientific article published on 8 September 2011

Comprehensive detection of genomic duplications and deletions in the DMD gene, by use of multiplex amplifiable probe hybridization

scientific article published on 08 July 2002

Correction: Interspecies Translation of Disease Networks Increases Robustness and Predictive Accuracy

scientific article published on 8 November 2011

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R.

scientific article published on 10 May 2012

Cost-effective HRMA pre-sequence typing of clone libraries; application to phage display selection

scientific article

Deep sequencing to reveal new variants in pooled DNA samples

scientific article published in December 2009

Deep sequencing-based expression analysis shows major advances in robustness, resolution and inter-lab portability over five microarray platforms

scientific article published on 15 October 2008

DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts

scientific article

Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients

scientific article published on 4 April 2011

Development of antisense-mediated exon skipping as a treatment for duchenne muscular dystrophy

scientific article

Dutch government invests in existing biobanks

scientific article published on January 1, 2010

Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates

scientific article

Enhanced exon-skipping induced by U7 snRNA carrying a splicing silencer sequence: Promising tool for DMD therapy

scientific article

Entries in the Leiden Duchenne muscular dystrophy mutation database: an overview of mutation types and paradoxical cases that confirm the reading-frame rule

scientific article

Epitope mapping of monoclonal antibody 4C8 recognizing the protein huntingtin

scientific article

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article published in November 2011

Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population.

scientific article published in November 2003

Exon skipping for DMD.

scientific article published on 22 November 2012

Exonic sequences provide better targets for antisense oligonucleotides than splice site sequences in the modulation of Duchenne muscular dystrophy splicing

scientific article published on April 2010

Exploring the frontiers of therapeutic exon skipping for Duchenne muscular dystrophy by double targeting within one or multiple exons

scientific article published on 06 June 2006

Facioscapulohumeral muscular dystrophy is uniquely associated with one of the two variants of the 4q subtelomere

scientific article

Familial resemblance for serum metabolite concentrations

scientific article published on 28 August 2013

Functional analysis of 114 exon-internal AONs for targeted DMD exon skipping: indication for steric hindrance of SR protein binding sites

scientific article

Gene expression profiling highlights defective myogenesis in DMD patients and a possible role for bone morphogenetic protein 4.

scientific article

Gene expression profiling to monitor therapeutic and adverse effects of antisense therapies for Duchenne muscular dystrophy.

scientific article

Gene expression variation between mouse inbred strains

scientific article

GeneHopper: a web-based search engine to link gene-expression platforms through GenBank accession numbers ⬇️

scientific article published on April 25, 2003

Generation and Characterization of Transgenic Mice with the Full-length HumanDMDGene

scientific article published in Journal of Biological Chemistry

Genetic evidence of assortative mating in humans

article

Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease

scientific article

Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

scientific article

Genome-wide assessment of differential roles for p300 and CBP in transcription regulation

scientific article

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

scientific article

Guidelines for antisense oligonucleotide design and insight into splice-modulating mechanisms

scientific article

Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response

scientific article

Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes

scientific article

Hundreds of variants clustered in genomic loci and biological pathways affect human height

scientific article

Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy

scientific article (publication date: 23 November 2003)

IL7R gene expression network associates with human healthy ageing

scientific article

In silico discovery and experimental validation of new protein-protein interactions

scientific article (publication date: 31 January 2011)

In vivo comparison of 2'-O-methyl phosphorothioate and morpholino antisense oligonucleotides for Duchenne muscular dystrophy exon skipping

scientific article

Inhibition of IL-1 Signaling by Antisense Oligonucleotide-mediated Exon Skipping of IL-1 Receptor Accessory Protein (IL-1RAcP).

scientific article published on 22 January 2013

Integrated analysis of DNA copy number and gene expression microarray data using gene sets

scientific article

Interspecies translation of disease networks increases robustness and predictive accuracy.

