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List of works by Clive Page

A Non Anti-coagulant Fraction of Heparin Inhibits Leukocyte Diapedesis into the Lung by an Effect on Platelets

scientific article published on 15 May 2016

A biochemical and functional assessment of monocyte phosphodiesterase activity in healthy and asthmatic subjects

scientific article published on 01 January 2000

A new model for the continuous monitoring of polymorphonuclear leukocyte trapping in the pulmonary vasculature of the rabbit

scientific article published in July 2002

A response to: ‘A manifesto for clinical pharmacology from principles to practice’ by Jeff Aronson ⬇️

scientific article published on December 1, 2010

A role for mitogen kinase kinase 3 in pulmonary inflammation validated from a proteomic approach.

scientific article published on 27 January 2014

Activation of corticotropin-releasing factor receptor-2 causes bronchorelaxation and inhibits pulmonary inflammation in mice

scientific article published on 19 July 2006

Adenosine monophosphate is elevated in the bronchoalveolar lavage fluid of mice with acute respiratory toxicity induced by nanoparticles with high surface hydrophobicity

scientific article published on 12 March 2014

Adenosine receptors and asthma.

scientific article

Airway irritability--a burning issue?

scientific article published on 20 July 2009

Allergen challenge alters lymphocyte phosphodiesterase activity in horses with heaves.

scientific article

Allergen induces the migration of platelets to lung tissue in allergic asthma

scientific article published on 20 December 2007

Alternative and/or integrative therapies for pneumonia under development.

scientific article published on May 2004

Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology

scientific article published on 27 May 2020

Anti-adhesive glycoproteins in echinoderm mucus secretions.

scientific article published in December 2004

Antigen-induced bronchial hyperresponsiveness in the rabbit is not dependent on M(2)-receptor dysfunction

scientific article published on 01 January 1999

Antitussive drugs--past, present, and future

scientific article

Antitussive effect of carcainium chloride in patients with chronic cough and idiopathic interstitial pneumonias: A pilot study.

scientific article published on 15 August 2016

Are phosphodiesterase 4 inhibitors just more theophylline?

scientific article published on 3 May 2006

Base-modified UDP-sugars reduce cell surface levels of P-selectin glycoprotein 1 (PSGL-1) on IL-1β-stimulated human monocytes

scientific article published on 27 May 2016

Bifunctional drugs for the treatment of asthma and chronic obstructive pulmonary disease.

scientific article published on 02 April 2014

Biochemical and functional assessment of equine lymphocyte phosphodiesterases and protein kinase C.

scientific article published in April 2004

Biochemical and functional characterization of glycosaminoglycans released from degranulating rat peritoneal mast cells: Insights into the physiological role of endogenous heparin

scientific article published on 03 November 2016

Bleomycin-induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI

scientific article published on 01 October 2007

Bleomycin-induced lung injury in mice investigated by MRI: model assessment for target analysis

scientific article published on 7 June 2011

Bradykinin and capsaicin induced airways obstruction in the guinea pig are platelet dependent

scientific article

Brain natriuretic peptide protects against hyperresponsiveness of human asthmatic airway smooth muscle via an epithelial cell-dependent mechanism

scientific article published in March 2014

Bronchial hyperresponsiveness induced by chronic treatment with albuterol: Role of sensory nerves.

scientific article

Capsaicin-induced mucus secretion in rat airways assessed in vivo and non-invasively by magnetic resonance imaging.

scientific article published on 12 March 2007

Celebrating the role of the British Pharmacological Society

scientific article published on 23 February 2006

Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration

scientific article

Differential inhibition of equine neutrophil function by phosphodiesterase inhibitors.

scientific article

Doxofylline, a novofylline inhibits lung inflammation induced by lipopolysacharide in the mouse

scientific article

Doxofylline: a "novofylline".

scientific article published on 07 April 2010

Dual PDE3/4 and PDE4 inhibitors: novel treatments for COPD and other inflammatory airway diseases.

scientific article published on 06 March 2014

Editorial overview: Respiratory: Cough: a burning issue.

scientific article published on 23 May 2015

Effect of Erdosteine on COPD Exacerbations in COPD Patients with Moderate Airflow Limitation

scientific article published on 02 December 2019

Effect of Mycobacterium tuberculosis chaperonins on bronchial eosinophilia and hyper-responsiveness in a murine model of allergic inflammation.

