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List of works by Steve Humphries

A Common Mutation in the Lipoprotein Lipase Gene Promoter, −93T/G, Is Associated With Lower Plasma Triglyceride Levels and Increased Promoter Activity In Vitro ⬇️

scientific article published on October 1, 1997

A double heterozygote for familial hypercholesterolaemia and familial defective apolipoprotein B-100.

scientific article published on 24 August 2010

A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium

scientific article

A gene-centric study of common carotid artery remodelling

scientific article published on 23 November 2012

A genetic instrument for Mendelian randomization of fibrinogen.

scientific article

A genome-wide association study identifies multiple loci for variation in human ear morphology

scientific article

A priori-defined Mediterranean-like dietary pattern predicts cardiovascular events better in north Europe than in Mediterranean countries

A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

scientific article

A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima–media thickness)

article

A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease

scientific article

A variant in LDLR is associated with abdominal aortic aneurysm

scientific journal article

ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk

scientific article published on 30 October 2008

APOE, CETP and LPL genes show strong association with lipid levels in Greek children

scientific article

APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men

scientific article

Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1

scientific article

Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis

scientific article published in December 2016

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

scientific article published on 31 May 2017

An analysis of drug modulation of abdominal aortic aneurysm growth through 25 years of surveillance

article

An association between arterial pulse pressure and variation in the fibrillin-1 gene ⬇️

scientific article published on October 1, 1997

Analysis of the Association of A Heat Shock Protein70‐1 Gene Promoter Polymorphism With Myocardial Infarction and Coronary Risk Traits ⬇️

scientific article published on 01 February 1998

Analysis of the frequency and spectrum of mutations recognised to cause familial hypercholesterolaemia in routine clinical practice in a UK specialist hospital lipid clinic

scientific article published on 18 April 2013

Analysis of the role of interleukin 6 receptor haplotypes in the regulation of circulating levels of inflammatory biomarkers and risk of coronary heart disease

scientific article

Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children

scientific article published on 12 September 2008

Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure

scientific article

Antibodies to citrullinated peptides and risk of coronary heart disease

scientific article published on 18 February 2013

Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males ⬇️

scientific article published on 01 September 1997

Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study

scientific article published on 12 June 2006

Apolipoprotein B signal peptide and apolipoprotein E genotypes as determinants of the hepatic secretion of VLDL apoB in obese men ⬇️

scientific article published on 01 September 1998

Apolipoprotein C-lll gene variation and dyslipidaemia ⬇️

scientific article published on June 1, 1997

Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals

scientific article

Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

scientific article published in August 2012

Applicability of LDLR flanking microsatellite polymorphisms for prenatal diagnosis of homozygous state for familial hypercholesterolemia ⬇️

scientific article published on May 1, 1998

Application of recombinant DNA technology to prenatal detection of inherited defects ⬇️

scientific article published on 01 October 1983

Application of statistical and functional methodologies for the investigation of genetic determinants of coronary heart disease biomarkers: lipoprotein lipase genotype and plasma triglycerides as an exemplar.

scientific article

Assessment of the association between genetic polymorphisms in transforming growth factor beta, and its binding protein (LTBP), and the presence, and expansion, of Abdominal Aortic Aneurysm

article

Association between IL6 gene variants -174G>C and -572G>C and serum IL-6 levels: interactions with social position in the Whitehall II cohort

scientific article published on 27 September 2008

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

scientific article

Association between periodontitis and common variants in the promoter of the interleukin-6 gene

article

Association between short leukocyte telomere length, endotoxemia, and severe periodontitis in people with diabetes: a cross-sectional survey

scientific article published in April 2014

Association between the adiponectin promoter rs266729 gene variant and oxidative stress in patients with diabetes mellitus

scientific article published on 26 March 2009

Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus

article

Association of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart disease

scientific article published on 12 December 2013

Association of TLL1 gene polymorphism (rs1503298, T > C) with coronary heart disease in PREDICT, UDACS and ED cohorts

scientific article

Association of a sequence variant in DAB2IP with coronary heart disease

scientific article

Association of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies.

