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List of works by Mervyn Singer

A Radical Approach To Diagnosing Infection.

scientific article published in October 2015

A new dawn for critical care research

scientific article published on 29 October 2013

A plea for balanced reporting

scientific article

A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators.

scientific article published on 08 May 2015

Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis

scientific article published on 14 March 2017

Activation-associated death of memory b cells in peripheral circulation in adults with sepsis.

scientific article

Acute haemodynamic effects of dobutamine in experimental sepsis-induced myocardial depression.

scientific article

Acute kidney injury

scientific article published in The Lancet

Admissions with airway emergencies in the ICU at a tertiary referral centre

scientific article

Adrenal function in sepsis: the retrospective Corticus cohort study.

scientific article

Advancing critical care: time to kiss the right frog

scientific article published on 12 March 2013

Alteration of the sublingual microvascular glycocalyx in critically ill patients

scientific article published on 26 August 2013

Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models.

scientific article

An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial.

scientific article

An integrated approach to assessing nitroso-redox balance in systemic inflammation

scientific article published on 14 June 2011

Angiotensin II blockade augments renal cortical microvascular pO2 indicating a novel, potentially renoprotective action

scientific article published on 01 January 2003

Animal models of sepsis: why does preclinical efficacy fail to translate to the clinical setting?

scientific article published on January 2009

Another nail in the hammer's coffin?

scientific article

Antibiotic use and impact on outcome from bacteraemic critical illness: the BActeraemia Study in Intensive Care (BASIC).

scientific article published on 24 March 2010

Antibiotics for Sepsis - Does Each Hour Really Count? Or is it Incestuous Amplification?

scientific article published on 15 May 2017

Arginine vasopressin vs. terlipressin in the treatment of shock states

scientific article published on June 2008

Arterial Hyperoxia and In-Hospital Mortality After Resuscitation From Cardiac Arrest

scientific article published in The Journal of the American Medical Association

Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis

scientific article published on 23 December 2014

Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

scientific article

Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial

scientific article published in August 2005

Association between mitochondrial dysfunction and severity and outcome of septic shock

scientific article

Audit of bacteraemia management in a university hospital ICU.

scientific article published on 17 March 2014

BK large conductance Ca²+-activated K+ channel-deficient mice are not resistant to hypotension and display reduced survival benefit following polymicrobial sepsis

scientific article published on May 2011

Bacteraemia incidence, causative organisms and resistance patterns, antibiotic strategies and outcomes in a single university hospital ICU: continuing improvement between 2000 and 2013.

scientific article published on 3 September 2014

Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective

scientific article published on 12 December 2012

Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure

scientific article published on January 2006

Bench-to-bedside review: the role of C1-esterase inhibitor in sepsis and other critical illnesses

scientific article published on 26 January 2011

Beta-blockade in experimental fluid-resuscitated sepsis: acute haemodynamic effects of esmolol differ in predicted survivors and non-survivors.

scientific article

Biomarkers in sepsis

scientific article

Bladder tissue oxygen tension monitoring in pigs subjected to a range of cardiorespiratory and pharmacological challenges.

scientific article published on 11 October 2012

British HIV Association and British Infection Association guidelines for the treatment of opportunistic infection in HIV-seropositive individuals 2011

article

Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis?

scientific article

Cardioprotection, attenuated systemic inflammation, and survival benefit of beta1-adrenoceptor blockade in severe sepsis in rats.

scientific article published in February 2010

Caring for Sepsis Patients: An Update

scientific article published on 19 October 2017

Case mix, outcome, and activity for admissions to UK critical care units with severe acute pancreatitis: a secondary analysis of the ICNARC Case Mix Programme Database

scientific article published on January 2007

Catecholamine treatment for shock—equally good or bad?

scientific article published in The Lancet

Catecholamines for inflammatory shock: a Jekyll-and-Hyde conundrum.

scientific article published on 12 February 2016

Cellular dysfunction in sepsis

scientific article published on December 2008

Cellular energetic metabolism in sepsis: the need for a systems approach

scientific article published on 23 April 2008

Cellular processes in sepsis

scientific article

Changes in CRH and ACTH synthesis during experimental and human septic shock

scientific article

Changes in dental plaque following hospitalisation in a critical care unit: an observational study

scientific article

Characterization of Brain-Heart Interactions in a Rodent Model of Sepsis

scientific article published on 26 May 2016

Chemistry, pharmacology, and cellular uptake mechanisms of thiometallate sulfide donors

scientific article published on 23 May 2019

Clinical Predictors of Survival and Functional Outcome of Stroke Patients Admitted to Critical Care.