scientific article

Effect of antagonists for NK(2)and B(2) receptors on antigen-induced airway responses in allergic rabbits

scientific article published on 01 January 2000

Effect of erdosteine on the rate and duration of COPD exacerbations: the RESTORE study

scientific article published on 12 October 2017

Effect of heparin on antigen-induced airway responses and pulmonary leukocyte accumulation in neonatally immunized rabbits.

scientific article

Effect of lipopolysaccharide on the responsiveness of equine bronchial tissue

scientific article published on 30 January 2018

Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses

scientific article published on 01 June 2007

Effect of the K+(ATP) channel opener, KCO912, on baseline and allergen induced airway hyperresponsiveness in allergic rabbits.

scientific article published in January 2004

Effect of the Mixed Phosphodiesterase 3/4 Inhibitor RPL554 on Human Isolated Bronchial Smooth Muscle Tone

scientific article published on 13 June 2013

Effects of heparin and related drugs on neutrophil function

scientific article published on 04 February 2012

Effects of heparin and related molecules upon neutrophil aggregation and elastase release in vitro.

scientific article published on June 2003

Effects of neuraminidase on equine isolated bronchi.

scientific article published on 26 February 2008

Effects of tetrandrine on growth factor-induced DNA synthesis and proliferative response of rat pulmonary artery smooth muscle cells.

scientific article published on January 2000

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

scientific article published on 25 October 2013

Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects.

scientific article published on 24 October 2007

Emerging anti-inflammatory strategies for COPD ⬇️

scientific article published on April 10, 2012

Evaluation of the effects of the R- and S-enantiomers of salbutamol on equine isolated bronchi

scientific article published on 31 December 2010

Evidence to suggest that the phosphodiesterase 4 isoenzyme is present and involved in the proliferation of umbilical cord blood mononuclear cells

article

Extracellular matrix composition influences the resistance of airway remodelling events towards glucocorticoid treatment ⬇️

scientific article published on April 1, 2003

Fucosylated chondroitin sulfates from the body wall of the sea cucumber Holothuria forskali: conformation, selectin binding, and biological activity

scientific article

Getting to the heart of asthma: can "beta blockers" be useful to treat asthma?

scientific article published on 8 June 2007

Gustav Born: pioneer in imaging platelet and leukocyte biology

scientific article published on 09 November 2018

Heparanase induces inflammatory cell recruitment in vivo by promoting adhesion to vascular endothelium

scientific article published on 16 April 2014

Heparin and related drugs: beyond anticoagulant activity.

scientific article published on 30 July 2013

Heparin and structurally related polymers attenuate eotaxin-1 (CCL11) release from human airway smooth muscle.

scientific article published on 21 April 2008

Heparin inhibits allergen-induced eosinophil infiltration into guinea-pig lung via a mechanism unrelated to its anticoagulant activity.

scientific article published in January 2001

High glucose enhances responsiveness of human airways smooth muscle via the Rho/ROCK pathway.

scientific article published on 31 May 2012

Human embryonic stem cells and lung regeneration

scientific article published on 25 August 2008

Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects

scientific article

Identification with MRI of the pleura as a major site of the acute inflammatory effects induced by ovalbumin and endotoxin challenge in the airways of the rat

scientific article published on 25 May 2006

Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system

scientific article published on 12 June 2006

Immunohistochemical localization of transient receptor potential vanilloid subtype 1 in the trachea of ovalbumin-sensitized Guinea pigs

scientific article published on 27 May 2008

Immunohistochemical localization of vanilloid receptor subtype 1 (TRPV1) in the guinea pig respiratory system.

scientific article published in January 2005

Impact of erdosteine on chronic bronchitis and COPD: A meta-analysis

scientific article published on 9 December 2017

In Vitro Multiparameter Assay Development Strategy toward Differentiating Macrophage Responses to Inhaled Medicines.

scientific article

Inhaled nebulised unfractionated heparin improves lung function in moderate to very severe COPD: A pilot study

scientific article

Insights on animal models to investigate inhalation therapy: Relevance for biotherapeutics.

scientific article

Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation.

scientific article published on 28 July 2015

LPS-induced Lung Platelet Recruitment Occurs Independently from Neutrophils, PSGL-1, and P-Selectin

scientific article published on 01 August 2019

Lipopolysaccharide (LPS) induced pulmonary neutrophil recruitment and platelet activation is mediated via the P2Y1 and P2Y14 receptors in mice.