scientific article

Association of genotypes at the matrix metalloproteinase (MMP) loci with carotid IMT and presence of carotid and femoral atherosclerotic plaques

Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation

scientific article

Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus

scientific article published on January 2012

Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study

scientific article

Associations between lipoprotein lipase gene polymorphisms and plasma correlations of lipids, lipoproteins and lipase activities in young myocardial infarction survivors and age-matched healthy individuals from Sweden

scientific article published on 01 December 1992

Awareness of lifestyle risk factors for cancer and heart disease among adults in the UK.

scientific article

Bayesian meta-analysis of genetic association studies with different sets of markers

scientific article published on April 2008

Blood pressure loci identified with a gene-centric array

scientific article

Body fat distribution in relation to smoking and exogenous hormones in British women

scientific article published in December 2012

Bone structure and geometry in young men: the influence of smoking, alcohol intake and physical activity

scientific article published on 14 September 2012

C-reactive protein and coronary heart disease: predictive test or therapeutic target?

scientific article published on 29 December 2008

C-reactive protein gene variant and the human left ventricular growth response to exercise: data from The LARGE Heart Study

scientific article

Candidate-Gene Studies of the Atherogenic Lipoprotein Phenotype: A Sib-Pair Linkage Analysis of DZ Women Twins ⬇️

scientific article published on February 1, 1998

Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis

scientific article

Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis

scientific article published on 28 December 2012

Characterization of DNA-binding proteins using multiplexed competitor EMSA

scientific article

Characterization of a new apolipoprotein E5 variant detected in two French-Canadian subjects ⬇️

scientific article published on 01 April 1991

Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk

scientific article (publication date: 2012)

Chromatin structure of the 5S ribonucleic acid genes of Xenopus laevis ⬇️

scientific article published on July 24, 1979

ClinVar database of global familial hypercholesterolemia-associated DNA variants

scientific article published on 01 November 2018

Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population

scientific article published on 2 July 2015

Clinical signs of familial hypercholesterolemia in patients with familial defective apolipoprotein B-100 and normal low density lipoprotein receptor function ⬇️

scientific article published on May 1, 1991

Clinical utility gene card for: hyperlipoproteinemia, TYPE II.

scientific article

Commentary PCSK9 variants: A new database

scientific article published in March 2009

Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease

scientific article

Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: The cardiovascular health study

scholarly article by Alexander P. Reiner et al published July 2005 in Atherosclerosis

Common variants associated with plasma triglycerides and risk for coronary artery disease

scientific article

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration

scientific article published on 30 July 2011

Comparison of coronary heart disease genetic assessment with conventional cardiovascular risk assessment in primary care: reflections on a feasibility study

scientific article published on 23 March 2015

Coronary heart disease risk prediction in the era of genome-wide association studies: current status and what the future holds

scientific article published on May 2010

Correction: Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population

scientific article published on 28 September 2015

Correction: Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium.

scientific article published on 24 September 2013

Corrigendum to “Interleukin 18 and coronary heart disease: Prospective study and systematic review” [Atherosclerosis 217 (2011) 227–233].

scientific article published in December 2011

CpG-PCR combined with sample pooling and mutant enrichment for CpG mutation screening in population studies ⬇️

scientific article published on 01 January 1998

Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts

scientific article

Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European population: the IMPROVE study

scientific article

Cytokine and cytokine receptor gene polymorphisms and their functionality.

