List of works - Louise Johnson

4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.

scientific article published on January 2003

Alternative binding modes of an inhibitor to two different kinases

scientific article

CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?

scientific article

Cyclin B and cyclin A confer different substrate recognition properties on CDK2

scientific article

Early days of structural biology

scientific article

Exploiting structural principles to design cyclin-dependent kinase inhibitors.

scientific article

Glucofuranose analogues of hydantocidin

Halogen bonds form the basis for selective P-TEFb inhibition by DRB

scientific article

Introducing Open Biology

scientific article published on 20 July 2011

Phototransformation of green fluorescent protein with UV and visible light leads to decarboxylation of glutamate 222

scientific article

Plk1 activation by Ste20-like kinase (Slk) phosphorylation and polo-box phosphopeptide binding assayed with the substrate translationally controlled tumor protein (TCTP).

scientific article

Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives

scientific article

Protein kinase inhibitors: contributions from structure to clinical compounds

scientific article published on February 2009

Protein kinase inhibitors: insights into drug design from structure.

scientific article published on March 2004

Recognition of Cdk2 by Cdk7

scientific article published on 01 June 2007

Simulation of diffusion time of small molecules in protein crystals

scientific article published in March 2006

Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A

scientific article

Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation

scientific article published on December 2005

Structural and functional studies of the response regulator HupR.

scientific article published on 15 March 2006

Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide

scientific article published on 01 March 2005

Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2.

scientific article

Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase

scientific article

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

scientific article

Structure-based design of cyclin-dependent kinase inhibitors

scientific article

Structures of the Dsk2 UBL and UBA domains and their complex.

scientific article

Substrates of Mitotic Kinases ⬇️

scientific article published on June 28, 2011

The HupR receiver domain crystal structure in its nonphospho and inhibitory phospho states

scientific article

The binding of flavopiridol to blood serum albumin

scientific article published on January 2010

The crystal structure of human CDK7 and its protein recognition properties

scientific article

The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex

scientific article

The regulation of protein phosphorylation

scientific article

The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.

scientific article

The structural basis for control of eukaryotic protein kinases

scientific article published on 05 April 2012

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

scientific article

The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles

scientific article

The structure of phosphorylase kinase holoenzyme at 9.9 angstroms resolution and location of the catalytic subunit and the substrate glycogen phosphorylase

scientific article

Three-dimensional structure of phosphorylase kinase at 22 A resolution and its complex with glycogen phosphorylase b

scientific article (publication date: 2002)

Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography.

scientific article published on October 2005

List of works by Louise Johnson

4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.

Alternative binding modes of an inhibitor to two different kinases

CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?

Cyclin B and cyclin A confer different substrate recognition properties on CDK2

Early days of structural biology

Exploiting structural principles to design cyclin-dependent kinase inhibitors.

Glucofuranose analogues of hydantocidin

Halogen bonds form the basis for selective P-TEFb inhibition by DRB

Introducing Open Biology

Phototransformation of green fluorescent protein with UV and visible light leads to decarboxylation of glutamate 222

Plk1 activation by Ste20-like kinase (Slk) phosphorylation and polo-box phosphopeptide binding assayed with the substrate translationally controlled tumor protein (TCTP).

Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives

Protein kinase inhibitors: contributions from structure to clinical compounds

Protein kinase inhibitors: insights into drug design from structure.

Recognition of Cdk2 by Cdk7

Simulation of diffusion time of small molecules in protein crystals

Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A

Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation

Structural and functional studies of the response regulator HupR.

Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide

Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2.

Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Structure-based design of cyclin-dependent kinase inhibitors

Structures of the Dsk2 UBL and UBA domains and their complex.

Substrates of Mitotic Kinases ⬇️

The HupR receiver domain crystal structure in its nonphospho and inhibitory phospho states

The binding of flavopiridol to blood serum albumin

The crystal structure of human CDK7 and its protein recognition properties

The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex

The regulation of protein phosphorylation

The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.

The structural basis for control of eukaryotic protein kinases

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles

The structure of phosphorylase kinase holoenzyme at 9.9 angstroms resolution and location of the catalytic subunit and the substrate glycogen phosphorylase

Three-dimensional structure of phosphorylase kinase at 22 A resolution and its complex with glycogen phosphorylase b

Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography.