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List of works by Detlef Zillikens

(MIF) Drives Murine Psoriasiform Dermatitis

59/f with oral and nasal mucosal erosions : Preparation for the specialist examination: part 18

scientific article published on 01 November 2018

A comparison of oral methylprednisolone plus azathioprine or mycophenolate mofetil for the treatment of bullous pemphigoid

scientific article

A distinct cutaneous microbiota profile in autoimmune bullous disease patients

scientific article published on 18 April 2017

A family with atypical Hailey Hailey disease--is there more to the underlying genetics than ATP2C1?

scientific article

A highly sensitive and simple assay for the detection of circulating autoantibodies against full-length bullous pemphigoid antigen 180.

scientific article published in June 2002

A recombinant fusion protein derived from dog hookworm inhibits autoantibody-induced dermal-epidermal separation ex vivo

scientific article

Aberrant expression and secretion of heat shock protein 90 in patients with bullous pemphigoid

scientific article

Allelic and copy-number variations of FcγRs affect granulocyte function and susceptibility for autoimmune blistering diseases

scientific article published on 29 May 2015

Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1.

scientific article

Anti-p200 pemphigoid

scientific article published on 24 April 2014

Anti-p200 pemphigoid: a novel autoimmune subepidermal blistering disease

scientific article published on January 2007

Autoantibodies against epidermal transglutaminase are a sensitive diagnostic marker in patients with dermatitis herpetiformis on a normal or gluten-free diet

scientific article published on 2 April 2009

Autoantibodies to type VII collagen mediate Fcgamma-dependent neutrophil activation and induce dermal-epidermal separation in cryosections of human skin

scientific article published on July 2002

Autoantibody-induced intestinal inflammation and weight loss in experimental epidermolysis bullosa acquisita

scientific article published on 7 March 2011

Autoimmune responses in patients with linear IgA bullous dermatosis: both autoantibodies and T lymphocytes recognize the NC16A domain of the BP180 molecule

scientific article

Autoimmune subepidermal blistering diseases in Uganda: correlation of autoantibody class with age of patients

scientific article published on September 2006

Automated direct immunofluorescence analyses of skin biopsies

scientific article published on 5 November 2015

Autoreactive T cell responses in pemphigus and pemphigoid

scientific article

B cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita

scientific article published on 19 August 2013

BP180 as the common autoantigen in blistering diseases with different clinical phenotypes.

scientific article

Barrier function and natural moisturizing factor levels after cumulative exposure to a fruit-derived organic acid and a detergent: different outcomes in atopic and healthy skin and relevance for occupational contact dermatitis in the food industry

scientific article published in October 2015

Bullous rheumatoid neutrophilic dermatosis

scientific article published in May 2005

CD11b-deficient mice exhibit an increased severity in the late phase of antibody transfer-induced experimental epidermolysis bullosa acquisita

scientific article

Case of subepidermal blistering disease with autoantibodies to both laminin‐γ1 and laminin‐α3 ⬇️

scientific article published on March 12, 2013

Childhood Epidermolysis Bullosa Acquisita: Confirmation of Diagnosis by Skin Deficient in Type VII Collagen, Enzyme-linked Immunosorbent Assay, and Immunoblotting

scientific article published on May 2016

Cicatricial pemphigoid with circulating IgA and IgG autoantibodies to the central portion of the BP180 ectodomain: Beneficial effect of adjuvant therapy with high-dose intravenous immunoglobulin ⬇️

scientific article published on January 1, 2002

Clinical and immunopathological spectrum of paraneoplastic pemphigus

scientific article published on 18 February 2010

Clinical course, treatment modalities, and quality of life in patients with congenital melanocytic nevi - data from the German CMN registry

scientific article

Clinical, histological and immunpathological findings in 32 patients with dermatitis herpetiformis Duhring

scientific article published on 28 October 2009

Concomitant Bullous Pemphigoid and Dermatitis Herpetiformis ⬇️

scientific article published on June 14, 2013

Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus

scientific article

Correlation of Serum Levels of IgE Autoantibodies Against BP180 With Bullous Pemphigoid Disease Activity

