List of works by Harold E. Varmus

5'-terminal sequences influence the segregation of ground squirrel hepatitis virus RNAs into polyribosomes and viral core particles.

scientific article published on January 1987

A Prize for Cancer Prevention

scientific article published on 5 September 2017

A Prize for Cancer Prevention

scientific article published in October 2017

A Rous sarcoma virus provirus is flanked by short direct repeats of a cellular DNA sequence present in only one copy prior to integration

scientific article

A cellular oncogene (c-Ki-ras) is amplified, overexpressed and located within karyotypic abnormalities in mouse adrenocortical tumour cells

scientific article published in Nature

A characteristic bent conformation of RNA pseudoknots promotes -1 frameshifting during translation of retroviral RNA.

scientific article published in July 1996

A comparative evaluation of beta-catenin and plakoglobin signaling activity

scientific article

A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice

scientific article

A conversation with Harold Varmus. Interview by Ushma S. Neill

scientific article published on April 2012

A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin

scientific article published on May 1985

A genetic screen identifies cellular factors involved in retroviral -1 frameshifting ⬇️

scientific article published on July 3, 1995

A growing role for reverse transcription

scientific article published on 01 September 1982

A joint produce of the genes gag and pol of avian sarcoma virus: a possible precursor of reverse transcriptase

scientific article published on December 1977

A member of the Frizzled protein family mediating axis induction by Wnt-5A

scientific article

A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha.

scientific article published in April 1999

A mover in the biomedical community. An interview with Harold Varmus, President of Memorial Sloan-Kettering Cancer Center in New York City and former Director of NIH by Holger Breithaupt

scientific article published on May 2001

A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration ⬇️

scientific article published on October 1, 1984

A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner

scientific article published on January 1989

A new initiative on precision medicine

scientific article (publication date: 26 February 2015)

A new nomenclature for int-1 and related genes: the Wnt gene family

scientific article published in January 1991

A nucleoprotein complex mediates the integration of retroviral DNA.

scientific article published in April 1989

A protein knockdown strategy to study the function of beta-catenin in tumorigenesis ⬇️

scientific article published on September 29, 2003

A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor

scientific article

A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line

scientific article published on September 1986

A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene ⬇️

scientific article published on October 1, 1983

A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors

scientific article published in November 1994

AIDS: the process of discovery

scientific article published in January 1997

Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis ⬇️

scientific article published on 01 August 1997

Abstract C113: ERBB3 independent activation of the PI3K pathway in EGFR mutant lung adenocarcinomas

Accelerating progress on non-communicable diseases

scientific article

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

scientific article

Activation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors

scientific article

Activity of Wnt-1 as a transmembrane protein

scientific article published on November 1993

Addressing the growing international challenge of cancer: a multinational perspective

scientific article published in March 2013

Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumour cells

scientific article

Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage

scientific article

Amplification of N-myc sequences in primary human neuroblastomas: correlation with advanced disease stage

scientific article published on 01 January 1985

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

scientific article published on September 1983

An RNA pseudoknot and an optimal heptameric shift site are required for highly efficient ribosomal frameshifting on a retroviral messenger RNA ⬇️

scientific article published on January 15, 1992

An aberrant avian leukosis virus provirus inserted downstream from the chicken c-myc coding sequence in a bursal lymphoma results from intrachromosomal recombination between two proviruses and deletion of cellular DNA

scientific article published on June 1987

An active National Institute of Mental Health.

scientific article

An overview of the FY-1996 budget for the National Institutes of Health

scientific article published on 01 May 1995

Analysis of avian leukosis virus DNA and RNA in bursal tumors: Viral gene expression is not required for maintenance of the tumor state ⬇️

scientific article published on February 1, 1981

Analysis of endogenous avian retrovirus DNA and RNA: viral and cellular determinants of retrovirus gene expression.

scientific article published in October 1981

Antibodies to pre-S and X determinants arise during natural infection with ground squirrel hepatitis virus

scientific article published on October 1986

Appearance of virus-specific DNA in mammalian cells following transformation by Rous sarcoma virus

scientific article published in March 1973

Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion

scientific article

Association of p60c-src with endosomal membranes in mammalian fibroblasts

scientific article published on July 1992

Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.

scientific article

At least 104 nucleotides are transposed from the 5′ terminus of the avian sarcoma virus genome to the 5′ termini of smaller viral mrnas ⬇️

scientific article published on September 1, 1978

Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene

scientific article published on December 1985

Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice

scientific article published on February 1998

Basic science and the NIH.