scientific article published on 30 March 2018

Clinical equipoise remains for issues of adrenocorticotropic hormone administration, cortisol testing, and therapeutic use of hydrocortisone

scientific article published in August 2003

Clinical review: Thinking outside the box--an iconoclastic view of current practice

scientific article

Clinical review: Update on hemodynamic monitoring--a consensus of 16

scientific article

Clinical review: a systematic review of corticosteroid use in infections

scientific article

Comparison of stroke volume measurement between non-invasive bioreactance and esophageal Doppler in patients undergoing major abdominal-pelvic surgery

scientific article published on 8 April 2017

Component reductions in oxygen delivery generate variable haemodynamic and stress hormone responses.

scientific article published on 22 May 2014

Composition of the Sepsis Definitions Task Force—Reply

scientific article published in The Journal of the American Medical Association

Continuous renal replacement therapy. Keeping the circuit open: lessons from the lab.

scientific article

Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

scholarly article by Marcin F Osuchowski et al published October 2018 in Infection

Critical Care Health Informatics Collaborative (CCHIC): Data, tools and methods for reproducible research: A multi-centre UK intensive care database

Critical care data processing tools

Critical care: advances and future perspectives ⬇️

scientific article published on October 11, 2010

Critical illness and flat batteries

scientific article published on 28 December 2017

Decatecholaminisation during sepsis

scientific article published on 4 October 2016

Deconstructing Hyperlactatemia in Sepsis Using Central Venous Oxygen Saturation and Base Deficit

scientific article published on 01 September 2019

Defining Septic Shock—Reply

scientific article published in The Journal of the American Medical Association

Definitions for Sepsis and Septic Shock—Reply

scientific article published in The Journal of the American Medical Association

Delay to admission to critical care and mortality among deteriorating ward patients in UK hospitals: a multicentre, prospective, observational cohort study

scientific article published on February 2015

Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist

scientific article

Detailed characterization of a long-term rodent model of critical illness and recovery

scientific article

Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study

scientific article published on 18 January 2018

Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

scientific article

Differences in Fat Metabolism Between Predicted Survivors And Non-Survivors of Faecal Peritonitis.

scientific article published in October 2015

Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis

scientific article published in October 2007

Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis

scientific article

Do critical care patients hibernate? Theoretical support for less is more

scientific article published on 08 November 2019

Do we need a new definition of sepsis?

scientific article published on 3 February 2015

Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis.

scientific article published in March 2013

Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis

scientific article

Early-onset candidemia: An increasing problem?*

scientific article published on 01 September 2009

Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit: The Oxygen-ICU Randomized Clinical Trial

scientific article published on 05 October 2016

Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial

scientific article published on October 2013

Effect of linezolid and teicoplanin on skin staphylococci

scientific article published on 05 April 2007

Effects of MGC-0109, a slow-release sulphide donor, on myocardial ischaemia/reperfusion injury.

scientific article

Effects of alterations in left ventricular filling, contractility, and systemic vascular resistance on the ascending aortic blood velocity waveform of normal subjects ⬇️

scientific article published on September 1, 1991

Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression

scientific article

Effects of short-term hyperoxia on erythropoietin levels and microcirculation in critically Ill patients: a prospective observational pilot study

scientific article

Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study).

scientific article published on 9 April 2018

Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis.

scientific article published on 14 May 2015

Esophageal Doppler: noninvasive cardiac output monitor

scientific article published on November 2003

Etomidate versus ketamine for sedation in acutely ill patients

scientific article

Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology

scientific article

Experience using high-dose glucose-insulin-potassium (GIK) in critically ill patients

scientific article published on 26 April 2017

Exploring alternative routes for oxygen administration

scientific article published on 10 October 2016

Fixed minimum fluid volume for resuscitation: Con

scientific article published on 31 October 2016

Fundamentals of oxygen delivery

scientific article published on January 2007

Ghrelin, appetite and critical illness

scientific article published on April 2012

Give oxygen, get a blood pressure... but don't overdo it.