scientific article published on 9 November 2016

Current status on B-cell depletion therapy in autoimmune diseases other than rheumatoid arthritis

scientific article published on 27 August 2009

Current therapy of the pemphigus group ⬇️

scientific article published on January 1, 2012

Current treatments and developments in pemphigoid diseases as paradigm diseases for autoantibody-driven, organ-specific autoimmune diseases

scientific article published on 7 April 2016

Development of ELISA for the specific determination of autoantibodies against envoplakin and periplakin in paraneoplastic pemphigus

scientific article

Development of NC1 and NC2 domains of type VII collagen ELISA for the diagnosis and analysis of the time course of epidermolysis bullosa acquisita patients

scientific article

Development of an ELISA for the detection of autoantibodies to BP230.

scientific article

Diagnosis and clinical severity markers of bullous pemphigoid ⬇️

scientific article published on February 24, 2009

Diagnosis of Autoimmune Blistering Diseases

Diagnosis of autoimmune bullous skin diseases.

scientific article published on January 2008

Differential role for mitogen-activated protein kinases in IgE-dependent signaling in human peripheral blood basophils: in contrast to p38 MAPK, c-Jun N-terminal kinase is poorly expressed and does not appear to control mediator release

scientific article published on 28 February 2005

Dimethylfumarate Impairs Neutrophil Functions

scientific article published in January 2016

Disorganization of the desmin cytoskeleton and mitochondrial dysfunction in plectin-related epidermolysis bullosa simplex with muscular dystrophy

scientific article published in June 2002

Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease

scientific article published on 16 February 2016

Effects of intravenous immunoglobulins on mice with experimental epidermolysis bullosa acquisita

scientific article published on 20 October 2014

Efficacy and safety of rituximab in pemphigus: experience of the German Registry of Autoimmune Diseases ⬇️

scientific article published on May 11, 2012

EndoS reduces the pathogenicity of anti-mCOL7 IgG through reduced binding of immune complexes to neutrophils

scientific article

Epidermolysis bullosa acquisita: what's new?

scientific article published on March 2010

European Guidelines (S1) on the use of high-dose intravenous immunoglobulin in dermatology.

scientific article published on 30 December 2016

Europäische Leitlinien (S1) für die Anwendung von hochdosierten intravenösen Immunglobulinen in der Dermatologie

scientific article published on 01 February 2017

Experimental Laminin 332 Mucous Membrane Pemphigoid Critically Involves C5aR1 and Reflects Clinical and Immunopathological Characteristics of the Human Disease

scientific article published on 26 April 2017

Extracellular cleavage of bullous pemphigoid antigen 180/type XVII collagen and its involvement in hemidesmosomal disassembly

scientific article published on February 2003

Fcγ receptors III and IV mediate tissue destruction in a novel adult mouse model of bullous pemphigoid

scientific article published in August 2014

Follicular and cystic regression of locally advanced basal cell carcinoma following short-term neoadjuvant vismodegib therapy

scientific article

Follikuläre und zystische Regression eines lokal fortgeschrittenen Basalzellkarzinoms nach kurzfristiger neoadjuvanter Therapie mit Vismodegib

scientific article published in October 2017

From anti-p200 pemphigoid to anti-laminin gamma1 pemphigoid

scientific article published on March 2010

GM-CSF modulates autoantibody production and skin blistering in experimental epidermolysis bullosa acquisita

scientific article published on 11 December 2013

Gene Expression Analysis Reveals Novel Shared Gene Signatures and Candidate Molecular Mechanisms between Pemphigus and Systemic Lupus Erythematosus in CD4+ T Cells

scientific article published in January 2017

Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

scientific article published on 10 September 2019

Generalized Netlike Erythema and Stroke in a Young Female

scientific article published on 13 September 2017

Generation and characterization of monoclonal antibodies against the intracellular domain of hemidesmosomal type XVII collagen

scientific article published on June 2006

Genetic control of psoriasis is relatively distinct from that of metabolic syndrome and coronary artery disease

scientific article published in August 2013

Genomewide association study identifies GALC as susceptibility gene for mucous membrane pemphigoid