scientific article

Bethesda Statement on Open Access Publishing ⬇️

copyright manifesto

Binding in vitro of phosphotyrosine-containing proteins to pp60c-src SH2 domain does not correlate with CEF transformation

scientific article

Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides

scientific article

Biochemical and genetic evidence for the hepatitis B virus replication strategy

scientific article published in April 1986

Biological and biochemical studies on the inactivation of avian oncoviruses by ultraviolet irradiation

scientific article

Biological characterization of acute infection with ground squirrel hepatitis virus.

scientific article published on October 1982

Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting

scientific article published in January 1989

Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae

scientific article

Cancer genes and hematopoiesis

scientific article

Casein kinase 2associates with and phosphorylates Dishevelled ⬇️

scientific article published on June 2, 1997

Casein kinase Iepsilon modulates the signaling specificities of dishevelled

scientific journal article

Cell-free translation of purified avian sarcoma virus src mRNA ⬇️

scientific article published on April 30, 1981

Cell-specific transduction of Prdm1-expressing lineages mediated by a receptor for avian leukosis virus subgroup B

scientific article published on 11 March 2009

Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA ⬇️

scientific article published on June 1, 1977

Cellular homologue (c-src) of the transforming gene of Rous sarcoma virus: isolation, mapping, and transcriptional analysis of c-src and flanking regions ⬇️

scientific article published on September 1, 1981

Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice

scientific article

Characteristics of cellular RNA related to the transforming gene of avian sarcoma viruses

scientific article published on February 1978

Characteristics of virus-specific RNA in avian sarcoma virus-transformed BHK-21 cells and revertants ⬇️

scientific article published on January 1, 1977

Characterization of dna complementary to nucleotide sequences adjacent to poly(A) at the 3′-terminus of the avian sarcoma virus genome ⬇️

scientific article published on June 1, 1977

Characterization of dna complementary to nucleotide sequences at the 5′-terminus of the avian sarcoma virus genome ⬇️

scientific article published on June 1, 1977

Characterization of ribosomal frameshifting in HIV-1 gag-pol expression

scientific article published in January 1988

Characterization of the nucleic acid product of the visna virus RNA dependent DNA polymerase

scientific article published in January 1974

Characterization of “early” temperature-sensitive mutants of avian sarcoma viruses: Biological properties, thermolability of reverse transcriptase in vitro, and synthesis of viral DNA in infected cells ⬇️

scientific article published on October 1, 1976

Characterizing the cancer genome in lung adenocarcinoma

scientific article

Chicken macrochromosomes contain an endogenous provirus and microchromosomes contain sequences related to the transforming gene of ASV ⬇️

scientific article published on April 1, 1977

Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc

scientific article

Closed circular viral DNA and asymmetrical heterogeneous forms in livers from animals infected with ground squirrel hepatitis virus.

scientific article published on October 1983

Comparison of mouse mammary tumor virus-specific DNA in inbred, wild and Asian mice, and in tumors and normal organs from inbred mice ⬇️

scientific article published on July 1, 1977

Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS

scholarly article

Construction of a clonable, infectious, and tumorigenic mouse mammary tumor virus provirus and a derivative genetic vector

scientific article

Correct integration of retroviral DNA in vitro

scientific journal article

Corrections to the nucleotide sequence of the src gene of Rous sarcoma virus ⬇️

scientific article published on February 24, 1983

DISTRIBUTION AND FUNCTION OF DEFINED REGIONS OF AVIAN TUMOR VIRUS GENOMES IN VIRUSES AND UNINFECTED CELLS

DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes.

scientific article published on October 1994

DNA intermediates in the replication of retroviruses are structurally (and perhaps functionally) related to transposable elements

scientific article published on 01 January 1981

DNA of Rous sarcoma virus: its nature and significance

scientific article published in January 1972

DNA of a chicken herpesvirus is associated with at least two chromosomes in a chicken lymphoblastoid cell line ⬇️

scientific article published on 01 August 1980

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA ⬇️

scientific article published on March 11, 1976

DOK2 inhibits EGFR-mutated lung adenocarcinoma

scientific article

Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice

scientific article

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability

scientific article published on 01 April 1995

Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis

scientific article

Defining the Steps in a Multistep Mouse Model for Mammary Carcinogenesis ⬇️

scientific article published on January 1, 1994

Definition of regions in human c-myc that are involved in transformation and nuclear localization

scientific article published on May 1987

Deletion of alpha-globin genes in haemoglobin-H disease demonstrates multiple alpha-globin structural loci

scientific article published on May 15, 1975

Demonstration of a DNA provirus in the lytic growth of visna virus

scientific article published in October 1973

Demonstration of non-functional beta-globin mRNA in homozygous beta (0) thalassemia ⬇️

