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List of works by Roger Pertwee

(-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens

scientific article

6"-Azidohex-2"-yne-cannabidiol: a potential neutral, competitive cannabinoid CB1 receptor antagonist

scientific article published in March 2004

A metabolic interactionin vivobetween cannabidiol and Δ1-tetrahydrocannabinol ⬇️

scientific article published on June 1, 1972

A preliminary investigation of the mechanisms underlying cannabinoid tolerance in the mouse vas deferens

scientific article published on 01 January 1995

AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.

scientific article

AM630, a competitive cannabinoid receptor antagonist

scientific article published on 01 January 1995

Action of delta-9-tetrahydrocannabinol on GABA(A) receptor-mediated responses in a grease-gap recording preparation of the rat hippocampal slice

scientific article published in October 1997

Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception

scientific article published in January 2001

Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis

scientific article published in February 2002

Activation of type II cannabinoid receptors improves myocardial tolerance to arrhythmogenic effects of coronary occlusion and reperfusion.

scientific article

Allosteric modulation of the cannabinoid CB1 receptor

scientific article

An investigation of the involvement of GABA in certain pharmacological effects of delta-9-tetrahydrocannabinol

scientific article published on 01 November 1991

Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis

article

Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

scientific article

Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase

scientific article

Brain levels and relative potency of the 1,2-dimethylheptyl analogue of delta1-tetrahydrocannabinol in mice

scientific article

CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.

scientific article published on 15 November 2012

CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency

scientific article published on 29 June 2015

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

scientific article published on February 2013

Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels.

scientific article

Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells

scientific article published on 28 December 2005

Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats

scientific article

Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation

scientific article

Cannabinoid receptor antagonists SR141716 and SR144528 exhibit properties of partial agonists in experiments on isolated perfused rat heart.

scientific article

Cannabinoid receptors and pain

scientific article (publication date: April 2001)

Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis

scientific article published on 26 November 2007

Cannabinoids and multiple sclerosis

scientific article published on 26 June 2007

Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators.

scientific article published on 26 October 2012

Cannabinoids and the gastrointestinal tract

scientific article

Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors.

scientific article published in June 2013

Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes

scientific article published on May 2009

Correlation between cannabinoid mediated effects on paired pulse depression and induction of long term potentiation in the rat hippocampal slice

scientific article published in September 1998

Delta-9-tetrahydrocannabinol-induced catalepsy in mice is enhanced by pretreatment with flurazepam or chlordiazepoxide

scientific article

Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats

scientific article published in December 2004

Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia

scientific article published on 25 September 2006

Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells

scientific article published on 01 April 2007

Drugs which stimulate or facilitate central GABAergic transmission interact synergistically with delta-9-tetrahydrocannabinol to produce marked catalepsy in mice

scientific article published on 01 December 1988

Drugs which stimulate or facilitate central cholinergic transmission interact synergistically with delta-9-tetrahydrocannabinol to produce marked catalepsy in mice.

scientific article published on January 1991

Early phytocannabinoid chemistry to endocannabinoids and beyond

scientific article published on 15 October 2014

Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence

scientific article

Effect of delta 9-tetrahydrocannabinol on circling in rats induced by intranigral muscimol administration.

scientific article published on August 1995

Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations

scientific article published in January 1995

Effect of sublingual application of cannabinoids on intraocular pressure: a pilot study.

scientific article

Effects of cannabinoid receptor ligands on electrophysiological properties of myenteric neurones of the guinea-pig ileum

scientific article published in September 1997

Effects of two endogenous fatty acid ethanolamides on mouse vasa deferentia

scientific article

Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications

scientific article

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

scientific article published on February 2009

Endocannabinoids and Their Pharmacological Actions

scientific article published on January 2015

Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism.

scientific article published in February 2002

Enhancement by chlordiazepoxide of catalepsy induced in rats by intravenous or intrapallidal injections of enantiomeric cannabinoids ⬇️

scientific article published on March 1, 1991

Enhancement of the hypothermic response of mice to delta-9-tetrahydrocannabinol by subhypothermic doses of chlorpromazine and phentolamine

scientific article published on 01 February 1987

Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals.

scientific article

Evidence that (-)-7-hydroxy-4'-dimethylheptyl-cannabidiol activates a non-CB(1), non-CB(2), non-TRPV1 target in the mouse vas deferens

scientific article published on 19 March 2005

Evidence that cannabinoid-induced inhibition of electrically evoked contractions of the myenteric plexus--longitudinal muscle preparation of guinea-pig small intestine can be modulated by Ca2+ and cAMP.