scientific article

DNA polymorphisms of the apolipoprotein B gene in Chinese coronary artery disease patients

scientific article published on 01 October 1992

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Demonstration of the presence of the "deleted" MIR122 gene in HepG2 cells

scientific article published on 26 March 2015

Denaturing Gradient Gel Electrophoretic Analysis of Codons 3456–3553 of the Apolipoprotein-B Gene in 106 Type 11a Hyperlipoproteinaemic Individuals ⬇️

scientific article published on 01 January 1998

Discovery and refinement of loci associated with lipid levels

scientific article

Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study

scientific article

Duration of preceding hypertension is associated with prolonged length of ICU stay

scientific article

ERRATUM: Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

article by Matthew B. Lanktree et al published June 2012 in American Journal of Human Genetics

Editor in Chief's Report for Atherosclerosis for 2011 ⬇️

scientific article published on November 16, 2011

Editor in Chief's report for Atherosclerosis for 2013.

scientific article

Editor's annual report

scientific article published in January 2009

Editor's report

Editor-in-Chief's report 2014

Editor-in-Chief's report 2015

Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials

scientific article

Effect of six type II diabetes susceptibility loci and an FTO variant on obesity in Pakistani subjects.

scientific article published on 23 September 2015

Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes

scientific article published on 14 May 2015

Effectiveness of a self-management intervention with personalised genetic and lifestyle-related risk information on coronary heart disease and diabetes-related risk in type 2 diabetes (CoRDia): study protocol for a randomised controlled trial

scientific article

Effects of genetic variation on chromatin structure and the transcriptional machinery: analysis of the IL6 gene locus ⬇️

scientific article published on August 16, 2012

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding

scientific article

Electrophoresis for genoptyping:temporal thermal gradient gel electrophoreisis for profiling of oiligonucleotide dissociation ⬇️

scientific article published on July 11, 1995

Erratum: A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

scientific article published on 12 May 2015

European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice ...

scientific article published in September 2007

European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by rep

scientific article published in September 2007

Expression of Matrix Metalloproteinases and Their Inhibitor TIMP-1 in the Rat Carotid Artery After Balloon Injury ⬇️

scientific article published on 01 September 1997

FH‐Pyrgos: a novel mutation in the promoter (−45delT) of the low‐density lipoprotein receptor gene associated with familial hypercholesterolemia ⬇️

scientific article published on 01 November 2003

FVII, FVIIa, and downstream markers of extrinsic pathway activation differ by EPCR Ser219Gly variant in healthy men

scientific article

Familial defective apolipoprotein B-100: a single mutation that causes hypercholesterolemia and premature coronary artery disease

scientific article published on October 1, 1992

Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment.

scientific article

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society

scientific article

Familial hypercholesterolaemia: a pressing issue for European health care

scientific article published on 02 October 2013

Familial hypercholesterolaemia: summary of NICE guidance

scientific article published in the British Medical Journal

Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy

scientific article published on 30 September 2011

Free protein S level as a risk factor for coronary heart disease and stroke in a prospective cohort study of healthy United Kingdom men.

scientific article published on 12 September 2011

Functional Analysis of a Carotid Intima-Media Thickness Locus Implicates BCAR1 and Suggests a Causal Variant

scientific article published on 14 August 2015

Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22.

scientific article

Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes ⬇️

scientific article published on 07 March 2012

Functional analysis of four LDLR 5'UTR and promoter variants in patients with familial hypercholesterolaemia

scientific article published on 24 September 2014

Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels

scientific article

GPs have key role in detecting familial hypercholesterolaemia

scientific article published on 01 February 2011

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

scientific article published in Nature Communications

GWAS-identified loci for coronary heart disease are associated with intima-media thickness and plaque presence at the carotid artery bulb

scientific article

Gene-Centric Analysis Identifies Variants Associated With Interleukin-6 Levels and Shared Pathways With Other Inflammation Markers

article

Gene-centric association signals for haemostasis and thrombosis traits identified with the HumanCVD BeadChip

scientific article published on 29 August 2013

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip

scientific article

Gene-targeted analysis of copy number variants identifies 3 novel associations with coronary heart disease traits.

scientific article

Genetic analysis of NR0B1 in congenital adrenal hypoplasia patients: identification of a rare regulatory variant resulting in congenital adrenal hypoplasia and hypogonadal hypogonadism without testicular carcinoma in situ.