scientific article published on December 1, 1975

Detection and Characterization of RNA Tumor Virus-specific DNA in Cells ⬇️

scientific article published on January 1, 1975

Detection and enumeration of transformation-defective strains of avian sarcoma virus with molecular hybridization ⬇️

scientific article published on February 1, 1977

Detection of Nucleotide Sequences Associated with Transformation by Avian Sarcoma Viruses ⬇️

scientific article published on October 1, 1975

Detection of antibodies against hepatitis B virus polymerase antigen in hepatitis B virus-infected patients

scientific article

Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs (reassociation kinetics-RNA tumor viruses-gas antigen-Rous sarcoma virus, chick cells).

scientific article

Development of a flexible and specific gene delivery system for production of murine tumor models

scientific article

Development of an avian leukosis-sarcoma virus subgroup A pseudotyped lentiviral vector

scientific article

Dexamethasone induction of the intracellular RNAs of mouse mammary tumor virus

scientific article published on December 1981

Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action ⬇️

scientific article published on November 1, 1975

Differences between genomes of two strains of mouse mammary tumor virus as shown by partial RNA sequence analysis ⬇️

scientific article published on July 15, 1976

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

scientific article

ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas

scientific article

Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase ⬇️

scientific article published on November 1, 1990

Efficient incorporation of human CD4 protein into avian leukosis virus particles

scientific article published on December 1990

Embryo research guidelines

scientific article published on 01 September 1994

Endogenous mammary tumour virus DNA varies among wild mice and segregates during inbreeding ⬇️

scientific article published on March 29, 1979

Endogenous mouse mammary tumor virus DNA is distributed among multiple mouse chromosomes ⬇️

scientific article published on January 15, 1979

Endogenous proviruses of random-bred chickens and ring-necked pheasants: Analysis with restriction endonucleases

scientific article published on 01 January 1981

Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma

scientific article published on August 1984

Epstein-Barr virus: an important vaccine target for cancer prevention

scientific article

Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma

scientific article published on 9 December 2009

Erratum: Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

scientific article published in Nature

Erratum: The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts: (RNA tumor viruses/reassociation kinetics/duck cells).

scientific article published on 27 May 2009

Ethical complexities of conducting research in developing countries

scientific article published on October 1997

Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian sarcoma virus ⬇️

scientific article published on February 13, 1975

Evaluating the burden of disease and spending the research dollars of the National Institutes of Health

scientific article

Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma

scientific article published on 5 June 2015

Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein ⬇️

scientific article published on October 1, 1978

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

scientific article

Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype

scientific article

Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting

scientific article published in December 1985

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

scientific article published on November 1988

Expression of the precore region of an avian hepatitis B virus is not required for viral replication

scientific article published on October 1987

Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos.

scientific article published in July 1987

Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src

scientific article

Extent of transcription by the RNA-dependent DNA polymerase of Rous sarcoma virus

scientific article published in September 1971

Extrachromosomal DNA forms of copia-like transposable elements, F elements and middle repetitive DNA sequences in Drosophila melanogaster. Variation in cultured cells and embryos.

scientific article published in March 1985

FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development

scientific article

Factors Affecting Phenotypic Reversion of Rat Cells Transformed by Avian Sarcoma Virus ⬇️

scientific article published on January 1, 1980

Features of the chicken c-myc gene that influence the structure of c-myc RNA in normal cells and bursal lymphomas

scientific article published on August 1986

Form and Function of Retroviral Proviruses ⬇️

scientific article published on May 21, 1982

Forum for agricultural biotechnology debates

scientific article published on 01 June 2001

Frameshift and intragenic suppressor mutations in a rous sarcoma provirus suggest src encodes two proteins ⬇️

scientific article published on March 1, 1983

Function, location, and regulation of the src protein-tyrosine kinase

scientific article published on 01 January 1989

Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity

scientific journal article

Fv-1 restriction and its effects on murine leukemia virus integration in vivo and in vitro

scientific article

Gene deletion as the cause of α thalassaemia: Genetic lesion in homozygous α thalassaemia (hydrops fetalis)

scientific article published in Nature

Gene localization by chromosome fractionation: globin genes are on at least two chromosomes and three estrogen-inducible genes are on three chromosomes ⬇️

scientific article published on March 1, 1979

Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells

scientific article published on 08 February 2019

Genesis of a virus-transforming gene

scientific article published on May 1, 1978

Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival

scientific article

Genetic mapping of the cloned subgroup A avian sarcoma and leukosis virus receptor gene to the TVA locus

scientific article

Genomic empowerment: the importance of public databases ⬇️

scientific article published on September 1, 2003

Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA ⬇️

scientific article published on July 1, 1977

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

scientific article

Harold E. Varmus, MD.