scientific article

Glucocorticoids in sepsis: dissecting facts from fiction

scientific article published on 13 October 2011

H1N1 pneumonitis treated with intravenous zanamivir

scientific article published on 3 September 2009

Haemophagocytic lymphohistiocytosis in adult critical care

scientific article published on 07 January 2020

Hazard Ratios and Hazardous Carbapenemase-Producing Enterobacteriaceae

scientific article published in November 2015

Heart rate reduction with esmolol is associated with improved arterial elastance in patients with septic shock: a prospective observational study.

scientific article

How do you prefer your resuscitation solution?: Do you want a little bit more salt?

scientific article published on December 2012

Human Septic Myopathy: Induction of Cyclooxygenase, Heme Oxygenase and Activation of the Ubiquitin Proteolytic Pathway

scientific article published on 01 September 2004

Hydrocortisone therapy for patients with septic shock

scientific article

Hyperglycemia in critical illness: a review

scientific article

Hyperpyrexia and rhabdomyolysis after MDMA ("ecstasy") abuse

scientific article published in March 1992

Hypothermia protects brain mitochondrial function from hypoxemia in a murine model of sepsis

scientific article

Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages

scientific article

Immunomodulators in COVID-19 - Two Sides to Every Coin

scientific article published on 14 September 2020

Impact of ghrelin on body composition and muscle function in a long-term rodent model of critical illness

scientific article published on 10 August 2017

Impact on mortality of prompt admission to critical care for deteriorating ward patients: an instrumental variable analysis using critical care bed strain.

scientific article

Importance of the environment for patient acquisition of methicillin-resistant Staphylococcus aureus in the intensive care unit: a baseline study.

scientific article published in October 2007

Improved Survival in a Long-Term Rat Model of Sepsis Is Associated With Reduced Mitochondrial Calcium Uptake Despite Increased Energetic Demand

scientific article published on 13 April 2017

Improved intensive care unit survival for critically ill allogeneic haematopoietic stem cell transplant recipients following reduced intensity conditioning

scientific article

In Vivo Imaging of Flavoprotein Fluorescence During Hypoxia Reveals the Importance of Direct Arterial Oxygen Supply to Cerebral Cortex Tissue.

scientific article published in January 2016

In vitro susceptibility of Gram-positive pathogens to linezolid and teicoplanin and effect on outcome in critically ill patients.

scientific article

In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent

scientific article

Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial

scientific article published on 16 December 2014

Infection in the critically ill--questions we should be asking

scientific article published on April 2011

Inflammation and endothelial function: direct vascular effects of human C-reactive protein on nitric oxide bioavailability

scientific article

Inflammation biomarkers and delirium in critically ill patients

scientific article

Inhibition of mitochondrial respiration during early stage sepsis.

scientific article published in January 2003

Inhibition of vascular adenosine triphosphate-sensitive potassium channels by sympathetic tone during sepsis

scientific article published in April 2012

Intensive care and emergency medicine: progress over the past 25 years

scientific article published on April 2006

Intramural feeding

scientific article published on 01 January 2005

Intraoperative intravascular volume optimisation and length of hospital stay after repair of proximal femoral fracture: randomised controlled trial ⬇️

scientific article published on October 11, 1997

Intravenous oxygen administration in a rat model of hypoxia.

scientific article

Is MOF an outcome parameter or a transient, adaptive state in critical illness?

scientific article published on October 2009

Is the inflammasome a potential therapeutic target in renal disease?

scientific article published on 23 January 2014

Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two-centre study

scientific article published in January 2005

Judging quality of current septic shock definitions and criteria

scientific article

Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl.

scientific article

Large variation in MRSA policies, procedures and prevalence in English intensive care units: a questionnaire analysis.

scientific article

Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis.

scientific article published on 5 October 2016

Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT

scientific article published on 16 November 2018

Linezolid resistance in clinical isolates of Staphylococcus aureus

scientific article

Linezolid versus teicoplanin in the treatment of Gram-positive infections in the critically ill: a randomized, double-blind, multicentre study.

scientific article

Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis

scientific article (publication date: 2012)

Low-molecular-weight polyethylene glycol improves survival in experimental sepsis

scientific article

Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study.

scientific article published on 17 April 2018

Management of a mixed overdose of calcium channel blockers, β-blockers and statins

scientific article

Management of fluid balance: a European perspective

scientific article published on February 2012

Managing critically ill patients with a pulmonary artery catheter

scientific article published on August 2006

Managing malaria in the intensive care unit

scientific article

Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix

scientific article published on March 2011

Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats

scientific article

Mechanisms of sepsis-induced cardiac dysfunction

scientific article published on June 2007

Mechanisms of sepsis-induced organ dysfunction

scientific article

Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit

scientific article

Metabolic dysfunction in lymphocytes promotes postoperative morbidity.