scientific article

Genetic and Environmental Determinants of Plasma Nitrogen Oxides and Risk of Ischemic Heart Disease ⬇️

scientific article published on November 1, 2001

Genetic evidence of assortative mating in humans

scholarly article

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

scientific article

Genetic loci on chromosome 5 are associated with circulating levels of interleukin-5 and eosinophil count in a European population with high risk for cardiovascular disease

scientific article

Genetic relationship between the 3'-VNTR and diallelic apolipoprotein B gene polymorphisms: haplotype analysis in individuals of European and south Asian origin

scientific article published on January 1, 1992

Genetic risk factors and Mendelian randomization in cardiovascular disease

scientific article published on May 2015

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChip

scientific article published on 28 April 2011

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals

scientific article published on 29 July 2010

Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts

scientific article published on 10 February 2009

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

scientific article published on 26 June 2011

Genome wide association studies of abdominal aortic aneurysms-biological insights and potential translation applications

scientific article published on March 2011

Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort

scientific article

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

scientific article

Genomic research to identify novel pathways in the development of abdominal aortic aneurysm

scientific article published on 29 January 2012

Guidelines for the identification and management of patients with familial hypercholesterolaemia (FH): Are we coming to a consensus? ⬇️

scientific article published on 01 October 2011

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

scientific article published on 24 September 2014

Haplotype and genotype effects of the F7 gene on circulating factor VII, coagulation activation markers and incident coronary heart disease in UK men.

scientific article published on November 2010

High-throughput method for determination of apolipoprotein E genotypes with use of restriction digestion analysis by microplate array diagonal gel electrophoresis ⬇️

scientific article published on 01 November 1995

Higher IL-6 levels but not IL6 -174G>C or -572G>C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery

scientific article

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

scientific article

Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo

scientific article published on February 2013

Human genetic evidence for involvement of CD137 in atherosclerosis

scientific article

Hyperlipidaemia associated with genetic variation in the apolipoprotein B gene ⬇️

scientific article published on August 1, 1995

IL-6 polymorphisms: a useful genetic tool for inflammation research?

scientific article

IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies

scientific article

IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.

scientific article published on 14 September 2011

Identification and management of familial hypercholesterolaemia: what does it mean to primary care?

scientific article published on October 2009

Identification of a common low density lipoprotein receptor mutation (C163Y) in the west of Scotland ⬇️

scientific article published on July 1, 1998

Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

scientific article published on 28 September 2017

Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk

scientific article

Identifying functional noncoding variants from genome-wide association studies for cardiovascular disease and related traits.

scientific article

Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach

scientific article

Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene

scientific article

Identifying patients with familial hypercholesterolaemia in primary care

scientific article published in June 2008

Improving detection of familial hypercholesterolaemia in primary care using electronic audit and nurse-led clinics

scientific article published on 26 November 2015

Improving identification of familial hypercholesterolaemia in primary care: derivation and validation of the familial hypercholesterolaemia case ascertainment tool (FAMCAT).

scientific article published on 20 December 2014

Improving the cost-effectiveness equation of cascade testing for familial hypercholesterolaemia

scientific article

Increased C-reactive protein levels in overweight and obese women taking exogenous hormones: the United Kingdom Women's Heart Study (UKWHS).

scientific article published on 6 March 2009

Increased levels of circulating fatty acids are associated with protective effects against future cardiovascular events in non-diabetics

scientific article published on 13 December 2017

Indices of obesity and cardiovascular risk factors in British women.

scientific article published on 14 August 2008

Inflammation and not cardiovascular risk factors is associated with short leukocyte telomere length in 13- to 16-year-old adolescents

scientific article published on 7 June 2012

Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream

scientific article

Influence of apolipoproteins on the anatomical distribution of arterial disease ⬇️

scientific article published on August 1, 1991

Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies

scientific article published on 13 September 2012

Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk

scientific article

Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip

scientific article published on 8 November 2012

Interleukin 18 and coronary heart disease: prospective study and systematic review.