scientific article

Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid

scientific article published in December 2004

Heat shock protein 90 inhibition: A potential double- or triple-edged sword in the treatment of mucous membrane pemphigoid

scientific article published on 27 June 2015

Heat shock protein 90 is required for ex vivo neutrophil-driven autoantibody-induced tissue damage in experimental epidermolysis bullosa acquisita

scientific article published on 25 March 2015

Heat shock protein 90: a pathophysiological factor and novel treatment target in autoimmune bullous skin diseases

scientific article published on 03 June 2015

High-dose intravenous immunoglobulin (IVIG) therapy in autoimmune skin blistering diseases

scientific article published on April 2010

Histopathology of anti-p200 pemphigoid

scientific article published in April 2007

Hsp90 blockade modulates bullous pemphigoid IgG-induced IL-8 production by keratinocytes

scientific article published on 6 May 2014

Identification of a Functional Risk Variant for Pemphigus Vulgaris in the ST18 Gene

scientific article

IgE-Selective Immunoadsorption for Severe Atopic Dermatitis

scientific article published on 12 February 2018

IgE-mediated mechanisms in bullous pemphigoid and other autoimmune bullous diseases

scientific article

IgG4 autoantibodies induce dermal-epidermal separation

scientific article

Immunoadsorption in Dermatology ⬇️

scientific article published on May 15, 2012

Immunoadsorption in dermatology

scientific article published on 05 January 2010

Immunoadsorption of Desmoglein-3-Specific IgG Abolishes the Blister-Inducing Capacity of Pemphigus Vulgaris IgG in Neonatal Mice

Immunoblotting and enzyme-linked immunosorbent assay for the diagnosis of pemphigoid gestationis

scientific article published in April 2004

Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen

scientific article

Inhibition of Rho A activity causes pemphigus skin blistering

scientific article published on 27 November 2006

Inhibitory effects of heat shock protein 90 blockade on proinflammatory human Th1 and Th17 cell subpopulations

scientific article

Initial Fc epsilon RI-mediated signal strength plays a key role in regulating basophil signaling and deactivation

scientific article

Intravenous Immunoglobulins for Rituximab-resistant Mucous Membrane Pemphigoid

scientific article published on 14 February 2018

Krankheitsverlauf, medizinische Versorgung und Lebensqualität von Patienten mit kongenitalen melanozytären Nävi - Auswertung des deutschsprachigen KMN-Registers

scientific article published in February 2017

Lack of a specific humoral autoreactivity in sera from patients with early erythema exsudativum multiforme majus

scientific article published on 6 June 2013

Linear IgA disease: successful application of immunoadsorption and review of the literature

scientific article published on 03 February 2010

Localisation of bullous pemphigoid antigen 180 (BP180) in cultured human keratinocytes: functionally relevant modification by calcium

scientific article published on 12 August 2006

Localized linear IgA disease induced by ampicillin/sulbactam

scientific article published in July 2004

Macrophages, but not T and B lymphocytes, are critical for subepidermal blister formation in experimental bullous pemphigoid: macrophage-mediated neutrophil infiltration depends on mast cell activation

scientific article published in October 2002

Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus

scientific article published on 13 October 2017

Mechanisms of blister induction by autoantibodies

scientific article

Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex vivo human skin

scientific article

Melatonin enhances mitochondrial ATP synthesis, reduces reactive oxygen species formation, and mediates translocation of the nuclear erythroid 2-related factor 2 resulting in activation of phase-2 antioxidant enzymes (γ-GCS, HO-1, NQO1) in ultraviol

scientific article published on 27 April 2016

Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission

scientific article

Meta-analysis of the clinical and immunopathological characteristics and treatment outcomes in epidermolysis bullosa acquisita patients

Methylprednisolone blocks autoantibody-induced tissue damage in experimental models of bullous pemphigoid and epidermolysis bullosa acquisita through inhibition of neutrophil activation

scientific article published on 28 February 2013

Modern diagnosis of autoimmune blistering skin diseases

scientific article published on 14 August 2010

Multiple and repeated sampling increases the sensitivity of direct immunofluorescence testing for the diagnosis of mucous membrane pemphigoid

scientific article

N-linked glycosylation on laminin γ1 influences recognition of anti-laminin γ1 pemphigoid autoantibodies

scientific article published on 5 January 2015

Nadroparin carries a potentially high risk of inducing cutaneous delayed-type hypersensitivity responses

scientific article

Nerve growth factor influences IgE-mediated human basophil activation: functional properties and intracellular mechanisms compared with IL-3.