scientific article published in June 1995

Harold Varmus [interview by Karen Birmingham]

scientific article published in January 2001

Harold Varmus, director, National Institutes of Health. Interview by Richard Horton

scientific article published in January 1994

Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases

scientific article published on October 1979

Highly conserved amino acids in the SH2 and catalytic domains of v-src are altered in naturally occurring, transformation-defective alleles.

scientific article published on January 1994

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma ⬇️

scientific article published on March 1, 1983

Homologies among the nucleotide sequences of the genomes of C-type viruses

scientific article published on 01 April 1974

Homologous recombination between hepadnaviral genomes following in vivo DNA transfection: implications for studies of viral infectivity

scientific article published on 01 August 1987

Hormonal regulation of the Rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformation

scientific article published in October 1984

How Cancer Genomics Drives Cancer Biology: Does Synthetic Lethality Explain Mutually Exclusive Oncogenic Mutations?

scientific article

Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture.

scientific article

Human immunodeficiency virus type 1 gag-pol frameshifting is dependent on downstream mRNA secondary structure: demonstration by expression in vivo ⬇️

scientific article published on August 1, 1992

Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection.

scientific article published in February 1996

Human immunodeficiency viruses

scientific article published on 01 May 1986

INFORMATION ACCESS: Building A "GenBank" of the Published Literature

scientific article (publication date: 23 March 2001)

Identification and characterization of dimeric and trimeric circular forms of avian sarcoma virus-specific DNA ⬇️

scientific article published on June 1, 1980

Identification and preliminary characterization of novel small molecules that inhibit growth of human lung adenocarcinoma cells

scientific article

Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells

scientific article

Identification of a provirally activated c-Ha-ras oncogene in an avian nephroblastoma via a novel procedure: cDNA cloning of a chimaeric viral-host transcript

scientific article

Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification.

scientific article

Identification of protein products encoded by the proto-oncogene int-1

scientific article published on November 1987

In vitro recombinants of ground squirrel and woodchuck hepatitis viral DNAs produce infectious virus in squirrels

scientific article published on October 1987

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

scientific article

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system

scientific article

Infection of cultured rat hepatoma cells by mouse mammary tumor virus ⬇️

scientific article published on January 1, 1977

Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

scientific article

Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide.

scientific article

Insurance for broad genomic tests in oncology

scientific article published in December 2017

Integrating cancer control into global health

scientific article published on September 2011

Integration and expression of several molecular forms of Rous sarcoma virus DNA used for transfection of mouse cells

scientific article published on July 1984

Integration and transcription of mouse mammary tumor virus DNA in rat hepatoma cells ⬇️

scientific article published on February 1, 1979

Integration of avian sarcoma virus DNA in chicken cells

scientific article

Integration of avian sarcoma virus specific DNA in mammalian chromatin ⬇️

scientific article published on July 1, 1975

Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts

scientific article

Integration of the DNA of mouse mammary tumor virus in virus-infected normal and neoplastic tissue of the mouse ⬇️

scientific article published on February 1, 1979

Interaction of Wnt-1 proteins with the binding protein BiP

scientific article published on February 1992

Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models

scholarly article

Isolation of a chicken gene that confers susceptibility to infection by subgroup A avian leukosis and sarcoma viruses

scientific article published on April 1993

Isolation of duplicated human c-src genes located on chromosomes 1 and 20

scientific article

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

scientific article

Kinetics of synthesis, structure and purification of avian sarcoma virus-specific DNA made in the cytoplasm of acutely infected cells ⬇️

scientific article published on March 25, 1978

Lessons from the life cycle of retroviruses.

scientific article

Letter: Evidence for non-repetitive subunits in the genome of Rous sarcoma virus

scientific article published in March 1974

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

scientific article published on 08 February 2024

Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA ⬇️

scientific article published on July 1, 1983

Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma

scientific article

Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors

scientific article

Lung cancer signatures in plasma based on proteome profiling of mouse tumor models

scientific article

MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family

scientific article published on 12 January 2009

Mammary tumour virus specific nucleotide sequences in mouse DNA.

scientific article published in August 1972

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome ⬇️

scientific article (publication date: November 1982)