scientific article published on 20 April 2015

Metabolic failure

scientific article

Metabolic monitoring in the intensive care unit: a comparison of the Medgraphics Ultima, Deltatrac II, and Douglas bag collection methods

scientific article

Microcirculatory dysfunction and resuscitation: why, when, and how

scientific article (publication date: September 2015)

Microvascular and Interstitial Oxygen Tension in the Renal Cortex and Medulla Studied in A 4-H Rat Model of LPS-Induced Endotoxemia

scientific article published on 01 July 2011

Microvascular effects of heart rate control with esmolol in patients with septic shock: a pilot study

scientific article published in September 2013

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

scholarly article by Marcin F. Osuchowski et al published 14 August 2018 in Infection

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis

Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

Mitochondrial Dysfunction in Sepsis

scientific article published in October 2003

Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure

scientific article published on 6 November 2003

Mitochondrial dysfunction in patients with severe sepsis: an EPR interrogation of individual respiratory chain components

scientific article

Mitochondrial function in sepsis: acute phase versus multiple organ failure

scientific article published on September 2007

Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness

scientific article published on 04 March 2016

Monitoring tissue perfusion, oxygenation, and metabolism in critically ill patients

scientific article published on June 2013

Multicenter comparison of cortisol as measured by different methods in samples of patients with septic shock

scientific article published on 16 September 2009

Multicenter, randomized, placebo-controlled phase III study of pyridoxalated hemoglobin polyoxyethylene in distributive shock (PHOENIX).

scientific article published on January 2015

Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation

scientific article published in August 2004

Near-infrared spectroscopy for assessing tissue oxygenation and microvascular reactivity in critically ill patients: a prospective observational study

scientific article published on October 2016

Nitrosopersulfide (SSNO-) targets soluble guanylyl cyclase and induces vasodilation in vivo

scientific article published on 2 September 2015

Nitrosyl heme production compared in endotoxemic and hemorrhagic shock

scientific article published in January 2005

ODM/CardioQ Esophageal Doppler Technology

scientific article published on 01 June 2003

Obituary - David Bennett

scientific article published on 12 December 2012

Oesophageal Doppler

scientific article published on June 2009

Oesophageal Doppler monitoring: should it be routine for high-risk surgical patients? ⬇️

scientific article published on April 1, 2011

Optimal intensive care outcome prediction over time using machine learning

scientific article published in PLoS ONE

Oral hygiene care for critically ill patients to prevent ventilator associated pneumonia

scientific article

Organ Failure in the ICU: Cellular Alterations ⬇️

scientific article published on October 11, 2011

Our favorite unproven ideas for future critical care

scientific article

Outcomes for patients with COVID-19: known knowns, known unknowns, and unknown unknowns

scientific article published on 09 December 2020

Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication

scientific article

Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis

scientific article published in December 2007

P2X7 receptor antagonism ameliorates renal dysfunction in a rat model of sepsis.

scientific article published in March 2018

Peripheral neural detection of danger-associated and pathogen-associated molecular patterns

scientific article

Personalizing Sepsis Care

scientific article published on 5 October 2017

Pharmacokinetic studies of linezolid and teicoplanin in the critically ill.

scientific article published on 10 February 2005

Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock.

scientific article published in June 2014

Post hoc insights from PAC-Man--the U.K. pulmonary artery catheter trial

scientific article published on June 2008

Potential economic consequences of a cardioprotective agent for patients with myocardial infarction: modelling study

scientific article

Potential metabolic consequences of statins in sepsis

scientific article published on June 2011

Powering Up Failed Organs

scientific article published on 01 October 2007

Preconditioning effects of levosimendan in coronary artery bypass grafting—a pilot study

scientific article published on 04 April 2006

Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit

scientific article

Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients.

scientific article published on 29 March 2012

Prospective audit of bacteraemia management in a university hospital ICU using a general strategy of short-course monotherapy

scientific article published on 16 September 2004

Protective effects of low dose stabilized haemoglobin solution in experimental global ischaemia-reperfusion injury

scientific article published in October 2015

Protocolised Management In Sepsis (ProMISe): a multicentre randomised controlled trial of the clinical effectiveness and cost-effectiveness of early, goal-directed, protocolised resuscitation for emerging septic shock

scientific article published in November 2015

Puerperal sepsis

scientific article published on 30 August 2013

Purinergic signaling in inflammatory renal disease

scientific article published in 2013

RADICAL study: rapid diagnosis of suspected bloodstream infections from direct blood testing using PCR/ESI-MS.

