List of works - Okihide Hikosaka

A neural correlate of motivational conflict in the superior colliculus of the macaque

scientific article published on 2 July 2008

A neural correlate of oculomotor sequences in supplementary eye field

scientific article published in April 2002

A neural correlate of response bias in monkey caudate nucleus.

scientific article

A new approach to the functional systems of the brain

scientific article published in January 2002

A pallidus-habenula-dopamine pathway signals inferred stimulus values

scientific article

A possible role of midbrain dopamine neurons in short- and long-term adaptation of saccades to position-reward mapping

scientific article

Abnormalities of voluntary saccades in Gilles de la Tourette's syndrome: pathophysiological consideration

scientific article published in December 2003

Amygdala activity for the modulation of goal-directed behavior in emotional contexts.

scientific article published on 5 June 2018

An Open Resource for Non-human Primate Optogenetics

scientific article published on 12 October 2020

Attention, reward, and information seeking.

scientific article

Basal ganglia circuits for reward value-guided behavior

scientific article

Basal ganglia mechanisms of reward-oriented eye movement

scientific article published on 14 March 2007

Basal ganglia orient eyes to reward

scientific article

Brain Networks Sensitive to Object Novelty, Value, and Their Combination

scientific article published on 29 July 2020

Brain mechanisms for switching from automatic to controlled eye movements

scientific article published on January 2008

Central mechanisms of motor skill learning

scientific article

Chunking during human visuomotor sequence learning

scientific article published on 18 July 2003

Coding of task reward value in the dorsal raphe nucleus

scientific article

Combining modalities with different latencies for optimal motor control

scientific article

Comparison of reward modulation in the frontal eye field and caudate of the macaque.

scientific article

Correlation of primate caudate neural activity and saccade parameters in reward-oriented behavior.

scientific article published on April 2003

Cortico‐basal ganglia mechanisms for overcoming innate, habitual and motivational behaviors ⬇️

scientific article published on June 1, 2011

Decision-making and learning by cortico-basal ganglia network

scientific article published in July 2008

Differential activation of monkey striatal neurons in the early and late stages of procedural learning

scientific article

Direct and indirect pathways for choosing objects and actions

scientific article published on 25 March 2018

Distinct basal ganglia circuits controlling behaviors guided by flexible and stable values

scientific article

Distinct tonic and phasic anticipatory activity in lateral habenula and dopamine neurons

scientific article

Diverse sources of reward value signals in the basal ganglia nuclei transmitted to the lateral habenula in the monkey

scientific article

Dopamine Neurons Encoding Long-Term Memory of Object Value for Habitual Behavior

scientific article

Dopamine in motivational control: rewarding, aversive, and alerting

scientific article

Dopamine neurons can represent context-dependent prediction error.

scientific article published in January 2004

Dopamine-Mediated Learning and Switching in Cortico-Striatal Circuit Explain Behavioral Changes in Reinforcement Learning ⬇️

scientific article published on March 21, 2011

Ecological Origins of Object Salience: Reward, Uncertainty, Aversiveness, and Novelty.

scientific article published on 19 August 2016

Effects of explicit knowledge of workspace rotation in visuomotor sequence learning.

scientific article published on 25 May 2006

Effects of motivational conflicts on visually elicited saccades in monkeys

scientific article published in August 2003

Electrical Stimulation of the Primate Lateral Habenula Suppresses Saccadic Eye Movement through a Learning Mechanism ⬇️

scientific article published on October 24, 2011

Emergence of rhythm during motor learning

scientific article

Extended LATER model can account for trial-by-trial variability of both pre- and post-processes

scientific article published on 12 September 2006

Facilitation of saccadic eye movements by postsaccadic electrical stimulation in the primate caudate.

scientific article published in December 2006

Feature-based anticipation of cues that predict reward in monkey caudate nucleus

scientific article

Flexible and Stable Value Coding Areas in Caudate Head and Tail Receive Anatomically Distinct Cortical and Subcortical Inputs.