Mapping of linear and circular forms of mouse mammary tumor virus DNA with restriction endonucleases: evidence for a large specific deletion occurring at high frequency during circularization ⬇️

scientific article published on May 1, 1978

Mapping the major transcripts of ground squirrel hepatitis virus: the presumptive template for reverse transcriptase is terminally redundant

scientific article published in August 1985

Mapping unintegrated avian sarcoma virus DNA: Termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA ⬇️

scientific article published on December 1, 1978

Mechanism of translation of the hepadnaviral polymerase (P) gene

scientific article

Medicine. The need for a global HIV vaccine enterprise

scientific article

Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling

scientific article published on October 1999

Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase

scientific article published in June 1989

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15 ⬇️

scientific article published on January 12, 1984

Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes

scientific article

Molecular biology: Reverse transcriptase rides again

scientific article published in Nature

Molecular cloning and characterization of avian sarcoma virus circular DNA molecules ⬇️

scientific article published on October 1, 1980

Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites.

scientific article published on November 1990

Mouse mammary tumor virus DNA in infected rat cells: Characterization of unintegrated forms ⬇️

scientific article published on January 1, 1977

Mouse mammary tumor virus genes: Regulation of expression by glucocorticoids and structural analysis with restriction endonucleases ⬇️

scientific article published on March 1, 1978

Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4.

scientific article

Mouse mammary tumors express elevated levels of RNA encoding the murine homology of SKY, a putative receptor tyrosine kinase

scientific article published on March 1995

Multiple alpha and beta tubulin genes represent unlinked and dispersed gene families

scientific article published on 01 March 1981

Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas ⬇️

scientific article published on January 21, 1982

Mutants of rous sarcoma virus with extensive deletions of the viral genome ⬇️

scientific article published on July 30, 1979

Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4

scientific article

Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line

scientific article published on May 1992

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma

scientific article published on 04 October 2016

Mutations associated with familial melanoma impair p16INK4 function.

scientific article published in May 1995

Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells

scientific article

NIH R&D priorities

scientific article published on 01 June 1994

NIH cancer chief wants more with less: by Meredith Wadman

scientific article published on 6 July 2011

NIH review of gene therapy protocols

scientific article published in March 1995

National Cancer Institute-supported clinical trials networks

scientific article published in December 2014

National Institutes of Health in the tropics.

scientific article published in July 1998

Newsmaker interview: Harold Varmus. Piloting cancer research with a shrinking budget. Interview by Jocelyn Kaiser

scientific article published in July 2011

Nobel lecture. Retroviruses and oncogenes. I.

scientific article published on October 1990

Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin

scientific journal article

Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection

scientific article published on May 29, 1992

Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene

scientific article published on December 1985

Nucleotide sequence homologies among mouse mammary tumor viruses

scientific article

Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product ⬇️

scientific article published on September 18, 1980

Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus ⬇️

scientific article published on August 1, 1984

Nucleotide sequence of cloned unintegrated avian sarcoma virus DNA: viral DNA contains direct and inverted repeats similar to those in transposable elements ⬇️

scientific article published on January 1, 1981

Nucleotide sequence of the 5' noncoding region and part of the gag gene of Rous sarcoma virus ⬇️

scientific article published on February 1, 1982

Nucleotide sequences at host–proviral junctions for mouse mammary tumour virus ⬇️

scientific article published on January 22, 1981

Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates ⬇️

scientific article (publication date: September 1978)

Nucleotide sequencing of an apparent proviral copy of env mRNA defines determinants of expression of the mouse mammary tumor virus env gene ⬇️

scientific article published on September 1, 1983

Of birds and mice and men: comments on the use of animal models and molecular hybridization in the search for human tumor viruses

scientific article published on 01 October 1974

Of oncogenes and open science: an interview with Harold Varmus

Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras

scholarly article

Oncogenes and transcriptional control

scientific article published on December 1987

Oncogenes come of age.

scientific article published on January 2005

Opinion: Addressing systemic problems in the biomedical research enterprise

scientific article

Organization of Endogenous and Exogenous Viral and Linked Nonviral Sequences ⬇️

scientific article published on January 1, 1980

Organization of mouse mammary tumor virus-specific DNA endogenous to BALB/c mice ⬇️

scientific article published on November 1, 1979

Organization of the endogenous proviruses of chickens: Implications for origin and expression ⬇️

scientific article published on January 15, 1981

Origin and Function of Avian Retrovirus Transforming Genes ⬇️

scientific article published on January 1, 1980

Overexpression of the Sky receptor tyrosine kinase at the cell surface or in the cytoplasm results in ligand-independent activation.