scientific article

Interleukin-6 receptor pathways in abdominal aortic aneurysm

scientific article published on 30 October 2012

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index

scientific article

LDL oxidative modification and carotid atherosclerosis: Results of a multicenter study

scientific article published on 01 September 2012

LPL promoter -93T/G transition influences fasting and postprandial plasma triglycerides response in African-Americans and Hispanics ⬇️

scientific article published on June 1, 1998

Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci.

scientific article

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

scientific article

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci

scientific article

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

scientific article

Left ventricular wall thickness and the presence of asymmetric hypertrophy in healthy young army recruits: data from the LARGE heart study

scientific article

Lipoprotein association studies: taking stock and moving forward

scientific article published on April 2011

Low levels of IgM antibodies against phosphorylcholine are associated with fast carotid intima media thickness progression and cardiovascular risk in men

Low-density lipoprotein receptor gene familial hypercholesterolemia variant database: update and pathological assessment

scientific article

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

scientific article

Marginal role for 53 common genetic variants in cardiovascular disease prediction

scientific article published on 30 June 2016

Measurements of Carotid Intima-Media Thickness and of Interadventitia Common Carotid Diameter Improve Prediction of Cardiovascular Events

scholarly article by Damiano Baldassarre et al published October 2012 in Journal of the American College of Cardiology

Mendelian randomisation, lipids, and cardiovascular disease ⬇️

scientific article published on May 17, 2012

Mendelian randomization of blood lipids for coronary heart disease

scientific article

Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts

scientific article published on 27 April 2011

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ⬇️

scientific article

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

scientific article

Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?

scientific article published on 23 October 2009

Multiplex MassARRAY spectrometry (iPLEX) produces a fast and economical test for 56 familial hypercholesterolaemia-causing mutations

scientific article published on 12 August 2008

Multiplex ligation-dependent probe amplification analysis to screen for deletions and duplications of theLDLRgene in patients with familial hypercholesterolaemia

article

Mutation detection in Croatian patients with familial hypercholesterolemia

scientific article published on 6 November 2012

Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade project

scientific article published on 13 March 2010

Mutation scanning by meltMADGE: validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare, and paucimorphic mutations in the general population

scientific article published in July 2005

Mutation screening in patients for familial hypercholesterolaemia (ADH)

scientific article published on 14 October 2009

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

Normal levels of inflammatory markers in treated patients with familial hypercholesterolaemia: a cross-sectional study

scientific article published on 30 June 2012

Novel and recurrent LDLR gene mutations in Pakistani hypercholesterolemia patients

scientific article

Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels

scientific article

Out with print in with e publication: Editor in Chief's Report for Atherosclerosis for 2012 ⬇️

scientific article published on January 1, 2013

Oxidative stress, chronic inflammation, and telomere length in patients with periodontitis

scientific article published on 30 December 2010

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

scientific article published on 28 November 2016

PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk

scientific article published on 12 January 2015

PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry

scientific article

Paraoxonase-1 is not associated with coronary artery calcification in type 2 diabetes: results from the PREDICT study

scientific article published on January 2012

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

scientific article published on 29 October 2019

Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.

scientific article published on 28 July 2016

Plasma Concentrations of Afamin Are Associated With Prevalent and Incident Type 2 Diabetes: A Pooled Analysis in More Than 20,000 Individuals

scientific article published on 6 September 2017

Plasma IL-5 concentration and subclinical carotid atherosclerosis

scientific article

Plasma autoantibodies against apolipoprotein B-100 peptide 210 in subclinical atherosclerosis

scientific article

Plasma fibrinogen concentration predicts the risk of myocardial infarction differently in various parts of Europe: effects of beta-fibrinogen genotype and environmental factors. The HIFMECH Study.