scientific article published in April 2005

Neutrophil adhesion is a prerequisite for antibody-mediated proteolytic tissue damage in experimental epidermolysis bullosa acquisita

scientific article published on 17 March 2018

Non-Uremic Calciphylaxis

scientific article

Novel ELISA systems for antibodies to desmoglein 1 and 3: correlation of disease activity with serum autoantibody levels in individual pemphigus patients

scientific article

PDE4 Inhibition as Potential Treatment of Epidermolysis Bullosa Acquisita

scientific article published on 4 July 2016

PI3Kβ plays a critical role in neutrophil activation by immune complexes

scientific article

Pathogenesis of Epidermolysis Bullosa Acquisita ⬇️

scientific article published on July 1, 2011

Pemphigoid diseases

scientific article published on 11 December 2012

Pemphigoid diseases: pathogenesis, diagnosis, and treatment

scientific article published on September 19, 2011

Pemphigoid gestationis: Toward a better understanding of the etiopathogenesis

scientific article published on 9 February 2016

Pemphigoid gestationis: new insights into the pathogenesis lead to novel diagnostic tools

scientific article

Pemphigus

scholarly article

Pemphigus IgG causes skin splitting in the presence of both desmoglein 1 and desmoglein 3.

scientific article

Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction

scientific article

Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction

scientific article

Periodontitis in oral pemphigus and pemphigoid: A systematic review of published studies

scientific article published on 28 December 2016

Polymorphisms in the mitochondrially encoded ATP synthase 8 gene are associated with susceptibility to bullous pemphigoid in the German population

scientific article

Population-Specific Association between a Polymorphic Variant in ST18, Encoding a Pro-Apoptotic Molecule, and Pemphigus Vulgaris

Prevalence and Age Distribution of Pemphigus and Pemphigoid Diseases in Germany

scientific article

Profibrotic phenotype of conjunctival fibroblasts from mucous membrane pemphigoid

scientific article

Prospective analysis of the incidence of autoimmune bullous disorders in Lower Franconia, Germany

scientific article published on 19 January 2009

Prospective analysis of the incidence of autoimmune bullous disorders in Lower Franconia, Germany

article

Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita

scientific article

Rapid remission of symptomatic brain metastases in melanoma by programmed-death-receptor-1 inhibition

scientific article published on 30 May 2016

Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction

scientific article

Recombinant human IgA1 and IgA2 autoantibodies to type VII collagen induce subepidermal blistering ex vivo

scientific article

Recombinant soluble CD32 suppresses disease progression in experimental epidermolysis bullosa acquisita

scientific article published on 20 October 2014

Recommendations for the use of immunoapheresis in the treatment of autoimmune bullous diseases

scientific article

Recommendations for the use of rituximab (anti-CD20 antibody) in the treatment of autoimmune bullous skin diseases

scientific article published on 14 January 2008

Reduced skin blistering in experimental epidermolysis bullosa acquisita after anti-TNF treatment

scientific article published on 20 December 2016

Regulatory T Cells Suppress Inflammation and Blistering in Pemphigoid Diseases

scientific article

Repetitive immunization breaks tolerance to type XVII collagen and leads to bullous pemphigoid in mice

scientific article published on 24 June 2011

Research in practice: diagnosis of subepidermal autoimmune bullous disorders

scientific article published on 22 January 2009

Response to imatinib mesylate depends on the presence of the V559A-mutated KIT oncogene

scientific article published in January 2010

Results of a survey of German dermatologists on the therapeutic approaches to pemphigus and bullous pemphigoid

scientific article

Risk factors for lethal outcome in patients with bullous pemphigoid: low serum albumin level, high dosage of glucocorticosteroids, and old age.