scientific article published on 24 November 2017

Functional differences between macaque prefrontal cortex and caudate nucleus during eye movements with and without reward

scientific article published in January 2007

Functional territories in primate substantia nigra pars reticulata separately signaling stable and flexible values

scientific article

Habenula: crossroad between the basal ganglia and the limbic system

scientific article published in November 2008

Immediate changes in anticipatory activity of caudate neurons associated with reversal of position-reward contingency.

scientific article published on 4 May 2005

Indirect Pathway of Caudal Basal Ganglia for Rejection of Valueless Visual Objects

scientific article published on May 2017

Indirect pathway from caudate tail mediates rejection of bad objects in periphery

scientific article published on 07 August 2019

Influence of reward expectation on visuospatial processing in macaque lateral prefrontal cortex.

scientific article published in March 2002

Influences of rewarding and aversive outcomes on activity in macaque lateral prefrontal cortex.

scientific article published in September 2006

Initiation and inhibitory control of saccades with the progression of Parkinson's disease - changes in three major drives converging on the superior colliculus

scientific article published on 21 March 2011

Lateral habenula as a source of negative reward signals in dopamine neurons

scientific article

Lateral habenula neurons signal errors in the prediction of reward information ⬇️

scientific article published on August 21, 2011

Learning to represent reward structure: A key to adapting to complex environments ⬇️

scientific article published on October 13, 2012

Long-Term Value Memory in the Primate Posterior Thalamus for Fast Automatic Action

scientific article published on 07 June 2020

Medial thalamus in the territory of oculomotor basal ganglia represents stable object value

article

Midbrain dopamine neurons signal preference for advance information about upcoming rewards

scientific article

Modulation of saccadic eye movements by predicted reward outcome

scientific article

Multiple neuronal circuits for variable object-action choices based on short- and long-term memories

scientific article published on 23 December 2019

Multiple timescales of memory in lateral habenula and dopamine neurons

scientific article

Negative motivational control of saccadic eye movement by the lateral habenula

scientific article published on January 2008

Negative reward signals from the lateral habenula to dopamine neurons are mediated by rostromedial tegmental nucleus in primates

scientific article published in August 2011

Neural correlates of rewarded and unrewarded eye movements in the primate caudate nucleus.

scientific article published on November 2003

Neuronal connections of direct and indirect pathways for stable value memory in caudal basal ganglia

scientific article published on 01 August 2018

Neurons in the Primate Medial Basal Forebrain Signal Combined Information about Reward Uncertainty, Value, and Punishment Anticipation.

scientific article published on May 2015

New insights on the subcortical representation of reward

scientific article

New perspectives on the pathophysiology of Parkinson's disease as assessed by saccade performance: a clinical review

scientific article published on 13 March 2013

Object-finding skill created by repeated reward experience.

scientific article published on August 2016

Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift

scientific article published on 20 April 2020

Parallel basal ganglia circuits for decision making.

scientific article published on 2 February 2017

Parallel basal ganglia circuits for voluntary and automatic behaviour to reach rewards

scientific article published on 16 May 2015

Positive and negative modulation of motor response in primate superior colliculus by reward expectation

scientific article

Prefrontal Cortex Represents Long-Term Memory of Object Values for Months

scientific article published on 28 June 2018

Primate Amygdalo-Nigral Pathway for Boosting Oculomotor Action in Motivating Situations

scientific article published on 23 May 2020

Regionally distinct processing of rewards and punishments by the primate ventromedial prefrontal cortex

scientific article

Representation of negative motivational value in the primate lateral habenula

scientific article

Responding to Modalities with Different Latencies ⬇️

scientific article published in January 2005

Reward processing by the lateral habenula in normal and depressive behaviors

scientific article

Reward value-contingent changes of visual responses in the primate caudate tail associated with a visuomotor skill

scientific article published on July 2013

Reward-Predicting Activity of Dopamine and Caudate Neurons—A Possible Mechanism of Motivational Control of Saccadic Eye Movement ⬇️

scientific article published on October 1, 2003

Reward-dependent gain and bias of visual responses in primate superior colliculus

scientific article published on August 2003

Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus

scientific article published in May 2008

Reward-dependent spatial selectivity of anticipatory activity in monkey caudate neurons

scientific article published on January 2002

Robust representation of stable object values in the oculomotor Basal Ganglia

scientific article

Role for subthalamic nucleus neurons in switching from automatic to controlled eye movement

scientific article

Role of dopamine in the primate caudate nucleus in reward modulation of saccades.