scientific article

Locally available heparin modulates inflammatory cell recruitment in a manner independent of anticoagulant activity.

scientific article

Lung inflammation does not affect the clearance kinetics of lipid nanocapsules following pulmonary administration.

scientific article published on 13 May 2016

Markers of disease severity in chronic obstructive pulmonary disease.

scientific article

Markers of exacerbation severity in chronic obstructive pulmonary disease

scientific article

Mechanism of adenosine-induced airways obstruction in allergic guinea pigs.

scientific article published in April 2006

Mycobacterium tuberculosis chaperonin 60.1 inhibits leukocyte diapedesis in a murine model of allergic lung inflammation

scientific article published on 23 March 2012

Neutrophil and platelet activation in equine recurrent airway obstruction is associated with increased neutrophil CD13 expression, but not platelet CD41/61 and CD62P or neutrophil-platelet aggregate formation.

scientific article published on 20 March 2009

Neutrophil and platelet complexes and their relevance to neutrophil recruitment and activation ⬇️

scientific article published on June 26, 2013

Noninvasive assessment of bleomycin-induced lung injury and the effects of short-term glucocorticosteroid treatment in rats using MRI

scientific article published on 01 March 2011

Novel approaches to the treatment of pneumonia.

scientific article

Novel bronchodilators for the treatment of chronic obstructive pulmonary disease ⬇️

scientific article published on June 16, 2011

Novel pharmacological approaches to airway and pulmonary vascular disease

scientific article published on 11 May 2009

Outcomes for COPD pharmacological trials: from lung function to biomarkers.

scientific article published on February 2008

Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs.

scientific article published on 02 February 2016

PDE inhibitors currently in early clinical trials for the treatment of asthma

scientific article published on 28 May 2014

Paradoxical pharmacology: turning our pharmacological models upside down ⬇️

scientific article published on March 31, 2011

Peripheral mechanisms II: the pharmacology of peripherally active antitussive drugs.

scientific article published on January 2009

Pharmacokinetic considerations concerning the use of bronchodilators in the treatment of chronic obstructive pulmonary disease

scientific article published on 09 October 2018

Pharmacological Modulation of the Inflammatory Actions of Platelets ⬇️

scientific article published on January 1, 2012

Pharmacological characterization of adenosine receptors on isolated human bronchi

scientific article published on 23 June 2011

Pharmacology and Therapeutics of Bronchodilators ⬇️

scientific article published on May 18, 2012

Pharmacology of Heparin and Related Drugs

scientific article published on January 2016

Phosphodiesterase activity in neutrophils from horses with chronic obstructive pulmonary disease

scientific article published on 01 October 2000

Phosphodiesterase inhibitors in the treatment of inflammatory diseases.

scientific article published on January 2011

Phosphodiesterase inhibitors.

scientific article

Phosphodiesterase isoenzymes in equine platelets and their influence on platelet adhesion

scientific article published on 01 December 2007

Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation

scientific article published on 04 November 2004

Platelet activation in asthma: integral to the inflammatory response

scientific article published on 01 April 2006

Platelet activation in ponies with airway inflammation

scientific article published on 01 November 2007

Platelets Play a Central Role in Sensitization to Allergen.

scientific article

Platelets and allergic inflammation.

scientific article published on July 2014

Platelets are essential for leukocyte recruitment in allergic inflammation.

scientific article published in July 2003

Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation

scientific article

Platelets coming of age: implications for our understanding of allergic inflammation.

scientific article published in March 2013

Polyvalent mechanical bacterial lysate for the prevention of recurrent respiratory infections: a meta-analysis.

scientific article

Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma

scientific article

Predicting the Fine Particle Fraction of Dry Powder Inhalers Using Artificial Neural Networks.

scientific article published on 9 November 2016

Prevention of pulmonary thromboembolism by NCX 4016, a nitric oxide-releasing aspirin

scientific article published on 01 May 2000

Protective effect of a PAR2-activating peptide on histamine-induced bronchoconstriction in guinea-pig

scientific article

Pulmonary biomarkers in chronic obstructive pulmonary disease.