scientific article published in December 2004

Plasma lecithin:cholesterol acyltransferase and carotid intima-media thickness in European individuals at high cardiovascular risk

scientific article

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis

scientific article published on 15 January 2016

Polymorphisms in the apolipoprotein (apo) AI-CIII-AIV gene cluster: detection of genetic variation determining plasma apo AI, apo CIII and apo AIV concentrations ⬇️

scientific article published on 01 February 1992

Polymorphisms in the thrombopoietin gene are associated with risk of myocardial infarction at a young age

article

Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium

scientific article (publication date: 2013)

Post-GWAS methodologies for localisation of functional non-coding variants: ANGPTL3.

scientific article

Progression of carotid intima-media thickness as predictor of vascular events: results from the IMPROVE study

scientific article published on 3 July 2013

Psychological and behavioural impact of genetic testing smokers for lung cancer risk: a phase II exploratory trial

scientific article published in May 2008

Public awareness of genetic influence on chronic disease risk: are genetic and lifestyle causal beliefs compatible?

scientific article published on 29 April 2010

Public health genomics and genetic test evaluation: the challenge of conducting behavioural research on the utility of lifestyle-genetic tests

scientific article

Realising the potential of the family history in risk assessment and primary prevention of coronary heart disease in primary care: ADDFAM study protocol

scientific article

Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study

scientific article

Refinement of variant selection for the LDL cholesterol genetic risk score in the diagnosis of the polygenic form of clinical familial hypercholesterolemia and replication in samples from 6 countries

scientific article published on 20 November 2014

Regarding “Analysis of risk factors for abdominal aortic aneurysm in a cohort of more than 3 million individuals”

Relationship between calcaneal quantitative ultrasound and hip dual energy X-ray absorptiometry in young healthy men

scientific article published on 06 January 2012

Response to Letter About Article, “Left Ventricular Wall Thickness and the Presence of Asymmetric Hypertrophy in Healthy Young Army Recruits: Data From the LARGE Heart Study”

scientific article published on 01 September 2013

Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study

scientific article published on 31 July 2013

Segregation analysis of collagen genes in two families with joint hypermobility syndrome

scientific article published on March 1, 1992

Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms

scientific article

Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion

scientific article

Serum 25-Hydroxyvitamin D Concentration in Subclinical Carotid Atherosclerosis

article

Sex hormone receptor gene variation associated with phenotype in male hypertrophic cardiomyopathy patients

article

Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease

scientific article

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

scientific article

Simplified Detection of a Mutation Causing Familial Hypercholesterolaemia Throughout Britain: Evidence for an Origin in a Common Distant Ancestor ⬇️

scientific article published on 01 March 1998

Sixty-five common genetic variants and prediction of type 2 diabetes

scientific article published on 4 December 2014

Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness

scientific article published on October 2016

Statin treatment of children with familial hypercholesterolemia--trying to balance incomplete evidence of long-term safety and clinical accountability: are we approaching a consensus?

scientific article published on 12 October 2012

Statins and familial hypercholesterolaemia

scientific article published in the British Medical Journal

Statins for children with familial hypercholesterolemia

scientific article (published 2014-07-23)

Statins for children with familial hypercholesterolemia

scientific article (published 2010-07-07)

Statins for children with familial hypercholesterolemia

scientific article

Statins for children with familial hypercholesterolemia

scientific article published on 7 July 2017

Statins for children with familial hypercholesterolemia

scientific article published on 07 November 2019

Substantial variation in qPCR measured mean blood telomere lengths in young men from eleven European countries

scientific article published on 10 January 2011

Telomere length in atherosclerosis and diabetes

scientific article published on 28 December 2009

Telomere shortening over 6 years is associated with increased subclinical carotid vascular damage and worse cardiovascular prognosis in the general population.