scientific article

Overview of the Alliance for Cellular Signaling

scientific article

PLoS Medicine— A Medical Journal for the Internet Age

scientific article

Persistence and expression of Marek's disease virus DNA in tumour cells and peripheral nerves studied by in situ hybridization

scientific article published on December 1981

Planning of US AIDS research

scientific article published in Nature

Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as well as for reverse transcription ⬇️

scientific article published on April 5, 1990

Production of mouse mammary tumor virus by cultured cells in the absence and presence of hormones: assay by molecular hybridization

scientific article

Production of p60c-src by baculovirus expression and immunoaffinity purification

scientific article published on January 1991

Progress toward public access to science

scientific article published in April 2008

Proposal for Naming Host Cell-Derived Inserts in Retrovirus Genomes ⬇️

scientific article published on December 1, 1981

Proviral deletions and oncogene base-substitutions in insertionally mutagenized c-myc alleles may contribute to the progression of avian bursal tumors ⬇️

scientific article published on February 1, 1984

Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites

scientific article published on December 1978

Proviruses of mouse mammary tumor virus in normal and neoplastic tissues from GR and C3Hf mouse strains ⬇️

scientific article published on August 1, 1980

Public health. Proliferation of National Institutes of Health

scientific article published on 01 March 2001

Public health. Grand Challenges in Global Health

scientific article

Public-access group supports PubMed Central

scientific article (publication date: 12 September 2002)

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

scientific article

Purification and translation of murine mammary tumor virus mRNA's ⬇️

scientific article published on July 1, 1981

Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses ⬇️

scientific article published on March 5, 1976

Purification of DNA complementary to the env gene of avian sarcoma virus and analysis of relationships among the env genes of avian leukosis-sarcoma viruses ⬇️

scientific article published on February 1, 1977

RNA complementary to the genome of RNA tumor viruses in virions and virus-producing cells ⬇️

scientific article published on October 1, 1976

RNA viruses: Reverse transcription in plants? ⬇️

scientific article published on July 14, 1983

RNA-directed DNA synthesis by virions of Rous sarcoma virus: further characterization of the templates and the extent of their transcription

scientific article published in March 1973

Rearrangement at the 5' end of amplified c-myc in human COLO 320 cells is associated with abnormal transcription

scientific article published on July 1986

Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis

scientific article

Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer

scientific article

Regulation of HIV and HTLV gene expression

scientific article published on September 1988

Regulation of Mouse Mammary Tumor Virus Gene Expression by Glucocorticoid Hormones ⬇️

scientific article published on January 1, 1979

Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin

scientific journal article

Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a

scientific article

Regulation of gene expression in Escherichia coli by cyclic AMP.

scientific article

Regulation of inducible enzyme synthesis in Escherichia coli by cyclic adenosine 3', 5'-monophosphate

scientific article published in November 1969

Regulation of lac mRNA synthesis in a soluble cell-free system

scientific article

Regulation of lac messenger ribonucleic acid synthesis by cyclic adenosine 3',5'-monophosphate and glucose

scientific article published in May 1970

Regulation of lac transcription in Escherichia coli by cyclic adenosine 3',5'-monophosphate. Studies with deoxyribonucleic acid-ribonucleic acid hybridization and hybridization competition.

scientific article

Regulation of lac transcription in antibiotic-treated E. coli.

scientific article

Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction

scientific article

Repair of lesions which cause premature termination of transcription in chicken embryo cells irradiated with ultraviolet light ⬇️

scientific article published on July 30, 1981

Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity

scientific journal article

Requirement for a Nuclear Function of β-Catenin in Wnt Signaling ⬇️

scientific article published on December 1, 2003

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk

scientific article

Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice

scientific article

Rescuing US biomedical research from its systemic flaws

scientific article

Restriction endonuclease mapping of the DNA of Rous-Associated virus 0 reveals extensive homology in structure and sequence with avian sarcoma virus DNA ⬇️

scientific article published on January 15, 1981

Retraction. Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites

scientific article published in December 1991

Retroviral DNA integrated during infection by an integration-deficient mutant of murine leukemia virus is oligomeric.

scientific article published on June 1987

Retroviral integration into minichromosomes in vitro ⬇️

scientific article published on January 1, 1992

Retroviral integration machinery as a probe for DNA structure and associated proteins.

scientific article published in January 1993

Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein

scientific journal article

Retroviruses

scientific article

Retroviruses as mutagens: Insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus ⬇️

scientific article published on July 1, 1981

Reverse transcription

scientific article published on September 1987

Reverse transcription in bacteria

scientific article published on March 1989

Revertants of an ASV-transformed rat cell line have lost the complete provirus or sustained mutations insrc ⬇️

scientific article published on January 15, 1981

Revitalization of the Warren G. Magnuson Clinical Center at the National Institutes of Health

scientific article published on May 1998

Ribonucleic acid directed deoxyribonucleic acid synthesis by the purified deoxyribonucleic acid polymerase of Rous sarcoma virus. Characterization of the enzymatic product

scientific article

SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src

scientific article published on December 1990

Science and the new administration

scientific article

Science funding: Provocative questions in cancer research

scientific article published in Nature

Seeding and propagation of untransformed mouse mammary cells in the lung

scientific article

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins

scientific article

Shattuck Lecture--biomedical research enters the steady state.