scientific article

Quantitative assessment of nanoparticle surface hydrophobicity and its influence on pulmonary biocompatibility

scientific article published on 19 March 2014

RSD931, a novel anti-tussive agent acting on airway sensory nerves

scientific article

Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse

scientific article published in February 2008

Regulating cough through modulation of sensory nerve function in the airways ⬇️

scientific article published on March 21, 2013

Relationship of airway responsiveness with airway morphometry in normal and immunized rabbits.

scientific article

Role of sex hormones in allergic inflammation in mice

scientific article published in March 2007

Selection of a 2-azabicyclo[2.2.2]octane-based alpha4beta1 integrin antagonist as an inhaled anti-asthmatic agent

scientific article published on 21 February 2006

Selective PDE inhibitors as novel treatments for respiratory diseases.

scientific article published on 11 April 2012

Sex differences in the influence of obesity on a murine model of allergic lung inflammation

scientific article published on 06 December 2019

Some structural determinants of the antiproliferative effect of heparin-like molecules on human airway smooth muscle

scientific article

Steroid sparing effects of doxofylline

scientific article published on 12 October 2017

Stimulation of airway sensory nerves by cyclosporin A and FK506 in guinea-pig isolated bronchus.

scientific article published in December 1998

Structural characterization and anti-inflammatory activity of two novel polysaccharides from the sea squirt, Ascidiella aspersa

scientific article published on 21 May 2016

TNF‐α‐induces airway hyperresponsiveness to cholinergic stimulation in guinea pig airways ⬇️

scientific article published on March 1, 2012

Targeting Mechanisms Linking COPD to Type 2 Diabetes Mellitus

scientific article published on 4 August 2017

The effect of N-acetylcysteine on biofilms: Implications for the treatment of respiratory tract infections

scientific article

The effect of anti-integrin monoclonal antibodies on antigen-induced pulmonary inflammation in allergic rabbits.

scientific article

The effect of phytocannabinoids on airway hyper-responsiveness, airway inflammation, and cough.

scientific article published on 5 February 2015

The effects of heparin and related molecules on vascular permeability and neutrophil accumulation in rabbit skin.

scientific article

The effects of heparin and related molecules upon the adhesion of human polymorphonuclear leucocytes to vascular endothelium in vitro.

scientific article

The effects of heparin on the adhesion of human peripheral blood mononuclear cells to human stimulated umbilical vein endothelial cells.

scientific article

The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways

scientific article

The future challenges facing the development of new antimicrobial drugs.

scientific article

The mechanism of action of doxofylline is unrelated to HDAC inhibition, PDE inhibition or adenosine receptor antagonism ⬇️

scientific article published on November 25, 2011

The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diis

scientific article

The rabbit as a model to study asthma and other lung diseases

scientific article published on 02 February 2008

The role of CD23 on allergen-induced IgE levels, pulmonary eosinophilia and bronchial hyperresponsiveness in mice

scientific article published on 01 May 2000

The role of adenosine receptors in the action of theophylline on human peripheral blood mononuclear cells from healthy and asthmatic subjects.

scientific article published in March 2000

The role of biomarkers in respiratory disease

scientific article published on 01 December 2010

The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus

scientific article published on 3 June 2015

The role of platelets in the pathophysiology of asthma.

scientific article

The role of proteoglycans in the regulation of airways inflammation and airways remodelling.

scientific article

The role of sensory nerves in propranolol-induced bronchial hyperresponsiveness in the guinea-pig

scientific article published on 01 January 1999

The safety and effects of the beta-blocker, nadolol, in mild asthma: an open-label pilot study

scientific article

The scientific legacy of Sir James W. Black.

scientific article published on 31 March 2011

Therapeutic monoclonal antibodies for respiratory diseases: Current challenges and perspectives, March 31 - April 1, 2016, Tours, France

scientific article published on 6 June 2016

Uncharged nucleoside inhibitors of β-1,4-galactosyltransferase with activity in cells

scientific article published on 16 February 2016

Use of indacaterol for the treatment of COPD: a pharmacokinetic evaluation.

scientific article published on 03 December 2013

Use of within-group designs to test anti-tussive drugs in conscious guinea-pigs.

scientific article published in March 2010

Using Salt Counterions to Modify β2-Agonist Behavior in Vivo.

scientific article

Validating 123I-metaiodobenzylguanidine as a platelet marker for non-invasive imaging in rabbits

scientific article published on 26 May 2010

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