scientific article published in May 2006

Role of primate substantia nigra pars reticulata in reward-oriented saccadic eye movement.

scientific article

Role of the basal ganglia in the control of purposive saccadic eye movements

scientific article

Selective and graded coding of reward uncertainty by neurons in the primate anterodorsal septal region

scientific article

Self-organization in the basal ganglia with modulation of reinforcement signals

scientific article

Separate groups of dopamine neurons innervate caudate head and tail encoding flexible and stable value memories

scientific article

Switching from automatic to controlled action by monkey medial frontal cortex

scientific article

Switching from automatic to controlled behavior: cortico-basal ganglia mechanisms

scientific article

Temporal development of asymmetric reward-induced bias in macaques

scientific article published on 4 October 2006

Temporal-prefrontal cortical network for discrimination of valuable objects in long-term memory

scientific article published in February 2018

The Caudal Part of Putamen Represents the Historical Object Value Information

scientific article published on 20 December 2018

The globus pallidus sends reward-related signals to the lateral habenula

scientific article

The habenula: from stress evasion to value-based decision-making

scientific article

The primate ventral pallidum encodes expected reward value and regulates motor action

scientific article

The role of the dorsal striatum in reward and decision-making

scientific article published on August 2007

To Wait or Not to Wait-Separate Mechanisms in the Oculomotor Circuit of Basal Ganglia

scientific article published on 11 April 2017

Two types of dopamine neuron distinctly convey positive and negative motivational signals

scientific article

Visual Neurons in the Superior Colliculus Discriminate Many Objects by Their Historical Values.

scientific article

Visual and anticipatory bias in three cortical eye fields of the monkey during an adaptive decision-making task.

scientific article

What and where information in the caudate tail guides saccades to visual objects

scientific article

What do eye movements tell us about patients with neurological disorders? - An introduction to saccade recording in the clinical setting

scientific article published in January 2017

Why skill matters.

scientific article

pyElectrode: an open-source tool using structural MRI for electrode positioning and neuron mapping

scientific article published on 20 December 2012

List of works by Okihide Hikosaka

A neural correlate of motivational conflict in the superior colliculus of the macaque

A neural correlate of oculomotor sequences in supplementary eye field

A neural correlate of response bias in monkey caudate nucleus.

A new approach to the functional systems of the brain

A pallidus-habenula-dopamine pathway signals inferred stimulus values

A possible role of midbrain dopamine neurons in short- and long-term adaptation of saccades to position-reward mapping

Abnormalities of voluntary saccades in Gilles de la Tourette's syndrome: pathophysiological consideration

Amygdala activity for the modulation of goal-directed behavior in emotional contexts.

An Open Resource for Non-human Primate Optogenetics

Attention, reward, and information seeking.

Basal ganglia circuits for reward value-guided behavior

Basal ganglia mechanisms of reward-oriented eye movement

Basal ganglia orient eyes to reward

Brain Networks Sensitive to Object Novelty, Value, and Their Combination

Brain mechanisms for switching from automatic to controlled eye movements

Central mechanisms of motor skill learning

Chunking during human visuomotor sequence learning

Coding of task reward value in the dorsal raphe nucleus

Combining modalities with different latencies for optimal motor control

Comparison of reward modulation in the frontal eye field and caudate of the macaque.

Correlation of primate caudate neural activity and saccade parameters in reward-oriented behavior.

Cortico‐basal ganglia mechanisms for overcoming innate, habitual and motivational behaviors ⬇️

Decision-making and learning by cortico-basal ganglia network

Differential activation of monkey striatal neurons in the early and late stages of procedural learning

Direct and indirect pathways for choosing objects and actions

Distinct basal ganglia circuits controlling behaviors guided by flexible and stable values

Distinct tonic and phasic anticipatory activity in lateral habenula and dopamine neurons

Diverse sources of reward value signals in the basal ganglia nuclei transmitted to the lateral habenula in the monkey

Dopamine Neurons Encoding Long-Term Memory of Object Value for Habitual Behavior

Dopamine in motivational control: rewarding, aversive, and alerting

Dopamine neurons can represent context-dependent prediction error.