scientific article published on September 1995

Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region

scientific article

Simian virus 40 minichromosomes as targets for retroviral integration in vivo ⬇️

scientific article published on October 1, 1992

Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro

scientific article published in January 1993

Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src

scientific article

Somatic mutations affect key pathways in lung adenocarcinoma

scientific article

Statement on scientific publication and security.

scientific article

Statement on the consideration of biodefence and biosecurity

scientific article published in Nature

Stimulation of lac mRNA synthesis by cyclic AMP in cell free extracts of Escherichia coli

scientific article published on 01 March 1970

Structural analysis of the intracellular RNAs of murine mammary tumor virus ⬇️

scientific article published on May 1, 1979

Structural and functional studies of retroviral RNA pseudoknots involved in ribosomal frameshifting: nucleotides at the junction of the two stems are important for efficient ribosomal frameshifting.

scientific article published on February 1995

Structure and variability of human chromosome ends

scientific article

Structure of a replication intermediate in the synthesis of Rous sarcoma virus DNA in vivo.

scientific article published on April 1982

Structure of viral DNA and RNA in mammalian cells infected with avian sarcoma virus ⬇️

scientific article published on November 15, 1980

Structures of unintegrated and integrated forms of the deoxyribonucleic acid of ribonucleic acid tumour viruses

scientific article published on January 1, 1979

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

scientific article

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines

scientific article

Synthesis of plus strands of retroviral DNA in cells infected with avian sarcoma virus and mouse mammary tumor virus ⬇️

scientific article published on January 1, 1981

Synthesis of viral DNA in the cytoplasm of duck embryo fibroblasts and in enucleated cells after infection by avian sarcoma virus

scientific article

Synthesis, Structure, and Integration of the DNA of RNA Tumor Viruses ⬇️

scientific article published on January 1, 1979

Synthesis, structure and function of avian sarcoma virus-specific DNA in permissive and nonpermissive cells

scientific article published on January 1975

Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation

scientific article published on July 1996

The National Institutes of Health and clinical research: a progress report

scientific article published on 01 November 2000

The Pastorian: a legacy of Louis Pasteur.

scientific article

The Wnt-1 proto-oncogene induces changes in morphology, gene expression, and growth factor responsiveness in PC12 cells

scientific article published on November 1993

The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma

scientific article published on February 2005

The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer

scientific article published on 17 December 2003

The challenge of making laws on the shifting terrain of science

scientific article published on 01 January 2000

The classic: integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts: (RNA tumor viruses/reassociation kinetics/duck cells). 1973

scientific article published on 3 July 2008

The cloned genome of ground squirrel hepatitis virus is infectious in the animal

scientific article published on September 1984

The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant

scientific article published on June 1988

The genesis of rous sarcoma virus messenger RNAs ⬇️

scientific article published on July 30, 1981

The impact of open access on biomedical research

scientific article

The importance of DNA size for successful transfection of chicken embryo fibroblasts

scientific article

The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway

scientific article published on November 1987

The knockout mouse project

scientific article

The leader sequence of the subgenomic mRNA's of Rous sarcoma virus is approximately 390 nucleotides ⬇️

scientific article published on February 1, 1982

The molecular biology of the hepatitis B viruses

scientific article published on January 1987

The molecular genetics of cellular oncogenes

scientific article published on January 1984

The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells

scientific article published on January 1992

The new era in cancer research

scientific article

The nucleotide sequence of an untranslated but conserved domain at the 3′ end of the avian sarcoma virus genome ⬇️

scientific article published on July 11, 1980

The origin and structure of endogenous retroviral DNA ⬇️

scientific article published on 01 January 1980

The persistence and expression of virus-specific DNA in revertants of Rous sarcoma virus-transformed BHK-21 cells

scientific article published in December 1974

The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid

scientific article published on May 1987

The presence and expression of RNA tumor virus genes in normal and infected cells: detection by molecular hybridization

scientific article published in July 1973

The purified product of the transforming gene of avian sarcoma virus phosphorylates tyrosine ⬇️

scientific article published on December 25, 1980

The receptor for the subgroup A avian leukosis-sarcoma viruses binds to subgroup A but not to subgroup C envelope glycoprotein.

