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List of works by Gareth Sanger

5-HT4 receptor agonists enhance both cholinergic and nitrergic activities in human isolated colon circular muscle

scientific article published on 01 September 2006

5-HT4 receptor antagonism potentiates inhibition of intestinal allodynia by 5-HT3 receptor antagonism in conscious rats

scientific article

5-Hydroxytryptamine (5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives

scientific article published in July 1990

5-Hydroxytryptamine3 receptor antagonism modulates a noxious visceral pseudoaffective reflex

scientific article published in March 1995

5-hydroxyindalpine, an agonist at the putative 5-HT receptor, has no activity on human recombinant monoamine receptors but accelerates distension-induced peristalsis in mouse isolated colon.

scientific article published on 2 March 2009

5-hydroxytryptamine and the gastrointestinal tract: where next?

scientific article

A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research

scholarly article by Gareth Sanger et al published 2018 in Frontiers in Pharmacology

A prostaglandin analogue which potently relaxes human uterus but not gut muscle

scientific article published on 01 June 1982

Abdominal vagal afferent neurones: an important target for the treatment of gastrointestinal dysfunction

scientific article

Activation of a myenteric 5-hydroxytryptamine-like receptor by metoclopramide

scientific article

Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon.

scientific article published on 10 March 2008

Adaptive upregulation of gastric and hypothalamic ghrelin receptors and increased plasma ghrelin in a model of cancer chemotherapy-induced dyspepsia

scientific article published on 25 March 2008

Analysis of factors that determine the compliance of rat jejunum to distension in vivo.

scientific article published in August 2003

Analysis of pancreatic polypeptide cDNA from the house musk shrew, Suncus murinus, suggests a phylogenetically closer relationship with humans than for other small laboratory animal species

scientific article published in July 2003

Analysis of the ghrelin receptor-independent vascular actions of ulimorelin

scientific article

Antagonism by SB 204070 of 5-HT-evoked Contractions in the Dog Stomach: an In-vivo Model of 5-HT4 Receptor Function

scientific article published on 01 March 1995

Antagonism by fenamates of prostaglandin action in guinea-pig and human alimentary muscle.

scientific article published on March 1980

Antagonism of prostanoid-induced contractions of rat gastric fundus muscle by SC-19220, sodium meclofenamate, indomethacin or trimethoquinol.

scientific article

Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic anti-cancer agent cisplatin.

scientific article

Anti-emetic and emetic effects of erythromycin in Suncus murinus: role of vagal nerve activation, gastric motility stimulation and motilin receptors.

scientific article

Anxiolytic-like actions of the selective 5-HT4 receptor antagonists SB 204070A and SB 207266A in rats.

scientific article

Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor.

scientific article published on 14 December 2008

Behavioural and hypothalamic molecular effects of the anti-cancer agent cisplatin in the rat: A model of chemotherapy-related malaise?

scientific article published on 26 January 2006

Benzotriazinones as virtual-ring mimics of o-methoxybenzamides: novel and potent 5-HT3 receptor antagonists

scientific article published on 01 November 1990

Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells

scientific article published on 10 July 2017

Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders.

scientific article

Changes in neuromuscular structure and functions of human colon during ageing are region-dependent

scientific article published on 18 September 2018

Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function.

scientific article

Cholinergic interactions between donepezil and prucalopride in human colon: potential to treat severe intestinal dysmotility

scientific article

Chronic constipation: improved understanding offers a new therapeutic approach

scientific article published in August 2016

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1.

scientific article

Constipation evoked by 5-HT3-receptor antagonism: evidence for heterogeneous efficacy among different antagonists in guinea-pigs.

scientific article

Defensive and pathological functions of the gastrointestinal NK3 receptor.

scientific article published on 28 June 2006

Differences between the abilities of tegaserod and motilin receptor agonists to stimulate gastric motility in vitro.