scientific article published on 3 December 2014

Randomised controlled trial assessing the impact of a nurse delivered, flow monitored protocol for optimisation of circulatory status after cardiac surgery

scientific article

Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections

scientific article published on 31 August 2015

Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine

scientific article

Reductions in tyrosine levels are associated with thyroid hormone and catecholamine disturbances in sepsis

scientific article published in October 2015

Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury.

scientific article published on 2 January 2018

Renal effects of levosimendan: a consensus report

scientific article published on December 2013

Reply to Tasker and to Lellouche and L'Her

scientific article published on 01 February 2020

Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A

scientific article published on August 2010

Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide

scientific article published in May 2005

Role of KATP channels in sepsis

scientific article published on 21 July 2006

Sepsis - thoughtful management for the non-expert.

scientific article published in February 2018

Sepsis results in early cholesterol and steroidogenesis pathway alterations.

scientific article published in October 2015

Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy

scientific article published on October 2016

Sepsis: personalization v protocolization?

scientific article published on 14 June 2019

Sequential Analysis of a Panel of Biomarkers and Pathologic Findings in a Resuscitated Rat Model of Sepsis and Recovery

scientific article

Seven unconfirmed ideas to improve future ICU practice.

scientific article published on 28 December 2017

Severe bloodstream infections from the community: risk factors and outcomes.

scientific article

Sex-Mediated Response to the Beta-Blocker Landiolol in Sepsis: An Experimental, Randomized Study.

scientific article

Short-Acting β-Blocker Administration in Patients With Septic Shock—Reply

scientific article published in The Journal of the American Medical Association

Short-term hypoxic vasodilation in vivo is mediated by bioactive nitric oxide metabolites, rather than free nitric oxide derived from haemoglobin-mediated nitrite reduction

scientific article published on 06 January 2014

Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis

scientific article published on 15 February 2017

Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis

scientific article published on 24 February 2015

So you want to be ... a critical care physician

scientific article published on 01 June 2010

Spreading the knowledge on the epidemiology of sepsis

scientific article

Statin use and mortality in the bacteremic critically ill patient*

scientific article published on 01 April 2006

Statins, fibrates, thiazolidinediones and resveratrol as adjunctive therapies in sepsis: could mitochondria be a common target?

scientific article published on 17 April 2014

Steroids in ARDS: more light is being shed

scientific article published on 04 September 2020

Steroids in Patients With Septic Shock

scientific article published on 01 July 2009

Strategies to modulate cellular energetic metabolism during sepsis.

scientific article published on January 2007

Stressing the obvious? An allostatic look at critical illness

scientific article published in October 2010

Succinate recovers mitochondrial oxygen consumption in septic rat skeletal muscle

scientific article published on 01 September 2007

Survival in critical illness is associated with early activation of mitochondrial biogenesis

scientific article

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

scientific article published on 18 January 2017

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

scientific article published on 17 January 2017

System interactions.

scientific article published on January 2007

TREM-1 promotes survival during septic shock in mice.

scientific article published in February 2007

Talactoferrin in Severe Sepsis: Results From the Phase II/III Oral tAlactoferrin in Severe sepsIS Trial

scientific article

Teicoplanin resistance in methicillin-resistant Staphylococcus aureus in an intensive care unit

scientific article published on 29 July 2003

Temporal changes in tissue cardiorespiratory function during faecal peritonitis.

scientific article

Terlipressin for norepinephrine-resistant septic shock

scientific article published in April 2002

The Effect of Sepsis on the Erythrocyte

scientific article published on 8 September 2017

The FTc is not an accurate marker of left ventricular preload

scientific article published on 28 April 2006

The Heart in Sepsis: From Basic Mechanisms to Clinical Management

scientific article published on 01 March 2013

The Pancreatitis Outcome Prediction (POP) Score: A new prognostic index for patients with severe acute pancreatitis*

scientific article published on 01 July 2007

The Pancreatitis Outcome Prediction (POP) score: How about hematocrit and leukopenia?

scientific article published on 01 November 2007

The Surviving Sepsis guidelines: evidence-based ... or evidence-biased?