scientific article

Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist

scientific article

Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist

scientific article

First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands

scientific article published on 29 December 2005

Functional expression of cell surface cannabinoid CB1 receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons

scientific article published on 01 January 2000

Further evidence for the presence of cannabinoid CB1 receptors in mouse vas deferens

scientific article published on 01 January 1996

Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats

scientific article published on 30 November 2007

Importance of the C-1 Substituent in Classical Cannabinoids to CB2Receptor Selectivity: Synthesis and Characterization of a Series ofO,2-Propano-Δ8-tetrahydrocannabinol Analogs

scientific article published on 01 September 1997

In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB(2) receptor inverse agonists

scientific article published on 2 December 2009

In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands.

scientific article

In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

scientific article

Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

scientific article published on 2 August 2015

Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase

scientific article published in November 2005

Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus

scientific article published in August 1997

Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol

scientific article

Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2.

scientific article

Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide.

scientific article

Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews

scientific article published on 18 January 2011

Interactions between synthetic vanilloids and the endogenous cannabinoid system

scientific article published on October 1998

Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue

scientific article

Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach.

scientific article

Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands

scientific article

Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors

scientific article

Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

scientific article published on June 2008

Lipoxin A 4 is an allosteric endocannabinoid that strengthens anandamide-induced CB 1 receptor activation ⬇️

scientific article published on November 30, 2012

Localisation of cannabinoid CB(1) receptor immunoreactivity in the guinea pig and rat myenteric plexus

scientific article

Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe

scientific article

Medical uses of cannabinoids: the way forward

scientific article published on 01 March 1999

Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differences.

scientific article published on 16 July 2007

Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459

scientific article published on April 2015

Modulation of l-α-Lysophosphatidylinositol/GPR55 Mitogen-activated Protein Kinase (MAPK) Signaling by Cannabinoids ⬇️

scientific article published on October 25, 2011

Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors

scientific article published on 4 August 2013

Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease.

scientific article

Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets.

scientific article published in December 2008

Novel compounds that interact with both leukotriene B4 receptors and vanilloid TRPV1 receptors.

scientific article published on 5 October 2005

Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines

scientific article published on October 12, 2011

Pharmacological actions and therapeutic uses of cannabis and cannabinoids.

scientific article

Pharmacological characterization of the anandamide cyclooxygenase metabolite: prostaglandin E2 ethanolamide

scientific article published in June 2002

Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens

scientific article published on 01 September 1995

Pharmacology of cannabinoid CB1 and CB2 receptors.

scientific article

Phytocannabinoids beyond the Cannabis plant - do they exist?

scientific article

Preliminary Experiments on the Chemistry and Pharmacology of Cannabis

scientific article published in Nature

Pure Δ9-tetrahydrocannabivarin and a Cannabis sativa extract with high content in Δ9-tetrahydrocannabivarin inhibit nitrite production in murine peritoneal macrophages

scientific article published on 3 August 2016

Relative pharmacological potency in mice of optical isomers of delta 1-tetrahydrocannabinol

scientific article

Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor

scientific article published on 16 November 2011

Role of cannabinoid receptors in the regulation of cardiac contractility during ischemia/reperfusion

scientific article published on 01 November 2006

Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors.

scientific article

Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts.

scientific article published on 6 January 2006

Selective cannabinoid receptor agonist HU-210 decreases pump function of isolated perfused heart: role of cAMP and cGMP.

scientific article published in December 2004

Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist.

scientific article

Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors

scientific article

Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist

scientific article published on 12 July 2014

Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson's disease

scientific article

Synthesis and pharmacological comparison of dimethylheptyl and pentyl analogs of anandamide

scientific article published in October 1997

Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

scientific article published on 17 February 2017

Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities ⬇️

scientific article published on December 5, 2012

The Cyclic AMP Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells

scientific article published in January 2016

The Displacement Binding Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells.

scientific article published in January 2016

The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.

scientific article published on December 1998

The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

scientific article published on May 2013

The design, synthesis and testing of desoxy-CBD: further evidence for a region of steric interference at the cannabinoid receptor

scientific article published on 01 January 1995

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin

scientific article

The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice

scientific article published in December 2001

The evidence for the existence of cannabinoid receptors.

scientific article

The pharmacology of cannabinoid receptors and their ligands: an overview

scientific article

The phytocannabinoid, Δ⁹-tetrahydrocannabivarin, can act through 5-HT₁A receptors to produce antipsychotic effects.

scientific article

The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice

scientific article

The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats.

scientific article published on 14 May 2007

WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction

scientific article

delta 9-Tetrahydrocannabinol and anandamide enhance the ability of muscimol to induce catalepsy in the globus pallidus of rats

scientific article published on 01 November 1993

Δ8 -Tetrahydrocannabivarin has potent anti-nicotine effects in several rodent models of nicotine dependence

scientific article published on 28 October 2019

Δ8-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors

scientific article

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