scientific article published on 19 July 2014

Telomeres are shorter in myocardial infarction patients compared to healthy subjects: correlation with environmental risk factors

scientific article

The Lichfield bone study: the skeletal response to exercise in healthy young men

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The UK10K project identifies rare variants in health and disease

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The Use of Recombinant DNA Technology to Study Polygenic Hyperlipidaemia ⬇️

scientific article published on 01 January 1984

The effect of WNT5B IVS3C>G on the susceptibility to type 2 diabetes in UK Caucasian subjects

scientific article published on 13 June 2008

The effect of pro-inflammatory conditioning and/or high glucose on telomere shortening of aging fibroblasts

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The effect of renin angiotensin system genetic variants in acute pancreatitis

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The effects of a single nucleotide polymorphism in SLCO1B1 on the pharmacodynamics of pravastatin

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The effects of genotype and infant weight on adult plasma levels of fibrinogen, factor VII, and LDL cholesterol are additive ⬇️

scientific article published on July 1, 1997

The frequency of an IL-18-associated haplotype in Africans

scientific article published on 29 August 2012

The genetic architecture of the familial hyperlipidaemia syndromes: rare mutations and common variants in multiple genes

scientific article published on August 2014

The genetic contribution to the risk of thrombosis and cardiovascular disease ⬇️

scientific article published on January 1, 1994

The genetic spectrum of familial hypercholesterolemia in Pakistan

scientific article published on 25 March 2013

The genetic spectrum of familial hypercholesterolemia in south-eastern Poland

scientific article published on 10 November 2015

The genetics of coronary heart disease

scientific article published on 09 May 2012

The interleukin-6 −174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men ⬇️

scientific article published on December 1, 2001

The isolation of a genomic clone containing the apolipoprotein CII gene and the detection of linkage disequilibrium between two common DNA polymorphisms around the gene ⬇️

scientific article published on 01 January 1984

The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management

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The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk

scientific article published on 9 September 2010

The use of haplotypes in the identification of interaction between SNPs

scientific article published on 7 May 2013

There are approximately 20 actin genes in the human genome ⬇️

scientific article published on October 10, 1981

Upregulation of gingival tissue miR-200b in obese periodontitis subjects

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Use of allele-specific FAIRE to determine functional regulatory polymorphism using large-scale genotyping arrays

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Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study

scientific article published on 22 February 2013

Use of targeted exome sequencing as a diagnostic tool for Familial Hypercholesterolaemia

scientific article (publication date: October 2012)

Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

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Utility of genetic determinants of lipids and cardiovascular events in assessing risk

scientific article published on 15 February 2011

Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids

scientific article published on 22 August 2016

Variants Within TSC2 Exons 25 and 31 Are Very Unlikely to Cause Clinically Diagnosable Tuberous Sclerosis

scientific article published on 25 December 2015

Variation in the uncoupling protein 2 and 3 genes and human performance

scientific article published on 12 January 2012

Variation of apolipoprotein B gene is associated with myocardial infarction and lipoprotein levels in Danes ⬇️

scientific article published on July 1, 1991

W64R Mutation in β-3-adrenergic receptor gene and weight in a large population sample ⬇️

scientific article published on 01 April 1998

What is the clinical utility of DNA testing in patients with familial hypercholesterolaemia?

scientific article published on August 2008

Whole exome sequencing of familial hypercholesterolaemia patients negative for LDLR/APOB/PCSK9 mutations

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Within-individual variation in serum cholesterol levels: association with DNA polymorphisms at the apolipoprotein B and AI-CIII-AIV loci in patients with peripheral arterial disease ⬇️

scientific article published on April 1, 1991

Would raising the total cholesterol diagnostic cut-off from 7.5 mmol/L to 9.3 mmol/L improve detection rate of patients with monogenic familial hypercholesterolaemia?

scientific article

β-Adrenergic Regulation of IL-6 Release from Adipose Tissue:In Vivoandin VitroStudies ⬇️

scientific article published on December 1, 2001

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