scientific article published on 8 January 2007

Differential amplification of intron-containing transcripts reveals long term potentiation-associated up-regulation of specific Pde10A phosphodiesterase splice variants.

scientific article published on 28 January 2004

Differential effects of dexamethasone, ondansetron and a tachykinin NK1 receptor antagonist (GR205171) on cisplatin-induced changes in behaviour, food intake, pica and gastric function in rats

scientific journal article

Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate.

scientific article published in February 2009

Do 5-HT4 Receptors Mediate the Intestinal Secretory Response to 5-HT in Rat In-vivo?

scientific article published on 01 March 1995

Dorsal root ganglion neurons show increased expression of the calcium channel alpha2delta-1 subunit following partial sciatic nerve injury

scientific article published in November 2001

Drugs acting at 5-HT4, D2, motilin, and ghrelin receptors differ markedly in how they affect neuromuscular functions in human isolated stomach

scientific article published on 20 April 2014

Effect of a selective and potent central nervous system penetrant, neurokinin-3 receptor antagonist (SB-222200), on cisplatin-induced emesis in the ferret

scientific article published on 2 December 2004

Effects of NMDA receptor antagonists on visceromotor reflexes and on intestinal motility, in vivo.

scientific article published on 21 May 2007

Effects of metoclopramide and domperidone on cholinergically mediated contractions of human isolated stomach muscle

scientific article published on 01 September 1985

Effects of neo-adjuvant chemotherapy for oesophago-gastric cancer on neuro-muscular gastric function

scientific article published on 29 June 2012

Effects of the peripherally acting NK receptor antagonist, SB-235375, on intestinal and somatic nociceptive responses and on intestinal motility in anaesthetized rats.

scientific article published in April 2004

Endocannabinoids and the gastrointestinal tract: what are the key questions?

scientific article published on 03 September 2007

Evidence for the involvement of central 5-HT7 receptors in the micturition reflex in anaesthetized female rats

scientific journal article

Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat

scientific journal article

Ex vivo study of human visceral nociceptors

scientific article published on 21 September 2016

Farnesoid X receptor - a molecular predictor of weight loss after vertical sleeve gastrectomy?

scientific article published on 26 March 2019

Functional and in situ hybridization evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors.

scientific article published on 6 January 2010

Functional brain networks and neuroanatomy underpinning nausea severity can predict nausea susceptibility using machine learning

scholarly article by James K. Ruffle et al published 10 January 2019 in Journal of Physiology

Functional brain networks and neuroanatomy underpinning nausea severity can predict nausea susceptibility using machine learning

scholarly article by James K Ruffle et al published March 2019 in Journal of Physiology

GABA(B) receptor function in the ileum and urinary bladder of wildtype and GABA(B1) subunit null mice.

scientific article

GSK962040: a small molecule motilin receptor agonist which increases gastrointestinal motility in conscious dogs ⬇️

scientific article published on September 5, 2011

GSK962040: a small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility

scientific article published in June 2009

Gastrointestinal neuropharmacology: identification of therapeutic targets

scientific article published on 01 December 2002

Gastrointestinal pharmacology: challenges ahead.

scientific article published on 21 May 2010

Ghrelin alleviates cancer chemotherapy-associated dyspepsia in rodents.

scientific article

Ghrelin and Motilin Control Systems in GI Physiology and Therapeutics.

scientific article published on 30 December 2016

Ghrelin and motilin receptor agonists: a long and winding misconception

scientific article

Ghrelin and motilin receptor agonists: time to introduce bias into drug design

scientific article

Ghrelin and motilin receptors as drug targets for gastrointestinal disorders

scientific article published on 22 September 2015

Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin

scientific article

Hormones of the gut-brain axis as targets for the treatment of upper gastrointestinal disorders.

scientific article published on March 2008

Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design

scientific article published on 5 August 2016

Hypersensitivity and hyperreactivity in the irritable bowel syndrome: An opportunity for drug discovery.

scientific article

Identification of arachidonic acid metabolites extracted from human uterus, and their effects on the isolated myometrium

scientific article published on 01 September 1981

Identification of differentially expressed genes in dorsal root ganglia following partial sciatic nerve injury

article

Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin

article

Identification of small molecule agonists of the motilin receptor

scientific article

Increased defaecation caused by 5-HT4 receptor activation in the mouse.

scientific article

Increased gastric cholinergic activity evoked by 5-hydroxy-L-tryptophan in the rat.

scientific article published in August 1986

Increased gut cholinergic activity and antagonism of 5-hydroxytryptamine M-receptors by BRL 24924: potential clinical importance of BRL 24924.

scientific article published on May 1987

Increased plasma ghrelin following infliximab in Crohn's disease

scientific article

Inhibition by tianeptine of neuronally mediated contractions in the rat isolated gastrointestinal tract

scientific article published on 25 March 2008

Intestinal anti-nociceptive behaviour of NK3 receptor antagonism in conscious rats: evidence to support a peripheral mechanism of action

scientific article published in August 2003

Intrinsic nerve circuits of the gastrointestinal tract: identification of drug targets.

scientific article

Investigational drug therapies for the treatment of gastroparesis.

scientific article published on 27 January 2017

Little or no ability of obestatin to interact with ghrelin or modify motility in the rat gastrointestinal tract.

scientific article published on 27 November 2006

Metabolites of arachidonic acid formed by human gastrointestinal tissues and their actions on the muscle layers.

scientific article

Modulation of peristalsis by NK3 receptor antagonism in guinea-pig isolated ileum is revealed as intraluminal pressure is raised

scientific article published in April 2007

Motilin receptor neuropharmacology: revised understanding.

scientific article published on 02 August 2012

Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases.

scientific article published on 20 February 2008

Motilin: towards a new understanding of the gastrointestinal neuropharmacology and therapeutic use of motilin receptor agonists ⬇️

scientific article published on December 1, 2013

N-[(1-Butyl-4-piperidinyl)methyl]-3,4- dihydro-2H-[1,3]oxazino[3,2-a]indole- 10-carboxamide hydrochloride: the first potent and selective 5-HT4 receptor antagonist amide with oral activity

scientific article published on 01 November 1995

Nausea and the quest for the perfect anti-emetic

scientific article published on 22 October 2013

Nerve injury-associated kinase: a sterile 20-like protein kinase up-regulated in dorsal root ganglia in a rat model of neuropathic pain

scientific article published on 01 January 2000

Neuropharmacology of emesis induced by anti-cancer therapy.

scientific article published on September 1988

New target profiling for gastrointestinal disorders: where are we going?

scientific article published on 02 November 2012

Pharmacological characterization of the vanilloid receptor in the rat dorsal spinal cord.

scientific article published on July 1997

Pica—A model of nausea? Species differences in response to cisplatin

scientific article published on 01 June 2005

Pinane thromboxane A2 analogues are non-selective prostanoid antagonists in rat and human stomach muscle.

scientific article

Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification

scientific article published on 25 September 2007

Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation

scientific article

Potentiation by cholinesterase inhibitors of cholinergic activity in rat isolated stomach and colon.

scientific article published on 9 September 2008

Prokineticin-2, motilin, ghrelin and metoclopramide: prokinetic utility in mouse stomach and colon

scientific article published on 19 October 2005

Prolonged anti-emetic activity and 5-HT3-receptor antagonism by BRL 46470 in conscious ferrets.

scientific article

RQ-00201894: A motilin receptor agonist causing long-lasting facilitation of human gastric cholinergically-mediated contractions

scientific article published on 19 November 2015

Regional differences in the responses to prostanoids of circular muscle from guinea-pig isolated intestine ⬇️

scientific article published on October 1, 1980

Regional- and agonist-dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists.