scientific article

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

scientific article

The cost of intensive care: a comparison on one unit between 1988 and 1991.

scientific article

The detection of microbial DNA but not cultured bacteria is associated with increased mortality in patients with suspected sepsis-a prospective multi-centre European observational study.

scientific article published on 23 November 2016

The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock

scientific article

The evolutionary role of nutrition and metabolic support in critical illness

scientific article published on July 2010

The impact of enhanced cleaning within the intensive care unit on contamination of the near-patient environment with hospital pathogens: a randomized crossover study in critical care units in two hospitals

scientific article published on April 2011

The impact of hospitalization on dental plaque accumulation: an observational study

scientific article published on 07 September 2012

The impact of inspired oxygen concentration on tissue oxygenation during progressive haemorrhage

scientific article published on 18 July 2009

The intensive care medicine research agenda on septic shock

scientific article

The key advance in the treatment of sepsis in the last 10 years...doing less

scientific article

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching

scientific article published on March 2013

The medical use of oxygen: a time for critical reappraisal

scientific article published on December 2013

The metabolic phenotype of rodent sepsis: cause for concern?

scientific article published on 29 October 2013

The new definitions of SEPSIS and SEPTIC SHOCK: What do they give us? An answer.

scientific article published on 17 January 2017

The new sepsis consensus definitions (Sepsis-3): the good, the not-so-bad, and the actually-quite-pretty

scientific article published on 3 November 2016

The oxygen cost of rehabilitation interventions in mechanically ventilated patients: an observational study

scientific article published on 02 July 2019

The pore-forming subunit of the K(ATP) channel is an important molecular target for LPS-induced vascular hyporeactivity in vitro

scientific article

The role of mitochondrial dysfunction in sepsis-induced multi-organ failure

scientific article

The stress response and critical illness: a review

scientific article published on December 2012

The validity of trans-esophageal Doppler ultrasonography as a measure of cardiac output in critically ill adults

scientific article published on 11 September 2004

Thinking outside the box: Introduction

scientific article published on 01 October 2010

Thirty years of critical care medicine

scientific article

Timely selection of adequate antifungal therapy for candidemia in the critically ill: Donʼt let the yeast rise!*

scientific article published on 01 November 2008

Tissue and plasma putrescine levels in non-survivors of sepsis in a fluid-resuscitated rat model of faecal peritonitis.

scientific article

Tissue oxygen and hemodynamics in renal medulla, cortex, and corticomedullary junction during hemorrhage-reperfusion

scientific article

Tissue oxygen monitoring in rodent models of shock

scientific article published on 23 March 2007

Tissue oxygen tension monitoring of organ perfusion: rationale, methodologies, and literature review

scientific article

Tissue oxygen tension monitoring: will it fill the void?

scientific article published on June 2011

Tracking changes in cardiac output: methodological considerations for the validation of monitoring devices

scientific article published on 11 July 2009

Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study.

scientific article

Treating critical illness: the importance of first doing no harm

scientific article

Trial of Early, Goal-Directed Resuscitation for Septic Shock

scientific article (publication date: 2 April 2015)

Understanding the benefits and harms of oxygen therapy

scientific article published on 30 January 2015

Understanding the benefits and harms of oxygen therapy: response to comments by Akca

scientific article published on 28 July 2015

Variability in management of early severe sepsis

scientific article published in February 2010

Variability of treatment duration for bacteraemia in the critically ill: a multinational survey.

scientific article published on 30 September 2003

Variable effects of inhibiting iNOS and closing the vascular ATP-sensitive potassium channel (via its pore-forming and sulfonylurea receptor subunits) in endotoxic shock

scientific article published in May 2009

Vasopressin synthesis by the magnocellular neurons is different in the supraoptic nucleus and in the paraventricular nucleus in human and experimental septic shock

scientific article published on 9 November 2009

Vasopressin: mechanisms of action on the vasculature in health and in septic shock

scientific article published on January 2007

What Faces Reveal: A Novel Method to Identify Patients at Risk of Deterioration Using Facial Expressions

scientific article published on 23 March 2018

What's in a beat?

scientific article published on 01 October 2003

Why aren't we practising homogenized medicine?

scientific article

[Pyr1]Apelin-13(1-12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr1]Apelin-13.

scientific article published on 28 February 2017

qSOFA, Cue Confusion

scientific article published on 6 February 2018

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