Dopamine-Mediated Learning and Switching in Cortico-Striatal Circuit Explain Behavioral Changes in Reinforcement Learning ⬇️

Ecological Origins of Object Salience: Reward, Uncertainty, Aversiveness, and Novelty.

Effects of explicit knowledge of workspace rotation in visuomotor sequence learning.

Effects of motivational conflicts on visually elicited saccades in monkeys

Electrical Stimulation of the Primate Lateral Habenula Suppresses Saccadic Eye Movement through a Learning Mechanism ⬇️

Emergence of rhythm during motor learning

Extended LATER model can account for trial-by-trial variability of both pre- and post-processes

Facilitation of saccadic eye movements by postsaccadic electrical stimulation in the primate caudate.

Feature-based anticipation of cues that predict reward in monkey caudate nucleus

Flexible and Stable Value Coding Areas in Caudate Head and Tail Receive Anatomically Distinct Cortical and Subcortical Inputs.

Functional differences between macaque prefrontal cortex and caudate nucleus during eye movements with and without reward

Functional territories in primate substantia nigra pars reticulata separately signaling stable and flexible values

Habenula: crossroad between the basal ganglia and the limbic system

Immediate changes in anticipatory activity of caudate neurons associated with reversal of position-reward contingency.

Indirect Pathway of Caudal Basal Ganglia for Rejection of Valueless Visual Objects

Indirect pathway from caudate tail mediates rejection of bad objects in periphery

Influence of reward expectation on visuospatial processing in macaque lateral prefrontal cortex.

Influences of rewarding and aversive outcomes on activity in macaque lateral prefrontal cortex.

Initiation and inhibitory control of saccades with the progression of Parkinson's disease - changes in three major drives converging on the superior colliculus

Lateral habenula as a source of negative reward signals in dopamine neurons

Lateral habenula neurons signal errors in the prediction of reward information ⬇️

Learning to represent reward structure: A key to adapting to complex environments ⬇️

Long-Term Value Memory in the Primate Posterior Thalamus for Fast Automatic Action

Medial thalamus in the territory of oculomotor basal ganglia represents stable object value

Midbrain dopamine neurons signal preference for advance information about upcoming rewards

Modulation of saccadic eye movements by predicted reward outcome

Multiple neuronal circuits for variable object-action choices based on short- and long-term memories

Multiple timescales of memory in lateral habenula and dopamine neurons

Negative motivational control of saccadic eye movement by the lateral habenula

Negative reward signals from the lateral habenula to dopamine neurons are mediated by rostromedial tegmental nucleus in primates

Neural correlates of rewarded and unrewarded eye movements in the primate caudate nucleus.

Neuronal connections of direct and indirect pathways for stable value memory in caudal basal ganglia

Neurons in the Primate Medial Basal Forebrain Signal Combined Information about Reward Uncertainty, Value, and Punishment Anticipation.

New insights on the subcortical representation of reward

New perspectives on the pathophysiology of Parkinson's disease as assessed by saccade performance: a clinical review

Object-finding skill created by repeated reward experience.

Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift

Parallel basal ganglia circuits for decision making.

Parallel basal ganglia circuits for voluntary and automatic behaviour to reach rewards

Positive and negative modulation of motor response in primate superior colliculus by reward expectation

Prefrontal Cortex Represents Long-Term Memory of Object Values for Months

Primate Amygdalo-Nigral Pathway for Boosting Oculomotor Action in Motivating Situations

Regionally distinct processing of rewards and punishments by the primate ventromedial prefrontal cortex

Representation of negative motivational value in the primate lateral habenula

Responding to Modalities with Different Latencies ⬇️

Reward processing by the lateral habenula in normal and depressive behaviors

Reward value-contingent changes of visual responses in the primate caudate tail associated with a visuomotor skill

Reward-Predicting Activity of Dopamine and Caudate Neurons—A Possible Mechanism of Motivational Control of Saccadic Eye Movement ⬇️