scientific article published on October 2012

Regionally dependent neuromuscular functions of motilin and 5-HT4receptors in human isolated esophageal body and gastric fundus

scientific article published on 23 July 2014

SB‐207266: 5‐HT4 receptor antagonism in human isolated gut and prevention of 5‐HT‐evoked sensitization of peristalsis and increased defaecation in animal models ⬇️

scientific article published on August 1, 1998

Secoverine hydrochloride is a muscarinic antagonist in human isolated gastrointestinal muscle and myometrium

scientific article published on 01 November 1981

Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron).

scientific article published in January 1989

Site-specific splice variation of the human P2X4 receptor

scientific article

Substituted benzamides with conformationally restricted side chains. 5. Azabicyclo[x.y.z] derivatives as 5-HT4 receptor agonists and gastric motility stimulants

scientific article published in March 1993

Synergy between 5-HT4 receptor activation and acetylcholinesterase inhibition in human colon and rat forestomach

scientific article

The Benefits of Olanzapine in Palliating Symptoms

scientific article published on 26 November 2020

The Concise Guide to PHARMACOLOGY 2013/14: overview

scientific article

The Relationship Between Symptom Improvement and Gastric Emptying in the Treatment of Gastroparesis: Remember the Pharmacology

scientific article published on 01 March 2014

The anti-emetic potential of the 5-hydroxytryptamine3 receptor antagonist BRL 43694.

scientific article

The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin.

scientific article

The effect of sympathetic nerve stimulation on serum gastrin, gastric acid secretion and mucosal blood flow responses to meat extract stimulation in anaesthetized cats

article

The effects of SB 204070, a highly potent and selective 5-HT4 receptor antagonist, on guinea-pig distal colon.

scientific article published on July 1994

The effects of various peptides on human isolated gut muscle

scientific article published on December 1, 1992

The effects of various pharmacological agents on the metoclopramide-induced increase in cholinergic-mediated contractions of rat isolated forestomach

scientific article published on 01 August 1985

The guinea-pig distal colon--a sensitive preparation for the investigation of 5-HT4 receptor-mediated contractions.

scientific article published on December 1993

The hungry stomach: physiology, disease, and drug development opportunities.

scientific article

The identification of and rationale for drugs which act at the motilin receptor.

scientific article published on January 2009

The pharmacodynamics, safety and pharmacokinetics of single doses of the motilin agonist, camicinal, in type 1 diabetes mellitus with slow gastric emptying

scientific article published on 29 February 2016

The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykininergic motor neurones

scientific article published on 27 June 2006

The rabbit motilin receptor: molecular characterisation and pharmacology.

scientific article published on 22 September 2003

The relationship between gastric motility and nausea: gastric prokinetic agents as treatments

scientific article

The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation

scientific article published in January 2007

The role of endogenous opioids in the control of gastrointestinal motility: predictions from in vitro modelling

scientific article published in October 2004

The translational value of rodent gastrointestinal functions: a cautionary tale.

scientific article published on 29 April 2011

The type 2 CCK/gastrin receptor antagonist YF476 acutely prevents NSAID-induced gastric ulceration while increasing iNOS expression

scientific article published on 24 November 2012

Thermal, But Not Mechanical, Nociceptive Behavior is Altered in the Zucker Diabetic Fatty Rat and Is Independent of Glycemic Status

scientific article published on 01 May 1999

Three different ways in which 5-hydroxytryptamine can affect cholinergic activity in guinea-pig isolated ileum

scientific article published in August 1985

Translating 5-HT receptor pharmacology.

scientific article

Translational neuropharmacology: the use of human isolated gastrointestinal tissues ⬇️

scientific article published on January 1, 2013

Treatment of nausea and vomiting: gaps in our knowledge.

scientific article

UDP-glucose modulates gastric function through P2Y14 receptor-dependent and -independent mechanisms

scientific article published on 22 January 2009

Visually induced nausea causes characteristic changes in cerebral, autonomic and endocrine function in humans.

scientific article published on 29 January 2015

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