scientific article

Rituximab in severe pemphigus

scientific article published on September 2009

S2k guideline for the diagnosis of pemphigus vulgaris/foliaceus and bullous pemphigoid

scientific article published in July 2015

S2k guidelines for the treatment of pemphigus vulgaris/foliaceus and bullous pemphigoid

scientific article published in August 2015

Scarring autoimmune bullous disease in a Ugandan patient with autoantibodies to BP180, BP230, and laminin 5.

scientific article published on February 2006

Serological diagnosis of autoimmune bullous skin diseases: Prospective comparison of the BIOCHIP mosaic-based indirect immunofluorescence technique with the conventional multi-step single test strategy ⬇️

scientific article published on August 9, 2012

Serration pattern analysis for differentiating epidermolysis bullosa acquisita from other pemphigoid diseases

scientific article published on 15 November 2017

Serum levels of autoantibodies to desmoglein 3 in patients with therapy-resistant pemphigus vulgaris successfully treated with adjuvant intravenous immunoglobulins

scientific article published in January 2004

Severe mucous membrane involvement in epidermolysis bullosa simplex with muscular dystrophy due to a novel plectin gene mutation

scientific article published on 13 February 2004

Skin-Specific Drug Delivery: A Rapid Solution to Skin Diseases? ⬇️

scientific article published on September 1, 2013

Specific immunoadsorption of pathogenic autoantibodies in pemphigus requires the entire ectodomains of desmogleins

scientific article

Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation

scientific article

Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study

scientific article

Subacute prurigo variant of bullous pemphigoid: autoantibodies show the same specificity compared with classic bullous pemphigoid

scientific article

Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model

scientific article published on 14 October 2008

Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes

scientific article published on 10 October 2013

T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis

scientific article published in November 2004

T cells are required for the production of blister-inducing autoantibodies in experimental epidermolysis bullosa acquisita

scientific article published on 28 December 2009

Targeting IgE Antibodies by Immunoadsorption in Atopic Dermatitis

scientific article published on 19 February 2018

The 21st century renaissance of the basophil? Current insights into its role in allergic responses and innate immunity

scientific article published on November 2006

The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation

The Leukotriene B4 and its Receptor BLT1 Act as Critical Drivers of Neutrophil Recruitment in Murine Bullous Pemphigoid-Like Epidermolysis Bullosa Acquisita

scientific article published on 17 January 2017

The autoantigen of anti-p200 pemphigoid is an acidic noncollagenous N-linked glycoprotein of the cutaneous basement membrane

scientific article published in December 2003

The diagnosis and treatment of autoimmune blistering skin diseases

scientific article published on 10 June 2011

The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators

scientific article

The genetic difference between C57Bl/6J and C57Bl/6N mice significantly impacts Aldara™-induced psoriasiform dermatitis

scientific article published on 20 December 2016

The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts

The pathophysiology of bullous pemphigoid

scientific article published on October 2007

The relevance of the IgG subclass of autoantibodies for blister induction in autoimmune bullous skin diseases

scientific article published on 3 February 2007

Tissue Destruction in Bullous Pemphigoid Can Be Complement Independent and May Be Mitigated by C5aR2.

scientific article published on 15 March 2018

Topically applied low-dose calcitriol ameliorates atopic eyelid dermatitis

Transition from pemphigus foliaceus to bullous pemphigoid: intermolecular B-cell epitope spreading without IgG subclass shifting

scientific article published on August 2009

Treatment of bullous pemphigoid with dapsone, methylprednisolone, and topical clobetasol propionate: a retrospective study of 62 cases

scientific article published in September 2005

Trehalose conserves expression of bullous pemphigoid antigen 180 during desiccation and freezing

scientific article published on April 2003

Use of high-dose immunoglobulins in dermatology

scientific article

Vesicular pemphigoid in a 16-year-old boy ⬇️

scientific article published on October 1, 2003

Visualization of autoantibodies and neutrophils in vivo identifies novel checkpoints in autoantibody-induced tissue injury

scientific article published on 11 March 2020

ptRNApred: computational identification and classification of post-transcriptional RNA

scientific article published on 10 October 2014

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