scientific article

The replication of subgroup E avian retroviruses is blocked at or before viral DNA synthesis in restrictive chicken cells ⬇️

scientific article published on December 1, 1979

The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model

scientific article published on January 1996

The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis viruses ⬇️

scientific article published on December 1, 1977

The spirit of Dakar: a call for action on malaria

scientific article (publication date: 10 April 1997)

The src protein contains multiple domains for specific attachment to membranes

scientific article

The structure and protein kinase activity of proteins encoded by nonconditional mutants and back mutants in thesrc gene of avian sarcoma virus ⬇️

scientific article published on January 15, 1981

The terminal redundancy of the retrovirus genome facilitates chain elongation by reverse transcriptase ⬇️

scientific article published on February 10, 1981

The vertebrate homolog of the putative transforming gene of avian myelocytomatosis virus: Characteristics of the DNA locus and its RNA transcript ⬇️

scientific article published on September 1, 1980

Three decades of Wnts: a personal perspective on how a scientific field developed

scientific article

Transcription of mouse mammary tumor virus genes in tissues from high and low tumor incidence mouse strains

scientific article published in October 1973

Transcription of ribonucleic acid by the ribonucleic acid directed deoxyribonucleic acid polymerase of Rous sarcoma virus and deoxyribonucleic acid polymerase I of Escherichia coli

scientific article published in January 1973

Transcription of the Rous sarcoma virus genome in vitro and in vivo

scientific article published on January 1975

Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region ⬇️

scientific article published on May 1, 1984

Transduction of a cellular oncogene: the genesis of Rous sarcoma virus ⬇️

scientific article published on May 1, 1983

Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice

scientific article published on January 1992

Transgenic mice and host cell mutants resistant to transformation as model systems for identifying multiple components in oncogenesis

scientific article

Transmission of ground squirrel hepatitis virus to homologous and heterologous hosts

scientific article

Two cellular proteins that immunoprecipitate with the transforming protein of Rous sarcoma virus ⬇️

scientific article published on September 1, 1981

Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins

scientific article

Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development

scientific article published on October 1986

Two wnt genes in Caenorhabditis elegans

scientific article published on July 1993

US support for malaria research ⬇️

scientific article published on July 31, 1997

Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.

scientific article published on 10 January 2012

Uncensored exchange of scientific results

scholarly article

Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses

scientific article published on February 1978

Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src) ⬇️

scientific article published on April 1, 1979

Unintegrated viral DNA is synthesized in the cytoplasm of avian sarcoma virus-transformed duck cells by viral DNA polymerase ⬇️

scientific article published on May 1, 1976

Use of DNA-DNA annealing to detect new virus-specific DNA sequences in chicken embryo fibroblasts after infection by avian sarcoma virus

scientific article published on October 1974

Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer

scientific article

Use of alkaline sucrose gradients in a zonal rotor to detect integrated and unintegrated avian sarcoma virus-specific DNA in cells ⬇️

scientific article published on May 1, 1976

Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance

scientific article

Using retroviruses as insertional mutagens to identify cellular oncogenes.

scientific article published on January 1983

Varmus Returns to His Roots in Cancer Genetics

scientific article published in July 2015

Varmus: the view from Bethesda. Interview by Eliot Marshall

scientific article

View from the top of a biomedical empire. Interview by Eliot Marshall

scientific article

Virion DNA of ground squirrel hepatitis virus: structural analysis and molecular cloning ⬇️

scientific article published on October 1, 1982

Virus-specific DNA in the cytoplasm of avian sarcoma virus-infected cells is a precursor to covalently closed circular viral DNA in the nucleus ⬇️

scientific article published on January 1, 1978

Virus-specific messenger RNAs in permissive cells infected by avian sarcoma virus ⬇️

scientific article published on August 25, 1979

Viruses, genes, and cancer. I. The discovery of cellular oncogenes and their role in neoplasia

scientific article

What to call the AIDS virus?

scientific article

Why PLoS became a publisher

scientific article

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival

scientific article

Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys

scientific article published on 01 April 1996

Winning the arguments on Capitol Hill

journal article; published in Nature on 2009-10-07

Wnt genes

scientific article

Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.

scientific article published on October 2004

Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors

scientific article

Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host

scientific article published on April 1991

YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.

scientific article published on 6 June 2018

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism

scientific article

env Gene of Chicken RNA Tumor Viruses: Extent of Conservation in Cellular and Viral Genomes ⬇️

scientific article published on September 1, 1978

rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases

scientific article

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