scientific article

LPAR1 and ITGA4 regulate peripheral blood monocyte counts

Large-scale gene expression analysis of human skeletal myoblast differentiation.

scientific article

Literature-aided meta-analysis of microarray data: a compendium study on muscle development and disease

scientific article

Local dystrophin restoration with antisense oligonucleotide PRO051

scientific article published on 01 December 2007

Low dystrophin levels increase survival and improve muscle pathology and function in dystrophin/utrophin double-knockout mice

scientific article

Meeting report: The Human Genome Meeting (HGM) 2019 in Seoul, Korea

scientific article published on 01 August 2019

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

Mutant huntingtin represses CBP, but not p300, by binding and protein degradation

scientific journal article

Mutant huntingtin represses CBP, but not p300, by binding and protein degradation

scientific article published in September 2005

Mutations in SWI/SNF chromatin remodeling complex gene ARID1B cause Coffin-Siris syndrome

scientific article

New insights in gene-derived therapy: the example of Duchenne muscular dystrophy

scientific article published on December 2010

Novel protein-protein interactions inferred from literature context

scientific article (publication date: 18 November 2009)

Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles

scientific article published on 14 February 2008

Preclinical PK and PD studies on 2'-O-methyl-phosphorothioate RNA antisense oligonucleotides in the mdx mouse model

scientific article

Prednisolone Treatment Does Not Interfere with 2′-O-Methyl Phosphorothioate Antisense-Mediated Exon Skipping in Duchenne Muscular Dystrophy ⬇️

scientific article published on January 26, 2012

Preventing formation of toxic N-terminal huntingtin fragments through antisense oligonucleotide-mediated protein modification

scientific article published on 31 December 2013

Progress in therapeutic antisense applications for neuromuscular disorders

scientific article published on 07 October 2009

Selection and characterization of llama single domain antibodies against N-terminal huntingtin

scientific article

Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene

scientific article published on March 2003

Serum protein profiling in mice: identification of Factor XIIIa as a potential biomarker for muscular dystrophy

scientific article

Small N-terminal mutant huntingtin fragments, but not wild type, are mainly present in monomeric form: Implications for pathogenesis

scientific article published on 27 December 2005

Strong aggregation and increased toxicity of polyleucine over polyglutamine stretches in mammalian cells

scientific article

Systemic administration of PRO051 in Duchenne's muscular dystrophy

scientific article

Targeted exon skipping as a potential gene correction therapy for Duchenne muscular dystrophy

scientific article published in October 2002

Targeted exon skipping in transgenic hDMD mice: A model for direct preclinical screening of human-specific antisense oligonucleotides

scientific article

Targeting TGF-β Signaling by Antisense Oligonucleotide-mediated Knockdown of TGF-β Type I Receptor

scientific article

Targeting several CAG expansion diseases by a single antisense oligonucleotide

scientific article (publication date: 2011)

The Complete Genome Sequence of the Murine Pathobiont Helicobacter typhlonius

scientific article

The Genome of the Netherlands: design, and project goals

scientific article (publication date: February 2014)

The Implicitome: A Resource for Rationalizing Gene-Disease Associations

scientific article

The Pathogenesis and Therapy of Muscular Dystrophies

scientific article published on 04 June 2015

The therapeutic potential of antisense-mediated exon skipping

scientific article published on April 2008

Theoretic applicability of antisense-mediated exon skipping for Duchenne muscular dystrophy mutations

scientific article

Therapeutic antisense-induced exon skipping in cultured muscle cells from six different DMD patients.

scientific article

Therapeutic exon skipping for dysferlinopathies?

scientific article

Tissue-specific transcript annotation and expression profiling with complementary next-generation sequencing technologies.

scientific article

Toward a roadmap in global biobanking for health

scientific article (publication date: November 2012)

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

scientific article (publication date: 2012)

Transcriptome and genome sequencing uncovers functional variation in humans

scientific article

Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck

scientific article published on 25 February 2016

Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels

article

Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2.

scientific article published on 29 January 2016

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