List of works - Steve Humphries

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Discovery and refinement of loci associated with lipid levels

scientific article

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by rep

scientific article published in September 2007

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society

scientific article

The UK10K project identifies rare variants in health and disease

scientific article

Common variants associated with plasma triglycerides and risk for coronary artery disease

scientific article

European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice ...

scientific article published in September 2007

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

scientific article

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

scientific article published on 24 September 2014

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

scientific article

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

scientific article

Mendelian randomization of blood lipids for coronary heart disease

scientific article

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

scientific article

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

scientific article published on 26 June 2011

Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

scientific article

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

scientific article

Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials

scientific article

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

scientific article published on 31 May 2017

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci

scientific article

Cytokine and cytokine receptor gene polymorphisms and their functionality.

scientific article

Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study

scientific article published on 22 February 2013

Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study

scientific article

The interleukin-6 −174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men

scientific article published on December 1, 2001

Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation

scientific article

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip

scientific article

Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment

scientific article published on May 25, 2015

Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study

scientific article

The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management

scientific article

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

scientific article published on 28 November 2016

Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts

scientific article

Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1

scientific article

Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream

scientific article

Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis

scientific article

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

scientific article

Low-density lipoprotein receptor gene familial hypercholesterolemia variant database: update and pathological assessment

scientific article

Measurements of Carotid Intima-Media Thickness and of Interadventitia Common Carotid Diameter Improve Prediction of Cardiovascular Events

scholarly article by Damiano Baldassarre et al published October 2012 in Journal of the American College of Cardiology

Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

scientific article published in August 2012

Familial hypercholesterolaemia: summary of NICE guidance

scientific article published in the British Medical Journal

Blood pressure loci identified with a gene-centric array

scientific article

β-Adrenergic Regulation of IL-6 Release from Adipose Tissue:In Vivoandin VitroStudies

scientific article published on December 1, 2001

ERRATUM: Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

article by Matthew B. Lanktree et al published June 2012 in American Journal of Human Genetics

Interleukin-6 receptor pathways in abdominal aortic aneurysm

scientific article published on 30 October 2012

IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies

scientific article

PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry

scientific article

Awareness of lifestyle risk factors for cancer and heart disease among adults in the UK.

scientific article

List of works by Steve Humphries

Genetic studies of body mass index yield new insights for obesity biology

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Discovery and refinement of loci associated with lipid levels

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Defining the role of common variation in the genomic and biological architecture of adult human height

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

New genetic loci link adipose and insulin biology to body fat distribution

European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by rep

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society

The UK10K project identifies rare variants in health and disease

Common variants associated with plasma triglycerides and risk for coronary artery disease

European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice ...

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

Mendelian randomization of blood lipids for coronary heart disease

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci

Cytokine and cytokine receptor gene polymorphisms and their functionality.

Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study

Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study

The interleukin-6 −174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men

Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip

Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment

Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study

The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts

Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1

Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream

Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

Low-density lipoprotein receptor gene familial hypercholesterolemia variant database: update and pathological assessment

Measurements of Carotid Intima-Media Thickness and of Interadventitia Common Carotid Diameter Improve Prediction of Cardiovascular Events

Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

Familial hypercholesterolaemia: summary of NICE guidance

Blood pressure loci identified with a gene-centric array

β-Adrenergic Regulation of IL-6 Release from Adipose Tissue:In Vivoandin VitroStudies

ERRATUM: Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

Interleukin-6 receptor pathways in abdominal aortic aneurysm

IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies

PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry

Awareness of lifestyle risk factors for cancer and heart disease among adults in the UK.